ULAG - ECOLI - GREMLIN Contacts

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ULAG - Probable L-ascorbate-6-phosphate lactonase UlaG

UniProt:	P39300	Sequences: MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPLMKQGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPKTCVDLWIGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDDRAVNYLFKTPGGSLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADMLRMGEALNAKVVIPFHHDIWSNFQADPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12492
Length:	354 (272)
Sequences:	1418 (963)
Seq/√Len:	58.4

ECOLI - ULAG
BACSU - YDDR
HALSA - Q9HR59 Q9HR33 Y1038

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
179_A	210_V	4.793	1.00
263_A	298_L	4.026	1.00
140_P	162_I	3.892	1.00
215_K	220_S	3.674	1.00
245_A	274_A	3.604	1.00
229_Y	271_A	3.564	1.00
48_I	280_F	3.524	1.00
180_L	213_L	3.333	1.00
148_V	163_V	3.310	1.00
269_G	277_V	3.212	1.00
176_E	215_K	3.102	1.00
213_L	242_I	2.980	1.00
145_K	165_K	2.790	1.00
51_K	57_N	2.784	1.00
213_L	240_H	2.594	1.00
243_D	275_K	2.573	1.00
58_V	112_A	2.554	1.00
65_G	124_D	2.538	1.00
41_W	320_K	2.538	1.00
116_T	223_H	2.482	1.00
169_V	176_E	2.480	1.00
266_L	302_K	2.478	1.00
178_H	215_K	2.369	1.00
294_E	298_L	2.362	1.00
72_G	85_M	2.351	1.00
260_M	268_M	2.287	1.00
113_V	141_F	2.247	1.00
178_H	240_H	2.178	1.00
223_H	280_F	2.140	1.00
60_V	116_T	2.094	1.00
267_R	271_A	1.893	1.00
40_M	244_V	1.885	1.00
148_V	152_I	1.867	1.00
164_V	179_A	1.828	1.00
245_A	269_G	1.775	0.99
47_G	60_V	1.769	0.99
180_L	211_N	1.765	0.99
237_G	242_I	1.760	0.99
235_K	238_N	1.759	0.99
169_V	178_H	1.748	0.99
142_I	177_I	1.702	0.99
39_A	320_K	1.699	0.99
282_H	296_R	1.667	0.99
177_I	212_Y	1.655	0.99
142_I	212_Y	1.616	0.99
67_G	93_P	1.606	0.99
167_G	239_E	1.605	0.99
246_L	278_I	1.574	0.98
265_M	277_V	1.568	0.98
220_S	242_I	1.564	0.98
114_L	214_F	1.554	0.98
235_K	239_E	1.552	0.98
67_G	87_G	1.551	0.98
234_A	238_N	1.536	0.98
302_K	305_R	1.530	0.98
43_L	101_V	1.510	0.98
267_R	270_E	1.509	0.98
53_E	216_T	1.495	0.98
64_C	127_V	1.493	0.98
48_I	246_L	1.490	0.98
247_G	272_L	1.489	0.98
103_D	106_A	1.481	0.98
118_D	150_L	1.470	0.98
234_A	271_A	1.459	0.98
42_W	282_H	1.441	0.97
270_E	306_L	1.416	0.97
60_V	223_H	1.412	0.97
136_A	139_V	1.410	0.97
114_L	210_V	1.404	0.97
164_V	168_D	1.397	0.97
182_A	227_S	1.397	0.97
171_K	176_E	1.381	0.97
144_P	212_Y	1.377	0.96
112_A	142_I	1.377	0.96
229_Y	267_R	1.359	0.96
43_L	64_C	1.352	0.96
167_G	181_D	1.336	0.96
63_W	68_K	1.332	0.96
293_Q	297_V	1.331	0.96
224_S	248_S	1.318	0.95
142_I	170_V	1.308	0.95
237_G	273_N	1.289	0.95
141_F	156_V	1.268	0.94
114_L	177_I	1.265	0.94
167_G	240_H	1.262	0.94
316_Q	319_G	1.258	0.94
147_C	207_D	1.237	0.94
211_N	224_S	1.228	0.93
233_Y	271_A	1.225	0.93
66_T	95_L	1.223	0.93
227_S	271_A	1.219	0.93
221_L	246_L	1.201	0.93
251_E	287_N	1.193	0.92
164_V	170_V	1.190	0.92
180_L	222_Y	1.189	0.92
112_A	177_I	1.188	0.92
277_V	312_P	1.182	0.92
276_V	311_K	1.181	0.92
299_W	312_P	1.175	0.92
71_H	85_M	1.170	0.92
39_A	322_T	1.146	0.91
298_L	301_M	1.145	0.91
43_L	47_G	1.144	0.91
269_G	274_A	1.143	0.91
71_H	86_A	1.136	0.90
264_D	267_R	1.116	0.90
112_A	172_V	1.108	0.89
214_F	221_L	1.102	0.89
167_G	236_H	1.089	0.88
213_L	237_G	1.082	0.88
291_D	294_E	1.079	0.88
183_F	230_S	1.071	0.87
48_I	278_I	1.067	0.87
143_G	212_Y	1.065	0.87
237_G	272_L	1.065	0.87
253_P	261_T	1.063	0.87
104_P	130_A	1.054	0.87
47_G	64_C	1.045	0.86
266_L	299_W	1.044	0.86
177_I	214_F	1.042	0.86
87_G	93_P	1.033	0.86
228_H	262_S	1.030	0.85
60_V	214_F	1.020	0.85
233_Y	268_M	1.019	0.85
238_N	273_N	1.019	0.85
105_F	130_A	1.019	0.85
261_T	265_M	1.018	0.85
50_L	221_L	1.016	0.85
253_P	298_L	1.013	0.84
56_T	173_K	1.007	0.84
60_V	114_L	1.001	0.84
151_W	161_C	0.996	0.83
118_D	207_D	0.987	0.83
247_G	260_M	0.984	0.83
302_K	306_L	0.968	0.82
261_T	264_D	0.966	0.81
96_R	284_I	0.963	0.81
245_A	277_V	0.962	0.81
203_D	206_D	0.952	0.80
144_P	210_V	0.947	0.80
143_G	147_C	0.942	0.80
171_K	174_D	0.941	0.80
261_T	298_L	0.937	0.79
253_P	257_T	0.936	0.79
254_R	257_T	0.935	0.79
56_T	112_A	0.933	0.79
47_G	63_W	0.931	0.79
98_T	317_V	0.925	0.79
185_R	204_G	0.925	0.79
224_S	280_F	0.922	0.78
267_R	306_L	0.920	0.78
39_A	51_K	0.913	0.78
252_N	295_I	0.912	0.78
93_P	96_R	0.911	0.77
290_A	295_I	0.911	0.77
107_I	110_I	0.907	0.77
251_E	295_I	0.904	0.77
255_G	261_T	0.904	0.77
147_C	185_R	0.900	0.77
167_G	180_L	0.899	0.77
248_S	261_T	0.898	0.76
303_K	312_P	0.897	0.76
98_T	284_I	0.894	0.76
104_P	127_V	0.885	0.75
128_A	141_F	0.881	0.75
187_A	207_D	0.877	0.75
283_D	296_R	0.877	0.75
211_N	272_L	0.877	0.75
123_I	128_A	0.869	0.74
187_A	204_G	0.861	0.73
257_T	264_D	0.856	0.73
115_A	225_G	0.853	0.73
144_P	179_A	0.851	0.72
115_A	143_G	0.848	0.72
49_W	107_I	0.841	0.72
115_A	123_I	0.840	0.72
110_I	113_V	0.838	0.71
22_S	26_E	0.838	0.71
56_T	175_I	0.835	0.71
145_K	208_R	0.833	0.71
200_V	203_D	0.830	0.71
87_G	96_R	0.829	0.71
249_Y	265_M	0.829	0.71
248_S	265_M	0.815	0.69
162_I	170_V	0.815	0.69
41_W	51_K	0.814	0.69
247_G	268_M	0.813	0.69
166_P	188_L	0.803	0.68
274_A	277_V	0.791	0.67
125_V	129_A	0.786	0.66
128_A	156_V	0.786	0.66
220_S	243_D	0.785	0.66
303_K	308_Y	0.783	0.66
50_L	60_V	0.780	0.66
50_L	214_F	0.779	0.66
70_S	120_N	0.779	0.66
46_T	248_S	0.776	0.65
247_G	265_M	0.770	0.65
165_K	168_D	0.768	0.65
222_Y	272_L	0.767	0.64
123_I	147_C	0.762	0.64
57_N	111_D	0.760	0.64
182_A	211_N	0.759	0.64
245_A	272_L	0.752	0.63
166_P	209_A	0.752	0.63
123_I	144_P	0.749	0.63
179_A	212_Y	0.749	0.63
25_N	28_I	0.747	0.62
183_F	228_H	0.747	0.62
140_P	160_R	0.744	0.62
117_H	122_H	0.741	0.62
251_E	284_I	0.739	0.62
255_G	289_Q	0.732	0.61
232_Y	268_M	0.731	0.61
222_Y	268_M	0.725	0.60
224_S	247_G	0.720	0.60
188_L	259_K	0.718	0.59
52_S	175_I	0.718	0.59
180_L	242_I	0.715	0.59
186_T	207_D	0.715	0.59
87_G	98_T	0.712	0.59
69_Q	86_A	0.711	0.59
117_H	121_D	0.710	0.59
287_N	295_I	0.709	0.58
115_A	151_W	0.708	0.58
40_M	50_L	0.706	0.58
38_F	57_N	0.706	0.58
135_C	139_V	0.704	0.58
227_S	268_M	0.700	0.57
218_G	273_N	0.700	0.57
185_R	205_M	0.698	0.57
117_H	226_D	0.697	0.57
107_I	113_V	0.696	0.57
142_I	164_V	0.694	0.57
237_G	271_A	0.694	0.57
29_E	33_V	0.693	0.57
125_V	154_W	0.688	0.56
117_H	184_D	0.686	0.56
45_C	188_L	0.684	0.56
184_D	226_D	0.683	0.56
48_I	214_F	0.679	0.55
172_V	214_F	0.679	0.55
115_A	247_G	0.678	0.55
113_V	131_V	0.678	0.55
64_C	72_G	0.677	0.55
118_D	187_A	0.674	0.55
45_C	259_K	0.673	0.54
213_L	222_Y	0.673	0.54
146_T	256_I	0.672	0.54
100_F	104_P	0.670	0.54
99_P	106_A	0.670	0.54
117_H	281_H	0.668	0.54
181_D	236_H	0.668	0.54
262_S	288_F	0.665	0.54
53_E	218_G	0.664	0.53
178_H	213_L	0.662	0.53
152_I	158_K	0.660	0.53
141_F	212_Y	0.659	0.53
30_Q	33_V	0.654	0.52
122_H	226_D	0.651	0.52
252_N	256_I	0.651	0.52
276_V	313_F	0.651	0.52
252_N	262_S	0.650	0.52
129_A	132_M	0.650	0.52
266_L	308_Y	0.649	0.52
142_I	179_A	0.648	0.52
72_G	126_N	0.648	0.52
142_I	162_I	0.647	0.52
304_D	309_G	0.645	0.51
266_L	306_L	0.643	0.51
38_F	219_G	0.641	0.51
59_C	127_V	0.638	0.51
118_D	147_C	0.637	0.51
45_C	120_N	0.636	0.50
254_R	261_T	0.636	0.50
167_G	235_K	0.632	0.50
40_M	48_I	0.632	0.50
42_W	317_V	0.630	0.50
244_V	278_I	0.628	0.50
120_N	208_R	0.626	0.49
67_G	251_E	0.625	0.49
153_G	200_V	0.625	0.49
112_A	140_P	0.624	0.49
22_S	27_E	0.622	0.49
27_E	31_E	0.622	0.49
249_Y	282_H	0.621	0.49
122_H	281_H	0.620	0.49
69_Q	93_P	0.619	0.49
259_K	295_I	0.618	0.48
43_L	104_P	0.616	0.48
268_M	272_L	0.614	0.48
186_T	209_A	0.609	0.47
120_N	209_A	0.609	0.47
268_M	279_P	0.608	0.47
169_V	325_L	0.599	0.46
151_W	264_D	0.598	0.46
43_L	60_V	0.597	0.46
139_V	175_I	0.597	0.46
148_V	161_C	0.595	0.46
226_D	281_H	0.594	0.46
114_L	212_Y	0.592	0.46
298_L	302_K	0.590	0.45
150_L	154_W	0.587	0.45
123_I	146_T	0.586	0.45
279_P	288_F	0.586	0.45
66_T	99_P	0.585	0.45
122_H	184_D	0.583	0.45
45_C	70_S	0.583	0.45
23_W	26_E	0.581	0.44
147_C	151_W	0.580	0.44
146_T	188_L	0.580	0.44
24_L	27_E	0.580	0.44
150_L	153_G	0.579	0.44
164_V	180_L	0.578	0.44
140_P	171_K	0.576	0.44
241_Q	295_I	0.574	0.44
227_S	245_A	0.573	0.43
114_L	172_V	0.572	0.43
276_V	309_G	0.572	0.43
249_Y	284_I	0.572	0.43
188_L	209_A	0.571	0.43
167_G	178_H	0.570	0.43
64_C	104_P	0.570	0.43
276_V	279_P	0.569	0.43
161_C	296_R	0.569	0.43
171_K	175_I	0.569	0.43
149_D	152_I	0.568	0.43
188_L	262_S	0.566	0.43
70_S	145_K	0.565	0.43
186_T	228_H	0.565	0.43
43_L	100_F	0.565	0.43
164_V	210_V	0.564	0.42
250_G	295_I	0.563	0.42
249_Y	299_W	0.562	0.42
118_D	186_T	0.561	0.42
123_I	228_H	0.561	0.42
85_M	205_M	0.560	0.42
65_G	285_W	0.560	0.42
184_D	259_K	0.560	0.42
87_G	124_D	0.557	0.42
132_M	156_V	0.557	0.42
296_R	314_I	0.556	0.42
211_N	225_G	0.554	0.41
62_F	184_D	0.554	0.41
124_D	285_W	0.553	0.41
50_L	64_C	0.551	0.41
26_E	29_E	0.550	0.41
169_V	240_H	0.550	0.41
292_P	315_W	0.550	0.41
65_G	69_Q	0.549	0.41
278_I	315_W	0.548	0.41
188_L	208_R	0.547	0.41
248_S	290_A	0.547	0.41
46_T	131_V	0.545	0.40
269_G	311_K	0.542	0.40
164_V	169_V	0.542	0.40
45_C	166_P	0.540	0.40
169_V	254_R	0.539	0.40
211_N	284_I	0.539	0.40
54_G	250_G	0.538	0.40
42_W	163_V	0.537	0.40
279_P	290_A	0.537	0.40
253_P	289_Q	0.537	0.40
209_A	228_H	0.536	0.39
256_I	288_F	0.536	0.39
113_V	127_V	0.536	0.39
127_V	258_D	0.536	0.39
266_L	270_E	0.535	0.39
33_V	38_F	0.534	0.39
166_P	208_R	0.534	0.39
261_T	288_F	0.534	0.39
185_R	290_A	0.533	0.39
182_A	236_H	0.533	0.39
56_T	60_V	0.531	0.39
216_T	320_K	0.529	0.39
37_T	322_T	0.527	0.39
175_I	216_T	0.525	0.38
47_G	104_P	0.522	0.38
247_G	312_P	0.522	0.38
65_G	126_N	0.521	0.38
56_T	111_D	0.521	0.38
301_M	305_R	0.521	0.38
247_G	277_V	0.519	0.38
228_H	256_I	0.517	0.37
146_T	262_S	0.516	0.37
29_E	36_G	0.516	0.37
56_T	311_K	0.516	0.37
270_E	310_F	0.514	0.37
141_F	151_W	0.514	0.37
110_I	139_V	0.514	0.37
101_V	284_I	0.513	0.37
251_E	286_S	0.511	0.37
151_W	156_V	0.511	0.37
46_T	135_C	0.509	0.37
53_E	219_G	0.508	0.37
69_Q	87_G	0.508	0.37
44_G	277_V	0.508	0.37
278_I	313_F	0.507	0.36
166_P	259_K	0.507	0.36
40_M	170_V	0.507	0.36
265_M	299_W	0.506	0.36
142_I	172_V	0.506	0.36
269_G	299_W	0.505	0.36
277_V	303_K	0.503	0.36
132_M	135_C	0.502	0.36
49_W	57_N	0.502	0.36
42_W	260_M	0.501	0.36
43_L	278_I	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qn9A	2	0.7994	100	0.482	Contact Map
3bv6A	5	0.9972	100	0.539	Contact Map
2wylA	5	0.8616	100	0.58	Contact Map
3rpcA	2	0.6949	100	0.632	Contact Map
4jo0A	2	0.7458	100	0.672	Contact Map
3kl7A	1	0.6186	100	0.748	Contact Map
3zwfA	2	0.5932	100	0.749	Contact Map
2cbnA	2	0.6921	100	0.761	Contact Map
1zkpA	2	0.6469	100	0.761	Contact Map
1y44A	2	0.7006	100	0.766	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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