GREMLIN Database
ULAD - 3-keto-L-gulonate-6-phosphate decarboxylase UlaD
UniProt: P39304 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12496
Length: 216 (205)
Sequences: 3278 (2195)
Seq/√Len: 153.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_R53_L3.8391.00
14_T17_S3.6181.00
199_S202_E3.5201.00
88_C110_Q3.2941.00
51_K82_D3.2291.00
90_A94_T2.5061.00
45_R48_R2.4791.00
201_V205_R2.3831.00
19_Y49_D2.3431.00
178_P210_S2.3311.00
92_I96_K2.2781.00
197_A203_A2.2731.00
150_E175_E2.2411.00
202_E206_Q2.2201.00
119_W130_I2.1931.00
99_L103_K2.1681.00
15_M49_D2.1101.00
157_K186_H2.0981.00
73_S100_D2.0751.00
6_L190_A2.0501.00
36_T40_V1.9941.00
178_P182_G1.8591.00
28_E205_R1.8241.00
179_L182_G1.8181.00
175_E183_I1.7941.00
157_K167_T1.7621.00
119_W123_Q1.7501.00
92_I124_Q1.7451.00
156_I167_T1.6601.00
73_S101_V1.6301.00
12_N21_T1.6221.00
185_I188_F1.6021.00
118_T121_Q1.5961.00
142_Q161_D1.5931.00
15_M46_A1.5721.00
7_Q31_I1.5211.00
40_V65_I1.5071.00
15_M42_E1.5021.00
93_N96_K1.4991.00
20_E24_L1.4921.00
96_K100_D1.4801.00
58_I82_D1.4791.00
49_D52_A1.4591.00
17_S20_E1.4541.00
34_V50_L1.4521.00
129_G132_Q1.4501.00
21_T25_I1.4461.00
135_Y159_L1.4051.00
93_N121_Q1.3971.00
6_L204_A1.3931.00
92_I144_A1.3791.00
38_L42_E1.3701.00
128_A136_H1.3431.00
24_L200_P1.3281.00
205_R209_R1.3181.00
6_L211_I1.3151.00
8_V29_V1.3091.00
150_E172_L1.3041.00
113_L117_W1.3011.00
92_I143_A1.2981.00
179_L183_I1.2941.00
9_A191_G1.2901.00
32_I57_K1.2841.00
18_A38_L1.2811.00
24_L199_S1.2811.00
76_C84_V1.2601.00
92_I140_D1.2531.00
119_W129_G1.2511.00
206_Q210_S1.2341.00
8_V195_R1.2241.00
15_M19_Y1.2201.00
206_Q209_R1.2181.00
202_E205_R1.2141.00
22_T32_I1.2011.00
128_A132_Q1.1961.00
203_A206_Q1.1921.00
7_Q187_V1.1901.00
167_T186_H1.1881.00
48_R52_A1.1751.00
154_T183_I1.1711.00
169_T185_I1.1581.00
133_V137_R1.1511.00
120_E124_Q1.1441.00
24_L201_V1.1311.00
139_R159_L1.1301.00
154_T158_R1.1301.00
142_Q160_S1.1271.00
65_I72_L1.1221.00
85_T109_V1.1130.99
72_L94_T1.1120.99
97_G100_D1.1090.99
101_V105_F1.1040.99
85_T111_I1.1010.99
31_I58_I1.0910.99
72_L98_A1.0890.99
13_Q17_S1.0870.99
156_I160_S1.0860.99
155_A159_L1.0790.99
70_K74_R1.0680.99
69_G94_T1.0610.99
113_L133_V1.0470.99
38_L46_A1.0460.99
19_Y23_R1.0460.99
117_W121_Q1.0370.99
123_Q127_D1.0330.99
29_V204_A1.0320.99
122_A126_R1.0150.99
31_I83_W1.0150.99
27_E201_V1.0050.99
89_C137_R0.9920.99
93_N97_G0.9900.99
153_I185_I0.9780.99
84_V102_A0.9570.98
6_L208_K0.9560.98
86_V108_D0.9540.98
22_T50_L0.9540.98
61_A81_A0.9540.98
76_C102_A0.9440.98
30_D57_K0.9420.98
181_K211_I0.9400.98
47_V79_A0.9360.98
42_E45_R0.9290.98
166_V186_H0.9270.98
78_E105_F0.9200.98
135_Y139_R0.9190.98
41_G78_E0.9060.98
181_K188_F0.9060.98
201_V204_A0.9010.98
89_C133_V0.8820.97
44_V47_V0.8800.97
37_I74_R0.8790.97
123_Q128_A0.8780.97
148_W167_T0.8770.97
19_Y22_T0.8710.97
109_V168_V0.8670.97
92_I95_A0.8640.97
39_C63_A0.8610.97
28_E201_V0.8550.97
153_I167_T0.8550.97
148_W156_I0.8540.97
135_Y155_A0.8530.97
5_M58_I0.8510.97
85_T95_A0.8490.97
95_A144_A0.8420.97
194_I204_A0.8420.97
97_G101_V0.8420.97
86_V95_A0.8410.96
88_C141_A0.8400.96
32_I50_L0.8400.96
204_A208_K0.8290.96
193_S207_F0.8290.96
112_E115_G0.8290.96
72_L90_A0.8290.96
99_L108_D0.8260.96
26_A32_I0.8220.96
39_C44_V0.8220.96
47_V51_K0.8210.96
175_E179_L0.8160.96
15_M45_R0.8150.96
47_V59_V0.8050.96
121_Q125_W0.8050.96
4_P30_D0.8050.96
74_R196_D0.8000.95
128_A133_V0.7980.95
10_L34_V0.7950.95
203_A210_S0.7900.95
12_N18_A0.7900.95
26_A29_V0.7840.95
89_C117_W0.7810.95
25_I201_V0.7800.95
8_V25_I0.7720.94
17_S24_L0.7690.94
60_L85_T0.7690.94
83_W109_V0.7680.94
190_A207_F0.7640.94
167_T187_V0.7640.94
76_C108_D0.7600.94
65_I75_M0.7600.94
21_T24_L0.7570.94
89_C113_L0.7550.94
131_G155_A0.7530.94
46_A49_D0.7530.94
83_W187_V0.7520.94
139_R160_S0.7490.93
50_L53_L0.7480.93
155_A158_R0.7450.93
30_D204_A0.7420.93
10_L50_L0.7410.93
207_F210_S0.7360.93
103_K106_N0.7340.93
42_E46_A0.7330.93
77_F106_N0.7330.93
151_A175_E0.7320.93
110_Q141_A0.7310.93
121_Q124_Q0.7300.93
31_I82_D0.7240.92
37_I195_R0.7230.92
146_V165_K0.7220.92
8_V194_I0.7220.92
89_C126_R0.7210.92
135_Y160_S0.7200.92
59_V81_A0.7190.92
49_D53_L0.7120.92
146_V156_I0.7060.91
27_E30_D0.7020.91
19_Y53_L0.7000.91
139_R143_A0.6990.91
4_P58_I0.6960.91
66_A89_C0.6950.91
104_E107_G0.6930.90
36_T75_M0.6910.90
26_A57_K0.6890.90
166_V187_V0.6870.90
45_R49_D0.6860.90
160_S165_K0.6860.90
16_D20_E0.6820.90
8_V21_T0.6800.90
126_R133_V0.6780.90
7_Q168_V0.6780.90
20_E23_R0.6750.89
85_T165_K0.6710.89
36_T65_I0.6710.89
146_V167_T0.6660.89
12_N195_R0.6650.89
77_F105_F0.6630.88
149_G152_D0.6630.88
65_I76_C0.6610.88
203_A207_F0.6550.88
16_D19_Y0.6510.88
188_F211_I0.6470.87
136_H140_D0.6440.87
98_A101_V0.6400.87
22_T42_E0.6390.87
199_S203_A0.6370.86
50_L57_K0.6350.86
29_V57_K0.6340.86
110_Q113_L0.6340.86
10_L22_T0.6290.86
21_T200_P0.6290.86
141_A145_G0.6250.85
112_E116_Y0.6240.85
5_M181_K0.6230.85
177_L188_F0.6210.85
100_D104_E0.6200.85
138_S142_Q0.6170.85
34_V38_L0.6140.84
146_V149_G0.6110.84
153_I157_K0.6100.84
77_F84_V0.6010.83
120_E123_Q0.5980.83
110_Q114_T0.5970.83
45_R52_A0.5960.83
177_L184_P0.5930.82
34_V46_A0.5920.82
28_E208_K0.5910.82
51_K59_V0.5890.82
64_K67_D0.5850.81
76_C98_A0.5850.81
25_I204_A0.5840.81
29_V208_K0.5810.81
201_V209_R0.5810.81
25_I57_K0.5790.81
177_L207_F0.5700.80
34_V39_C0.5680.80
60_L115_G0.5670.79
73_S97_G0.5660.79
87_I170_G0.5650.79
125_W130_I0.5640.79
27_E57_K0.5620.79
37_I71_I0.5590.78
31_I57_K0.5570.78
40_V63_A0.5550.78
139_R142_Q0.5540.78
86_V98_A0.5500.77
66_A87_I0.5500.77
113_L137_R0.5430.76
152_D173_A0.5400.76
38_L41_G0.5380.76
133_V136_H0.5380.76
124_Q128_A0.5380.76
87_I114_T0.5350.75
161_D164_F0.5330.75
60_L83_W0.5280.74
29_V32_I0.5250.74
133_V156_I0.5230.74
112_E146_V0.5230.74
66_A117_W0.5210.73
6_L167_T0.5200.73
10_L18_A0.5180.73
31_I187_V0.5160.73
9_A195_R0.5160.73
157_K187_V0.5150.73
100_D103_K0.5150.73
110_Q115_G0.5140.72
22_T54_Y0.5110.72
119_W122_A0.5100.72
32_I194_I0.5090.72
153_I184_P0.5080.72
77_F102_A0.5070.71
13_Q74_R0.5060.71
83_W147_A0.5050.71
208_K211_I0.5050.71
33_E170_G0.5040.71
131_G135_Y0.5040.71
26_A30_D0.5010.71
152_D156_I0.5010.71
109_V116_Y0.5010.71
92_I125_W0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gdmA 2 0.9583 100 0.3 Contact Map
3qw4B 4 0.9676 100 0.307 Contact Map
3qw3A 2 0.963 100 0.319 Contact Map
2ffcA 2 0.9815 100 0.33 Contact Map
4mjzA 2 0.9769 100 0.343 Contact Map
3ldvA 2 0.9676 100 0.345 Contact Map
3r89A 2 0.9907 100 0.352 Contact Map
3tr2A 2 0.963 100 0.355 Contact Map
1eixA 2 0.9722 100 0.357 Contact Map
3tfxA 2 0.9769 100 0.358 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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