GREMLIN Database
ULAF - L-ribulose-5-phosphate 4-epimerase UlaF
UniProt: P39306 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12498
Length: 228 (197)
Sequences: 6321 (3826)
Seq/√Len: 272.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_D63_K5.0531.00
174_K178_D3.3761.00
191_K195_I3.1941.00
98_H195_I3.1931.00
37_L57_V2.9711.00
4_L30_A2.7761.00
107_L197_R2.6871.00
38_V79_L2.5881.00
208_S212_N2.5881.00
39_V55_M2.5601.00
7_Q177_H2.5491.00
88_L172_W2.1831.00
80_E145_K2.1241.00
37_L65_V2.1041.00
101_A195_I2.0831.00
98_H191_K2.0791.00
97_T191_K2.0691.00
98_H194_W1.9781.00
9_F52_A1.9741.00
207_D210_L1.9331.00
6_Q10_E1.9281.00
51_K54_D1.9151.00
30_A176_A1.9001.00
80_E83_R1.8971.00
161_G186_M1.8801.00
39_V57_V1.8321.00
92_V179_A1.7811.00
89_G175_D1.7331.00
14_E18_Y1.7181.00
195_I198_G1.7041.00
32_D39_V1.6991.00
175_D178_D1.6191.00
58_V75_T1.6181.00
90_G176_A1.6121.00
8_V28_V1.5851.00
11_A180_V1.5791.00
106_G165_Y1.5301.00
18_Y184_V1.4921.00
61_S83_R1.4801.00
84_R152_G1.4771.00
139_Y145_K1.4701.00
9_F13_M1.4321.00
173_G178_D1.4281.00
169_P186_M1.4261.00
134_E146_V1.4121.00
108_A123_D1.4061.00
97_T101_A1.4031.00
13_M17_R1.3951.00
64_V67_G1.3721.00
110_P193_A1.3711.00
125_P154_A1.3641.00
85_Y88_L1.3641.00
6_Q52_A1.3641.00
94_T183_A1.3601.00
8_V55_M1.3461.00
38_V60_M1.3451.00
80_E84_R1.3371.00
30_A90_G1.3191.00
109_I190_A1.3041.00
79_L83_R1.2951.00
84_R148_I1.2861.00
95_H167_H1.2831.00
171_A183_A1.2791.00
57_V66_E1.2431.00
102_W197_R1.2351.00
210_L213_K1.2341.00
9_F55_M1.2331.00
29_S91_I1.2281.00
122_G212_N1.2211.00
14_E17_R1.2101.00
29_S82_Y1.1651.00
33_R37_L1.1561.00
146_V149_E1.1521.00
99_A169_P1.1491.00
45_V54_D1.1371.00
105_A199_I1.1271.00
11_A176_A1.1261.00
40_I72_S1.1231.00
97_T188_E1.1211.00
15_L28_V1.1191.00
164_V170_F1.1151.00
93_H167_H1.1131.00
31_I89_G1.1121.00
193_A197_R1.1101.00
194_W199_I1.1091.00
160_P182_N1.1071.00
82_Y91_I1.0961.00
161_G171_A1.0911.00
100_T103_A1.0891.00
197_R201_P1.0881.00
16_P48_E1.0701.00
15_L92_V1.0691.00
145_K149_E1.0601.00
32_D57_V1.0591.00
94_T169_P1.0551.00
85_Y172_W1.0451.00
45_V69_Y1.0441.00
147_I164_V1.0371.00
194_W198_G1.0361.00
32_D35_R1.0241.00
98_H187_E1.0181.00
99_A186_M1.0141.00
187_E191_K1.0071.00
12_N28_V0.9971.00
112_L193_A0.9961.00
59_D65_V0.9911.00
4_L32_D0.9891.00
151_L172_W0.9861.00
151_L162_I0.9711.00
60_M83_R0.9631.00
188_E191_K0.9571.00
206_I210_L0.9551.00
132_E136_Q0.9531.00
108_A126_C0.9531.00
42_P45_V0.9531.00
38_V75_T0.9501.00
173_G182_N0.9451.00
32_D37_L0.9441.00
54_D69_Y0.9431.00
96_S99_A0.9311.00
212_N215_F0.9301.00
7_Q10_E0.9231.00
15_L180_V0.9121.00
7_Q30_A0.9081.00
196_A203_L0.9071.00
11_A28_V0.9071.00
54_D68_E0.9061.00
92_V183_A0.9041.00
42_P55_M0.8981.00
18_Y180_V0.8941.00
209_F213_K0.8911.00
122_G208_S0.8761.00
97_T195_I0.8751.00
56_V70_R0.8681.00
38_V58_V0.8651.00
50_M54_D0.8631.00
77_T170_F0.8541.00
9_F50_M0.8461.00
149_E152_G0.8411.00
132_E165_Y0.8341.00
121_F208_S0.8341.00
31_I36_G0.8300.99
81_L88_L0.8290.99
101_A194_W0.8270.99
77_T147_I0.8240.99
125_P162_I0.8200.99
133_E136_Q0.8100.99
169_P183_A0.8090.99
80_E148_I0.8060.99
123_D127_T0.8060.99
134_E137_G0.8050.99
210_L214_H0.8050.99
49_T177_H0.8030.99
106_G202_Q0.8000.99
209_F212_N0.7990.99
206_I211_M0.7980.99
81_L151_L0.7960.99
104_Q112_L0.7940.99
40_I74_D0.7940.99
31_I60_M0.7900.99
109_I189_V0.7850.99
10_E49_T0.7840.99
36_G60_M0.7820.99
96_S187_E0.7770.99
148_I151_L0.7770.99
132_E146_V0.7750.99
96_S183_A0.7740.99
43_S70_R0.7730.99
12_N47_Y0.7700.99
5_K39_V0.7660.99
89_G174_K0.7630.99
84_R149_E0.7580.99
109_I163_V0.7580.99
14_E180_V0.7550.99
5_K66_E0.7530.99
178_D182_N0.7490.99
29_S40_I0.7450.99
127_T146_V0.7450.99
133_E137_G0.7440.99
19_G191_K0.7400.99
102_W193_A0.7340.99
207_D213_K0.7300.99
106_G204_N0.7230.99
186_M190_A0.7220.99
75_T79_L0.7220.99
33_R36_G0.7120.98
45_V50_M0.7000.98
4_L7_Q0.6980.98
103_A163_V0.6920.98
107_L201_P0.6900.98
41_K50_M0.6890.98
21_V28_V0.6870.98
83_R148_I0.6860.98
132_E149_E0.6850.98
24_T43_S0.6840.98
111_A116_H0.6720.98
41_K82_Y0.6630.98
96_S169_P0.6560.97
196_A202_Q0.6550.97
49_T54_D0.6530.97
23_F181_H0.6500.97
171_A182_N0.6500.97
81_L170_F0.6500.97
90_G179_A0.6480.97
112_L197_R0.6450.97
133_E138_E0.6440.97
46_A49_T0.6410.97
208_S211_M0.6310.97
127_T164_V0.6300.97
108_A125_P0.6280.97
104_Q113_G0.6280.97
102_W190_A0.6280.97
22_T188_E0.6270.97
100_T192_M0.6260.97
43_S72_S0.6250.96
105_A201_P0.6230.96
57_V65_V0.6220.96
15_L20_L0.6190.96
178_D181_H0.6190.96
26_G47_Y0.6140.96
100_T168_G0.6090.96
27_N72_S0.6090.96
27_N74_D0.6070.96
62_G79_L0.6070.96
160_P174_K0.6060.96
31_I38_V0.6020.96
22_T25_W0.5980.95
81_L91_I0.5970.95
124_I186_M0.5970.95
114_T117_A0.5960.95
5_K57_V0.5940.95
4_L39_V0.5920.95
199_I203_L0.5910.95
146_V150_T0.5900.95
134_E138_E0.5890.95
92_V171_A0.5860.95
108_A154_A0.5850.95
119_Y182_N0.5840.95
87_S174_K0.5830.95
37_L60_M0.5800.95
76_A80_E0.5800.95
160_P178_D0.5750.94
8_V39_V0.5730.94
127_T150_T0.5730.94
16_P21_V0.5730.94
8_V12_N0.5670.94
148_I152_G0.5650.94
150_T162_I0.5640.94
201_P204_N0.5630.94
102_W194_W0.5620.94
58_V64_V0.5610.94
101_A192_M0.5600.94
43_S73_S0.5580.94
150_T154_A0.5580.94
99_A183_A0.5570.93
60_M79_L0.5550.93
98_H101_A0.5540.93
123_D154_A0.5540.93
62_G65_V0.5540.93
211_M214_H0.5520.93
99_A163_V0.5470.93
85_Y151_L0.5460.93
8_V30_A0.5440.93
123_D126_C0.5430.93
150_T153_N0.5410.92
85_Y160_P0.5400.92
147_I162_I0.5380.92
16_P22_T0.5370.92
105_A194_W0.5370.92
12_N41_K0.5360.92
198_G201_P0.5340.92
16_P47_Y0.5330.92
105_A196_A0.5320.92
12_N50_M0.5310.92
162_I170_F0.5290.92
106_G203_L0.5280.92
7_Q175_D0.5280.92
119_Y185_V0.5280.92
5_K52_A0.5240.91
37_L59_D0.5230.91
163_V169_P0.5220.91
5_K55_M0.5200.91
7_Q176_A0.5190.91
5_K42_P0.5170.91
99_A190_A0.5160.91
135_V138_E0.5130.90
59_D62_G0.5120.90
27_N41_K0.5090.90
122_G215_F0.5070.90
102_W107_L0.5070.90
100_T113_G0.5060.90
14_E23_F0.5050.90
112_L116_H0.5030.89
181_H188_E0.5020.89
115_T185_V0.5010.89
113_G116_H0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c24A 3 0.9035 100 0.126 Contact Map
1k0wA 3 0.9386 100 0.142 Contact Map
1e4cP 3 0.8904 100 0.153 Contact Map
3ocrA 4 0.9474 100 0.154 Contact Map
4xxfA 3 0.9123 100 0.181 Contact Map
2opiA 3 0.8772 100 0.182 Contact Map
2z7bA 3 0.9298 100 0.188 Contact Map
2v9lA 3 0.9518 100 0.204 Contact Map
1pvtA 3 0.8465 100 0.207 Contact Map
2fk5A 4 0.8246 100 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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