GREMLIN Database
YTFB - Uncharacterized protein YtfB
UniProt: P39310 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12502
Length: 212 (176)
Sequences: 124 (102)
Seq/√Len: 7.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_R157_A2.4920.73
133_V162_A2.4800.73
177_I189_T2.4290.71
167_S183_G2.4060.71
134_E137_K2.4050.71
191_D208_F2.3780.70
142_L153_V2.3770.70
27_L47_L2.3330.68
156_M185_V2.2830.66
49_P143_F2.2190.64
25_D34_G2.1520.62
140_A157_A2.0410.57
152_D188_L2.0130.56
143_F148_L2.0070.56
37_I41_V1.9470.54
143_F183_G1.8960.52
68_Q71_S1.8720.51
165_P210_R1.8660.50
48_L151_T1.8580.50
111_Q115_T1.8560.50
82_Q89_D1.8400.49
108_E111_Q1.8380.49
189_T211_A1.8190.48
160_E210_R1.7950.48
161_G202_R1.7920.47
148_L152_D1.7600.46
121_D204_P1.7330.45
169_L185_V1.7300.45
141_Q175_V1.7200.45
24_M35_I1.7150.44
128_W173_Q1.6620.42
45_G177_I1.6080.40
142_L175_V1.6000.40
60_T67_I1.5680.39
57_P168_N1.5540.38
115_T139_M1.5410.38
41_V74_P1.5340.37
43_V170_Q1.5090.36
136_G172_G1.4790.35
178_R187_G1.4580.35
89_D113_T1.4580.35
161_G165_P1.4470.34
43_V87_Q1.4260.33
21_F24_M1.4160.33
28_P31_H1.4120.33
132_R156_M1.4090.33
167_S202_R1.4080.33
131_Y173_Q1.4070.33
23_F150_A1.4010.32
160_E165_P1.3860.32
61_R64_Q1.3800.32
24_M142_L1.3780.32
43_V150_A1.3670.31
143_F152_D1.3590.31
196_Q208_F1.3450.31
48_L123_G1.3220.30
121_D133_V1.2990.29
173_Q189_T1.2980.29
41_V208_F1.2950.29
143_F157_A1.2820.28
144_R202_R1.2630.28
63_A69_S1.2470.27
76_E107_E1.2190.26
176_K189_T1.2170.26
73_P112_T1.2120.26
31_H143_F1.2080.26
140_A188_L1.2030.26
137_K159_V1.1970.26
137_K169_L1.1950.26
165_P173_Q1.1880.25
177_I211_A1.1830.25
79_L106_P1.1800.25
159_V169_L1.1730.25
159_V185_V1.1570.25
45_G211_A1.1480.24
153_V177_I1.1420.24
30_M37_I1.1280.24
20_N37_I1.1270.24
161_G167_S1.1250.24
140_A152_D1.1210.23
29_P133_V1.1150.23
161_G200_F1.1080.23
142_L146_H1.0980.23
24_M150_A1.0880.23
128_W202_R1.0830.22
141_Q146_H1.0730.22
170_Q190_I1.0650.22
186_T189_T1.0640.22
131_Y167_S1.0600.22
123_G204_P1.0540.22
49_P183_G1.0530.22
190_I210_R1.0520.22
143_F166_L1.0350.21
32_R155_A1.0330.21
85_T111_Q1.0280.21
166_L183_G1.0270.21
31_H49_P1.0250.21
128_W144_R1.0250.21
26_P175_V1.0240.21
187_G211_A1.0180.21
150_A153_V1.0140.21
202_R206_G1.0120.20
35_I48_L1.0120.20
142_L169_L0.9740.20
144_R161_G0.9720.19
35_I135_P0.9710.19
142_L158_Q0.9690.19
45_G48_L0.9610.19
76_E90_P0.9600.19
146_H170_Q0.9570.19
178_R189_T0.9520.19
24_M48_L0.9520.19
87_Q111_Q0.9490.19
24_M169_L0.9460.19
81_A84_V0.9430.19
130_S174_M0.9400.19
153_V201_T0.9400.19
134_E163_G0.9300.18
150_A169_L0.9290.18
127_Q132_R0.9250.18
141_Q156_M0.9240.18
107_E110_P0.9240.18
179_Q187_G0.9190.18
128_W160_E0.9180.18
46_F204_P0.9120.18
22_R26_P0.8910.18
155_A200_F0.8900.17
77_E89_D0.8890.17
186_T201_T0.8870.17
49_P152_D0.8860.17
39_A116_Q0.8850.17
79_L87_Q0.8790.17
163_G198_V0.8790.17
145_D169_L0.8750.17
146_H154_Y0.8700.17
141_Q202_R0.8530.17
163_G208_F0.8520.17
44_V151_T0.8520.17
61_R72_Q0.8140.16
186_T199_L0.8140.16
86_P106_P0.8120.16
20_N116_Q0.8110.16
31_H160_E0.8080.16
82_Q88_N0.7980.15
85_T88_N0.7940.15
81_A115_T0.7920.15
42_L51_D0.7920.15
190_I196_Q0.7870.15
148_L183_G0.7850.15
158_Q205_D0.7820.15
160_E164_K0.7810.15
62_E67_I0.7640.15
153_V185_V0.7610.15
199_L209_I0.7600.15
108_E114_Q0.7500.14
118_F121_D0.7460.14
154_Y208_F0.7440.14
39_A48_L0.7400.14
106_P115_T0.7370.14
55_N119_Q0.7330.14
118_F133_V0.7330.14
142_L159_V0.7280.14
69_S171_N0.7220.14
142_L201_T0.7210.14
43_V133_V0.7190.14
200_F206_G0.7140.14
39_A204_P0.7140.14
146_H179_Q0.7130.14
128_W165_P0.7120.14
48_L182_S0.7100.14
143_F200_F0.7060.14
161_G206_G0.7020.14
131_Y164_K0.7010.14
126_N129_R0.6940.13
40_I111_Q0.6910.13
23_F153_V0.6890.13
51_D133_V0.6890.13
128_W161_G0.6890.13
157_A188_L0.6830.13
41_V67_I0.6810.13
43_V135_P0.6790.13
41_V87_Q0.6790.13
87_Q113_T0.6760.13
25_D187_G0.6720.13
27_L200_F0.6710.13
62_E65_L0.6670.13
177_I186_T0.6630.13
203_Q207_S0.6600.13
121_D195_N0.6590.13
112_T117_P0.6550.13
148_L166_L0.6540.13
153_V158_Q0.6520.13
140_A148_L0.6500.13
32_R145_D0.6490.13
56_A108_E0.6480.13
157_A173_Q0.6460.13
20_N23_F0.6450.13
83_L106_P0.6360.12
84_V106_P0.6360.12
106_P112_T0.6310.12
47_L113_T0.6280.12
147_G168_N0.6200.12
148_L167_S0.6200.12
53_T74_P0.6190.12
21_F87_Q0.6190.12
21_F62_E0.6180.12
77_E108_E0.6170.12
178_R201_T0.6090.12
170_Q191_D0.6070.12
31_H35_I0.6070.12
132_R146_H0.6070.12
107_E112_T0.6060.12
143_F188_L0.6030.12
152_D197_Q0.6010.12
169_L177_I0.5970.12
51_D121_D0.5950.12
36_I53_T0.5950.12
86_P89_D0.5900.12
148_L188_L0.5890.12
150_A186_T0.5800.11
137_K142_L0.5760.11
138_T164_K0.5740.11
69_S106_P0.5740.11
63_A67_I0.5720.11
157_A160_E0.5720.11
41_V139_M0.5700.11
63_A68_Q0.5660.11
23_F26_P0.5610.11
87_Q109_Q0.5580.11
198_V208_F0.5550.11
148_L154_Y0.5540.11
58_V73_P0.5450.11
56_A62_E0.5420.11
184_V203_Q0.5410.11
83_L86_P0.5390.11
144_R200_F0.5360.11
29_P190_I0.5350.11
148_L157_A0.5340.11
141_Q166_L0.5340.11
178_R186_T0.5330.11
114_Q133_V0.5330.11
49_P148_L0.5320.11
42_L87_Q0.5310.11
23_F182_S0.5290.11
81_A106_P0.5270.11
59_V90_P0.5260.11
124_I174_M0.5260.11
156_M175_V0.5250.11
83_L110_P0.5230.11
126_N132_R0.5220.11
106_P162_A0.5200.10
161_G210_R0.5190.10
153_V169_L0.5190.10
38_A176_K0.5180.10
81_A112_T0.5170.10
180_N183_G0.5160.10
74_P120_P0.5160.10
39_A75_T0.5130.10
63_A66_D0.5100.10
124_I154_Y0.5100.10
28_P49_P0.5060.10
152_D167_S0.5000.10
178_R203_Q0.5000.10
141_Q167_S0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sluA 1 0.4292 99.5 0.777 Contact Map
2gu1A 1 0.4009 99.4 0.78 Contact Map
2djpA 1 0.3632 98.8 0.835 Contact Map
4rnzA 1 0.3774 98.7 0.841 Contact Map
1e0gA 1 0.2264 98.5 0.848 Contact Map
4pxvA 1 0.2264 98.3 0.858 Contact Map
2mkxA 1 0.2406 98.3 0.859 Contact Map
4a1kA 2 0.3679 98.2 0.859 Contact Map
2mpwA 1 0.4623 98.2 0.86 Contact Map
4b8vA 2 0.4009 98.2 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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