GREMLIN Database
QUEG - Epoxyqueuosine reductase
UniProt: P39288 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12481
Length: 379 (338)
Sequences: 2113 (1273)
Seq/√Len: 69.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_S288_K4.7451.00
17_W20_E4.2551.00
13_K128_H3.4431.00
237_P347_Q3.2911.00
165_N172_F3.2141.00
143_I178_L3.2071.00
14_I125_I3.1881.00
197_V201_T3.1031.00
161_S214_V3.0761.00
304_L334_H2.9051.00
243_I313_A2.7291.00
200_M208_I2.6171.00
76_I179_V2.5421.00
73_L182_P2.5301.00
15_K28_I2.5141.00
146_R162_L2.4351.00
235_L238_L2.4321.00
317_A348_Q2.4161.00
78_V175_G2.4161.00
202_I252_I2.4071.00
244_Y301_I2.3951.00
122_G134_F2.3931.00
11_A15_K2.3641.00
77_S176_E2.3571.00
303_H307_L2.2701.00
15_K186_D2.2471.00
42_A46_K2.2401.00
28_I74_R2.2331.00
79_R174_L2.1941.00
102_S173_F2.1661.00
11_A28_I2.1661.00
311_A326_A2.1411.00
330_R342_A2.1291.00
323_I345_I2.1281.00
108_R295_G2.0841.00
17_W124_M2.0711.00
41_Q45_D2.0651.00
133_N180_D2.0541.00
30_D151_K2.0091.00
21_L121_L1.9771.00
74_R185_V1.9731.00
11_A184_P1.9661.00
48_Y213_T1.9511.00
64_R67_E1.9281.00
326_A329_S1.9211.00
168_A172_F1.9201.00
243_I310_I1.9021.00
208_I214_V1.8881.00
218_R235_L1.8711.00
291_K294_E1.8611.00
338_D342_A1.8511.00
301_I305_R1.8121.00
58_H61_L1.7991.00
282_F314_L1.7961.00
324_L327_L1.7701.00
25_Q165_N1.7601.00
103_R251_L1.7581.00
157_T163_I1.7571.00
18_G26_V1.7271.00
72_T178_L1.7251.00
230_A339_E1.7121.00
228_E305_R1.6911.00
191_E212_Y1.6470.99
51_E227_L1.6130.99
242_R248_D1.6040.99
130_V180_D1.5970.99
30_D74_R1.5750.99
137_F141_A1.5730.99
75_V178_L1.5400.99
277_E280_E1.5360.99
25_Q167_E1.5170.99
197_V200_M1.5050.99
218_R234_E1.5040.99
40_L55_M1.4980.99
14_I28_I1.4900.99
314_L322_T1.4780.99
154_L163_I1.4780.99
75_V148_L1.4760.99
26_V78_V1.4750.99
77_S152_A1.4660.99
322_T326_A1.4530.99
146_R157_T1.4520.99
332_G338_D1.4490.99
37_E64_R1.4460.99
11_A186_D1.4400.98
333_E341_I1.4180.98
17_W21_L1.4040.98
123_E126_Q1.3960.98
44_L59_G1.3860.98
103_R106_L1.3740.98
122_G177_L1.3730.98
50_G217_R1.3700.98
339_E342_A1.3520.98
79_R172_F1.3490.98
31_T72_T1.3450.98
41_Q63_A1.3220.97
286_E290_L1.3210.97
116_N120_K1.3120.97
166_R189_V1.3120.97
136_P177_L1.2980.97
37_E63_A1.2920.97
319_W348_Q1.2840.97
130_V133_N1.2580.96
24_Q81_N1.2560.96
223_L235_L1.2490.96
310_I314_L1.2320.96
14_I26_V1.2270.96
332_G341_I1.2250.96
265_E268_S1.2200.96
145_E174_L1.2120.96
331_K338_D1.2100.95
156_W192_G1.2040.95
332_G337_L1.1990.95
283_A325_T1.1960.95
322_T327_L1.1920.95
290_L293_T1.1860.95
53_D56_A1.1780.95
80_M117_R1.1770.95
108_R266_D1.1750.95
98_L277_E1.1740.95
85_A268_S1.1730.95
99_G278_L1.1660.94
13_K124_M1.1660.94
311_A341_I1.1650.94
342_A346_A1.1580.94
338_D341_I1.1580.94
215_D218_R1.1580.94
123_E127_Q1.1470.94
15_K19_L1.1470.94
231_I312_V1.1370.94
60_M63_A1.1360.94
334_H338_D1.1260.93
189_V192_G1.1210.93
100_Y106_L1.1190.93
210_E213_T1.1070.93
232_P235_L1.1040.93
132_L179_V1.1030.93
92_T100_Y1.1010.93
29_T148_L1.0840.92
200_M211_P1.0800.92
303_H332_G1.0800.92
69_L72_T1.0650.91
78_V177_L1.0580.91
9_Q13_K1.0580.91
146_R163_I1.0570.91
34_S37_E1.0560.91
312_V340_H1.0550.91
117_R264_E1.0390.90
325_T328_E1.0370.90
160_H170_S1.0350.90
290_L299_R1.0350.90
56_A61_L1.0340.90
305_R308_R1.0330.90
116_N123_E1.0220.90
15_K26_V1.0190.89
20_E124_M1.0150.89
40_L54_W1.0140.89
42_A45_D1.0130.89
244_Y296_S1.0110.89
146_R212_Y1.0080.89
68_L141_A1.0030.89
220_I223_L0.9980.88
103_R171_F0.9980.88
294_E299_R0.9930.88
74_R182_P0.9930.88
262_T268_S0.9840.88
99_G276_P0.9830.88
71_G133_N0.9810.87
53_D57_R0.9800.87
282_F310_I0.9780.87
255_W258_Y0.9750.87
43_W55_M0.9730.87
25_Q79_R0.9720.87
210_E221_S0.9700.87
12_Q16_Q0.9690.87
159_K197_V0.9660.87
26_V76_I0.9650.87
336_L339_E0.9620.86
67_E70_P0.9500.86
30_D185_V0.9480.86
323_I327_L0.9450.85
230_A340_H0.9430.85
328_E331_K0.9370.85
226_E300_R0.9370.85
69_L178_L0.9370.85
161_S208_I0.9300.85
324_L328_E0.9270.84
24_Q263_T0.9230.84
38_P42_A0.9220.84
69_L137_F0.9160.84
244_Y298_I0.9130.83
288_K291_K0.9120.83
156_W255_W0.9050.83
50_G227_L0.9030.83
170_S250_Q0.9020.83
93_L100_Y0.8990.82
51_E229_G0.8990.82
145_E162_L0.8980.82
21_L120_K0.8970.82
284_W288_K0.8930.82
60_M67_E0.8920.82
157_T160_H0.8920.82
293_T299_R0.8880.82
156_W164_L0.8870.82
302_G305_R0.8850.81
146_R160_H0.8830.81
46_K213_T0.8750.81
61_L67_E0.8750.81
54_W171_F0.8720.81
48_Y209_V0.8690.80
132_L181_I0.8640.80
209_V215_D0.8630.80
13_K17_W0.8630.80
306_W310_I0.8600.80
33_L36_S0.8580.79
322_T329_S0.8560.79
248_D252_I0.8540.79
61_L143_I0.8530.79
220_I224_T0.8510.79
296_S299_R0.8500.79
16_Q19_L0.8500.79
164_L170_S0.8490.79
126_Q131_S0.8490.79
15_K18_G0.8490.79
78_V114_L0.8470.79
10_L129_C0.8430.78
159_K194_G0.8420.78
289_F298_I0.8390.78
236_R343_W0.8380.78
331_K342_A0.8330.77
172_F264_E0.8320.77
37_E60_M0.8280.77
166_R192_G0.8270.77
320_D327_L0.8270.77
59_G64_R0.8250.77
126_Q133_N0.8230.77
115_R137_F0.8220.76
147_P157_T0.8220.76
100_Y242_R0.8190.76
79_R168_A0.8190.76
220_I231_I0.8170.76
161_S211_P0.8150.76
74_R183_L0.8150.76
68_L137_F0.8150.76
154_L174_L0.8120.76
60_M64_R0.8110.75
171_F251_L0.8090.75
272_P292_V0.8080.75
32_D151_K0.8080.75
318_P348_Q0.8070.75
35_E38_P0.8060.75
36_S150_E0.8050.75
280_E292_V0.8050.75
145_E226_E0.8050.75
244_Y305_R0.8010.75
288_K292_V0.7930.74
160_H212_Y0.7920.74
18_G78_V0.7890.73
95_N98_L0.7880.73
102_S301_I0.7850.73
333_E338_D0.7850.73
129_C132_L0.7830.73
99_G310_I0.7810.73
61_L178_L0.7800.73
323_I329_S0.7770.72
233_E339_E0.7760.72
76_I177_L0.7730.72
72_T75_V0.7710.72
202_I206_G0.7700.72
231_I235_L0.7660.71
282_F326_A0.7650.71
44_L49_H0.7650.71
29_T185_V0.7640.71
323_I326_A0.7640.71
150_E191_E0.7600.71
41_Q59_G0.7570.70
108_R112_K0.7540.70
289_F297_A0.7500.70
155_G163_I0.7460.69
37_E67_E0.7450.69
99_G243_I0.7430.69
118_L175_G0.7410.69
102_S221_S0.7400.69
125_I181_I0.7390.69
159_K200_M0.7370.68
91_S94_K0.7370.68
68_L115_R0.7360.68
170_S256_N0.7350.68
321_E328_E0.7330.68
330_R345_I0.7320.68
320_D326_A0.7270.67
37_E41_Q0.7230.67
161_S212_Y0.7210.67
150_E157_T0.7190.66
36_S147_P0.7190.66
271_K274_H0.7170.66
117_R120_K0.7170.66
144_L147_P0.7170.66
310_I313_A0.7150.66
270_R273_L0.7130.66
115_R141_A0.7130.66
287_E302_G0.7090.65
119_K136_P0.7090.65
103_R257_R0.7090.65
331_K347_Q0.7080.65
31_T75_V0.7080.65
37_E59_G0.7070.65
49_H56_A0.7070.65
321_E327_L0.7040.65
338_D345_I0.7030.65
107_G272_P0.7030.65
232_P236_R0.6990.64
11_A74_R0.6970.64
339_E346_A0.6960.64
223_L227_L0.6930.64
325_T329_S0.6930.64
335_P346_A0.6930.64
157_T162_L0.6930.64
227_L312_V0.6920.63
307_L332_G0.6910.63
78_V118_L0.6880.63
135_R146_R0.6870.63
126_Q134_F0.6870.63
311_A337_L0.6850.63
312_V316_N0.6830.62
41_Q60_M0.6820.62
27_G152_A0.6810.62
31_T151_K0.6810.62
17_W128_H0.6810.62
80_M114_L0.6780.62
335_P339_E0.6770.62
279_I314_L0.6760.62
59_G67_E0.6750.62
266_D269_P0.6730.61
283_A328_E0.6710.61
43_W49_H0.6700.61
276_P281_L0.6690.61
101_V195_K0.6690.61
105_A296_S0.6670.61
161_S213_T0.6670.61
11_A185_V0.6660.60
10_L125_I0.6640.60
52_M300_R0.6630.60
330_R341_I0.6620.60
320_D323_I0.6570.59
112_K295_G0.6550.59
230_A312_V0.6550.59
116_N124_M0.6550.59
206_G238_L0.6540.59
29_T152_A0.6530.59
228_E336_L0.6520.59
11_A26_V0.6510.59
28_I76_I0.6450.58
311_A315_G0.6430.58
286_E303_H0.6390.57
99_G274_H0.6390.57
322_T348_Q0.6390.57
160_H208_I0.6360.57
284_W293_T0.6350.57
233_E236_R0.6310.56
113_L117_R0.6310.56
124_M128_H0.6300.56
307_L329_S0.6300.56
286_E304_L0.6300.56
101_V298_I0.6290.56
13_K16_Q0.6250.56
318_P327_L0.6240.56
137_F302_G0.6240.56
33_L151_K0.6210.55
40_L63_A0.6210.55
37_E55_M0.6200.55
233_E342_A0.6190.55
24_Q168_A0.6190.55
102_S162_L0.6180.55
92_T98_L0.6180.55
159_K211_P0.6180.55
131_S180_D0.6170.55
164_L167_E0.6150.54
36_S144_L0.6150.54
235_L239_M0.6150.54
80_M264_E0.6140.54
194_G255_W0.6140.54
304_L307_L0.6130.54
27_G178_L0.6120.54
122_G126_Q0.6080.54
333_E342_A0.6080.54
14_I181_I0.6080.54
50_G216_A0.6070.54
119_K122_G0.6070.54
303_H310_I0.6060.53
12_Q15_K0.6060.53
227_L235_L0.6050.53
96_P202_I0.6020.53
108_R299_R0.6000.53
126_Q132_L0.5990.53
322_T328_E0.5980.52
320_D348_Q0.5970.52
165_N168_A0.5960.52
113_L266_D0.5940.52
69_L180_D0.5920.52
129_C181_I0.5890.51
81_N264_E0.5870.51
233_E347_Q0.5860.51
65_P141_A0.5850.51
38_P63_A0.5830.51
192_G255_W0.5820.51
135_R142_P0.5820.51
28_I186_D0.5820.51
28_I185_V0.5820.51
121_L177_L0.5810.50
289_F302_G0.5780.50
324_L329_S0.5780.50
307_L310_I0.5740.50
71_G180_D0.5730.49
329_S341_I0.5730.49
157_T257_R0.5710.49
97_K234_E0.5690.49
334_H339_E0.5690.49
284_W292_V0.5680.49
28_I183_L0.5680.49
321_E324_L0.5670.49
209_V214_V0.5660.49
150_E189_V0.5630.48
119_K123_E0.5620.48
38_P41_Q0.5580.48
334_H342_A0.5570.47
125_I132_L0.5540.47
250_Q256_N0.5540.47
198_A252_I0.5500.47
104_Y226_E0.5500.47
112_K299_R0.5490.47
27_G77_S0.5480.46
200_M209_V0.5460.46
68_L178_L0.5450.46
122_G132_L0.5440.46
11_A183_L0.5440.46
25_Q168_A0.5430.46
9_Q12_Q0.5430.46
105_A297_A0.5430.46
284_W306_W0.5420.46
320_D331_K0.5420.46
234_E238_L0.5420.46
91_S321_E0.5410.46
61_L64_R0.5400.45
19_L26_V0.5400.45
17_W120_K0.5400.45
304_L332_G0.5400.45
336_L342_A0.5400.45
227_L232_P0.5380.45
282_F307_L0.5380.45
312_V339_E0.5370.45
164_L191_E0.5360.45
229_G232_P0.5350.45
39_K42_A0.5350.45
211_P214_V0.5350.45
35_E74_R0.5340.45
23_F78_V0.5330.45
248_D251_L0.5330.45
111_H139_D0.5330.45
74_R184_P0.5320.44
278_L281_L0.5320.44
117_R124_M0.5310.44
112_K116_N0.5300.44
329_S348_Q0.5300.44
338_D346_A0.5290.44
238_L347_Q0.5280.44
324_L348_Q0.5270.44
122_G179_V0.5260.44
192_G258_Y0.5250.44
331_K346_A0.5250.44
329_S337_L0.5250.44
48_Y220_I0.5250.44
234_E237_P0.5250.44
132_L180_D0.5250.44
315_G343_W0.5230.43
159_K205_T0.5210.43
107_G273_L0.5210.43
52_M226_E0.5200.43
18_G121_L0.5200.43
147_P162_L0.5200.43
147_P150_E0.5190.43
221_S244_Y0.5190.43
84_P244_Y0.5180.43
195_K198_A0.5180.43
218_R287_E0.5170.43
33_L37_E0.5160.43
69_L135_R0.5160.43
301_I306_W0.5140.42
75_V176_E0.5140.42
287_E291_K0.5140.42
319_W324_L0.5120.42
136_P175_G0.5120.42
13_K200_M0.5110.42
236_R315_G0.5110.42
105_A298_I0.5090.42
202_I248_D0.5080.42
29_T151_K0.5070.42
272_P276_P0.5060.41
35_E39_K0.5050.41
24_Q80_M0.5050.41
33_L75_V0.5050.41
43_W50_G0.5040.41
320_D324_L0.5020.41
14_I183_L0.5010.41
160_H202_I0.5010.41
16_Q20_E0.5000.41
226_E301_I0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rasA 2 0.8285 100 0.603 Contact Map
4uquA 2 0.7098 100 0.7 Contact Map
2bs2B 1 0.6069 99.4 0.896 Contact Map
3i9v9 1 0.3219 98.8 0.917 Contact Map
4jw2A 1 0.19 98.7 0.922 Contact Map
4jw3C 1 0.2559 98.1 0.934 Contact Map
1te4A 1 0.2902 98 0.935 Contact Map
2v2kA 1 0.2612 97.8 0.939 Contact Map
3ltmA 1 0.285 97.8 0.939 Contact Map
2zvsA 1 0.2032 97.7 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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