GREMLIN Database
ULAG - Probable L-ascorbate-6-phosphate lactonase UlaG
UniProt: P39300 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12492
Length: 354 (272)
Sequences: 1418 (963)
Seq/√Len: 58.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_A210_V4.7931.00
263_A298_L4.0261.00
140_P162_I3.8921.00
215_K220_S3.6741.00
245_A274_A3.6041.00
229_Y271_A3.5641.00
48_I280_F3.5241.00
180_L213_L3.3331.00
148_V163_V3.3101.00
269_G277_V3.2121.00
176_E215_K3.1021.00
213_L242_I2.9801.00
145_K165_K2.7901.00
51_K57_N2.7841.00
213_L240_H2.5941.00
243_D275_K2.5731.00
58_V112_A2.5541.00
65_G124_D2.5381.00
41_W320_K2.5381.00
116_T223_H2.4821.00
169_V176_E2.4801.00
266_L302_K2.4781.00
178_H215_K2.3691.00
294_E298_L2.3621.00
72_G85_M2.3511.00
260_M268_M2.2871.00
113_V141_F2.2471.00
178_H240_H2.1781.00
223_H280_F2.1401.00
60_V116_T2.0941.00
267_R271_A1.8931.00
40_M244_V1.8851.00
148_V152_I1.8671.00
164_V179_A1.8281.00
245_A269_G1.7750.99
47_G60_V1.7690.99
180_L211_N1.7650.99
237_G242_I1.7600.99
235_K238_N1.7590.99
169_V178_H1.7480.99
142_I177_I1.7020.99
39_A320_K1.6990.99
282_H296_R1.6670.99
177_I212_Y1.6550.99
142_I212_Y1.6160.99
67_G93_P1.6060.99
167_G239_E1.6050.99
246_L278_I1.5740.98
265_M277_V1.5680.98
220_S242_I1.5640.98
114_L214_F1.5540.98
235_K239_E1.5520.98
67_G87_G1.5510.98
234_A238_N1.5360.98
302_K305_R1.5300.98
43_L101_V1.5100.98
267_R270_E1.5090.98
53_E216_T1.4950.98
64_C127_V1.4930.98
48_I246_L1.4900.98
247_G272_L1.4890.98
103_D106_A1.4810.98
118_D150_L1.4700.98
234_A271_A1.4590.98
42_W282_H1.4410.97
270_E306_L1.4160.97
60_V223_H1.4120.97
136_A139_V1.4100.97
114_L210_V1.4040.97
164_V168_D1.3970.97
182_A227_S1.3970.97
171_K176_E1.3810.97
144_P212_Y1.3770.96
112_A142_I1.3770.96
229_Y267_R1.3590.96
43_L64_C1.3520.96
167_G181_D1.3360.96
63_W68_K1.3320.96
293_Q297_V1.3310.96
224_S248_S1.3180.95
142_I170_V1.3080.95
237_G273_N1.2890.95
141_F156_V1.2680.94
114_L177_I1.2650.94
167_G240_H1.2620.94
316_Q319_G1.2580.94
147_C207_D1.2370.94
211_N224_S1.2280.93
233_Y271_A1.2250.93
66_T95_L1.2230.93
227_S271_A1.2190.93
221_L246_L1.2010.93
251_E287_N1.1930.92
164_V170_V1.1900.92
180_L222_Y1.1890.92
112_A177_I1.1880.92
277_V312_P1.1820.92
276_V311_K1.1810.92
299_W312_P1.1750.92
71_H85_M1.1700.92
39_A322_T1.1460.91
298_L301_M1.1450.91
43_L47_G1.1440.91
269_G274_A1.1430.91
71_H86_A1.1360.90
264_D267_R1.1160.90
112_A172_V1.1080.89
214_F221_L1.1020.89
167_G236_H1.0890.88
213_L237_G1.0820.88
291_D294_E1.0790.88
183_F230_S1.0710.87
48_I278_I1.0670.87
143_G212_Y1.0650.87
237_G272_L1.0650.87
253_P261_T1.0630.87
104_P130_A1.0540.87
47_G64_C1.0450.86
266_L299_W1.0440.86
177_I214_F1.0420.86
87_G93_P1.0330.86
228_H262_S1.0300.85
60_V214_F1.0200.85
233_Y268_M1.0190.85
238_N273_N1.0190.85
105_F130_A1.0190.85
261_T265_M1.0180.85
50_L221_L1.0160.85
253_P298_L1.0130.84
56_T173_K1.0070.84
60_V114_L1.0010.84
151_W161_C0.9960.83
118_D207_D0.9870.83
247_G260_M0.9840.83
302_K306_L0.9680.82
261_T264_D0.9660.81
96_R284_I0.9630.81
245_A277_V0.9620.81
203_D206_D0.9520.80
144_P210_V0.9470.80
143_G147_C0.9420.80
171_K174_D0.9410.80
261_T298_L0.9370.79
253_P257_T0.9360.79
254_R257_T0.9350.79
56_T112_A0.9330.79
47_G63_W0.9310.79
98_T317_V0.9250.79
185_R204_G0.9250.79
224_S280_F0.9220.78
267_R306_L0.9200.78
39_A51_K0.9130.78
252_N295_I0.9120.78
93_P96_R0.9110.77
290_A295_I0.9110.77
107_I110_I0.9070.77
251_E295_I0.9040.77
255_G261_T0.9040.77
147_C185_R0.9000.77
167_G180_L0.8990.77
248_S261_T0.8980.76
303_K312_P0.8970.76
98_T284_I0.8940.76
104_P127_V0.8850.75
128_A141_F0.8810.75
187_A207_D0.8770.75
283_D296_R0.8770.75
211_N272_L0.8770.75
123_I128_A0.8690.74
187_A204_G0.8610.73
257_T264_D0.8560.73
115_A225_G0.8530.73
144_P179_A0.8510.72
115_A143_G0.8480.72
49_W107_I0.8410.72
115_A123_I0.8400.72
110_I113_V0.8380.71
22_S26_E0.8380.71
56_T175_I0.8350.71
145_K208_R0.8330.71
200_V203_D0.8300.71
87_G96_R0.8290.71
249_Y265_M0.8290.71
248_S265_M0.8150.69
162_I170_V0.8150.69
41_W51_K0.8140.69
247_G268_M0.8130.69
166_P188_L0.8030.68
274_A277_V0.7910.67
125_V129_A0.7860.66
128_A156_V0.7860.66
220_S243_D0.7850.66
303_K308_Y0.7830.66
50_L60_V0.7800.66
50_L214_F0.7790.66
70_S120_N0.7790.66
46_T248_S0.7760.65
247_G265_M0.7700.65
165_K168_D0.7680.65
222_Y272_L0.7670.64
123_I147_C0.7620.64
57_N111_D0.7600.64
182_A211_N0.7590.64
245_A272_L0.7520.63
166_P209_A0.7520.63
123_I144_P0.7490.63
179_A212_Y0.7490.63
25_N28_I0.7470.62
183_F228_H0.7470.62
140_P160_R0.7440.62
117_H122_H0.7410.62
251_E284_I0.7390.62
255_G289_Q0.7320.61
232_Y268_M0.7310.61
222_Y268_M0.7250.60
224_S247_G0.7200.60
188_L259_K0.7180.59
52_S175_I0.7180.59
180_L242_I0.7150.59
186_T207_D0.7150.59
87_G98_T0.7120.59
69_Q86_A0.7110.59
117_H121_D0.7100.59
287_N295_I0.7090.58
115_A151_W0.7080.58
40_M50_L0.7060.58
38_F57_N0.7060.58
135_C139_V0.7040.58
227_S268_M0.7000.57
218_G273_N0.7000.57
185_R205_M0.6980.57
117_H226_D0.6970.57
107_I113_V0.6960.57
142_I164_V0.6940.57
237_G271_A0.6940.57
29_E33_V0.6930.57
125_V154_W0.6880.56
117_H184_D0.6860.56
45_C188_L0.6840.56
184_D226_D0.6830.56
48_I214_F0.6790.55
172_V214_F0.6790.55
115_A247_G0.6780.55
113_V131_V0.6780.55
64_C72_G0.6770.55
118_D187_A0.6740.55
45_C259_K0.6730.54
213_L222_Y0.6730.54
146_T256_I0.6720.54
100_F104_P0.6700.54
99_P106_A0.6700.54
117_H281_H0.6680.54
181_D236_H0.6680.54
262_S288_F0.6650.54
53_E218_G0.6640.53
178_H213_L0.6620.53
152_I158_K0.6600.53
141_F212_Y0.6590.53
30_Q33_V0.6540.52
122_H226_D0.6510.52
252_N256_I0.6510.52
276_V313_F0.6510.52
252_N262_S0.6500.52
129_A132_M0.6500.52
266_L308_Y0.6490.52
142_I179_A0.6480.52
72_G126_N0.6480.52
142_I162_I0.6470.52
304_D309_G0.6450.51
266_L306_L0.6430.51
38_F219_G0.6410.51
59_C127_V0.6380.51
118_D147_C0.6370.51
45_C120_N0.6360.50
254_R261_T0.6360.50
167_G235_K0.6320.50
40_M48_I0.6320.50
42_W317_V0.6300.50
244_V278_I0.6280.50
120_N208_R0.6260.49
67_G251_E0.6250.49
153_G200_V0.6250.49
112_A140_P0.6240.49
22_S27_E0.6220.49
27_E31_E0.6220.49
249_Y282_H0.6210.49
122_H281_H0.6200.49
69_Q93_P0.6190.49
259_K295_I0.6180.48
43_L104_P0.6160.48
268_M272_L0.6140.48
186_T209_A0.6090.47
120_N209_A0.6090.47
268_M279_P0.6080.47
169_V325_L0.5990.46
151_W264_D0.5980.46
43_L60_V0.5970.46
139_V175_I0.5970.46
148_V161_C0.5950.46
226_D281_H0.5940.46
114_L212_Y0.5920.46
298_L302_K0.5900.45
150_L154_W0.5870.45
123_I146_T0.5860.45
279_P288_F0.5860.45
66_T99_P0.5850.45
122_H184_D0.5830.45
45_C70_S0.5830.45
23_W26_E0.5810.44
147_C151_W0.5800.44
146_T188_L0.5800.44
24_L27_E0.5800.44
150_L153_G0.5790.44
164_V180_L0.5780.44
140_P171_K0.5760.44
241_Q295_I0.5740.44
227_S245_A0.5730.43
114_L172_V0.5720.43
276_V309_G0.5720.43
249_Y284_I0.5720.43
188_L209_A0.5710.43
167_G178_H0.5700.43
64_C104_P0.5700.43
276_V279_P0.5690.43
161_C296_R0.5690.43
171_K175_I0.5690.43
149_D152_I0.5680.43
188_L262_S0.5660.43
70_S145_K0.5650.43
186_T228_H0.5650.43
43_L100_F0.5650.43
164_V210_V0.5640.42
250_G295_I0.5630.42
249_Y299_W0.5620.42
118_D186_T0.5610.42
123_I228_H0.5610.42
85_M205_M0.5600.42
65_G285_W0.5600.42
184_D259_K0.5600.42
87_G124_D0.5570.42
132_M156_V0.5570.42
296_R314_I0.5560.42
211_N225_G0.5540.41
62_F184_D0.5540.41
124_D285_W0.5530.41
50_L64_C0.5510.41
26_E29_E0.5500.41
169_V240_H0.5500.41
292_P315_W0.5500.41
65_G69_Q0.5490.41
278_I315_W0.5480.41
188_L208_R0.5470.41
248_S290_A0.5470.41
46_T131_V0.5450.40
269_G311_K0.5420.40
164_V169_V0.5420.40
45_C166_P0.5400.40
169_V254_R0.5390.40
211_N284_I0.5390.40
54_G250_G0.5380.40
42_W163_V0.5370.40
279_P290_A0.5370.40
253_P289_Q0.5370.40
209_A228_H0.5360.39
256_I288_F0.5360.39
113_V127_V0.5360.39
127_V258_D0.5360.39
266_L270_E0.5350.39
33_V38_F0.5340.39
166_P208_R0.5340.39
261_T288_F0.5340.39
185_R290_A0.5330.39
182_A236_H0.5330.39
56_T60_V0.5310.39
216_T320_K0.5290.39
37_T322_T0.5270.39
175_I216_T0.5250.38
47_G104_P0.5220.38
247_G312_P0.5220.38
65_G126_N0.5210.38
56_T111_D0.5210.38
301_M305_R0.5210.38
247_G277_V0.5190.38
228_H256_I0.5170.37
146_T262_S0.5160.37
29_E36_G0.5160.37
56_T311_K0.5160.37
270_E310_F0.5140.37
141_F151_W0.5140.37
110_I139_V0.5140.37
101_V284_I0.5130.37
251_E286_S0.5110.37
151_W156_V0.5110.37
46_T135_C0.5090.37
53_E219_G0.5080.37
69_Q87_G0.5080.37
44_G277_V0.5080.37
278_I313_F0.5070.36
166_P259_K0.5070.36
40_M170_V0.5070.36
265_M299_W0.5060.36
142_I172_V0.5060.36
269_G299_W0.5050.36
277_V303_K0.5030.36
132_M135_C0.5020.36
49_W57_N0.5020.36
42_W260_M0.5010.36
43_L278_I0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qn9A 2 0.7994 100 0.482 Contact Map
3bv6A 5 0.9972 100 0.539 Contact Map
2wylA 5 0.8616 100 0.58 Contact Map
3rpcA 2 0.6949 100 0.632 Contact Map
4jo0A 2 0.7458 100 0.672 Contact Map
3kl7A 1 0.6186 100 0.748 Contact Map
3zwfA 2 0.5932 100 0.749 Contact Map
2cbnA 2 0.6921 100 0.761 Contact Map
1zkpA 2 0.6469 100 0.761 Contact Map
1y44A 2 0.7006 100 0.766 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.