GREMLIN Database
ULAA - Ascorbate-specific permease IIC component UlaA
UniProt: P39301 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12493
Length: 465 (413)
Sequences: 717 (350)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
315_C366_T5.7461.00
116_I130_I4.8311.00
110_L163_A4.7401.00
28_C32_I4.6931.00
181_T370_F4.5881.00
193_G312_A4.3431.00
340_A389_M3.8411.00
207_A374_F3.7211.00
24_G49_I3.6831.00
180_P205_K3.4771.00
29_L33_L3.2940.99
27_T48_T2.9340.98
57_A61_I2.9270.98
223_P226_L2.9230.98
131_M195_Q2.8980.98
299_N303_Q2.8810.98
332_W335_I2.8690.98
340_A392_I2.8220.98
215_E219_D2.8070.98
331_M335_I2.8060.98
371_A380_A2.7900.98
32_I41_I2.7010.97
190_F317_A2.5770.96
38_V41_I2.5260.96
31_Y44_G2.5260.96
54_L289_M2.4970.96
214_E219_D2.4910.96
271_Q275_S2.4670.95
177_M197_Q2.4180.95
155_M158_T2.4060.95
114_L167_S2.3940.95
339_I385_L2.3660.94
72_K248_L2.2860.93
45_T49_I2.2710.93
336_G385_L2.2560.93
28_C45_T2.2430.92
217_V325_A2.1800.91
332_W381_L2.1680.91
129_T178_Y2.1430.90
203_A383_I2.1230.90
120_L124_I2.1150.90
141_A166_V2.1030.90
115_N167_S2.0970.89
222_L226_L2.0590.89
136_I195_Q2.0510.88
218_E372_N2.0490.88
180_P208_P2.0450.88
212_K378_R2.0060.87
238_I381_L2.0050.87
188_C310_V1.9800.86
284_T306_I1.9550.86
133_T193_G1.9530.86
272_T275_S1.9330.85
313_I316_A1.9130.85
318_I369_V1.9010.84
179_K182_Q1.8950.84
131_M136_I1.8670.83
38_V42_I1.8640.83
281_F285_Q1.8510.82
144_I166_V1.8270.82
55_L282_I1.8090.81
241_T273_G1.7930.80
76_V250_S1.7870.80
156_W160_I1.7260.78
335_I381_L1.7080.77
302_S305_L1.6860.76
121_L171_G1.6730.75
47_K231_D1.6630.75
107_A162_T1.6540.75
217_V322_A1.6150.73
133_T136_I1.6070.72
248_L269_I1.5870.71
178_Y191_S1.5850.71
313_I317_A1.5740.71
242_I381_L1.5710.71
363_S387_M1.5690.70
181_T318_I1.5650.70
190_F321_F1.5620.70
359_P365_A1.5490.69
24_G274_F1.5350.69
183_E213_K1.5080.67
29_L32_I1.4950.67
202_I386_V1.4790.66
61_I282_I1.4730.65
36_K40_V1.4680.65
215_E377_W1.4600.65
222_L377_W1.4600.65
198_F415_I1.4540.64
50_I233_I1.4440.64
180_P209_F1.4400.64
389_M393_F1.4220.63
69_V73_M1.4210.63
197_Q201_W1.4200.62
173_T233_I1.4200.62
29_L305_L1.4170.62
205_K208_P1.4080.62
137_M170_W1.4050.62
178_Y182_Q1.4010.61
169_Y173_T1.3800.60
33_L301_I1.3760.60
33_L277_A1.3670.59
384_C413_W1.3550.59
87_Y90_M1.3510.59
254_D258_A1.3470.58
78_G258_A1.3450.58
267_V271_Q1.3420.58
212_K215_E1.3410.58
129_T175_N1.3260.57
173_T197_Q1.3120.56
108_V284_T1.3060.56
225_W229_F1.2940.55
244_F354_I1.2800.54
62_L283_I1.2620.53
254_D257_Q1.2460.52
179_K313_I1.2440.52
127_I172_I1.2430.52
123_R307_P1.2410.52
249_L343_I1.2390.52
32_I423_G1.2390.52
371_A379_A1.2370.52
28_C237_A1.2360.52
232_N317_A1.2290.51
95_D338_L1.2190.51
114_L121_L1.2190.51
210_L382_K1.2080.50
133_T362_F1.2070.50
338_L392_I1.1980.49
207_A371_A1.1980.49
326_V383_I1.1920.49
168_L172_I1.1870.49
21_L294_L1.1800.48
210_L213_K1.1700.48
337_Q360_M1.1690.48
278_V317_A1.1680.48
275_S365_A1.1670.48
182_Q313_I1.1660.47
213_K219_D1.1630.47
26_V98_G1.1610.47
94_I139_Q1.1560.47
333_G337_Q1.1540.47
378_R382_K1.1520.47
205_K209_F1.1490.46
168_L419_P1.1480.46
160_I164_I1.1450.46
215_E308_G1.1420.46
342_G346_A1.1390.46
249_L346_A1.1330.45
136_I413_W1.1310.45
242_I246_A1.1230.45
44_G133_T1.1160.44
136_I406_A1.1090.44
198_F208_P1.1080.44
290_F308_G1.1060.44
29_L242_I1.1040.44
144_I420_M1.1040.44
68_P244_F1.1010.44
207_A304_R1.0930.43
368_G380_A1.0890.43
46_I327_V1.0890.43
284_T316_A1.0750.42
93_T136_I1.0750.42
163_A384_C1.0740.42
422_Q425_F1.0700.42
64_S120_L1.0650.41
182_Q312_A1.0620.41
93_T131_M1.0620.41
29_L192_I1.0600.41
177_M184_V1.0560.41
10_V13_N1.0560.41
211_G220_L1.0540.41
120_L305_L1.0440.40
69_V243_F1.0410.40
309_A343_I1.0370.40
299_N302_S1.0360.40
77_Y115_N1.0360.40
228_I410_M1.0350.40
214_E242_I1.0300.39
109_L163_A1.0300.39
101_Y142_G1.0300.39
107_A145_A1.0280.39
49_I274_F1.0180.39
97_M396_V1.0150.39
186_D306_I1.0140.39
14_Q259_M1.0120.38
256_V260_A1.0090.38
18_N263_V1.0090.38
196_Q391_E1.0010.38
15_V229_F0.9970.38
289_M317_A0.9960.38
201_W354_I0.9920.37
173_T184_V0.9800.37
130_I306_I0.9780.36
34_L294_L0.9770.36
345_V396_V0.9750.36
165_L302_S0.9720.36
161_C242_I0.9680.36
93_T195_Q0.9680.36
33_L305_L0.9680.36
255_T260_A0.9640.36
87_Y139_Q0.9630.36
110_L160_I0.9620.36
188_C309_A0.9620.36
153_Y234_V0.9620.36
325_A369_V0.9620.36
165_L246_A0.9620.36
93_T200_S0.9610.36
357_F409_G0.9530.35
174_S312_A0.9500.35
130_I343_I0.9500.35
141_A336_G0.9480.35
236_T281_F0.9450.35
252_G255_T0.9420.35
151_F306_I0.9380.34
245_G266_T0.9350.34
203_A212_K0.9340.34
111_A141_A0.9330.34
336_G368_G0.9280.34
18_N33_L0.9280.34
62_L303_Q0.9240.34
139_Q337_Q0.9230.33
344_L349_S0.9210.33
84_S87_Y0.9120.33
222_L225_W0.9110.33
179_K208_P0.9100.33
354_I392_I0.9080.33
79_I393_F0.9030.32
180_P201_W0.9030.32
67_K71_A0.9010.32
294_L311_L0.9010.32
274_F307_P0.9000.32
380_A420_M0.8990.32
345_V349_S0.8970.32
28_C213_K0.8960.32
61_I138_F0.8930.32
273_G277_A0.8920.32
81_G88_A0.8910.32
244_F291_V0.8900.32
46_I274_F0.8890.32
212_K219_D0.8890.32
110_L113_A0.8880.32
211_G378_R0.8870.32
239_V365_A0.8830.31
163_A170_W0.8790.31
78_G261_G0.8790.31
173_T192_I0.8760.31
344_L406_A0.8750.31
9_T13_N0.8690.31
10_V14_Q0.8650.30
174_S367_I0.8640.30
236_T294_L0.8640.30
256_V263_V0.8630.30
317_A321_F0.8620.30
37_S40_V0.8600.30
304_R339_I0.8590.30
17_T68_P0.8590.30
284_T354_I0.8570.30
267_V386_V0.8570.30
53_M339_I0.8510.30
136_I166_V0.8500.30
282_I353_I0.8500.30
21_L33_L0.8470.30
151_F424_F0.8450.29
70_V391_E0.8420.29
277_A365_A0.8420.29
112_L360_M0.8400.29
115_N125_T0.8390.29
294_L313_I0.8390.29
192_I318_I0.8370.29
71_A78_G0.8350.29
112_L236_T0.8350.29
110_L331_M0.8340.29
121_L124_I0.8330.29
343_I347_C0.8330.29
17_T83_I0.8300.29
196_Q363_S0.8300.29
387_M399_V0.8280.29
371_A383_I0.8260.29
306_I313_I0.8230.28
116_I305_L0.8220.28
180_P204_Y0.8210.28
140_Q195_Q0.8200.28
84_S140_Q0.8200.28
86_T410_M0.8170.28
46_I50_I0.8150.28
141_A195_Q0.8130.28
94_I171_G0.8110.28
185_T321_F0.8080.28
79_I274_F0.8060.28
114_L160_I0.8000.27
101_Y107_A0.7990.27
215_E378_R0.7980.27
112_L281_F0.7960.27
233_I274_F0.7950.27
64_S267_V0.7930.27
279_A283_I0.7920.27
64_S275_S0.7910.27
154_S157_T0.7900.27
42_I258_A0.7890.27
345_V348_G0.7890.27
23_L308_G0.7890.27
344_L365_A0.7860.27
24_G165_L0.7840.26
50_I213_K0.7840.26
130_I277_A0.7840.26
241_T274_F0.7810.26
36_K223_P0.7770.26
238_I270_L0.7730.26
108_V137_M0.7710.26
170_W413_W0.7710.26
36_K54_L0.7700.26
151_F253_I0.7690.26
35_R160_I0.7680.26
135_H170_W0.7680.26
188_C367_I0.7680.26
208_P211_G0.7660.26
54_L198_F0.7650.26
34_L310_V0.7650.26
173_T299_N0.7640.26
53_M274_F0.7640.26
108_V321_F0.7640.26
111_A303_Q0.7610.25
77_Y167_S0.7590.25
17_T33_L0.7590.25
240_M252_G0.7550.25
395_C410_M0.7550.25
146_V427_I0.7510.25
140_Q356_G0.7510.25
332_W336_G0.7480.25
155_M418_P0.7480.25
157_T160_I0.7470.25
196_Q337_Q0.7470.25
252_G268_Y0.7460.25
193_G301_I0.7450.25
112_L143_L0.7440.25
279_A296_E0.7430.25
19_A234_V0.7430.25
60_G270_L0.7430.25
25_I331_M0.7420.25
116_I156_W0.7390.24
229_F393_F0.7360.24
172_I331_M0.7340.24
23_L55_L0.7330.24
146_V158_T0.7330.24
46_I184_V0.7330.24
55_L363_S0.7320.24
114_L202_I0.7280.24
282_I343_I0.7270.24
31_Y297_A0.7270.24
246_A378_R0.7260.24
40_V43_K0.7240.24
73_M302_S0.7190.24
64_S370_F0.7190.24
419_P422_Q0.7190.24
284_T299_N0.7150.23
114_L164_I0.7130.23
33_L42_I0.7110.23
47_K293_E0.7100.23
270_L278_V0.7080.23
277_A290_F0.7070.23
328_W384_C0.7060.23
23_L48_T0.7040.23
42_I160_I0.7040.23
46_I222_L0.7030.23
356_G410_M0.7030.23
242_I428_G0.7020.23
81_G152_G0.7020.23
73_M395_C0.6990.23
201_W204_Y0.6990.23
221_K357_F0.6990.23
243_F269_I0.6990.23
32_I38_V0.6970.23
130_I168_L0.6930.22
153_Y161_C0.6910.22
18_N24_G0.6910.22
81_G356_G0.6910.22
192_I370_F0.6900.22
36_K192_I0.6900.22
391_E395_C0.6890.22
124_I186_D0.6890.22
98_G125_T0.6880.22
406_A413_W0.6880.22
20_P23_L0.6830.22
139_Q192_I0.6820.22
111_A417_A0.6820.22
46_I349_S0.6820.22
61_I279_A0.6800.22
359_P391_E0.6800.22
181_T306_I0.6800.22
13_N17_T0.6790.22
28_C227_N0.6770.22
59_S63_T0.6770.22
165_L221_K0.6770.22
106_Y110_L0.6760.22
107_A111_A0.6750.22
190_F319_Y0.6740.22
95_D113_A0.6730.22
182_Q188_C0.6730.22
11_F17_T0.6710.22
68_P165_L0.6700.21
184_V345_V0.6680.21
192_I409_G0.6670.21
160_I203_A0.6660.21
76_V366_T0.6660.21
78_G270_L0.6650.21
362_F370_F0.6650.21
69_V310_V0.6640.21
244_F336_G0.6630.21
115_N293_E0.6610.21
69_V295_S0.6600.21
176_M189_G0.6590.21
210_L339_I0.6570.21
55_L196_Q0.6530.21
73_M236_T0.6480.21
112_L313_I0.6480.21
394_G418_P0.6470.21
199_A363_S0.6470.21
273_G352_L0.6430.20
94_I169_Y0.6430.20
289_M354_I0.6420.20
29_L219_D0.6390.20
28_C41_I0.6380.20
79_I270_L0.6370.20
312_A402_T0.6360.20
83_I356_G0.6350.20
48_T313_I0.6340.20
130_I264_H0.6330.20
207_A318_I0.6320.20
206_V335_I0.6310.20
28_C38_V0.6300.20
387_M391_E0.6290.20
79_I277_A0.6290.20
157_T172_I0.6290.20
181_T310_V0.6270.20
143_L365_A0.6270.20
156_W309_A0.6270.20
139_Q363_S0.6270.20
85_D409_G0.6260.20
20_P156_W0.6230.20
182_Q189_G0.6230.20
37_S369_V0.6230.20
176_M197_Q0.6220.20
85_D112_L0.6210.20
94_I116_I0.6210.20
174_S379_A0.6200.20
252_G397_W0.6190.19
68_P278_V0.6170.19
231_D332_W0.6160.19
116_I144_I0.6150.19
249_L258_A0.6150.19
111_A166_V0.6140.19
15_V342_G0.6130.19
233_I354_I0.6110.19
164_I260_A0.6090.19
17_T303_Q0.6090.19
200_S395_C0.6080.19
177_M201_W0.6080.19
235_S356_G0.6070.19
182_Q187_G0.6070.19
23_L94_I0.6070.19
166_V195_Q0.6060.19
249_L423_G0.6030.19
335_I402_T0.6030.19
207_A370_F0.6030.19
211_G222_L0.6020.19
177_M354_I0.6020.19
75_E255_T0.6020.19
305_L315_C0.6010.19
256_V259_M0.6010.19
216_S321_F0.5990.19
283_I399_V0.5990.19
177_M192_I0.5980.19
116_I371_A0.5950.19
183_E397_W0.5950.19
46_I409_G0.5940.19
45_T345_V0.5940.19
112_L384_C0.5930.19
64_S253_I0.5930.19
324_N372_N0.5920.18
159_I263_V0.5920.18
209_F213_K0.5910.18
48_T55_L0.5910.18
139_Q357_F0.5900.18
231_D368_G0.5890.18
41_I161_C0.5890.18
69_V236_T0.5890.18
204_Y389_M0.5880.18
22_L97_M0.5880.18
198_F423_G0.5870.18
15_V265_W0.5870.18
140_Q333_G0.5850.18
18_N97_M0.5840.18
121_L168_L0.5840.18
366_T385_L0.5840.18
349_S396_V0.5830.18
231_D248_L0.5810.18
80_N381_L0.5790.18
230_H334_T0.5780.18
50_I280_I0.5760.18
257_Q260_A0.5750.18
360_M384_C0.5730.18
108_V369_V0.5730.18
57_A244_F0.5730.18
171_G302_S0.5710.18
26_V109_L0.5710.18
139_Q236_T0.5710.18
379_A383_I0.5700.18
283_I410_M0.5700.18
35_R183_E0.5680.18
333_G360_M0.5680.18
89_S407_W0.5680.18
139_Q143_L0.5670.18
124_I212_K0.5670.18
25_I267_V0.5660.18
59_S101_Y0.5660.18
138_F345_V0.5650.18
246_A282_I0.5650.18
232_N280_I0.5650.18
40_V225_W0.5650.18
15_V57_A0.5640.18
41_I159_I0.5640.18
325_A366_T0.5640.18
16_M29_L0.5640.18
145_A415_I0.5620.17
385_L389_M0.5620.17
335_I339_I0.5610.17
280_I398_A0.5600.17
21_L221_K0.5600.17
136_I388_G0.5590.17
350_S396_V0.5590.17
34_L181_T0.5580.17
113_A209_F0.5580.17
63_T315_C0.5570.17
332_W384_C0.5570.17
141_A267_V0.5570.17
210_L215_E0.5560.17
123_R306_I0.5560.17
238_I393_F0.5560.17
129_T410_M0.5550.17
242_I370_F0.5540.17
206_V382_K0.5540.17
55_L356_G0.5530.17
146_V224_G0.5520.17
239_V277_A0.5520.17
171_G280_I0.5520.17
151_F421_M0.5520.17
80_N176_M0.5510.17
167_S268_Y0.5510.17
227_N321_F0.5500.17
41_I386_V0.5500.17
37_S62_L0.5490.17
94_I97_M0.5490.17
350_S357_F0.5490.17
57_A348_G0.5480.17
168_L343_I0.5470.17
165_L244_F0.5460.17
116_I147_T0.5450.17
257_Q262_K0.5450.17
200_S366_T0.5430.17
25_I199_A0.5430.17
236_T290_F0.5430.17
77_Y244_F0.5420.17
12_F116_I0.5410.17
244_F295_S0.5400.17
24_G89_S0.5400.17
136_I200_S0.5390.17
302_S394_G0.5370.17
122_R128_R0.5370.17
153_Y423_G0.5370.17
120_L386_V0.5370.17
66_F395_C0.5360.17
130_I386_V0.5360.17
133_T158_T0.5330.16
207_A373_H0.5320.16
133_T367_I0.5320.16
11_F19_A0.5310.16
235_S256_V0.5300.16
120_L343_I0.5290.16
40_V45_T0.5280.16
211_G214_E0.5280.16
160_I237_A0.5280.16
40_V328_W0.5270.16
139_Q333_G0.5270.16
282_I419_P0.5260.16
359_P362_F0.5250.16
64_S309_A0.5240.16
70_V89_S0.5240.16
31_Y367_I0.5230.16
39_S227_N0.5230.16
171_G316_A0.5230.16
179_K306_I0.5230.16
18_N428_G0.5210.16
121_L198_F0.5200.16
35_R426_S0.5190.16
200_S315_C0.5180.16
300_G309_A0.5170.16
32_I120_L0.5160.16
25_I343_I0.5130.16
14_Q81_G0.5120.16
237_A342_G0.5120.16
42_I238_I0.5110.16
148_L242_I0.5110.16
191_S252_G0.5110.16
21_L34_L0.5110.16
332_W385_L0.5110.16
69_V234_V0.5100.16
139_Q195_Q0.5100.16
113_A342_G0.5090.16
84_S88_A0.5080.16
86_T139_Q0.5080.16
367_I371_A0.5080.16
233_I281_F0.5070.16
367_I379_A0.5070.16
232_N247_I0.5070.16
58_G284_T0.5060.16
283_I417_A0.5030.15
143_L283_I0.5020.15
251_F256_V0.5010.15
14_Q409_G0.5010.15
43_K116_I0.5010.15
41_I309_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rp9A 2 0.9634 100 0.272 Contact Map
4pypA 1 0.7914 57.5 0.977 Contact Map
2cfqA 1 0.7914 32.5 0.98 Contact Map
4m64A 1 0.7978 29.5 0.981 Contact Map
1pw4A 1 0.8 19.1 0.982 Contact Map
3qnqA 2 0.7892 15.8 0.983 Contact Map
2rddB 1 0.0796 15.4 0.983 Contact Map
3wdoA 1 0.7785 12.8 0.983 Contact Map
2kncA 1 0.1161 12.1 0.984 Contact Map
2l2tA 2 0.0946 11.8 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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