GREMLIN Database
ULAE - L-ribulose-5-phosphate 3-epimerase UlaE
UniProt: P39305 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12497
Length: 284 (246)
Sequences: 17117 (12051)
Seq/√Len: 768.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_R144_M3.1991.00
181_Q208_V3.0551.00
26_Q67_T2.7751.00
135_R174_Y2.7491.00
231_D234_R2.7021.00
61_V65_V2.6751.00
104_Q148_A2.4361.00
201_Q238_T2.4091.00
151_T208_V2.3601.00
62_N66_E2.3431.00
214_D226_G2.2941.00
35_F247_P2.2831.00
22_L63_A2.1971.00
104_Q144_M2.1611.00
20_C23_E2.1371.00
151_T181_Q2.1191.00
153_A208_V2.0791.00
96_L140_E2.0631.00
131_R170_G2.0561.00
107_Q148_A2.0441.00
170_G174_Y1.9961.00
169_L202_A1.9241.00
143_E177_N1.9071.00
113_V153_A1.8641.00
265_A269_D1.8601.00
238_T241_Q1.7971.00
63_A67_T1.7771.00
63_A66_E1.7711.00
169_L173_H1.7451.00
26_Q30_T1.7271.00
54_R108_D1.7171.00
106_A111_I1.6701.00
132_R174_Y1.6571.00
56_Q59_A1.6551.00
103_I148_A1.6521.00
64_I71_V1.6431.00
29_K67_T1.6331.00
93_A97_E1.6291.00
58_L108_D1.6231.00
131_R174_Y1.6111.00
144_M147_R1.6061.00
201_Q241_Q1.5871.00
153_A183_Y1.5711.00
198_M202_A1.5491.00
142_V180_F1.5481.00
233_E237_E1.5471.00
92_R137_G1.5231.00
91_V94_Q1.5231.00
259_D262_A1.5131.00
195_D198_M1.5101.00
27_L30_T1.5001.00
97_E101_K1.4991.00
146_S179_W1.4941.00
164_S167_K1.4821.00
135_R139_K1.4811.00
103_I145_A1.4691.00
57_R108_D1.4611.00
129_E132_R1.4531.00
26_Q63_A1.4501.00
214_D228_G1.4391.00
126_A129_E1.4311.00
144_M148_A1.4271.00
101_K104_Q1.4211.00
210_V239_L1.4161.00
113_V151_T1.4131.00
132_R136_D1.4031.00
136_D139_K1.4001.00
197_Q234_R1.3971.00
133_R136_D1.3871.00
237_E241_Q1.3861.00
22_L66_E1.3841.00
59_A62_N1.3831.00
199_E203_G1.3811.00
143_E147_R1.3551.00
23_E26_Q1.3421.00
181_Q206_H1.3391.00
25_L67_T1.3161.00
227_E266_K1.3031.00
186_I235_C1.3031.00
238_T242_S1.2941.00
262_A266_K1.2921.00
100_R140_E1.2811.00
163_S167_K1.2781.00
59_A63_A1.2571.00
204_I242_S1.2401.00
62_N65_V1.2391.00
142_V175_L1.2361.00
100_R104_Q1.2011.00
197_Q201_Q1.1941.00
156_I189_L1.1941.00
31_L268_R1.1901.00
58_L62_N1.1871.00
96_L100_R1.1861.00
168_A182_L1.1811.00
166_S202_A1.1811.00
149_Q179_W1.1761.00
103_I144_M1.1741.00
54_R58_L1.1741.00
22_L59_A1.1721.00
170_G173_H1.1691.00
97_E100_R1.1621.00
93_A140_E1.1591.00
216_K223_V1.1551.00
27_L261_A1.1521.00
27_L31_L1.1511.00
25_L63_A1.1491.00
61_V108_D1.1481.00
184_P189_L1.1451.00
146_S177_N1.1411.00
29_K68_G1.1291.00
140_E143_E1.1251.00
234_R238_T1.1231.00
103_I150_V1.1131.00
139_K176_N1.1121.00
169_L206_H1.0921.00
146_S178_P1.0911.00
135_R175_L1.0901.00
139_K175_L1.0871.00
35_F70_R1.0871.00
173_H206_H1.0841.00
88_D91_V1.0691.00
131_R135_R1.0591.00
28_A33_F1.0521.00
200_L204_I1.0511.00
89_D93_A1.0501.00
25_L64_I1.0441.00
127_N167_K1.0441.00
100_R147_R1.0431.00
104_Q108_D1.0391.00
145_A152_L1.0381.00
201_Q242_S1.0381.00
99_M141_S1.0371.00
22_L26_Q1.0351.00
224_P227_E1.0301.00
169_L203_G1.0101.00
74_M106_A1.0041.00
261_A265_A0.9941.00
33_F268_R0.9931.00
128_N170_G0.9871.00
266_K270_W0.9761.00
35_F72_P0.9761.00
113_V208_V0.9761.00
96_L137_G0.9631.00
266_K269_D0.9631.00
198_M201_Q0.9631.00
139_K143_E0.9621.00
57_R105_F0.9611.00
100_R148_A0.9601.00
64_I69_V0.9571.00
239_L242_S0.9561.00
33_F250_I0.9551.00
139_K177_N0.9471.00
92_R136_D0.9451.00
190_S229_V0.9411.00
200_L242_S0.9391.00
262_A265_A0.9371.00
143_E146_S0.9301.00
53_S56_Q0.9291.00
94_Q97_E0.9291.00
104_Q107_Q0.9271.00
136_D140_E0.9231.00
38_M71_V0.9161.00
129_E133_R0.9141.00
37_E73_S0.9111.00
37_E209_A0.9111.00
112_R151_T0.9081.00
30_T261_A0.9061.00
57_R61_V0.9041.00
55_E59_A0.9011.00
172_A206_H0.9011.00
86_S91_V0.8911.00
115_Q183_Y0.8901.00
197_Q238_T0.8891.00
128_N132_R0.8881.00
142_V179_W0.8851.00
230_V235_C0.8821.00
142_V177_N0.8791.00
64_I67_T0.8761.00
29_K34_D0.8691.00
236_F240_K0.8681.00
138_L180_F0.8621.00
19_E27_L0.8601.00
76_L79_H0.8571.00
155_E251_E0.8571.00
75_C78_A0.8511.00
185_D251_E0.8481.00
165_I194_N0.8461.00
72_P247_P0.8391.00
166_S170_G0.8381.00
106_A114_I0.8371.00
70_R112_R0.8361.00
92_R133_R0.8351.00
28_A36_V0.8331.00
210_V248_Y0.8291.00
58_L61_V0.8201.00
107_Q149_Q0.8191.00
84_L137_G0.8181.00
225_F267_A0.8151.00
175_L180_F0.8141.00
258_E262_A0.8121.00
187_G213_K0.8101.00
61_V110_G0.8101.00
127_N130_T0.8051.00
151_T179_W0.8041.00
105_F109_V0.8031.00
182_L203_G0.8021.00
188_N213_K0.8011.00
234_R237_E0.7951.00
98_I101_K0.7951.00
165_I202_A0.7931.00
212_V232_F0.7901.00
264_V268_R0.7891.00
26_Q66_E0.7731.00
131_R167_K0.7721.00
107_Q150_V0.7721.00
172_A182_L0.7691.00
57_R109_V0.7691.00
133_R137_G0.7631.00
216_K221_K0.7611.00
216_K229_V0.7551.00
223_V227_E0.7541.00
70_R247_P0.7481.00
264_V267_A0.7431.00
71_V111_I0.7371.00
176_N179_W0.7361.00
199_E202_A0.7331.00
263_E266_K0.7321.00
260_P263_E0.7221.00
187_G215_T0.7191.00
101_K105_F0.7171.00
140_E144_M0.7171.00
137_G140_E0.7161.00
37_E249_L0.7131.00
12_E15_L0.7111.00
139_K174_Y0.7111.00
13_K16_P0.7071.00
90_A94_Q0.7071.00
25_L29_K0.7051.00
213_K253_W0.7051.00
186_I232_F0.7031.00
200_L238_T0.7021.00
138_L171_Y0.7011.00
162_M168_A0.6971.00
75_C117_A0.6961.00
212_V248_Y0.6941.00
142_V152_L0.6931.00
19_E23_E0.6911.00
267_A270_W0.6911.00
89_D133_R0.6881.00
201_Q204_I0.6881.00
200_L203_G0.6861.00
232_F236_F0.6831.00
23_E27_L0.6801.00
200_L207_I0.6781.00
92_R96_L0.6691.00
209_A249_L0.6661.00
29_K69_V0.6661.00
134_F171_Y0.6641.00
204_I238_T0.6631.00
26_Q29_K0.6621.00
204_I207_I0.6591.00
190_S230_V0.6581.00
142_V146_S0.6561.00
243_G246_G0.6551.00
156_I168_A0.6551.00
34_D70_R0.6541.00
184_P200_L0.6511.00
167_K170_G0.6501.00
95_G98_I0.6481.00
89_D92_R0.6451.00
263_E267_A0.6451.00
143_E179_W0.6441.00
114_I145_A0.6441.00
199_E204_I0.6421.00
222_N225_F0.6421.00
121_V124_Q0.6411.00
162_M171_Y0.6391.00
22_L67_T0.6391.00
183_Y209_A0.6381.00
130_T133_R0.6381.00
74_M77_S0.6341.00
113_V209_A0.6311.00
141_S152_L0.6301.00
116_L152_L0.6291.00
94_Q98_I0.6281.00
213_K222_N0.6281.00
172_A180_F0.6261.00
25_L36_V0.6221.00
155_E211_H0.6211.00
24_R28_A0.6211.00
218_G221_K0.6181.00
102_A114_I0.6131.00
190_S196_V0.6131.00
25_L69_V0.6131.00
74_M111_I0.6101.00
135_R171_Y0.6081.00
250_I267_A0.6051.00
106_A150_V0.6041.00
132_R135_R0.6031.00
236_F248_Y0.6021.00
11_Y14_A0.6001.00
131_R171_Y0.6001.00
177_N180_F0.5991.00
31_L265_A0.5991.00
103_I114_I0.5971.00
33_F264_V0.5951.00
65_V110_G0.5931.00
61_V64_I0.5921.00
90_A93_A0.5911.00
196_V200_L0.5901.00
112_R149_Q0.5881.00
96_L141_S0.5871.00
121_V126_A0.5851.00
265_A268_R0.5851.00
25_L60_L0.5841.00
172_A176_N0.5811.00
240_K248_Y0.5791.00
125_E130_T0.5781.00
165_I169_L0.5771.00
200_L235_C0.5751.00
121_V127_N0.5731.00
165_I198_M0.5711.00
217_P220_F0.5711.00
134_F138_L0.5701.00
189_L199_E0.5701.00
176_N206_H0.5691.00
145_A150_V0.5681.00
196_V199_E0.5681.00
60_L63_A0.5671.00
225_F270_W0.5651.00
93_A96_L0.5631.00
73_S249_L0.5611.00
186_I212_V0.5601.00
30_T265_A0.5601.00
61_V109_V0.5591.00
153_A181_Q0.5581.00
115_Q157_M0.5561.00
92_R140_E0.5551.00
205_G242_S0.5541.00
184_P199_E0.5541.00
76_L102_A0.5521.00
96_L144_M0.5501.00
125_E133_R0.5481.00
218_G222_N0.5471.00
209_A247_P0.5441.00
158_D161_L0.5401.00
182_L207_I0.5391.00
104_Q147_R0.5361.00
135_R170_G0.5321.00
145_A148_A0.5301.00
258_E266_K0.5281.00
239_L244_Y0.5271.00
185_D213_K0.5271.00
260_P264_V0.5241.00
184_P207_I0.5231.00
110_G150_V0.5211.00
224_P263_E0.5211.00
15_L27_L0.5181.00
96_L99_M0.5181.00
169_L172_A0.5151.00
134_F137_G0.5151.00
16_P31_L0.5121.00
203_G207_I0.5121.00
227_E270_W0.5111.00
210_V244_Y0.5061.00
155_E188_N0.5051.00
24_R27_L0.5011.00
171_Y175_L0.5011.00
160_P163_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cqjA 2 0.9718 100 0.209 Contact Map
1i60A 1 0.9401 100 0.239 Contact Map
2zdsA 5 0.9577 100 0.256 Contact Map
3wqoA 2 0.9261 100 0.259 Contact Map
3u0hA 3 0.9296 100 0.26 Contact Map
3kwsA 2 0.8979 100 0.266 Contact Map
3dx5A 2 0.9014 100 0.268 Contact Map
4ovxA 1 0.9155 100 0.268 Contact Map
2qw5A 3 0.9296 100 0.268 Contact Map
3vniA 4 0.919 100 0.269 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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