QOR2 - ECOLI - GREMLIN Contacts

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QOR2 - Quinone oxidoreductase 2

UniProt:	P39315	Sequences: MIAITGATGQLGHYVIESLMKTVPASQIVAIVRNPAKAQALAAQGITVRQADYGDEAALTSALQGVEKLLLISSSEVGQRAPQHRNVINAAKAAGVKFIAYTSLLHADTSPLGLADEHIETEKMLADSGIVYTLLRNGWYSENYLASAPAALEHGVFIGAAGDGKIASATRADYAAAAARVISEAGHEGKVYELAGDSAWTLTQLAAELTKQSGKQVTYQNLSEADFAAALKSVGLPDGLADMLADSDVGASKGGLFDDSKTLSKLIGHPTTTLAESVSHLFNVNN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12507
Length:	286 (238)
Sequences:	56005 (41559)
Seq/√Len:	2693.9

ECOLI - QOR2 GM4D YBJS RMLB2 YBJT RMLB1 GALE HLDD YFCH RMLD FCL YEEZ YRAR
BACSU - YESF RMLB GALE YFNG YTCB YFHF YHFK SPSK YHEG YWNB YTBQ EPSC
HALSA - Q9HML4 Q9HSV1 Q9HNV3 Q9HSU9 Q9HRD1 Q9HS50 Q9HSE7 Q9HR86 Q9HSQ3 Q9HPF1
SULSO - Q980W1 Q97VN5 Q97XG1 Q7LXE8 Q97UM3 Q97XJ9 Q7LXG5 Q7LX44

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
7_A	30_A	3.219	1.00
60_T	93_A	2.831	1.00
18_S	176_A	2.724	1.00
31_I	51_A	2.610	1.00
177_A	194_L	2.512	1.00
78_G	82_P	2.481	1.00
55_D	58_A	2.454	1.00
68_K	182_I	2.326	1.00
3_A	66_V	2.314	1.00
51_A	58_A	2.288	1.00
56_E	89_N	2.268	1.00
18_S	22_T	2.191	1.00
29_V	47_T	2.071	1.00
4_I	16_I	2.068	1.00
67_E	97_K	2.065	1.00
98_F	131_V	2.049	1.00
29_V	66_V	1.996	1.00
125_L	132_Y	1.943	1.00
29_V	49_R	1.898	1.00
203_T	207_A	1.888	1.00
5_T	71_L	1.882	1.00
176_A	180_R	1.870	1.00
18_S	179_A	1.856	1.00
137_N	178_A	1.812	1.00
54_G	78_G	1.782	1.00
102_T	178_A	1.765	1.00
71_L	101_Y	1.749	1.00
85_R	89_N	1.725	1.00
135_L	181_V	1.701	1.00
70_L	182_I	1.675	1.00
60_T	90_A	1.672	1.00
27_Q	47_T	1.665	1.00
85_R	124_M	1.661	1.00
22_T	183_S	1.653	1.00
201_T	204_Q	1.651	1.00
56_E	60_T	1.644	1.00
56_E	86_N	1.643	1.00
58_A	61_S	1.627	1.00
37_K	40_A	1.618	1.00
18_S	21_K	1.617	1.00
34_N	48_V	1.602	1.00
208_E	211_K	1.598	1.00
84_H	121_T	1.593	1.00
25_A	28_I	1.588	1.00
15_V	70_L	1.575	1.00
208_E	212_Q	1.564	1.00
15_V	175_A	1.561	1.00
119_I	123_K	1.536	1.00
204_Q	207_A	1.490	1.00
149_P	153_E	1.485	1.00
53_Y	83_Q	1.460	1.00
92_K	128_S	1.451	1.00
150_A	155_G	1.444	1.00
16_I	30_A	1.444	1.00
69_L	91_A	1.435	1.00
98_F	133_T	1.435	1.00
15_V	72_I	1.431	1.00
60_T	94_A	1.397	1.00
203_T	221_N	1.396	1.00
179_A	183_S	1.384	1.00
82_P	85_R	1.380	1.00
89_N	92_K	1.362	1.00
72_I	102_T	1.361	1.00
210_T	216_Q	1.358	1.00
223_S	226_D	1.355	1.00
68_K	98_F	1.344	1.00
103_S	107_A	1.341	1.00
11_L	140_Y	1.329	1.00
101_Y	125_L	1.299	1.00
136_R	191_V	1.298	1.00
91_A	99_I	1.290	1.00
59_L	90_A	1.280	1.00
22_T	179_A	1.275	1.00
123_K	126_A	1.271	1.00
26_S	183_S	1.269	1.00
180_R	184_E	1.268	1.00
61_S	64_Q	1.268	1.00
102_T	137_N	1.254	1.00
60_T	64_Q	1.253	1.00
135_L	178_A	1.252	1.00
8_T	32_V	1.251	1.00
122_E	136_R	1.250	1.00
87_V	99_I	1.248	1.00
22_T	26_S	1.244	1.00
30_A	46_I	1.233	1.00
80_R	117_E	1.228	1.00
165_K	199_A	1.218	1.00
126_A	134_L	1.209	1.00
28_I	33_R	1.206	1.00
136_R	193_E	1.205	1.00
101_Y	121_T	1.202	1.00
79_Q	83_Q	1.201	1.00
18_S	175_A	1.198	1.00
7_A	16_I	1.197	1.00
17_E	21_K	1.188	1.00
239_G	243_M	1.188	1.00
114_L	118_H	1.180	1.00
49_R	62_A	1.167	1.00
3_A	31_I	1.167	1.00
64_Q	94_A	1.156	1.00
131_V	188_E	1.144	1.00
91_A	96_V	1.140	1.00
70_L	178_A	1.136	1.00
63_L	69_L	1.133	1.00
59_L	86_N	1.126	1.00
101_Y	134_L	1.125	1.00
158_I	220_Q	1.123	1.00
88_I	99_I	1.122	1.00
163_D	203_T	1.121	1.00
20_M	46_I	1.109	1.00
82_P	86_N	1.106	1.00
141_S	170_T	1.102	1.00
18_S	172_A	1.093	1.00
31_I	59_L	1.091	1.00
57_A	61_S	1.076	1.00
56_E	93_A	1.068	1.00
100_A	135_L	1.063	1.00
89_N	93_A	1.063	1.00
225_A	228_A	1.059	1.00
63_L	66_V	1.057	1.00
10_Q	142_E	1.056	1.00
229_A	232_K	1.054	1.00
57_A	60_T	1.049	1.00
63_L	90_A	1.047	1.00
71_L	84_H	1.044	1.00
137_N	174_Y	1.040	1.00
88_I	124_M	1.038	1.00
20_M	45_G	1.038	1.00
31_I	62_A	1.013	1.00
27_Q	45_G	1.012	1.00
32_V	48_V	1.012	1.00
86_N	89_N	1.009	1.00
228_A	232_K	1.007	1.00
167_A	197_D	1.005	1.00
29_V	65_G	1.004	1.00
187_H	192_Y	0.999	1.00
75_S	79_Q	0.995	1.00
124_M	127_D	0.990	1.00
149_P	152_L	0.989	1.00
190_K	240_L	0.989	1.00
116_D	120_E	0.987	1.00
187_H	190_K	0.985	1.00
14_Y	172_A	0.984	1.00
99_I	125_L	0.983	1.00
140_Y	174_Y	0.978	1.00
126_A	191_V	0.974	1.00
58_A	62_A	0.964	1.00
81_A	120_E	0.963	1.00
146_A	149_P	0.960	1.00
63_L	91_A	0.958	1.00
35_P	50_Q	0.955	1.00
31_I	58_A	0.955	1.00
63_L	94_A	0.955	1.00
72_I	178_A	0.949	1.00
207_A	210_T	0.947	1.00
33_R	52_D	0.943	1.00
53_Y	73_S	0.941	1.00
163_D	201_T	0.938	1.00
69_L	99_I	0.937	1.00
103_S	122_E	0.919	1.00
42_A	46_I	0.915	1.00
14_Y	18_S	0.911	1.00
14_Y	17_E	0.910	1.00
92_K	130_I	0.907	1.00
227_F	231_L	0.899	1.00
34_N	37_K	0.895	1.00
231_L	234_V	0.895	1.00
105_L	138_G	0.890	1.00
156_V	218_T	0.889	1.00
88_I	125_L	0.888	1.00
90_A	93_A	0.887	1.00
146_A	150_A	0.884	1.00
19_L	179_A	0.882	1.00
171_R	175_A	0.881	1.00
85_R	120_E	0.879	1.00
34_N	50_Q	0.874	1.00
69_L	87_V	0.873	1.00
229_A	233_S	0.872	1.00
180_R	183_S	0.872	1.00
90_A	94_A	0.870	1.00
26_S	67_E	0.867	1.00
5_T	87_V	0.859	1.00
169_A	174_Y	0.858	1.00
173_D	196_G	0.854	1.00
126_A	132_Y	0.827	1.00
20_M	28_I	0.827	1.00
97_K	131_V	0.827	1.00
210_T	217_V	0.825	1.00
227_F	230_A	0.821	1.00
86_N	90_A	0.821	1.00
84_H	125_L	0.820	1.00
238_D	242_D	0.817	1.00
237_P	240_L	0.815	1.00
225_A	229_A	0.815	1.00
175_A	179_A	0.814	1.00
15_V	102_T	0.814	1.00
22_T	25_A	0.813	1.00
15_V	19_L	0.805	1.00
225_A	234_V	0.795	1.00
16_I	28_I	0.793	1.00
10_Q	171_R	0.793	1.00
92_K	129_G	0.791	1.00
145_L	148_A	0.790	1.00
32_V	36_A	0.787	1.00
121_T	125_L	0.786	1.00
210_T	215_K	0.785	1.00
123_K	127_D	0.785	1.00
107_A	136_R	0.783	1.00
156_V	220_Q	0.778	1.00
89_N	124_M	0.775	1.00
228_A	233_S	0.774	1.00
28_I	32_V	0.772	1.00
33_R	36_A	0.768	1.00
134_L	191_V	0.767	1.00
84_H	88_I	0.767	1.00
210_T	219_Y	0.765	1.00
200_W	205_L	0.764	1.00
54_G	79_Q	0.762	1.00
210_T	213_S	0.761	1.00
137_N	140_Y	0.757	1.00
37_K	41_L	0.755	1.00
229_A	234_V	0.746	1.00
145_L	149_P	0.745	1.00
56_E	90_A	0.742	1.00
106_H	115_A	0.740	1.00
120_E	123_K	0.738	1.00
200_W	204_Q	0.736	1.00
204_Q	208_E	0.735	1.00
88_I	128_S	0.730	1.00
173_D	176_A	0.727	1.00
2_I	26_S	0.727	1.00
170_T	173_D	0.726	1.00
162_G	203_T	0.725	1.00
91_A	94_A	0.725	1.00
227_F	232_K	0.724	1.00
206_A	210_T	0.723	1.00
207_A	211_K	0.721	1.00
228_A	231_L	0.719	1.00
13_H	17_E	0.716	1.00
240_L	243_M	0.713	1.00
228_A	234_V	0.711	1.00
132_Y	189_G	0.711	1.00
88_I	92_K	0.711	1.00
71_L	87_V	0.709	1.00
103_S	136_R	0.708	1.00
20_M	44_Q	0.708	1.00
68_K	97_K	0.702	1.00
122_E	134_L	0.699	1.00
176_A	179_A	0.695	1.00
144_Y	147_S	0.695	1.00
239_G	242_D	0.694	1.00
3_A	63_L	0.693	1.00
4_I	19_L	0.692	1.00
63_L	87_V	0.692	1.00
167_A	196_G	0.691	1.00
10_Q	14_Y	0.690	1.00
13_H	40_A	0.689	1.00
5_T	73_S	0.684	1.00
69_L	96_V	0.676	1.00
85_R	127_D	0.675	1.00
135_L	194_L	0.673	1.00
108_D	119_I	0.669	1.00
116_D	123_K	0.667	1.00
104_L	107_A	0.666	1.00
88_I	127_D	0.665	1.00
230_A	234_V	0.665	1.00
3_A	51_A	0.665	1.00
150_A	154_H	0.663	1.00
230_A	233_S	0.662	1.00
85_R	88_I	0.660	1.00
53_Y	59_L	0.659	1.00
83_Q	86_N	0.649	1.00
55_D	59_L	0.649	1.00
226_D	230_A	0.646	1.00
32_V	35_P	0.645	1.00
11_L	102_T	0.644	1.00
165_K	201_T	0.639	1.00
167_A	199_A	0.639	1.00
223_S	227_F	0.638	1.00
22_T	180_R	0.634	1.00
68_K	100_A	0.633	1.00
120_E	124_M	0.629	1.00
143_N	170_T	0.621	1.00
43_A	46_I	0.620	1.00
223_S	228_A	0.620	1.00
140_Y	169_A	0.618	1.00
133_T	181_V	0.615	1.00
237_P	242_D	0.612	1.00
38_A	50_Q	0.611	1.00
218_T	221_N	0.608	1.00
29_V	62_A	0.602	1.00
49_R	58_A	0.601	1.00
116_D	127_D	0.601	1.00
125_L	134_L	0.600	1.00
59_L	63_L	0.599	1.00
184_E	187_H	0.596	1.00
62_A	66_V	0.593	1.00
177_A	180_R	0.592	1.00
14_Y	175_A	0.588	1.00
42_A	45_G	0.587	1.00
237_P	241_A	0.587	1.00
8_T	34_N	0.585	1.00
150_A	153_E	0.584	1.00
74_S	80_R	0.584	1.00
52_D	55_D	0.582	1.00
91_A	130_I	0.582	1.00
226_D	229_A	0.582	1.00
107_A	122_E	0.577	1.00
20_M	43_A	0.574	1.00
224_E	228_A	0.574	1.00
148_A	152_L	0.572	1.00
54_G	83_Q	0.572	1.00
184_E	192_Y	0.571	1.00
4_I	30_A	0.569	1.00
145_L	150_A	0.569	1.00
179_A	182_I	0.568	1.00
79_Q	82_P	0.568	1.00
224_E	227_F	0.568	1.00
116_D	119_I	0.563	1.00
8_T	33_R	0.562	1.00
88_I	130_I	0.562	1.00
138_G	195_A	0.562	1.00
26_S	68_K	0.561	1.00
22_T	176_A	0.561	1.00
63_L	96_V	0.559	1.00
75_S	80_R	0.559	1.00
128_S	131_V	0.557	1.00
71_L	99_I	0.555	1.00
14_Y	171_R	0.554	1.00
150_A	158_I	0.553	1.00
30_A	48_V	0.549	1.00
19_L	70_L	0.548	1.00
3_A	69_L	0.548	1.00
51_A	62_A	0.548	1.00
81_A	117_E	0.547	1.00
225_A	230_A	0.542	1.00
13_H	16_I	0.541	1.00
80_R	118_H	0.541	1.00
99_I	130_I	0.539	1.00
51_A	59_L	0.537	1.00
226_D	233_S	0.536	1.00
154_H	215_K	0.531	1.00
238_D	241_A	0.531	1.00
84_H	101_Y	0.527	1.00
175_A	178_A	0.522	1.00
133_T	190_K	0.520	1.00
66_V	91_A	0.513	1.00
168_S	202_L	0.509	1.00
128_S	132_Y	0.509	1.00
17_E	172_A	0.507	1.00
164_G	202_L	0.507	1.00
88_I	91_A	0.505	1.00
147_S	150_A	0.504	1.00
135_L	177_A	0.504	1.00
225_A	231_L	0.503	1.00
225_A	233_S	0.500	1.00
5_T	31_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zcuA	2	0.9615	100	0.225	Contact Map
2jl1A	2	0.986	100	0.236	Contact Map
2x4gA	2	0.9056	100	0.281	Contact Map
1rkxA	3	0.8951	100	0.287	Contact Map
2pzmA	2	0.8986	100	0.288	Contact Map
1orrA	3	0.9091	100	0.291	Contact Map
3wj7A	3	0.979	100	0.293	Contact Map
3slgA	4	0.9196	100	0.294	Contact Map
2q1sA	2	0.8881	100	0.294	Contact Map
3rufA	2	0.9091	100	0.295	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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