QUEG - ECOLI - GREMLIN Contacts

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QUEG - Epoxyqueuosine reductase

UniProt:	P39288	Sequences: MSEPLDLNQLAQKIKQWGLELGFQQVGITDTDLSESEPKLQAWLDKQYHGEMDWMARHGMLRARPHELLPGTLRVISVRMNYLPANAAFASTLKNPKLGYVSRYALGRDYHKLLRNRLKKLGEMIQQHCVSLNFRPFVDSAPILERPLAEKAGLGWTGKHSLILNREAGSFFFLGELLVDIPLPVDQPVEEGCGKCVACMTICPTGAIVEPYTVDARRCISYLTIELEGAIPEELRPLMGNRIYGCDDCQLICPWNRYSQLTTEEDFSPRKPLHAPELIELFAWSEEKFLKVTEGSAIRRIGHLRWLRNIAVALGNAPWDETILTALESRKGEHPLLDEHIAWAIAQQIERRNACIVEVQLPKKQRLVRVIEKGLPRDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12481
Length:	379 (338)
Sequences:	2113 (1273)
Seq/√Len:	69.2

ECOLI - QUEG
BACSU - QUEG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
285_S	288_K	4.745	1.00
17_W	20_E	4.255	1.00
13_K	128_H	3.443	1.00
237_P	347_Q	3.291	1.00
165_N	172_F	3.214	1.00
143_I	178_L	3.207	1.00
14_I	125_I	3.188	1.00
197_V	201_T	3.103	1.00
161_S	214_V	3.076	1.00
304_L	334_H	2.905	1.00
243_I	313_A	2.729	1.00
200_M	208_I	2.617	1.00
76_I	179_V	2.542	1.00
73_L	182_P	2.530	1.00
15_K	28_I	2.514	1.00
146_R	162_L	2.435	1.00
235_L	238_L	2.432	1.00
317_A	348_Q	2.416	1.00
78_V	175_G	2.416	1.00
202_I	252_I	2.407	1.00
244_Y	301_I	2.395	1.00
122_G	134_F	2.393	1.00
11_A	15_K	2.364	1.00
77_S	176_E	2.357	1.00
303_H	307_L	2.270	1.00
15_K	186_D	2.247	1.00
42_A	46_K	2.240	1.00
28_I	74_R	2.233	1.00
79_R	174_L	2.194	1.00
102_S	173_F	2.166	1.00
11_A	28_I	2.166	1.00
311_A	326_A	2.141	1.00
330_R	342_A	2.129	1.00
323_I	345_I	2.128	1.00
108_R	295_G	2.084	1.00
17_W	124_M	2.071	1.00
41_Q	45_D	2.065	1.00
133_N	180_D	2.054	1.00
30_D	151_K	2.009	1.00
21_L	121_L	1.977	1.00
74_R	185_V	1.973	1.00
11_A	184_P	1.966	1.00
48_Y	213_T	1.951	1.00
64_R	67_E	1.928	1.00
326_A	329_S	1.921	1.00
168_A	172_F	1.920	1.00
243_I	310_I	1.902	1.00
208_I	214_V	1.888	1.00
218_R	235_L	1.871	1.00
291_K	294_E	1.861	1.00
338_D	342_A	1.851	1.00
301_I	305_R	1.812	1.00
58_H	61_L	1.799	1.00
282_F	314_L	1.796	1.00
324_L	327_L	1.770	1.00
25_Q	165_N	1.760	1.00
103_R	251_L	1.758	1.00
157_T	163_I	1.757	1.00
18_G	26_V	1.727	1.00
72_T	178_L	1.725	1.00
230_A	339_E	1.712	1.00
228_E	305_R	1.691	1.00
191_E	212_Y	1.647	0.99
51_E	227_L	1.613	0.99
242_R	248_D	1.604	0.99
130_V	180_D	1.597	0.99
30_D	74_R	1.575	0.99
137_F	141_A	1.573	0.99
75_V	178_L	1.540	0.99
277_E	280_E	1.536	0.99
25_Q	167_E	1.517	0.99
197_V	200_M	1.505	0.99
218_R	234_E	1.504	0.99
40_L	55_M	1.498	0.99
14_I	28_I	1.490	0.99
314_L	322_T	1.478	0.99
154_L	163_I	1.478	0.99
75_V	148_L	1.476	0.99
26_V	78_V	1.475	0.99
77_S	152_A	1.466	0.99
322_T	326_A	1.453	0.99
146_R	157_T	1.452	0.99
332_G	338_D	1.449	0.99
37_E	64_R	1.446	0.99
11_A	186_D	1.440	0.98
333_E	341_I	1.418	0.98
17_W	21_L	1.404	0.98
123_E	126_Q	1.396	0.98
44_L	59_G	1.386	0.98
103_R	106_L	1.374	0.98
122_G	177_L	1.373	0.98
50_G	217_R	1.370	0.98
339_E	342_A	1.352	0.98
79_R	172_F	1.349	0.98
31_T	72_T	1.345	0.98
41_Q	63_A	1.322	0.97
286_E	290_L	1.321	0.97
116_N	120_K	1.312	0.97
166_R	189_V	1.312	0.97
136_P	177_L	1.298	0.97
37_E	63_A	1.292	0.97
319_W	348_Q	1.284	0.97
130_V	133_N	1.258	0.96
24_Q	81_N	1.256	0.96
223_L	235_L	1.249	0.96
310_I	314_L	1.232	0.96
14_I	26_V	1.227	0.96
332_G	341_I	1.225	0.96
265_E	268_S	1.220	0.96
145_E	174_L	1.212	0.96
331_K	338_D	1.210	0.95
156_W	192_G	1.204	0.95
332_G	337_L	1.199	0.95
283_A	325_T	1.196	0.95
322_T	327_L	1.192	0.95
290_L	293_T	1.186	0.95
53_D	56_A	1.178	0.95
80_M	117_R	1.177	0.95
108_R	266_D	1.175	0.95
98_L	277_E	1.174	0.95
85_A	268_S	1.173	0.95
99_G	278_L	1.166	0.94
13_K	124_M	1.166	0.94
311_A	341_I	1.165	0.94
342_A	346_A	1.158	0.94
338_D	341_I	1.158	0.94
215_D	218_R	1.158	0.94
123_E	127_Q	1.147	0.94
15_K	19_L	1.147	0.94
231_I	312_V	1.137	0.94
60_M	63_A	1.136	0.94
334_H	338_D	1.126	0.93
189_V	192_G	1.121	0.93
100_Y	106_L	1.119	0.93
210_E	213_T	1.107	0.93
232_P	235_L	1.104	0.93
132_L	179_V	1.103	0.93
92_T	100_Y	1.101	0.93
29_T	148_L	1.084	0.92
200_M	211_P	1.080	0.92
303_H	332_G	1.080	0.92
69_L	72_T	1.065	0.91
78_V	177_L	1.058	0.91
9_Q	13_K	1.058	0.91
146_R	163_I	1.057	0.91
34_S	37_E	1.056	0.91
312_V	340_H	1.055	0.91
117_R	264_E	1.039	0.90
325_T	328_E	1.037	0.90
160_H	170_S	1.035	0.90
290_L	299_R	1.035	0.90
56_A	61_L	1.034	0.90
305_R	308_R	1.033	0.90
116_N	123_E	1.022	0.90
15_K	26_V	1.019	0.89
20_E	124_M	1.015	0.89
40_L	54_W	1.014	0.89
42_A	45_D	1.013	0.89
244_Y	296_S	1.011	0.89
146_R	212_Y	1.008	0.89
68_L	141_A	1.003	0.89
220_I	223_L	0.998	0.88
103_R	171_F	0.998	0.88
294_E	299_R	0.993	0.88
74_R	182_P	0.993	0.88
262_T	268_S	0.984	0.88
99_G	276_P	0.983	0.88
71_G	133_N	0.981	0.87
53_D	57_R	0.980	0.87
282_F	310_I	0.978	0.87
255_W	258_Y	0.975	0.87
43_W	55_M	0.973	0.87
25_Q	79_R	0.972	0.87
210_E	221_S	0.970	0.87
12_Q	16_Q	0.969	0.87
159_K	197_V	0.966	0.87
26_V	76_I	0.965	0.87
336_L	339_E	0.962	0.86
67_E	70_P	0.950	0.86
30_D	185_V	0.948	0.86
323_I	327_L	0.945	0.85
230_A	340_H	0.943	0.85
328_E	331_K	0.937	0.85
226_E	300_R	0.937	0.85
69_L	178_L	0.937	0.85
161_S	208_I	0.930	0.85
324_L	328_E	0.927	0.84
24_Q	263_T	0.923	0.84
38_P	42_A	0.922	0.84
69_L	137_F	0.916	0.84
244_Y	298_I	0.913	0.83
288_K	291_K	0.912	0.83
156_W	255_W	0.905	0.83
50_G	227_L	0.903	0.83
170_S	250_Q	0.902	0.83
93_L	100_Y	0.899	0.82
51_E	229_G	0.899	0.82
145_E	162_L	0.898	0.82
21_L	120_K	0.897	0.82
284_W	288_K	0.893	0.82
60_M	67_E	0.892	0.82
157_T	160_H	0.892	0.82
293_T	299_R	0.888	0.82
156_W	164_L	0.887	0.82
302_G	305_R	0.885	0.81
146_R	160_H	0.883	0.81
46_K	213_T	0.875	0.81
61_L	67_E	0.875	0.81
54_W	171_F	0.872	0.81
48_Y	209_V	0.869	0.80
132_L	181_I	0.864	0.80
209_V	215_D	0.863	0.80
13_K	17_W	0.863	0.80
306_W	310_I	0.860	0.80
33_L	36_S	0.858	0.79
322_T	329_S	0.856	0.79
248_D	252_I	0.854	0.79
61_L	143_I	0.853	0.79
220_I	224_T	0.851	0.79
296_S	299_R	0.850	0.79
16_Q	19_L	0.850	0.79
164_L	170_S	0.849	0.79
126_Q	131_S	0.849	0.79
15_K	18_G	0.849	0.79
78_V	114_L	0.847	0.79
10_L	129_C	0.843	0.78
159_K	194_G	0.842	0.78
289_F	298_I	0.839	0.78
236_R	343_W	0.838	0.78
331_K	342_A	0.833	0.77
172_F	264_E	0.832	0.77
37_E	60_M	0.828	0.77
166_R	192_G	0.827	0.77
320_D	327_L	0.827	0.77
59_G	64_R	0.825	0.77
126_Q	133_N	0.823	0.77
115_R	137_F	0.822	0.76
147_P	157_T	0.822	0.76
100_Y	242_R	0.819	0.76
79_R	168_A	0.819	0.76
220_I	231_I	0.817	0.76
161_S	211_P	0.815	0.76
74_R	183_L	0.815	0.76
68_L	137_F	0.815	0.76
154_L	174_L	0.812	0.76
60_M	64_R	0.811	0.75
171_F	251_L	0.809	0.75
272_P	292_V	0.808	0.75
32_D	151_K	0.808	0.75
318_P	348_Q	0.807	0.75
35_E	38_P	0.806	0.75
36_S	150_E	0.805	0.75
280_E	292_V	0.805	0.75
145_E	226_E	0.805	0.75
244_Y	305_R	0.801	0.75
288_K	292_V	0.793	0.74
160_H	212_Y	0.792	0.74
18_G	78_V	0.789	0.73
95_N	98_L	0.788	0.73
102_S	301_I	0.785	0.73
333_E	338_D	0.785	0.73
129_C	132_L	0.783	0.73
99_G	310_I	0.781	0.73
61_L	178_L	0.780	0.73
323_I	329_S	0.777	0.72
233_E	339_E	0.776	0.72
76_I	177_L	0.773	0.72
72_T	75_V	0.771	0.72
202_I	206_G	0.770	0.72
231_I	235_L	0.766	0.71
282_F	326_A	0.765	0.71
44_L	49_H	0.765	0.71
29_T	185_V	0.764	0.71
323_I	326_A	0.764	0.71
150_E	191_E	0.760	0.71
41_Q	59_G	0.757	0.70
108_R	112_K	0.754	0.70
289_F	297_A	0.750	0.70
155_G	163_I	0.746	0.69
37_E	67_E	0.745	0.69
99_G	243_I	0.743	0.69
118_L	175_G	0.741	0.69
102_S	221_S	0.740	0.69
125_I	181_I	0.739	0.69
159_K	200_M	0.737	0.68
91_S	94_K	0.737	0.68
68_L	115_R	0.736	0.68
170_S	256_N	0.735	0.68
321_E	328_E	0.733	0.68
330_R	345_I	0.732	0.68
320_D	326_A	0.727	0.67
37_E	41_Q	0.723	0.67
161_S	212_Y	0.721	0.67
150_E	157_T	0.719	0.66
36_S	147_P	0.719	0.66
271_K	274_H	0.717	0.66
117_R	120_K	0.717	0.66
144_L	147_P	0.717	0.66
310_I	313_A	0.715	0.66
270_R	273_L	0.713	0.66
115_R	141_A	0.713	0.66
287_E	302_G	0.709	0.65
119_K	136_P	0.709	0.65
103_R	257_R	0.709	0.65
331_K	347_Q	0.708	0.65
31_T	75_V	0.708	0.65
37_E	59_G	0.707	0.65
49_H	56_A	0.707	0.65
321_E	327_L	0.704	0.65
338_D	345_I	0.703	0.65
107_G	272_P	0.703	0.65
232_P	236_R	0.699	0.64
11_A	74_R	0.697	0.64
339_E	346_A	0.696	0.64
223_L	227_L	0.693	0.64
325_T	329_S	0.693	0.64
335_P	346_A	0.693	0.64
157_T	162_L	0.693	0.64
227_L	312_V	0.692	0.63
307_L	332_G	0.691	0.63
78_V	118_L	0.688	0.63
135_R	146_R	0.687	0.63
126_Q	134_F	0.687	0.63
311_A	337_L	0.685	0.63
312_V	316_N	0.683	0.62
41_Q	60_M	0.682	0.62
27_G	152_A	0.681	0.62
31_T	151_K	0.681	0.62
17_W	128_H	0.681	0.62
80_M	114_L	0.678	0.62
335_P	339_E	0.677	0.62
279_I	314_L	0.676	0.62
59_G	67_E	0.675	0.62
266_D	269_P	0.673	0.61
283_A	328_E	0.671	0.61
43_W	49_H	0.670	0.61
276_P	281_L	0.669	0.61
101_V	195_K	0.669	0.61
105_A	296_S	0.667	0.61
161_S	213_T	0.667	0.61
11_A	185_V	0.666	0.60
10_L	125_I	0.664	0.60
52_M	300_R	0.663	0.60
330_R	341_I	0.662	0.60
320_D	323_I	0.657	0.59
112_K	295_G	0.655	0.59
230_A	312_V	0.655	0.59
116_N	124_M	0.655	0.59
206_G	238_L	0.654	0.59
29_T	152_A	0.653	0.59
228_E	336_L	0.652	0.59
11_A	26_V	0.651	0.59
28_I	76_I	0.645	0.58
311_A	315_G	0.643	0.58
286_E	303_H	0.639	0.57
99_G	274_H	0.639	0.57
322_T	348_Q	0.639	0.57
160_H	208_I	0.636	0.57
284_W	293_T	0.635	0.57
233_E	236_R	0.631	0.56
113_L	117_R	0.631	0.56
124_M	128_H	0.630	0.56
307_L	329_S	0.630	0.56
286_E	304_L	0.630	0.56
101_V	298_I	0.629	0.56
13_K	16_Q	0.625	0.56
318_P	327_L	0.624	0.56
137_F	302_G	0.624	0.56
33_L	151_K	0.621	0.55
40_L	63_A	0.621	0.55
37_E	55_M	0.620	0.55
233_E	342_A	0.619	0.55
24_Q	168_A	0.619	0.55
102_S	162_L	0.618	0.55
92_T	98_L	0.618	0.55
159_K	211_P	0.618	0.55
131_S	180_D	0.617	0.55
164_L	167_E	0.615	0.54
36_S	144_L	0.615	0.54
235_L	239_M	0.615	0.54
80_M	264_E	0.614	0.54
194_G	255_W	0.614	0.54
304_L	307_L	0.613	0.54
27_G	178_L	0.612	0.54
122_G	126_Q	0.608	0.54
333_E	342_A	0.608	0.54
14_I	181_I	0.608	0.54
50_G	216_A	0.607	0.54
119_K	122_G	0.607	0.54
303_H	310_I	0.606	0.53
12_Q	15_K	0.606	0.53
227_L	235_L	0.605	0.53
96_P	202_I	0.602	0.53
108_R	299_R	0.600	0.53
126_Q	132_L	0.599	0.53
322_T	328_E	0.598	0.52
320_D	348_Q	0.597	0.52
165_N	168_A	0.596	0.52
113_L	266_D	0.594	0.52
69_L	180_D	0.592	0.52
129_C	181_I	0.589	0.51
81_N	264_E	0.587	0.51
233_E	347_Q	0.586	0.51
65_P	141_A	0.585	0.51
38_P	63_A	0.583	0.51
192_G	255_W	0.582	0.51
135_R	142_P	0.582	0.51
28_I	186_D	0.582	0.51
28_I	185_V	0.582	0.51
121_L	177_L	0.581	0.50
289_F	302_G	0.578	0.50
324_L	329_S	0.578	0.50
307_L	310_I	0.574	0.50
71_G	180_D	0.573	0.49
329_S	341_I	0.573	0.49
157_T	257_R	0.571	0.49
97_K	234_E	0.569	0.49
334_H	339_E	0.569	0.49
284_W	292_V	0.568	0.49
28_I	183_L	0.568	0.49
321_E	324_L	0.567	0.49
209_V	214_V	0.566	0.49
150_E	189_V	0.563	0.48
119_K	123_E	0.562	0.48
38_P	41_Q	0.558	0.48
334_H	342_A	0.557	0.47
125_I	132_L	0.554	0.47
250_Q	256_N	0.554	0.47
198_A	252_I	0.550	0.47
104_Y	226_E	0.550	0.47
112_K	299_R	0.549	0.47
27_G	77_S	0.548	0.46
200_M	209_V	0.546	0.46
68_L	178_L	0.545	0.46
122_G	132_L	0.544	0.46
11_A	183_L	0.544	0.46
25_Q	168_A	0.543	0.46
9_Q	12_Q	0.543	0.46
105_A	297_A	0.543	0.46
284_W	306_W	0.542	0.46
320_D	331_K	0.542	0.46
234_E	238_L	0.542	0.46
91_S	321_E	0.541	0.46
61_L	64_R	0.540	0.45
19_L	26_V	0.540	0.45
17_W	120_K	0.540	0.45
304_L	332_G	0.540	0.45
336_L	342_A	0.540	0.45
227_L	232_P	0.538	0.45
282_F	307_L	0.538	0.45
312_V	339_E	0.537	0.45
164_L	191_E	0.536	0.45
229_G	232_P	0.535	0.45
39_K	42_A	0.535	0.45
211_P	214_V	0.535	0.45
35_E	74_R	0.534	0.45
23_F	78_V	0.533	0.45
248_D	251_L	0.533	0.45
111_H	139_D	0.533	0.45
74_R	184_P	0.532	0.44
278_L	281_L	0.532	0.44
117_R	124_M	0.531	0.44
112_K	116_N	0.530	0.44
329_S	348_Q	0.530	0.44
338_D	346_A	0.529	0.44
238_L	347_Q	0.528	0.44
324_L	348_Q	0.527	0.44
122_G	179_V	0.526	0.44
192_G	258_Y	0.525	0.44
331_K	346_A	0.525	0.44
329_S	337_L	0.525	0.44
48_Y	220_I	0.525	0.44
234_E	237_P	0.525	0.44
132_L	180_D	0.525	0.44
315_G	343_W	0.523	0.43
159_K	205_T	0.521	0.43
107_G	273_L	0.521	0.43
52_M	226_E	0.520	0.43
18_G	121_L	0.520	0.43
147_P	162_L	0.520	0.43
147_P	150_E	0.519	0.43
221_S	244_Y	0.519	0.43
84_P	244_Y	0.518	0.43
195_K	198_A	0.518	0.43
218_R	287_E	0.517	0.43
33_L	37_E	0.516	0.43
69_L	135_R	0.516	0.43
301_I	306_W	0.514	0.42
75_V	176_E	0.514	0.42
287_E	291_K	0.514	0.42
319_W	324_L	0.512	0.42
136_P	175_G	0.512	0.42
13_K	200_M	0.511	0.42
236_R	315_G	0.511	0.42
105_A	298_I	0.509	0.42
202_I	248_D	0.508	0.42
29_T	151_K	0.507	0.42
272_P	276_P	0.506	0.41
35_E	39_K	0.505	0.41
24_Q	80_M	0.505	0.41
33_L	75_V	0.505	0.41
43_W	50_G	0.504	0.41
320_D	324_L	0.502	0.41
14_I	183_L	0.501	0.41
160_H	202_I	0.501	0.41
16_Q	20_E	0.500	0.41
226_E	301_I	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rasA	2	0.8285	100	0.603	Contact Map
4uquA	2	0.7098	100	0.7	Contact Map
2bs2B	1	0.6069	99.4	0.896	Contact Map
3i9v9	1	0.3219	98.8	0.917	Contact Map
4jw2A	1	0.19	98.7	0.922	Contact Map
4jw3C	1	0.2559	98.1	0.934	Contact Map
1te4A	1	0.2902	98	0.935	Contact Map
2v2kA	1	0.2612	97.8	0.939	Contact Map
3ltmA	1	0.285	97.8	0.939	Contact Map
2zvsA	1	0.2032	97.7	0.94	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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