GREMLIN Database
YTFT - Inner membrane ABC transporter permease protein YtfT
UniProt: P39328 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12520
Length: 341 (269)
Sequences: 30980 (19371)
Seq/√Len: 1181.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_L235_L3.9681.00
119_I231_V3.6601.00
119_I235_L3.0841.00
96_T117_T2.9871.00
123_L231_V2.8921.00
212_I226_V2.8361.00
100_M113_S2.7141.00
74_T285_S2.6241.00
67_A185_A2.5781.00
205_I229_T2.5001.00
221_N224_I2.4991.00
131_I223_R2.4471.00
122_G234_G2.3811.00
118_G238_A2.3511.00
195_L201_L2.3161.00
224_I228_L2.2971.00
193_W197_R2.2251.00
194_L198_K2.1971.00
125_N143_L2.1861.00
123_L227_M2.1841.00
263_D296_N2.1581.00
204_F225_I2.1121.00
201_L228_L2.1001.00
127_I131_I2.0861.00
191_L195_L2.0281.00
91_A151_A2.0121.00
106_S109_I1.9811.00
69_L264_A1.9591.00
97_T114_A1.9451.00
115_L239_I1.9221.00
108_P112_L1.9101.00
118_G234_G1.8921.00
63_A293_Q1.7721.00
190_I194_L1.7701.00
97_T242_I1.7651.00
111_L242_I1.7621.00
208_V225_I1.7421.00
70_A285_S1.7031.00
76_V233_S1.6931.00
207_A215_A1.6831.00
145_V148_R1.6771.00
126_G227_M1.6371.00
75_L192_F1.6241.00
200_A204_F1.5911.00
67_A289_A1.5671.00
101_T110_V1.5641.00
172_S175_L1.5611.00
63_A290_L1.5551.00
263_D313_K1.5491.00
121_A147_G1.5371.00
78_A206_E1.5191.00
201_L205_I1.5041.00
92_I121_A1.4811.00
115_L242_I1.4801.00
213_R216_K1.4731.00
212_I216_K1.4551.00
99_A154_I1.4541.00
88_A148_R1.4441.00
131_I227_M1.4311.00
100_M103_A1.4251.00
100_M105_F1.4231.00
189_L286_V1.4191.00
69_L90_M1.4141.00
143_L147_G1.4051.00
228_L231_V1.3931.00
90_M244_V1.3911.00
204_F215_A1.3711.00
79_T229_T1.3681.00
204_F220_V1.3681.00
271_G284_L1.3541.00
281_N284_L1.3391.00
169_W172_S1.3331.00
72_G236_C1.3101.00
105_F109_I1.3061.00
109_I112_L1.3021.00
75_L229_T1.2921.00
55_S297_T1.2921.00
271_G288_G1.2901.00
68_L243_I1.2801.00
68_L240_A1.2801.00
168_S172_S1.2791.00
220_V225_I1.2571.00
71_I192_F1.2571.00
127_I227_M1.2451.00
215_A220_V1.2331.00
81_G136_P1.2291.00
227_M231_V1.2261.00
110_V114_A1.2231.00
81_G226_V1.2151.00
86_V237_A1.2151.00
130_A223_R1.2151.00
114_A118_G1.2091.00
67_A286_V1.2091.00
59_I293_Q1.2021.00
208_V222_T1.2011.00
252_D255_N1.2001.00
73_M264_A1.1991.00
96_T100_M1.1931.00
73_M268_V1.1931.00
112_L116_G1.1901.00
208_V215_A1.1891.00
165_P168_S1.1801.00
105_F113_S1.1791.00
171_G174_S1.1681.00
99_A155_T1.1651.00
116_G119_I1.1591.00
59_I294_G1.1501.00
81_G230_Y1.1431.00
231_V235_L1.1331.00
193_W198_K1.1301.00
173_G176_L1.1271.00
89_V121_A1.1221.00
197_R206_E1.1181.00
297_T300_L1.1051.00
70_A268_V1.1001.00
188_T236_C1.0991.00
70_A267_A1.0931.00
169_W174_S1.0921.00
97_T246_A1.0851.00
216_K223_R1.0751.00
169_W173_G1.0671.00
234_G238_A1.0601.00
296_N313_K1.0571.00
166_D169_W1.0561.00
63_A289_A1.0521.00
183_I187_L1.0451.00
78_A280_F1.0431.00
168_S171_G1.0421.00
57_I61_N1.0411.00
176_L183_I1.0411.00
120_L123_L1.0391.00
114_A242_I1.0371.00
95_A151_A1.0351.00
228_L232_L1.0311.00
130_A140_T1.0291.00
192_F232_L1.0281.00
95_A253_A1.0251.00
72_G86_V1.0241.00
128_L139_A1.0141.00
88_A147_G1.0131.00
267_A288_G1.0121.00
148_R152_Q1.0061.00
98_A102_V1.0041.00
190_I193_W1.0031.00
225_I228_L1.0031.00
216_K222_T1.0001.00
189_L236_C0.9881.00
308_M311_V0.9871.00
168_S174_S0.9861.00
232_L236_C0.9841.00
187_L191_L0.9841.00
119_I238_A0.9821.00
69_L240_A0.9811.00
125_N139_A0.9761.00
74_T268_V0.9751.00
260_L263_D0.9691.00
205_I225_I0.9671.00
144_M148_R0.9661.00
92_I96_T0.9611.00
83_D86_V0.9561.00
292_I313_K0.9561.00
283_L287_V0.9511.00
241_G245_A0.9491.00
87_G261_E0.9481.00
201_L225_I0.9421.00
267_A289_A0.9401.00
64_A182_V0.9361.00
180_T183_I0.9351.00
74_T280_F0.9351.00
127_I132_L0.9301.00
77_I268_V0.9161.00
94_G256_A0.9071.00
88_A144_M0.9031.00
233_S237_A0.9021.00
319_C323_V0.9001.00
299_I312_V0.8991.00
100_M110_V0.8971.00
193_W283_L0.8891.00
203_M206_E0.8831.00
112_L115_L0.8831.00
214_A218_A0.8811.00
224_I227_M0.8771.00
128_L132_L0.8751.00
65_P240_A0.8741.00
70_A289_A0.8731.00
54_G57_I0.8711.00
67_A189_L0.8701.00
185_A189_L0.8661.00
79_T205_I0.8661.00
89_V237_A0.8651.00
71_I188_T0.8621.00
76_V83_D0.8601.00
95_A155_T0.8601.00
133_K212_I0.8581.00
94_G245_A0.8571.00
56_P298_G0.8551.00
153_L308_M0.8481.00
87_G259_W0.8481.00
186_V190_I0.8441.00
99_A103_A0.8431.00
259_W263_D0.8431.00
208_V229_T0.8391.00
93_A114_A0.8381.00
93_A118_G0.8371.00
68_L185_A0.8371.00
287_V329_I0.8361.00
78_A197_R0.8361.00
150_V154_I0.8331.00
129_V139_A0.8301.00
73_M86_V0.8271.00
109_I113_S0.8271.00
97_T101_T0.8251.00
169_W175_L0.8251.00
115_L238_A0.8231.00
116_G120_L0.8211.00
181_P243_I0.8181.00
196_T205_I0.8171.00
75_L232_L0.8141.00
90_M260_L0.8131.00
237_A241_G0.8101.00
62_R66_V0.8081.00
279_R283_L0.8031.00
123_L127_I0.8031.00
222_T226_V0.7981.00
126_G130_A0.7981.00
211_N214_A0.7971.00
167_L171_G0.7961.00
96_T99_A0.7921.00
180_T184_I0.7901.00
93_A241_G0.7891.00
281_N285_S0.7881.00
124_W128_L0.7881.00
168_S175_L0.7871.00
285_S289_A0.7851.00
71_I285_S0.7791.00
120_L124_W0.7761.00
223_R227_M0.7731.00
315_V319_C0.7721.00
159_I162_F0.7711.00
149_G152_Q0.7701.00
75_L196_T0.7691.00
266_L317_V0.7661.00
235_L238_A0.7641.00
90_M257_G0.7621.00
223_R226_V0.7601.00
208_V226_V0.7591.00
182_V186_V0.7581.00
98_A251_A0.7541.00
89_V118_G0.7491.00
126_G131_I0.7441.00
212_I222_T0.7391.00
297_T301_L0.7391.00
195_L198_K0.7381.00
69_L86_V0.7301.00
55_S301_L0.7301.00
290_L294_G0.7301.00
97_T110_V0.7271.00
68_L188_T0.7241.00
66_V263_D0.7241.00
84_L265_I0.7201.00
155_T160_V0.7201.00
63_A67_A0.7181.00
204_F221_N0.7171.00
115_L119_I0.7171.00
72_G237_A0.7121.00
58_D62_R0.7041.00
77_I265_I0.7011.00
90_M240_A0.6991.00
235_L239_I0.6971.00
191_L194_L0.6901.00
69_L72_G0.6891.00
92_I118_G0.6811.00
325_S328_F0.6801.00
122_G231_V0.6781.00
296_N309_N0.6771.00
94_G251_A0.6751.00
146_A150_V0.6741.00
59_I297_T0.6721.00
89_V125_N0.6721.00
307_E310_Q0.6681.00
64_A185_A0.6671.00
136_P230_Y0.6641.00
155_T161_T0.6641.00
310_Q313_K0.6621.00
148_R261_E0.6621.00
93_A117_T0.6611.00
175_L183_I0.6591.00
74_T282_L0.6551.00
168_S173_G0.6551.00
74_T78_A0.6541.00
192_F196_T0.6541.00
92_I147_G0.6511.00
165_P169_W0.6441.00
89_V93_A0.6421.00
129_V136_P0.6351.00
130_A227_M0.6321.00
81_G212_I0.6321.00
111_L115_L0.6321.00
76_V230_Y0.6281.00
189_L193_W0.6241.00
188_T239_I0.6241.00
60_L64_A0.6221.00
119_I122_G0.6221.00
58_D297_T0.6211.00
61_N247_D0.6191.00
66_V267_A0.6171.00
201_L232_L0.6161.00
192_F236_C0.6151.00
155_T159_I0.6151.00
100_M117_T0.6121.00
238_A242_I0.6101.00
289_A293_Q0.6101.00
195_L228_L0.6091.00
270_I320_V0.6081.00
96_T113_S0.6081.00
118_G122_G0.6071.00
232_L235_L0.6071.00
105_F110_V0.6041.00
244_V248_I0.6021.00
59_I63_A0.6011.00
89_V234_G0.6011.00
298_G302_S0.5991.00
72_G76_V0.5971.00
320_V324_Q0.5971.00
61_N182_V0.5951.00
156_A160_V0.5941.00
161_T164_S0.5941.00
170_F174_S0.5941.00
66_V289_A0.5941.00
157_G162_F0.5911.00
194_L197_R0.5901.00
255_N258_L0.5891.00
231_V234_G0.5881.00
85_S125_N0.5881.00
299_I304_F0.5851.00
93_A237_A0.5851.00
160_V163_N0.5841.00
222_T225_I0.5821.00
270_I288_G0.5791.00
158_Q161_T0.5761.00
167_L170_F0.5751.00
89_V147_G0.5731.00
101_T246_A0.5701.00
171_G175_L0.5681.00
157_G160_V0.5671.00
263_D310_Q0.5661.00
215_A222_T0.5661.00
105_F108_P0.5651.00
195_L199_T0.5651.00
266_L313_K0.5641.00
107_L246_A0.5631.00
167_L173_G0.5621.00
97_T241_G0.5601.00
79_T208_V0.5601.00
89_V122_G0.5551.00
65_P244_V0.5551.00
187_L190_I0.5551.00
75_L195_L0.5551.00
66_V260_L0.5541.00
267_A271_G0.5541.00
133_K223_R0.5531.00
79_T226_V0.5511.00
71_I189_L0.5491.00
267_A285_S0.5481.00
234_G237_A0.5471.00
166_D173_G0.5471.00
115_L118_G0.5471.00
244_V260_L0.5461.00
226_V229_T0.5461.00
129_V230_Y0.5421.00
56_P60_L0.5411.00
324_Q328_F0.5391.00
175_L179_P0.5381.00
271_G285_S0.5381.00
151_A155_T0.5371.00
141_L145_V0.5351.00
53_F56_P0.5351.00
119_I234_G0.5351.00
267_A292_I0.5341.00
193_W281_N0.5331.00
76_V81_G0.5331.00
91_A256_A0.5321.00
96_T118_G0.5281.00
54_G58_D0.5281.00
144_M261_E0.5271.00
174_S177_F0.5231.00
60_L63_A0.5221.00
155_T158_Q0.5201.00
258_L261_E0.5181.00
188_T192_F0.5161.00
206_E280_F0.5131.00
213_R217_N0.5111.00
145_V149_G0.5101.00
83_D233_S0.5101.00
92_I117_T0.5091.00
156_A159_I0.5071.00
86_V233_S0.5071.00
98_A160_V0.5061.00
62_R297_T0.5061.00
151_A154_I0.5041.00
284_L288_G0.5041.00
99_A102_V0.5031.00
311_V315_V0.5021.00
140_T144_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi9A 2 0.8651 97.3 0.879 Contact Map
2nq2A 2 0.824 96.5 0.892 Contact Map
4g1uA 2 0.7859 96.2 0.895 Contact Map
3d31C 2 0.6921 71.3 0.934 Contact Map
2onkC 2 0.7009 61.6 0.938 Contact Map
1u7gA 3 0.566 50.4 0.942 Contact Map
2cfqA 1 0.563 42.7 0.945 Contact Map
2gfpA 2 0.5513 42.6 0.945 Contact Map
4tphA 2 0.5777 16.8 0.955 Contact Map
4m64A 1 0.5924 14.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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