ULAE - ECOLI - GREMLIN Contacts

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ULAE - L-ribulose-5-phosphate 3-epimerase UlaE

UniProt:	P39305	Sequences: MLSKQIPLGIYEKALPAGECWLERLQLAKTLGFDFVEMSVDETDDRLSRLNWSREQRLALVNAIVETGVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQEANNETRRRFRDGLKESVEMASRAQVTLAMEIMDYPLMSSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAEDPAAEVAKARDWVKARMAKAGMVEAA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12497
Length:	284 (246)
Sequences:	17117 (12051)
Seq/√Len:	768.3

ECOLI - ULAE SGBU FRLC YCJR YGBM HYI YIHM
BACSU - IOLI IOLH IOLE YFIH
SULSO - Q97UI8 Q97UG9 Q97UI3 Q7LX49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
100_R	144_M	3.199	1.00
181_Q	208_V	3.055	1.00
26_Q	67_T	2.775	1.00
135_R	174_Y	2.749	1.00
231_D	234_R	2.702	1.00
61_V	65_V	2.675	1.00
104_Q	148_A	2.436	1.00
201_Q	238_T	2.409	1.00
151_T	208_V	2.360	1.00
62_N	66_E	2.343	1.00
214_D	226_G	2.294	1.00
35_F	247_P	2.283	1.00
22_L	63_A	2.197	1.00
104_Q	144_M	2.161	1.00
20_C	23_E	2.137	1.00
151_T	181_Q	2.119	1.00
153_A	208_V	2.079	1.00
96_L	140_E	2.063	1.00
131_R	170_G	2.056	1.00
107_Q	148_A	2.044	1.00
170_G	174_Y	1.996	1.00
169_L	202_A	1.924	1.00
143_E	177_N	1.907	1.00
113_V	153_A	1.864	1.00
265_A	269_D	1.860	1.00
238_T	241_Q	1.797	1.00
63_A	67_T	1.777	1.00
63_A	66_E	1.771	1.00
169_L	173_H	1.745	1.00
26_Q	30_T	1.727	1.00
54_R	108_D	1.717	1.00
106_A	111_I	1.670	1.00
132_R	174_Y	1.657	1.00
56_Q	59_A	1.655	1.00
103_I	148_A	1.652	1.00
64_I	71_V	1.643	1.00
29_K	67_T	1.633	1.00
93_A	97_E	1.629	1.00
58_L	108_D	1.623	1.00
131_R	174_Y	1.611	1.00
144_M	147_R	1.606	1.00
201_Q	241_Q	1.587	1.00
153_A	183_Y	1.571	1.00
198_M	202_A	1.549	1.00
142_V	180_F	1.548	1.00
233_E	237_E	1.547	1.00
92_R	137_G	1.523	1.00
91_V	94_Q	1.523	1.00
259_D	262_A	1.513	1.00
195_D	198_M	1.510	1.00
27_L	30_T	1.500	1.00
97_E	101_K	1.499	1.00
146_S	179_W	1.494	1.00
164_S	167_K	1.482	1.00
135_R	139_K	1.481	1.00
103_I	145_A	1.469	1.00
57_R	108_D	1.461	1.00
129_E	132_R	1.453	1.00
26_Q	63_A	1.450	1.00
214_D	228_G	1.439	1.00
126_A	129_E	1.431	1.00
144_M	148_A	1.427	1.00
101_K	104_Q	1.421	1.00
210_V	239_L	1.416	1.00
113_V	151_T	1.413	1.00
132_R	136_D	1.403	1.00
136_D	139_K	1.400	1.00
197_Q	234_R	1.397	1.00
133_R	136_D	1.387	1.00
237_E	241_Q	1.386	1.00
22_L	66_E	1.384	1.00
59_A	62_N	1.383	1.00
199_E	203_G	1.381	1.00
143_E	147_R	1.355	1.00
23_E	26_Q	1.342	1.00
181_Q	206_H	1.339	1.00
25_L	67_T	1.316	1.00
227_E	266_K	1.303	1.00
186_I	235_C	1.303	1.00
238_T	242_S	1.294	1.00
262_A	266_K	1.292	1.00
100_R	140_E	1.281	1.00
163_S	167_K	1.278	1.00
59_A	63_A	1.257	1.00
204_I	242_S	1.240	1.00
62_N	65_V	1.239	1.00
142_V	175_L	1.236	1.00
100_R	104_Q	1.201	1.00
197_Q	201_Q	1.194	1.00
156_I	189_L	1.194	1.00
31_L	268_R	1.190	1.00
58_L	62_N	1.187	1.00
96_L	100_R	1.186	1.00
168_A	182_L	1.181	1.00
166_S	202_A	1.181	1.00
149_Q	179_W	1.176	1.00
103_I	144_M	1.174	1.00
54_R	58_L	1.174	1.00
22_L	59_A	1.172	1.00
170_G	173_H	1.169	1.00
97_E	100_R	1.162	1.00
93_A	140_E	1.159	1.00
216_K	223_V	1.155	1.00
27_L	261_A	1.152	1.00
27_L	31_L	1.151	1.00
25_L	63_A	1.149	1.00
61_V	108_D	1.148	1.00
184_P	189_L	1.145	1.00
146_S	177_N	1.141	1.00
29_K	68_G	1.129	1.00
140_E	143_E	1.125	1.00
234_R	238_T	1.123	1.00
103_I	150_V	1.113	1.00
139_K	176_N	1.112	1.00
169_L	206_H	1.092	1.00
146_S	178_P	1.091	1.00
135_R	175_L	1.090	1.00
139_K	175_L	1.087	1.00
35_F	70_R	1.087	1.00
173_H	206_H	1.084	1.00
88_D	91_V	1.069	1.00
131_R	135_R	1.059	1.00
28_A	33_F	1.052	1.00
200_L	204_I	1.051	1.00
89_D	93_A	1.050	1.00
25_L	64_I	1.044	1.00
127_N	167_K	1.044	1.00
100_R	147_R	1.043	1.00
104_Q	108_D	1.039	1.00
145_A	152_L	1.038	1.00
201_Q	242_S	1.038	1.00
99_M	141_S	1.037	1.00
22_L	26_Q	1.035	1.00
224_P	227_E	1.030	1.00
169_L	203_G	1.010	1.00
74_M	106_A	1.004	1.00
261_A	265_A	0.994	1.00
33_F	268_R	0.993	1.00
128_N	170_G	0.987	1.00
266_K	270_W	0.976	1.00
35_F	72_P	0.976	1.00
113_V	208_V	0.976	1.00
96_L	137_G	0.963	1.00
266_K	269_D	0.963	1.00
198_M	201_Q	0.963	1.00
139_K	143_E	0.962	1.00
57_R	105_F	0.961	1.00
100_R	148_A	0.960	1.00
64_I	69_V	0.957	1.00
239_L	242_S	0.956	1.00
33_F	250_I	0.955	1.00
139_K	177_N	0.947	1.00
92_R	136_D	0.945	1.00
190_S	229_V	0.941	1.00
200_L	242_S	0.939	1.00
262_A	265_A	0.937	1.00
143_E	146_S	0.930	1.00
53_S	56_Q	0.929	1.00
94_Q	97_E	0.929	1.00
104_Q	107_Q	0.927	1.00
136_D	140_E	0.923	1.00
38_M	71_V	0.916	1.00
129_E	133_R	0.914	1.00
37_E	73_S	0.911	1.00
37_E	209_A	0.911	1.00
112_R	151_T	0.908	1.00
30_T	261_A	0.906	1.00
57_R	61_V	0.904	1.00
55_E	59_A	0.901	1.00
172_A	206_H	0.901	1.00
86_S	91_V	0.891	1.00
115_Q	183_Y	0.890	1.00
197_Q	238_T	0.889	1.00
128_N	132_R	0.888	1.00
142_V	179_W	0.885	1.00
230_V	235_C	0.882	1.00
142_V	177_N	0.879	1.00
64_I	67_T	0.876	1.00
29_K	34_D	0.869	1.00
236_F	240_K	0.868	1.00
138_L	180_F	0.862	1.00
19_E	27_L	0.860	1.00
76_L	79_H	0.857	1.00
155_E	251_E	0.857	1.00
75_C	78_A	0.851	1.00
185_D	251_E	0.848	1.00
165_I	194_N	0.846	1.00
72_P	247_P	0.839	1.00
166_S	170_G	0.838	1.00
106_A	114_I	0.837	1.00
70_R	112_R	0.836	1.00
92_R	133_R	0.835	1.00
28_A	36_V	0.833	1.00
210_V	248_Y	0.829	1.00
58_L	61_V	0.820	1.00
107_Q	149_Q	0.819	1.00
84_L	137_G	0.818	1.00
225_F	267_A	0.815	1.00
175_L	180_F	0.814	1.00
258_E	262_A	0.812	1.00
187_G	213_K	0.810	1.00
61_V	110_G	0.810	1.00
127_N	130_T	0.805	1.00
151_T	179_W	0.804	1.00
105_F	109_V	0.803	1.00
182_L	203_G	0.802	1.00
188_N	213_K	0.801	1.00
234_R	237_E	0.795	1.00
98_I	101_K	0.795	1.00
165_I	202_A	0.793	1.00
212_V	232_F	0.790	1.00
264_V	268_R	0.789	1.00
26_Q	66_E	0.773	1.00
131_R	167_K	0.772	1.00
107_Q	150_V	0.772	1.00
172_A	182_L	0.769	1.00
57_R	109_V	0.769	1.00
133_R	137_G	0.763	1.00
216_K	221_K	0.761	1.00
216_K	229_V	0.755	1.00
223_V	227_E	0.754	1.00
70_R	247_P	0.748	1.00
264_V	267_A	0.743	1.00
71_V	111_I	0.737	1.00
176_N	179_W	0.736	1.00
199_E	202_A	0.733	1.00
263_E	266_K	0.732	1.00
260_P	263_E	0.722	1.00
187_G	215_T	0.719	1.00
101_K	105_F	0.717	1.00
140_E	144_M	0.717	1.00
137_G	140_E	0.716	1.00
37_E	249_L	0.713	1.00
12_E	15_L	0.711	1.00
139_K	174_Y	0.711	1.00
13_K	16_P	0.707	1.00
90_A	94_Q	0.707	1.00
25_L	29_K	0.705	1.00
213_K	253_W	0.705	1.00
186_I	232_F	0.703	1.00
200_L	238_T	0.702	1.00
138_L	171_Y	0.701	1.00
162_M	168_A	0.697	1.00
75_C	117_A	0.696	1.00
212_V	248_Y	0.694	1.00
142_V	152_L	0.693	1.00
19_E	23_E	0.691	1.00
267_A	270_W	0.691	1.00
89_D	133_R	0.688	1.00
201_Q	204_I	0.688	1.00
200_L	203_G	0.686	1.00
232_F	236_F	0.683	1.00
23_E	27_L	0.680	1.00
200_L	207_I	0.678	1.00
92_R	96_L	0.669	1.00
209_A	249_L	0.666	1.00
29_K	69_V	0.666	1.00
134_F	171_Y	0.664	1.00
204_I	238_T	0.663	1.00
26_Q	29_K	0.662	1.00
204_I	207_I	0.659	1.00
190_S	230_V	0.658	1.00
142_V	146_S	0.656	1.00
243_G	246_G	0.655	1.00
156_I	168_A	0.655	1.00
34_D	70_R	0.654	1.00
184_P	200_L	0.651	1.00
167_K	170_G	0.650	1.00
95_G	98_I	0.648	1.00
89_D	92_R	0.645	1.00
263_E	267_A	0.645	1.00
143_E	179_W	0.644	1.00
114_I	145_A	0.644	1.00
199_E	204_I	0.642	1.00
222_N	225_F	0.642	1.00
121_V	124_Q	0.641	1.00
162_M	171_Y	0.639	1.00
22_L	67_T	0.639	1.00
183_Y	209_A	0.638	1.00
130_T	133_R	0.638	1.00
74_M	77_S	0.634	1.00
113_V	209_A	0.631	1.00
141_S	152_L	0.630	1.00
116_L	152_L	0.629	1.00
94_Q	98_I	0.628	1.00
213_K	222_N	0.628	1.00
172_A	180_F	0.626	1.00
25_L	36_V	0.622	1.00
155_E	211_H	0.621	1.00
24_R	28_A	0.621	1.00
218_G	221_K	0.618	1.00
102_A	114_I	0.613	1.00
190_S	196_V	0.613	1.00
25_L	69_V	0.613	1.00
74_M	111_I	0.610	1.00
135_R	171_Y	0.608	1.00
250_I	267_A	0.605	1.00
106_A	150_V	0.604	1.00
132_R	135_R	0.603	1.00
236_F	248_Y	0.602	1.00
11_Y	14_A	0.600	1.00
131_R	171_Y	0.600	1.00
177_N	180_F	0.599	1.00
31_L	265_A	0.599	1.00
103_I	114_I	0.597	1.00
33_F	264_V	0.595	1.00
65_V	110_G	0.593	1.00
61_V	64_I	0.592	1.00
90_A	93_A	0.591	1.00
196_V	200_L	0.590	1.00
112_R	149_Q	0.588	1.00
96_L	141_S	0.587	1.00
121_V	126_A	0.585	1.00
265_A	268_R	0.585	1.00
25_L	60_L	0.584	1.00
172_A	176_N	0.581	1.00
240_K	248_Y	0.579	1.00
125_E	130_T	0.578	1.00
165_I	169_L	0.577	1.00
200_L	235_C	0.575	1.00
121_V	127_N	0.573	1.00
165_I	198_M	0.571	1.00
217_P	220_F	0.571	1.00
134_F	138_L	0.570	1.00
189_L	199_E	0.570	1.00
176_N	206_H	0.569	1.00
145_A	150_V	0.568	1.00
196_V	199_E	0.568	1.00
60_L	63_A	0.567	1.00
225_F	270_W	0.565	1.00
93_A	96_L	0.563	1.00
73_S	249_L	0.561	1.00
186_I	212_V	0.560	1.00
30_T	265_A	0.560	1.00
61_V	109_V	0.559	1.00
153_A	181_Q	0.558	1.00
115_Q	157_M	0.556	1.00
92_R	140_E	0.555	1.00
205_G	242_S	0.554	1.00
184_P	199_E	0.554	1.00
76_L	102_A	0.552	1.00
96_L	144_M	0.550	1.00
125_E	133_R	0.548	1.00
218_G	222_N	0.547	1.00
209_A	247_P	0.544	1.00
158_D	161_L	0.540	1.00
182_L	207_I	0.539	1.00
104_Q	147_R	0.536	1.00
135_R	170_G	0.532	1.00
145_A	148_A	0.530	1.00
258_E	266_K	0.528	1.00
239_L	244_Y	0.527	1.00
185_D	213_K	0.527	1.00
260_P	264_V	0.524	1.00
184_P	207_I	0.523	1.00
110_G	150_V	0.521	1.00
224_P	263_E	0.521	1.00
15_L	27_L	0.518	1.00
96_L	99_M	0.518	1.00
169_L	172_A	0.515	1.00
134_F	137_G	0.515	1.00
16_P	31_L	0.512	1.00
203_G	207_I	0.512	1.00
227_E	270_W	0.511	1.00
210_V	244_Y	0.506	1.00
155_E	188_N	0.505	1.00
24_R	27_L	0.501	1.00
171_Y	175_L	0.501	1.00
160_P	163_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cqjA	2	0.9718	100	0.209	Contact Map
1i60A	1	0.9401	100	0.239	Contact Map
2zdsA	5	0.9577	100	0.256	Contact Map
3wqoA	2	0.9261	100	0.259	Contact Map
3u0hA	3	0.9296	100	0.26	Contact Map
3kwsA	2	0.8979	100	0.266	Contact Map
3dx5A	2	0.9014	100	0.268	Contact Map
4ovxA	1	0.9155	100	0.268	Contact Map
2qw5A	3	0.9296	100	0.268	Contact Map
3vniA	4	0.919	100	0.269	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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