GREMLIN Database
RSGA - Putative ribosome biogenesis GTPase RsgA
UniProt: P39286 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12479
Length: 350 (289)
Sequences: 3953 (2659)
Seq/√Len: 156.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
323_E327_E4.1081.00
80_V99_A3.8381.00
80_V101_H3.6201.00
43_I78_R3.5311.00
82_R98_E3.4281.00
125_Q210_S3.2081.00
314_E318_E3.1421.00
154_E186_R3.0381.00
55_E257_H2.9521.00
298_K309_G2.7311.00
132_I159_L2.5921.00
240_S243_S2.5741.00
41_E101_H2.5511.00
126_I148_C2.5371.00
149_E185_Y2.5301.00
42_G54_V2.3581.00
186_R204_A2.3271.00
234_I256_Y2.3091.00
293_Y315_A2.3071.00
127_V210_S2.2491.00
127_V156_I2.2331.00
56_S81_W2.2121.00
156_I204_A2.1931.00
125_Q208_R2.1711.00
229_G232_K2.1241.00
160_N192_S2.0931.00
124_D208_R2.0901.00
104_T124_D2.0791.00
305_D330_H2.0581.00
64_C95_G1.9831.00
142_D328_N1.9781.00
178_D181_R1.9751.00
303_K306_T1.9691.00
127_V158_V1.9421.00
46_S254_R1.9221.00
120_A265_I1.9171.00
127_V212_F1.9011.00
53_D63_R1.8621.00
194_T197_G1.8101.00
126_I211_I1.7991.00
192_S222_S1.7941.00
326_F330_H1.7661.00
56_S59_G1.7651.00
41_E80_V1.7531.00
123_I211_I1.7201.00
177_M181_R1.7041.00
293_Y321_I1.6841.00
54_V81_W1.6641.00
150_T282_Q1.6451.00
311_A315_A1.6311.00
44_V54_V1.6131.00
305_D333_L1.6131.00
212_F264_V1.5991.00
311_A314_E1.5951.00
126_I153_I1.5341.00
41_E78_R1.5231.00
147_A273_F1.4961.00
197_G200_P1.4921.00
290_F294_L1.4851.00
44_V73_L1.4761.00
188_L204_A1.4731.00
313_R317_E1.4701.00
178_D182_N1.4551.00
202_E260_H1.4481.00
191_S222_S1.4401.00
237_N247_Q1.4321.00
289_E325_R1.4121.00
43_I209_I1.4091.00
130_S141_I1.4051.00
62_H81_W1.4031.00
125_Q156_I1.3921.00
179_I322_A1.3811.00
257_H263_D1.3791.00
234_I252_A1.3771.00
142_D180_Y1.3731.00
195_Q226_A1.3681.00
54_V64_C1.3581.00
296_L311_A1.3531.00
316_V326_F1.3511.00
154_E208_R1.3511.00
228_L231_Q1.3481.00
225_N236_T1.3371.00
108_T116_V1.3221.00
107_L153_I1.3201.00
52_A97_V1.3061.00
259_P262_G1.2961.00
141_I157_I1.2941.00
228_L232_K1.2931.00
68_R71_R1.2861.00
334_E338_Q1.2841.00
293_Y311_A1.2811.00
200_P203_E1.2801.00
139_N328_N1.2761.00
78_R104_T1.2731.00
166_D169_G1.2701.00
64_C68_R1.2701.00
73_L100_V1.2651.00
279_E282_Q1.2641.00
45_I55_E1.2561.00
174_N178_D1.2501.00
174_N177_M1.2451.00
290_F293_Y1.2411.00
125_Q205_L1.2391.00
303_K333_L1.2271.00
158_V201_L1.2251.00
222_S236_T1.2191.00
42_G81_W1.2121.00
199_K202_E1.2061.00
81_W95_G1.1971.00
228_L259_P1.1901.00
149_E288_V1.1741.00
46_S53_D1.1571.00
224_L264_V1.1561.00
127_V201_L1.1541.00
203_E206_T1.1521.00
177_M189_M1.1521.00
314_E317_E1.1491.00
105_S124_D1.1481.00
106_V118_P1.1471.00
148_C155_P1.1451.00
191_S197_G1.1381.00
85_K92_N1.1261.00
162_I189_M1.1201.00
146_V287_F1.1161.00
132_I162_I1.1131.00
283_I333_L1.1051.00
56_S62_H1.1020.99
299_Y308_P1.0910.99
145_L185_Y1.0910.99
131_A218_V1.0890.99
284_T290_F1.0870.99
317_E323_E1.0840.99
294_L312_I1.0840.99
64_C70_I1.0800.99
221_S234_I1.0770.99
324_T328_N1.0770.99
149_E291_H1.0490.99
283_I336_M1.0380.99
207_G261_G1.0350.99
293_Y320_K1.0290.99
119_I253_A1.0260.99
56_S60_D1.0250.99
131_A136_L1.0240.99
313_R326_F1.0220.99
289_E321_I1.0130.99
205_L210_S1.0120.99
74_V106_V1.0120.99
127_V205_L1.0010.99
139_N331_R0.9960.99
42_G56_S0.9950.99
78_R209_I0.9920.99
46_S252_A0.9890.99
278_L283_I0.9840.99
329_Y333_L0.9750.99
125_Q204_A0.9740.99
136_L176_Q0.9720.99
225_N234_I0.9720.99
127_V204_A0.9660.99
160_N223_L0.9640.99
206_T261_G0.9560.99
186_R200_P0.9510.98
190_V222_S0.9340.98
192_S226_A0.9330.98
129_V160_N0.9250.98
198_L202_E0.9230.98
125_Q154_E0.9160.98
315_A320_K0.9160.98
66_I70_I0.9110.98
255_L263_D0.9070.98
138_L176_Q0.9070.98
174_N189_M0.9040.98
280_P337_A0.9020.98
144_Y213_A0.9000.98
229_G233_E0.8960.98
42_G95_G0.8960.98
119_I270_V0.8910.98
162_I196_D0.8900.98
129_V223_L0.8850.98
74_V118_P0.8770.97
211_I267_S0.8730.97
291_H294_L0.8730.97
295_G312_I0.8710.97
62_H83_P0.8690.97
105_S123_I0.8690.97
131_A239_I0.8670.97
55_E263_D0.8590.97
65_N97_V0.8570.97
312_I326_F0.8570.97
158_V188_L0.8570.97
69_T98_E0.8560.97
295_G311_A0.8540.97
181_R186_R0.8540.97
328_N332_I0.8530.97
84_G93_V0.8520.97
205_L262_G0.8490.97
165_L169_G0.8490.97
290_F321_I0.8470.97
107_L211_I0.8450.97
158_V190_V0.8380.97
136_L215_Q0.8360.97
315_A321_I0.8340.97
287_F328_N0.8340.97
150_T286_G0.8240.96
133_L244_G0.8230.96
45_I61_V0.8220.96
239_I243_S0.8200.96
290_F312_I0.8190.96
42_G64_C0.8190.96
139_N143_R0.8140.96
327_E330_H0.8140.96
146_V286_G0.8090.96
79_V100_V0.8070.96
140_I215_Q0.8060.96
198_L226_A0.8060.96
133_L239_I0.7980.96
298_K308_P0.7910.95
84_G94_K0.7880.95
67_R70_I0.7850.95
179_I324_T0.7850.95
43_I263_D0.7770.95
156_I188_L0.7760.95
131_A215_Q0.7690.95
188_L200_P0.7660.94
63_R66_I0.7660.94
177_M187_V0.7660.94
192_S197_G0.7660.94
316_V323_E0.7640.94
212_F223_L0.7630.94
108_T276_W0.7610.94
143_R335_S0.7600.94
290_F295_G0.7600.94
306_T313_R0.7590.94
160_N190_V0.7540.94
179_I182_N0.7520.94
284_T291_H0.7480.94
157_I180_Y0.7470.94
133_L165_L0.7460.94
145_L288_V0.7460.94
132_I165_L0.7460.94
66_I71_R0.7440.94
283_I332_I0.7400.93
51_H65_N0.7400.93
66_I73_L0.7380.93
65_N84_G0.7370.93
282_Q285_Q0.7360.93
309_G313_R0.7360.93
198_L223_L0.7340.93
51_H63_R0.7320.93
181_R189_M0.7310.93
137_S215_Q0.7290.93
131_A134_P0.7280.93
175_E178_D0.7260.93
137_S245_L0.7240.93
174_N181_R0.7230.93
282_Q286_G0.7210.92
275_L332_I0.7140.92
305_D334_E0.7130.92
66_I69_T0.7120.92
190_V223_L0.7110.92
139_N245_L0.7070.92
275_L336_M0.7060.92
141_I176_Q0.7040.92
62_H93_V0.7020.91
145_L149_E0.7000.91
85_K93_V0.6980.91
241_D244_G0.6970.91
209_I263_D0.6950.91
330_H333_L0.6920.91
157_I185_Y0.6900.91
152_Q282_Q0.6890.91
134_P244_G0.6880.91
316_V321_I0.6880.91
285_Q291_H0.6870.91
107_L148_C0.6860.91
257_H262_G0.6840.90
128_I213_A0.6830.90
154_E288_V0.6820.90
70_I73_L0.6810.90
195_Q198_L0.6790.90
146_V336_M0.6780.90
176_Q180_Y0.6740.90
285_Q294_L0.6740.90
143_R248_H0.6700.89
130_S215_Q0.6700.89
188_L205_L0.6700.89
123_I153_I0.6670.89
305_D313_R0.6650.89
82_R96_I0.6620.89
130_S140_I0.6610.89
52_A71_R0.6610.89
307_D313_R0.6580.89
138_L324_T0.6580.89
183_I289_E0.6550.88
79_V97_V0.6550.88
253_A265_I0.6540.88
191_S226_A0.6520.88
191_S198_L0.6510.88
193_H197_G0.6500.88
83_P95_G0.6490.88
299_Y309_G0.6470.88
210_S262_G0.6440.88
74_V121_A0.6410.87
139_N324_T0.6410.87
63_R94_K0.6400.87
147_A287_F0.6390.87
84_G92_N0.6380.87
292_D295_G0.6360.87
196_D199_K0.6330.87
120_A123_I0.6330.87
135_E215_Q0.6320.87
239_I244_G0.6310.86
63_R71_R0.6280.86
175_E179_I0.6270.86
305_D337_A0.6270.86
258_F262_G0.6260.86
215_Q218_V0.6220.86
229_G234_I0.6210.86
110_P114_D0.6190.85
191_S194_T0.6180.85
229_G340_K0.6150.85
199_K203_E0.6140.85
280_P340_K0.6140.85
57_A78_R0.6120.85
158_V272_E0.6100.85
245_L267_S0.6090.85
218_V222_S0.6080.84
145_L155_P0.6080.84
291_H295_G0.6080.84
239_I248_H0.6080.84
224_L256_Y0.6070.84
50_M66_I0.6050.84
162_I173_V0.6030.84
228_L233_E0.6000.84
243_S328_N0.5990.84
160_N191_S0.5990.84
146_V332_I0.5970.83
47_R70_I0.5970.83
202_E259_P0.5960.83
67_R96_I0.5960.83
85_K94_K0.5940.83
105_S151_L0.5940.83
133_L169_G0.5920.83
202_E227_L0.5920.83
144_Y273_F0.5900.83
165_L168_E0.5860.82
293_Y296_L0.5860.82
55_E59_G0.5860.82
152_Q156_I0.5850.82
149_E184_G0.5840.82
112_F115_G0.5840.82
110_P113_Y0.5830.82
64_C67_R0.5830.82
43_I55_E0.5820.82
288_V293_Y0.5820.82
82_R85_K0.5810.82
149_E155_P0.5790.81
165_L173_V0.5780.81
119_I251_T0.5770.81
326_F329_Y0.5740.81
303_K307_D0.5740.81
284_T294_L0.5730.81
78_R101_H0.5730.81
168_E174_N0.5720.81
159_L162_I0.5720.81
225_N233_E0.5720.81
140_I253_A0.5700.80
159_L187_V0.5700.80
209_I255_L0.5690.80
240_S245_L0.5690.80
232_K256_Y0.5680.80
53_D61_V0.5630.80
157_I187_V0.5580.79
65_N70_I0.5580.79
143_R225_N0.5580.79
131_A160_N0.5550.79
132_I136_L0.5540.79
276_W339_V0.5540.79
293_Y316_V0.5530.78
182_N185_Y0.5530.78
140_I301_D0.5520.78
49_G253_A0.5510.78
292_D296_L0.5510.78
160_N201_L0.5510.78
147_A332_I0.5500.78
197_G226_A0.5480.78
185_Y288_V0.5480.78
120_A211_I0.5470.78
258_F261_G0.5460.78
314_E320_K0.5440.77
327_E331_R0.5440.77
152_Q285_Q0.5430.77
119_I271_R0.5390.77
44_V56_S0.5350.76
201_L204_A0.5350.76
160_N267_S0.5350.76
333_L337_A0.5340.76
47_R51_H0.5340.76
168_E189_M0.5340.76
107_L244_G0.5330.76
65_N94_K0.5330.76
68_R73_L0.5320.76
48_F51_H0.5290.75
227_L258_F0.5280.75
144_Y251_T0.5270.75
73_L141_I0.5270.75
213_A224_L0.5250.75
144_Y215_Q0.5250.75
138_L328_N0.5250.75
130_S136_L0.5240.75
206_T262_G0.5230.75
147_A150_T0.5160.74
283_I329_Y0.5160.74
245_L251_T0.5160.74
105_S153_I0.5150.73
66_I72_S0.5140.73
52_A252_A0.5140.73
179_I279_E0.5130.73
179_I183_I0.5130.73
160_N222_S0.5120.73
203_E207_G0.5110.73
105_S272_E0.5110.73
159_L189_M0.5100.73
194_T222_S0.5080.72
47_R52_A0.5080.72
296_L322_A0.5060.72
201_L227_L0.5060.72
305_D316_V0.5050.72
157_I179_I0.5030.72
222_S226_A0.5030.72
242_N247_Q0.5030.72
119_I272_E0.5020.72
284_T303_K0.5010.71
330_H334_E0.5010.71
48_F53_D0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rcnA 2 0.7886 100 0.268 Contact Map
1t9hA 1 0.7943 100 0.391 Contact Map
1u0lA 1 0.7771 100 0.398 Contact Map
2yv5A 1 0.82 100 0.408 Contact Map
3cnlA 1 0.5657 99.9 0.799 Contact Map
1pujA 1 0.5657 99.9 0.802 Contact Map
3ec1A 1 0.6343 99.9 0.809 Contact Map
3h2yA 1 0.6429 99.9 0.81 Contact Map
4tmxA 1 0.8257 99.8 0.836 Contact Map
1mkyA 1 0.7343 99.7 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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