GREMLIN Database
YJFP - Esterase YjfP
UniProt: P39298 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12490
Length: 249 (213)
Sequences: 48743 (35722)
Seq/√Len: 2447.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_A133_C4.5621.00
63_P90_E3.7341.00
125_T134_T3.1251.00
195_L227_P3.0901.00
224_S240_A3.0161.00
53_A242_V2.8241.00
195_L225_W2.5161.00
202_A225_W2.4581.00
226_Q240_A2.3701.00
33_Y91_F2.2231.00
136_S139_G2.1311.00
92_T128_H2.1291.00
110_A245_F2.0411.00
92_T124_I2.0201.00
184_L187_R1.9761.00
29_C56_R1.8881.00
95_R109_L1.8731.00
92_T96_A1.8681.00
111_V121_A1.8681.00
206_L225_W1.8591.00
46_F238_L1.7981.00
19_P56_R1.7951.00
121_A134_T1.7901.00
108_R132_R1.7431.00
123_G127_R1.6991.00
27_L56_R1.6941.00
240_A243_T1.6871.00
53_A246_R1.6781.00
16_H56_R1.6761.00
49_A53_A1.6711.00
189_L212_L1.6541.00
33_Y62_A1.6401.00
96_A130_T1.6121.00
180_H183_Q1.5841.00
202_A206_L1.5741.00
122_L136_S1.5731.00
222_T240_A1.5611.00
91_F124_I1.5471.00
18_Y56_R1.5371.00
209_Q223_C1.5171.00
58_I94_L1.5061.00
206_L210_Q1.5021.00
22_Q27_L1.4741.00
118_A139_G1.4721.00
135_A241_A1.4691.00
88_M123_G1.4471.00
55_L246_R1.4401.00
97_A101_E1.4351.00
40_S67_S1.4301.00
17_A59_M1.4261.00
193_H202_A1.4161.00
207_R211_A1.4161.00
193_H205_S1.4161.00
92_T127_R1.4071.00
190_L224_S1.4031.00
226_Q229_V1.4021.00
110_A132_R1.3981.00
29_C58_I1.3961.00
35_G115_S1.3911.00
47_A59_M1.3621.00
30_V55_L1.3601.00
124_I128_H1.3481.00
49_A238_L1.3461.00
239_D243_T1.3431.00
123_G126_A1.3361.00
49_A242_V1.3341.00
33_Y121_A1.3201.00
28_P108_R1.3161.00
137_M237_A1.3061.00
134_T189_L1.2891.00
89_Q127_R1.2821.00
99_A130_T1.2781.00
33_Y60_P1.2701.00
49_A52_Q1.2701.00
114_A138_M1.2631.00
58_I98_I1.2571.00
242_V246_R1.2521.00
209_Q215_T1.2321.00
32_F112_G1.2271.00
36_F116_M1.2091.00
51_A57_V1.2031.00
84_L87_S1.2021.00
15_L40_S1.2011.00
97_A100_E1.1921.00
237_A241_A1.1851.00
196_D228_G1.1801.00
135_A245_F1.1671.00
168_I171_P1.1621.00
30_V112_G1.1601.00
195_L228_G1.1601.00
60_P91_F1.1561.00
34_H62_A1.1541.00
213_S216_G1.1501.00
112_G137_M1.1341.00
16_H58_I1.1261.00
207_R210_Q1.1191.00
28_P55_L1.1181.00
62_A120_T1.1131.00
29_C98_I1.0981.00
96_A100_E1.0961.00
14_V58_I1.0941.00
32_F57_V1.0931.00
111_V124_I1.0761.00
33_Y111_V1.0731.00
96_A128_H1.0721.00
60_P94_L1.0711.00
195_L202_A1.0711.00
126_A180_H1.0691.00
48_V52_Q1.0571.00
95_R131_V1.0521.00
34_H65_H1.0481.00
182_E211_A1.0471.00
110_A135_A1.0411.00
193_H225_W1.0391.00
164_E167_N1.0281.00
14_V94_L1.0271.00
93_T96_A1.0251.00
206_L223_C1.0251.00
55_L110_A1.0071.00
37_T65_H0.9961.00
38_S42_V0.9921.00
112_G135_A0.9921.00
13_P67_S0.9911.00
192_W226_Q0.9881.00
138_M197_D0.9761.00
114_A137_M0.9761.00
123_G180_H0.9601.00
86_Q89_Q0.9591.00
29_C109_L0.9571.00
55_L245_F0.9521.00
193_H223_C0.9491.00
30_V50_L0.9311.00
85_L127_R0.9301.00
31_I95_R0.9291.00
192_W224_S0.9261.00
44_S48_V0.9211.00
28_P110_A0.9161.00
138_M233_I0.9141.00
136_S191_L0.9111.00
83_I86_Q0.9071.00
193_H200_V0.9071.00
71_G74_A0.9051.00
122_L208_L0.9021.00
191_L209_Q0.8971.00
19_P27_L0.8961.00
134_T187_R0.8961.00
37_T115_S0.8871.00
62_A116_M0.8861.00
191_L205_S0.8861.00
40_S59_M0.8851.00
192_W237_A0.8791.00
47_A51_A0.8791.00
203_D206_L0.8581.00
91_F120_T0.8571.00
229_V233_I0.8521.00
32_F47_A0.8431.00
209_Q213_S0.8421.00
191_L208_L0.8391.00
125_T187_R0.8341.00
18_Y22_Q0.8271.00
94_L98_I0.8261.00
122_L139_G0.8201.00
135_A190_L0.8141.00
127_R180_H0.8121.00
13_P61_D0.8121.00
89_Q93_T0.8111.00
40_S61_D0.8091.00
92_T130_T0.8091.00
165_F168_I0.8071.00
163_N167_N0.7961.00
119_M140_S0.7951.00
89_Q92_T0.7951.00
203_D207_R0.7911.00
173_A179_N0.7881.00
32_F43_Y0.7871.00
85_L89_Q0.7861.00
176_E179_N0.7831.00
114_A232_R0.7751.00
162_Q165_F0.7721.00
62_A65_H0.7651.00
22_Q25_T0.7581.00
178_T211_A0.7571.00
138_M194_G0.7551.00
16_H19_P0.7521.00
133_C137_M0.7511.00
169_V172_L0.7481.00
17_A51_A0.7441.00
94_L97_A0.7411.00
209_Q216_G0.7381.00
17_A57_V0.7381.00
38_S119_M0.7381.00
205_S223_C0.7381.00
21_G27_L0.7331.00
133_C245_F0.7211.00
43_Y46_F0.7211.00
150_L153_P0.7151.00
138_M193_H0.7141.00
95_R124_I0.7121.00
149_S153_P0.7121.00
204_E207_R0.7091.00
198_D230_R0.7071.00
88_M92_T0.7071.00
99_A102_N0.7061.00
18_Y21_G0.7051.00
162_Q166_N0.7051.00
205_S209_Q0.7041.00
95_R100_E0.7031.00
47_A57_V0.7021.00
238_L241_A0.6991.00
206_L209_Q0.6921.00
30_V57_V0.6891.00
133_C244_F0.6891.00
28_P107_D0.6891.00
137_M241_A0.6861.00
229_V236_E0.6861.00
152_P155_I0.6861.00
82_Q86_Q0.6761.00
212_L215_T0.6741.00
114_A234_T0.6731.00
149_S152_P0.6691.00
50_L112_G0.6651.00
142_Y207_R0.6621.00
31_I60_P0.6611.00
148_R151_F0.6591.00
151_F154_L0.6571.00
87_S120_T0.6531.00
102_N106_D0.6511.00
32_F59_M0.6471.00
82_Q85_L0.6471.00
88_M120_T0.6441.00
112_G241_A0.6421.00
190_L222_T0.6411.00
179_N182_E0.6401.00
163_N166_N0.6391.00
48_V51_A0.6371.00
168_I172_L0.6361.00
145_S148_R0.6351.00
61_D66_G0.6351.00
30_V245_F0.6341.00
113_G121_A0.6341.00
118_A136_S0.6331.00
177_A180_H0.6321.00
17_A47_A0.6301.00
170_A174_E0.6291.00
45_Y48_V0.6281.00
178_T207_R0.6251.00
31_I58_I0.6251.00
95_R99_A0.6211.00
14_V97_A0.6161.00
243_T246_R0.6141.00
109_L131_V0.6141.00
137_M192_W0.6131.00
141_G208_L0.6131.00
92_T95_R0.6091.00
30_V110_A0.6081.00
29_C100_E0.6061.00
202_A223_C0.6051.00
124_I131_V0.6031.00
100_E109_L0.6021.00
122_L141_G0.5991.00
166_N169_V0.5991.00
150_L155_I0.5951.00
170_A173_A0.5951.00
147_A150_L0.5921.00
44_S59_M0.5901.00
13_P40_S0.5891.00
190_L240_A0.5891.00
167_N171_P0.5871.00
178_T181_L0.5821.00
152_P156_P0.5821.00
191_L212_L0.5821.00
165_F169_V0.5801.00
37_T116_M0.5751.00
99_A106_D0.5751.00
164_E171_P0.5751.00
142_Y145_S0.5731.00
111_V131_V0.5721.00
49_A239_D0.5721.00
41_L44_S0.5701.00
150_L154_L0.5661.00
51_A54_G0.5651.00
129_P185_S0.5601.00
31_I109_L0.5581.00
151_F155_I0.5571.00
26_P56_R0.5561.00
166_N170_A0.5551.00
137_M234_T0.5521.00
238_L242_V0.5511.00
36_F65_H0.5491.00
115_S231_H0.5411.00
119_M123_G0.5371.00
111_V134_T0.5351.00
142_Y176_E0.5351.00
126_A183_Q0.5341.00
33_Y120_T0.5331.00
55_L242_V0.5311.00
88_M127_R0.5281.00
181_L211_A0.5261.00
210_Q214_E0.5261.00
50_L241_A0.5241.00
230_R236_E0.5241.00
135_A192_W0.5221.00
62_A87_S0.5211.00
165_F172_L0.5201.00
15_L18_Y0.5191.00
167_N170_A0.5171.00
58_I102_N0.5151.00
192_W240_A0.5151.00
36_F62_A0.5111.00
22_Q26_P0.5101.00
95_R130_T0.5051.00
146_L150_L0.5051.00
87_S116_M0.5041.00
118_A200_V0.5041.00
84_L116_M0.5031.00
50_L57_V0.5021.00
99_A107_D0.5021.00
191_L223_C0.5021.00
68_R72_D0.5001.00
61_D67_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z3zA 2 0.9478 100 0.27 Contact Map
4q1vA 2 0.9478 100 0.27 Contact Map
2ecfA 2 0.9478 100 0.274 Contact Map
1xfdA 2 0.9478 100 0.275 Contact Map
4wjlA 2 0.9478 100 0.285 Contact Map
3azoA 1 0.9759 100 0.285 Contact Map
4hxfB 4 0.9679 100 0.288 Contact Map
3o4hA 2 0.9398 100 0.298 Contact Map
1z68A 2 0.9558 100 0.298 Contact Map
4a5sA 2 0.9558 100 0.301 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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