GREMLIN Database
QOR2 - Quinone oxidoreductase 2
UniProt: P39315 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12507
Length: 286 (238)
Sequences: 56005 (41559)
Seq/√Len: 2693.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_A30_A3.2191.00
60_T93_A2.8311.00
18_S176_A2.7241.00
31_I51_A2.6101.00
177_A194_L2.5121.00
78_G82_P2.4811.00
55_D58_A2.4541.00
68_K182_I2.3261.00
3_A66_V2.3141.00
51_A58_A2.2881.00
56_E89_N2.2681.00
18_S22_T2.1911.00
29_V47_T2.0711.00
4_I16_I2.0681.00
67_E97_K2.0651.00
98_F131_V2.0491.00
29_V66_V1.9961.00
125_L132_Y1.9431.00
29_V49_R1.8981.00
203_T207_A1.8881.00
5_T71_L1.8821.00
176_A180_R1.8701.00
18_S179_A1.8561.00
137_N178_A1.8121.00
54_G78_G1.7821.00
102_T178_A1.7651.00
71_L101_Y1.7491.00
85_R89_N1.7251.00
135_L181_V1.7011.00
70_L182_I1.6751.00
60_T90_A1.6721.00
27_Q47_T1.6651.00
85_R124_M1.6611.00
22_T183_S1.6531.00
201_T204_Q1.6511.00
56_E60_T1.6441.00
56_E86_N1.6431.00
58_A61_S1.6271.00
37_K40_A1.6181.00
18_S21_K1.6171.00
34_N48_V1.6021.00
208_E211_K1.5981.00
84_H121_T1.5931.00
25_A28_I1.5881.00
15_V70_L1.5751.00
208_E212_Q1.5641.00
15_V175_A1.5611.00
119_I123_K1.5361.00
204_Q207_A1.4901.00
149_P153_E1.4851.00
53_Y83_Q1.4601.00
92_K128_S1.4511.00
150_A155_G1.4441.00
16_I30_A1.4441.00
69_L91_A1.4351.00
98_F133_T1.4351.00
15_V72_I1.4311.00
60_T94_A1.3971.00
203_T221_N1.3961.00
179_A183_S1.3841.00
82_P85_R1.3801.00
89_N92_K1.3621.00
72_I102_T1.3611.00
210_T216_Q1.3581.00
223_S226_D1.3551.00
68_K98_F1.3441.00
103_S107_A1.3411.00
11_L140_Y1.3291.00
101_Y125_L1.2991.00
136_R191_V1.2981.00
91_A99_I1.2901.00
59_L90_A1.2801.00
22_T179_A1.2751.00
123_K126_A1.2711.00
26_S183_S1.2691.00
180_R184_E1.2681.00
61_S64_Q1.2681.00
102_T137_N1.2541.00
60_T64_Q1.2531.00
135_L178_A1.2521.00
8_T32_V1.2511.00
122_E136_R1.2501.00
87_V99_I1.2481.00
22_T26_S1.2441.00
30_A46_I1.2331.00
80_R117_E1.2281.00
165_K199_A1.2181.00
126_A134_L1.2091.00
28_I33_R1.2061.00
136_R193_E1.2051.00
101_Y121_T1.2021.00
79_Q83_Q1.2011.00
18_S175_A1.1981.00
7_A16_I1.1971.00
17_E21_K1.1881.00
239_G243_M1.1881.00
114_L118_H1.1801.00
49_R62_A1.1671.00
3_A31_I1.1671.00
64_Q94_A1.1561.00
131_V188_E1.1441.00
91_A96_V1.1401.00
70_L178_A1.1361.00
63_L69_L1.1331.00
59_L86_N1.1261.00
101_Y134_L1.1251.00
158_I220_Q1.1231.00
88_I99_I1.1221.00
163_D203_T1.1211.00
20_M46_I1.1091.00
82_P86_N1.1061.00
141_S170_T1.1021.00
18_S172_A1.0931.00
31_I59_L1.0911.00
57_A61_S1.0761.00
56_E93_A1.0681.00
100_A135_L1.0631.00
89_N93_A1.0631.00
225_A228_A1.0591.00
63_L66_V1.0571.00
10_Q142_E1.0561.00
229_A232_K1.0541.00
57_A60_T1.0491.00
63_L90_A1.0471.00
71_L84_H1.0441.00
137_N174_Y1.0401.00
88_I124_M1.0381.00
20_M45_G1.0381.00
31_I62_A1.0131.00
27_Q45_G1.0121.00
32_V48_V1.0121.00
86_N89_N1.0091.00
228_A232_K1.0071.00
167_A197_D1.0051.00
29_V65_G1.0041.00
187_H192_Y0.9991.00
75_S79_Q0.9951.00
124_M127_D0.9901.00
149_P152_L0.9891.00
190_K240_L0.9891.00
116_D120_E0.9871.00
187_H190_K0.9851.00
14_Y172_A0.9841.00
99_I125_L0.9831.00
140_Y174_Y0.9781.00
126_A191_V0.9741.00
58_A62_A0.9641.00
81_A120_E0.9631.00
146_A149_P0.9601.00
63_L91_A0.9581.00
35_P50_Q0.9551.00
31_I58_A0.9551.00
63_L94_A0.9551.00
72_I178_A0.9491.00
207_A210_T0.9471.00
33_R52_D0.9431.00
53_Y73_S0.9411.00
163_D201_T0.9381.00
69_L99_I0.9371.00
103_S122_E0.9191.00
42_A46_I0.9151.00
14_Y18_S0.9111.00
14_Y17_E0.9101.00
92_K130_I0.9071.00
227_F231_L0.8991.00
34_N37_K0.8951.00
231_L234_V0.8951.00
105_L138_G0.8901.00
156_V218_T0.8891.00
88_I125_L0.8881.00
90_A93_A0.8871.00
146_A150_A0.8841.00
19_L179_A0.8821.00
171_R175_A0.8811.00
85_R120_E0.8791.00
34_N50_Q0.8741.00
69_L87_V0.8731.00
229_A233_S0.8721.00
180_R183_S0.8721.00
90_A94_A0.8701.00
26_S67_E0.8671.00
5_T87_V0.8591.00
169_A174_Y0.8581.00
173_D196_G0.8541.00
126_A132_Y0.8271.00
20_M28_I0.8271.00
97_K131_V0.8271.00
210_T217_V0.8251.00
227_F230_A0.8211.00
86_N90_A0.8211.00
84_H125_L0.8201.00
238_D242_D0.8171.00
237_P240_L0.8151.00
225_A229_A0.8151.00
175_A179_A0.8141.00
15_V102_T0.8141.00
22_T25_A0.8131.00
15_V19_L0.8051.00
225_A234_V0.7951.00
16_I28_I0.7931.00
10_Q171_R0.7931.00
92_K129_G0.7911.00
145_L148_A0.7901.00
32_V36_A0.7871.00
121_T125_L0.7861.00
210_T215_K0.7851.00
123_K127_D0.7851.00
107_A136_R0.7831.00
156_V220_Q0.7781.00
89_N124_M0.7751.00
228_A233_S0.7741.00
28_I32_V0.7721.00
33_R36_A0.7681.00
134_L191_V0.7671.00
84_H88_I0.7671.00
210_T219_Y0.7651.00
200_W205_L0.7641.00
54_G79_Q0.7621.00
210_T213_S0.7611.00
137_N140_Y0.7571.00
37_K41_L0.7551.00
229_A234_V0.7461.00
145_L149_P0.7451.00
56_E90_A0.7421.00
106_H115_A0.7401.00
120_E123_K0.7381.00
200_W204_Q0.7361.00
204_Q208_E0.7351.00
88_I128_S0.7301.00
173_D176_A0.7271.00
2_I26_S0.7271.00
170_T173_D0.7261.00
162_G203_T0.7251.00
91_A94_A0.7251.00
227_F232_K0.7241.00
206_A210_T0.7231.00
207_A211_K0.7211.00
228_A231_L0.7191.00
13_H17_E0.7161.00
240_L243_M0.7131.00
228_A234_V0.7111.00
132_Y189_G0.7111.00
88_I92_K0.7111.00
71_L87_V0.7091.00
103_S136_R0.7081.00
20_M44_Q0.7081.00
68_K97_K0.7021.00
122_E134_L0.6991.00
176_A179_A0.6951.00
144_Y147_S0.6951.00
239_G242_D0.6941.00
3_A63_L0.6931.00
4_I19_L0.6921.00
63_L87_V0.6921.00
167_A196_G0.6911.00
10_Q14_Y0.6901.00
13_H40_A0.6891.00
5_T73_S0.6841.00
69_L96_V0.6761.00
85_R127_D0.6751.00
135_L194_L0.6731.00
108_D119_I0.6691.00
116_D123_K0.6671.00
104_L107_A0.6661.00
88_I127_D0.6651.00
230_A234_V0.6651.00
3_A51_A0.6651.00
150_A154_H0.6631.00
230_A233_S0.6621.00
85_R88_I0.6601.00
53_Y59_L0.6591.00
83_Q86_N0.6491.00
55_D59_L0.6491.00
226_D230_A0.6461.00
32_V35_P0.6451.00
11_L102_T0.6441.00
165_K201_T0.6391.00
167_A199_A0.6391.00
223_S227_F0.6381.00
22_T180_R0.6341.00
68_K100_A0.6331.00
120_E124_M0.6291.00
143_N170_T0.6211.00
43_A46_I0.6201.00
223_S228_A0.6201.00
140_Y169_A0.6181.00
133_T181_V0.6151.00
237_P242_D0.6121.00
38_A50_Q0.6111.00
218_T221_N0.6081.00
29_V62_A0.6021.00
49_R58_A0.6011.00
116_D127_D0.6011.00
125_L134_L0.6001.00
59_L63_L0.5991.00
184_E187_H0.5961.00
62_A66_V0.5931.00
177_A180_R0.5921.00
14_Y175_A0.5881.00
42_A45_G0.5871.00
237_P241_A0.5871.00
8_T34_N0.5851.00
150_A153_E0.5841.00
74_S80_R0.5841.00
52_D55_D0.5821.00
91_A130_I0.5821.00
226_D229_A0.5821.00
107_A122_E0.5771.00
20_M43_A0.5741.00
224_E228_A0.5741.00
148_A152_L0.5721.00
54_G83_Q0.5721.00
184_E192_Y0.5711.00
4_I30_A0.5691.00
145_L150_A0.5691.00
179_A182_I0.5681.00
79_Q82_P0.5681.00
224_E227_F0.5681.00
116_D119_I0.5631.00
8_T33_R0.5621.00
88_I130_I0.5621.00
138_G195_A0.5621.00
26_S68_K0.5611.00
22_T176_A0.5611.00
63_L96_V0.5591.00
75_S80_R0.5591.00
128_S131_V0.5571.00
71_L99_I0.5551.00
14_Y171_R0.5541.00
150_A158_I0.5531.00
30_A48_V0.5491.00
19_L70_L0.5481.00
3_A69_L0.5481.00
51_A62_A0.5481.00
81_A117_E0.5471.00
225_A230_A0.5421.00
13_H16_I0.5411.00
80_R118_H0.5411.00
99_I130_I0.5391.00
51_A59_L0.5371.00
226_D233_S0.5361.00
154_H215_K0.5311.00
238_D241_A0.5311.00
84_H101_Y0.5271.00
175_A178_A0.5221.00
133_T190_K0.5201.00
66_V91_A0.5131.00
168_S202_L0.5091.00
128_S132_Y0.5091.00
17_E172_A0.5071.00
164_G202_L0.5071.00
88_I91_A0.5051.00
147_S150_A0.5041.00
135_L177_A0.5041.00
225_A231_L0.5031.00
225_A233_S0.5001.00
5_T31_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zcuA 2 0.9615 100 0.225 Contact Map
2jl1A 2 0.986 100 0.236 Contact Map
2x4gA 2 0.9056 100 0.281 Contact Map
1rkxA 3 0.8951 100 0.287 Contact Map
2pzmA 2 0.8986 100 0.288 Contact Map
1orrA 3 0.9091 100 0.291 Contact Map
3wj7A 3 0.979 100 0.293 Contact Map
3slgA 4 0.9196 100 0.294 Contact Map
2q1sA 2 0.8881 100 0.294 Contact Map
3rufA 2 0.9091 100 0.295 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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