GREMLIN Database
BDCR - HTH-type transcriptional repressor BdcR
UniProt: P39334 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12529
Length: 197 (179)
Sequences: 48266 (38528)
Seq/√Len: 2879.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_A50_P4.1971.00
32_K41_E4.0951.00
27_V45_Y3.7591.00
58_G62_G2.8381.00
29_F37_V2.4711.00
59_S62_G2.2381.00
43_T53_L2.1171.00
19_E70_E2.1081.00
28_L45_Y2.0701.00
24_A45_Y2.0421.00
18_P66_R2.0271.00
31_Q45_Y2.0081.00
28_L37_V1.9701.00
17_A20_Q1.9241.00
20_Q24_A1.8881.00
142_Y146_A1.8751.00
28_L41_E1.8721.00
88_P91_E1.8611.00
40_A44_D1.8301.00
28_L32_K1.7941.00
145_I148_R1.7941.00
26_K70_E1.7911.00
19_E23_S1.7751.00
186_M190_A1.7011.00
49_N52_S1.6951.00
24_A27_V1.6871.00
25_A29_F1.6681.00
138_E142_Y1.6451.00
39_V54_Y1.5971.00
39_V50_P1.5611.00
138_E154_Q1.5561.00
27_V31_Q1.5401.00
41_E44_D1.5211.00
66_R69_N1.5001.00
41_E45_Y1.4911.00
22_I66_R1.4791.00
98_K184_A1.4721.00
25_A63_L1.4661.00
26_K71_Y1.4581.00
140_T144_Y1.4541.00
70_E74_T1.4481.00
26_K67_V1.4371.00
159_F163_V1.4251.00
65_S69_N1.4181.00
33_G37_V1.3951.00
38_S41_E1.3931.00
69_N129_I1.3921.00
23_S70_E1.3731.00
16_F20_Q1.3531.00
37_V42_V1.3501.00
57_F66_R1.3371.00
143_D147_R1.3321.00
39_V53_L1.3121.00
94_V185_A1.3121.00
16_F19_E1.3071.00
29_F34_F1.2961.00
33_G36_A1.2951.00
18_P56_A1.2951.00
52_S55_A1.2661.00
62_G66_R1.2601.00
98_K181_C1.2581.00
94_V188_G1.2311.00
142_Y153_A1.2101.00
24_A28_L1.2051.00
152_R155_C1.2041.00
142_Y145_I1.2001.00
50_P54_Y1.1951.00
91_E95_E1.1891.00
94_V98_K1.1731.00
32_K36_A1.1691.00
144_Y149_H1.1671.00
48_I52_S1.1571.00
78_P99_E1.1551.00
24_A46_L1.1471.00
134_Y138_E1.1381.00
52_S56_A1.1221.00
90_G94_V1.1201.00
22_I67_V1.1121.00
53_L63_L1.1071.00
34_F64_F1.0991.00
51_P55_A1.0851.00
61_A65_S1.0801.00
162_T166_G1.0791.00
155_C182_A1.0751.00
22_I57_F1.0591.00
135_H139_T1.0561.00
62_G65_S1.0511.00
155_C186_M1.0501.00
179_Q182_A1.0501.00
69_N73_G1.0401.00
42_V63_L1.0361.00
92_C143_D1.0341.00
49_N55_A1.0341.00
25_A67_V1.0331.00
95_E98_K1.0151.00
54_Y59_S1.0121.00
32_K45_Y1.0041.00
23_S27_V1.0001.00
17_A56_A0.9981.00
145_I149_H0.9971.00
176_S179_Q0.9971.00
65_S125_Q0.9881.00
61_A123_D0.9841.00
144_Y148_R0.9741.00
14_R55_A0.9731.00
151_Q156_V0.9711.00
145_I150_P0.9691.00
78_P81_D0.9531.00
140_T143_D0.9381.00
26_K30_H0.9331.00
82_I99_E0.9201.00
129_I132_Q0.9161.00
117_E121_S0.9121.00
91_E94_V0.9101.00
15_R19_E0.9091.00
171_A174_G0.9071.00
103_R107_N0.9051.00
143_D146_A0.9041.00
185_A189_E0.8911.00
77_I81_D0.8911.00
70_E73_G0.8891.00
66_R70_E0.8881.00
139_T143_D0.8761.00
142_Y154_Q0.8741.00
99_E102_R0.8711.00
122_H126_A0.8681.00
71_Y74_T0.8661.00
43_T50_P0.8641.00
128_D132_Q0.8631.00
50_P55_A0.8621.00
181_C185_A0.8611.00
92_C147_R0.8581.00
107_N110_C0.8541.00
22_I70_E0.8501.00
116_L119_I0.8481.00
80_A84_R0.8441.00
95_E99_E0.8351.00
136_A139_T0.8291.00
92_C144_Y0.8251.00
145_I151_Q0.8201.00
82_I95_E0.8161.00
154_Q158_D0.8091.00
178_E182_A0.8081.00
153_A157_T0.8081.00
98_K102_R0.8041.00
184_A188_G0.8031.00
98_K185_A0.7971.00
76_A136_A0.7961.00
34_F60_K0.7921.00
20_Q23_S0.7881.00
155_C159_F0.7861.00
13_P17_A0.7821.00
127_R131_V0.7801.00
73_G77_I0.7771.00
80_A140_T0.7711.00
12_R16_F0.7681.00
17_A48_I0.7671.00
98_K188_G0.7671.00
20_Q46_L0.7611.00
155_C158_D0.7561.00
182_A186_M0.7541.00
44_D50_P0.7531.00
21_A46_L0.7531.00
76_A80_A0.7511.00
13_P16_F0.7501.00
137_A144_Y0.7441.00
12_R15_R0.7421.00
132_Q136_A0.7371.00
86_D92_C0.7341.00
32_K37_V0.7311.00
61_A125_Q0.7251.00
80_A136_A0.7251.00
180_L183_T0.7161.00
186_M189_E0.7121.00
146_A149_H0.7111.00
170_K174_G0.7081.00
185_A188_G0.7071.00
118_G121_S0.7041.00
124_P127_R0.7031.00
31_Q41_E0.7031.00
22_I26_K0.7031.00
21_A53_L0.6991.00
74_T77_I0.6931.00
39_V60_K0.6901.00
135_H138_E0.6881.00
39_V43_T0.6831.00
139_T142_Y0.6811.00
146_A153_A0.6781.00
23_S26_K0.6771.00
14_R17_A0.6751.00
40_A54_Y0.6731.00
144_Y147_R0.6691.00
34_F37_V0.6661.00
125_Q128_D0.6661.00
85_D95_E0.6611.00
46_L49_N0.6591.00
28_L31_Q0.6511.00
89_V144_Y0.6451.00
170_K173_E0.6441.00
102_R180_L0.6411.00
145_I153_A0.6391.00
21_A56_A0.6371.00
162_T165_S0.6371.00
86_D95_E0.6371.00
81_D85_D0.6321.00
159_F162_T0.6311.00
88_P149_H0.6231.00
124_P128_D0.6221.00
88_P92_C0.6201.00
165_S170_K0.6191.00
187_A190_A0.6191.00
27_V109_G0.6161.00
184_A187_A0.6141.00
97_L160_M0.6131.00
123_D126_A0.6091.00
178_E181_C0.6071.00
114_M117_E0.6051.00
12_R17_A0.6041.00
77_I80_A0.6031.00
163_V166_G0.5971.00
136_A140_T0.5851.00
162_T170_K0.5851.00
128_D131_V0.5851.00
26_K74_T0.5851.00
102_R106_Q0.5821.00
82_I86_D0.5811.00
183_T187_A0.5771.00
131_V135_H0.5761.00
17_A52_S0.5721.00
14_R56_A0.5721.00
125_Q129_I0.5721.00
130_A134_Y0.5691.00
138_E158_D0.5681.00
105_S180_L0.5681.00
34_F61_A0.5621.00
122_H125_Q0.5621.00
94_V97_L0.5621.00
117_E120_H0.5591.00
182_A185_A0.5501.00
177_I181_C0.5461.00
46_L50_P0.5421.00
133_Y137_A0.5421.00
17_A49_N0.5401.00
152_R156_V0.5401.00
100_A104_Y0.5391.00
29_F64_F0.5391.00
150_P153_A0.5391.00
163_V187_A0.5381.00
181_C184_A0.5381.00
65_S129_I0.5361.00
43_T49_N0.5311.00
129_I133_Y0.5301.00
28_L38_S0.5281.00
81_D99_E0.5251.00
82_I85_D0.5151.00
97_L164_M0.5131.00
112_G117_E0.5111.00
115_V120_H0.5091.00
123_D127_R0.5081.00
180_L184_A0.5081.00
50_P53_L0.5061.00
150_P156_V0.5051.00
113_C117_E0.5041.00
42_V46_L0.5021.00
102_R105_S0.5021.00
94_V189_E0.5021.00
14_R18_P0.5001.00
87_R95_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kz9A 2 0.9949 100 0.214 Contact Map
2oerA 2 0.9239 100 0.225 Contact Map
3dcfA 2 0.8985 100 0.227 Contact Map
2ibdA 2 0.934 100 0.233 Contact Map
4gckA 2 0.9239 100 0.237 Contact Map
4udsA 2 0.9086 100 0.24 Contact Map
3bruA 2 0.9137 100 0.24 Contact Map
3npiA 2 0.9289 100 0.241 Contact Map
3g7rA 2 0.9848 100 0.241 Contact Map
3g1oA 2 0.9239 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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