GREMLIN Database
YJEM - Inner membrane transporter YjeM
UniProt: P39282 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12475
Length: 500 (429)
Sequences: 24701 (16607)
Seq/√Len: 801.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_T369_C4.3921.00
351_P363_I4.3571.00
414_F418_R3.4541.00
354_R363_I3.1251.00
238_K242_K3.0721.00
9_S234_E2.9031.00
72_Y345_K2.7861.00
235_N238_K2.6671.00
233_T239_N2.6411.00
43_I47_L2.6371.00
88_T342_G2.6301.00
406_L438_T2.6041.00
356_N362_S2.5391.00
343_T353_T2.5351.00
139_V373_T2.5191.00
14_I246_F2.5021.00
285_V288_K2.4701.00
351_P354_R2.4511.00
178_S261_L2.4251.00
231_D344_P2.3861.00
311_W315_I2.3211.00
59_E416_K2.3161.00
42_Y45_S2.3131.00
176_L180_T2.2791.00
10_L246_F2.2551.00
76_N84_A2.1691.00
340_I344_P2.1521.00
232_K337_K2.1501.00
147_V151_K2.1291.00
366_W370_G2.0881.00
154_N158_R2.0691.00
46_A252_S2.0521.00
285_V289_S2.0371.00
146_T365_M2.0311.00
10_L14_I2.0221.00
143_I373_T2.0191.00
150_S362_S2.0161.00
13_L233_T1.9991.00
10_L239_N1.9931.00
435_M439_V1.9621.00
409_A437_A1.9321.00
139_V376_I1.9261.00
76_N81_P1.9211.00
165_I169_C1.9171.00
79_V414_F1.8901.00
14_I250_V1.8881.00
352_M367_M1.8871.00
242_K246_F1.8811.00
9_S12_G1.8791.00
56_M409_A1.8771.00
138_A376_I1.8631.00
47_L51_I1.8551.00
346_A350_E1.8191.00
92_F368_Q1.8181.00
39_I42_Y1.8121.00
79_V410_L1.8051.00
267_N270_Q1.7441.00
143_I369_C1.7391.00
478_L482_A1.7341.00
12_G161_A1.7291.00
451_F455_Q1.7241.00
235_N239_N1.7181.00
245_V249_I1.7081.00
42_Y47_L1.7071.00
75_M87_G1.7001.00
431_H435_M1.6991.00
356_N360_M1.6871.00
281_N285_V1.6871.00
169_C173_V1.6671.00
450_V454_I1.6411.00
87_G407_F1.6361.00
8_M12_G1.6331.00
42_Y49_F1.6321.00
39_I43_I1.6271.00
477_S480_A1.6131.00
149_A329_F1.5961.00
448_A452_T1.5941.00
150_S366_W1.5841.00
432_L436_I1.5811.00
270_Q289_S1.5711.00
358_M362_S1.5671.00
103_S328_F1.5641.00
80_G83_F1.5591.00
142_M372_V1.5521.00
449_N452_T1.5521.00
17_I247_A1.5361.00
282_I286_L1.5351.00
452_T455_Q1.5301.00
249_I253_I1.5301.00
99_M372_V1.5281.00
410_L438_T1.5241.00
133_V136_L1.5061.00
5_I359_G1.5031.00
229_L333_Y1.4571.00
414_F417_A1.4451.00
43_I49_F1.4401.00
282_I291_G1.4391.00
42_Y50_F1.4321.00
110_F137_L1.4311.00
363_I367_M1.4251.00
170_L319_S1.4241.00
335_P368_Q1.4231.00
235_N242_K1.4191.00
54_A248_A1.4061.00
474_V478_L1.4061.00
42_Y46_A1.4041.00
151_K358_M1.4031.00
339_I364_A1.3981.00
430_T434_A1.3931.00
476_F480_A1.3891.00
472_G476_F1.3891.00
68_E231_D1.3781.00
340_I355_L1.3771.00
37_S209_M1.3681.00
106_V141_W1.3641.00
336_L365_M1.3621.00
103_S142_M1.3621.00
350_E354_R1.3581.00
472_G475_F1.3571.00
314_R318_L1.3561.00
43_I50_F1.3531.00
288_K313_A1.3511.00
146_T366_W1.3501.00
350_E353_T1.3491.00
268_W271_V1.3361.00
82_R481_M1.3351.00
12_G157_A1.3331.00
142_M369_C1.3311.00
447_F451_F1.3301.00
22_F25_A1.3291.00
179_I261_L1.3271.00
282_I285_V1.3251.00
410_L414_F1.3201.00
465_S476_F1.3161.00
139_V143_I1.3121.00
75_M407_F1.3081.00
64_Y77_N1.3021.00
286_L291_G1.2961.00
106_V321_F1.2951.00
198_S201_P1.2941.00
449_N453_I1.2911.00
354_R362_S1.2861.00
432_L435_M1.2821.00
79_V83_F1.2731.00
470_I474_V1.2671.00
444_V448_A1.2621.00
168_M172_L1.2611.00
41_F212_F1.2501.00
10_L242_K1.2391.00
53_F409_A1.2361.00
464_D467_L1.2341.00
54_A244_I1.2311.00
175_L257_L1.2311.00
339_I348_W1.2271.00
38_A42_Y1.2251.00
283_T291_G1.2251.00
473_P477_S1.2181.00
434_A438_T1.2171.00
429_K433_S1.2151.00
253_I257_L1.2101.00
188_H192_D1.2101.00
145_V328_F1.2071.00
468_W472_G1.2071.00
456_P459_E1.2061.00
477_S481_M1.2011.00
236_P241_A1.2011.00
73_S77_N1.1981.00
431_H434_A1.1911.00
102_T327_A1.1891.00
425_F428_F1.1861.00
447_F450_V1.1851.00
78_S411_A1.1841.00
21_V251_I1.1801.00
200_N203_Y1.1701.00
8_M13_L1.1631.00
283_T286_L1.1631.00
13_L243_G1.1611.00
174_L178_S1.1591.00
239_N242_K1.1561.00
189_F192_D1.1491.00
37_S200_N1.1411.00
445_V448_A1.1371.00
443_L447_F1.1341.00
8_M157_A1.1341.00
191_Q194_N1.1241.00
55_L245_V1.1221.00
17_I226_V1.1191.00
466_T470_I1.1151.00
195_F200_N1.1131.00
419_Q423_R1.1071.00
455_Q458_V1.1001.00
41_F49_F1.0991.00
63_A423_R1.0991.00
57_M71_I1.0981.00
355_L359_G1.0941.00
291_G309_G1.0941.00
234_E239_N1.0901.00
182_L264_V1.0901.00
288_K310_V1.0881.00
75_M83_F1.0861.00
18_F250_V1.0831.00
200_N204_Q1.0821.00
178_S265_S1.0781.00
471_G475_F1.0781.00
11_I15_L1.0751.00
135_G139_V1.0751.00
160_T329_F1.0701.00
40_P43_I1.0701.00
363_I366_W1.0631.00
413_P435_M1.0631.00
173_V177_V1.0611.00
72_Y341_Q1.0611.00
92_F339_I1.0581.00
148_V159_I1.0571.00
450_V453_I1.0551.00
43_I46_A1.0541.00
85_F89_F1.0541.00
63_A421_L1.0501.00
42_Y48_L1.0491.00
445_V449_N1.0451.00
61_G74_W1.0451.00
452_T457_V1.0441.00
439_V443_L1.0431.00
146_T150_S1.0411.00
419_Q422_D1.0401.00
39_I260_F1.0321.00
446_T449_N1.0211.00
370_G374_V1.0171.00
433_S437_A1.0131.00
291_G312_F1.0131.00
189_F194_N1.0101.00
159_I163_G1.0101.00
107_W137_L1.0091.00
448_A454_I1.0081.00
475_F479_L1.0071.00
451_F456_P1.0061.00
7_K234_E1.0051.00
140_A144_L1.0051.00
221_G401_M1.0051.00
56_M434_A1.0001.00
440_V444_V0.9981.00
201_P204_Q0.9971.00
110_F321_F0.9971.00
283_T287_M0.9951.00
344_P353_T0.9951.00
172_L176_L0.9941.00
163_G326_G0.9941.00
429_K432_L0.9941.00
38_A41_F0.9921.00
195_F198_S0.9891.00
16_M229_L0.9881.00
462_D476_F0.9841.00
430_T433_S0.9831.00
197_A200_N0.9781.00
188_H191_Q0.9781.00
18_F251_I0.9731.00
143_I147_V0.9671.00
158_R162_V0.9621.00
110_F114_L0.9591.00
150_S360_M0.9571.00
332_C369_C0.9551.00
195_F199_P0.9541.00
47_L436_I0.9541.00
153_I333_Y0.9431.00
441_V444_V0.9351.00
168_M254_G0.9271.00
463_W467_L0.9271.00
452_T456_P0.9251.00
80_G482_A0.9221.00
136_L140_A0.9211.00
412_F434_A0.9201.00
59_E62_A0.9181.00
444_V449_N0.9141.00
309_G312_F0.9121.00
144_L325_T0.9101.00
41_F45_S0.9081.00
268_W272_L0.9081.00
453_I456_P0.9031.00
175_L261_L0.9031.00
465_S468_W0.9021.00
406_L410_L0.8931.00
451_F454_I0.8911.00
45_S49_F0.8891.00
224_E228_G0.8891.00
101_S218_F0.8851.00
76_N345_K0.8821.00
479_L482_A0.8791.00
101_S394_T0.8771.00
469_M473_P0.8741.00
474_V477_S0.8681.00
11_I161_A0.8681.00
476_F482_A0.8651.00
167_V323_A0.8641.00
444_V451_F0.8641.00
39_I49_F0.8611.00
310_V314_R0.8601.00
62_A424_P0.8551.00
465_S472_G0.8541.00
287_M291_G0.8531.00
211_S215_F0.8531.00
448_A451_F0.8521.00
45_S50_F0.8491.00
230_V240_F0.8481.00
107_W138_A0.8471.00
362_S366_W0.8461.00
450_V455_Q0.8421.00
23_G27_S0.8401.00
471_G474_V0.8401.00
196_L200_N0.8391.00
274_N285_V0.8381.00
246_F250_V0.8381.00
36_Y39_I0.8371.00
352_M363_I0.8361.00
286_L289_S0.8321.00
369_C373_T0.8311.00
447_F453_I0.8301.00
28_P105_K0.8281.00
69_G72_Y0.8261.00
420_D423_R0.8261.00
12_G158_R0.8241.00
15_L161_A0.8241.00
462_D465_S0.8231.00
434_A437_A0.8231.00
145_V329_F0.8201.00
180_T184_L0.8191.00
150_S356_N0.8191.00
63_A424_P0.8181.00
444_V452_T0.8151.00
82_R86_I0.8151.00
260_F264_V0.8141.00
89_F348_W0.8131.00
7_K154_N0.8131.00
46_A220_Y0.8111.00
442_V446_T0.8091.00
60_M412_F0.8071.00
190_A194_N0.8061.00
467_L471_G0.8041.00
452_T458_V0.8041.00
406_L442_V0.8021.00
348_W352_M0.8011.00
179_I183_L0.8001.00
197_A201_P0.7971.00
267_N289_S0.7961.00
471_G477_S0.7941.00
444_V447_F0.7941.00
36_Y263_G0.7931.00
107_W134_V0.7931.00
175_L179_I0.7921.00
22_F27_S0.7901.00
69_G73_S0.7841.00
446_T450_V0.7831.00
454_I457_V0.7831.00
270_Q273_S0.7821.00
476_F481_M0.7821.00
135_G376_I0.7791.00
356_N359_G0.7741.00
200_N209_M0.7711.00
106_V324_Y0.7671.00
147_V150_S0.7621.00
225_A334_S0.7611.00
137_L140_A0.7611.00
37_S40_P0.7591.00
452_T459_E0.7591.00
183_L186_G0.7581.00
478_L481_M0.7581.00
284_Y288_K0.7561.00
142_M376_I0.7561.00
467_L470_I0.7561.00
75_M411_A0.7551.00
449_N455_Q0.7541.00
281_N286_L0.7531.00
465_S474_V0.7481.00
252_S256_S0.7481.00
435_M438_T0.7441.00
10_L243_G0.7441.00
158_R161_A0.7431.00
23_G28_P0.7431.00
470_I477_S0.7421.00
351_P367_M0.7401.00
89_F472_G0.7391.00
40_P44_F0.7371.00
468_W476_F0.7361.00
83_F407_F0.7331.00
269_Q273_S0.7331.00
440_V443_L0.7321.00
184_L187_G0.7301.00
184_L192_D0.7281.00
189_F193_I0.7241.00
204_Q209_M0.7211.00
106_V325_T0.7201.00
451_F458_V0.7191.00
104_A393_L0.7181.00
265_S286_L0.7171.00
111_S134_V0.7161.00
46_A50_F0.7151.00
46_A49_F0.7141.00
41_F46_A0.7121.00
433_S436_I0.7111.00
455_Q459_E0.7091.00
68_E340_I0.7091.00
174_L287_M0.7071.00
447_F452_T0.7071.00
180_T183_L0.7061.00
476_F479_L0.7051.00
283_T288_K0.7031.00
448_A453_I0.7021.00
151_K155_K0.7011.00
66_K77_N0.7011.00
470_I473_P0.6981.00
467_L472_G0.6981.00
187_G192_D0.6951.00
423_R426_V0.6881.00
282_I290_L0.6861.00
413_P417_A0.6851.00
241_A244_I0.6841.00
41_F48_L0.6831.00
96_I371_L0.6811.00
114_L117_S0.6811.00
449_N456_P0.6801.00
45_S216_A0.6791.00
396_M400_S0.6751.00
412_F416_K0.6751.00
468_W471_G0.6741.00
45_S48_L0.6731.00
416_K419_Q0.6721.00
370_G373_T0.6711.00
37_S42_Y0.6711.00
357_A362_S0.6671.00
180_T186_G0.6671.00
145_V332_C0.6661.00
198_S202_G0.6661.00
221_G405_Y0.6661.00
60_M74_W0.6661.00
421_L424_P0.6661.00
231_D340_I0.6661.00
269_Q272_L0.6651.00
78_S414_F0.6631.00
157_A161_A0.6631.00
91_W95_Y0.6631.00
117_S133_V0.6631.00
179_I257_L0.6621.00
199_P203_Y0.6621.00
7_K153_I0.6611.00
51_I436_I0.6601.00
337_K340_I0.6601.00
430_T435_M0.6581.00
19_T164_G0.6571.00
18_F164_G0.6561.00
281_N284_Y0.6541.00
33_L36_Y0.6531.00
41_F44_F0.6531.00
98_W397_A0.6521.00
57_M408_L0.6521.00
469_M472_G0.6511.00
315_I319_S0.6501.00
339_I367_M0.6491.00
100_V393_L0.6461.00
246_F249_I0.6451.00
311_W314_R0.6451.00
427_I430_T0.6441.00
440_V451_F0.6421.00
90_M404_P0.6421.00
22_F26_N0.6421.00
100_V375_F0.6401.00
175_L258_A0.6381.00
468_W480_A0.6371.00
155_K158_R0.6361.00
208_A211_S0.6351.00
43_I256_S0.6321.00
14_I243_G0.6321.00
450_V456_P0.6321.00
135_G138_A0.6321.00
467_L477_S0.6311.00
11_I158_R0.6311.00
196_L199_P0.6281.00
149_A333_Y0.6261.00
182_L261_L0.6261.00
149_A365_M0.6251.00
462_D466_T0.6241.00
437_A441_V0.6231.00
150_S358_M0.6231.00
37_S41_F0.6221.00
22_F167_V0.6211.00
284_Y287_M0.6211.00
282_I287_M0.6191.00
39_I263_G0.6191.00
66_K73_S0.6191.00
94_S401_M0.6181.00
43_I48_L0.6161.00
438_T442_V0.6161.00
257_L261_L0.6131.00
417_A431_H0.6131.00
20_S330_T0.6121.00
78_S415_F0.6101.00
468_W473_P0.6091.00
250_V254_G0.6091.00
187_G193_I0.6081.00
166_A319_S0.6061.00
98_W101_S0.6061.00
177_V181_I0.6061.00
199_P202_G0.6031.00
72_Y76_N0.6011.00
227_G244_I0.6011.00
332_C336_L0.6001.00
141_W145_V0.5991.00
258_A262_W0.5991.00
191_Q196_L0.5981.00
21_V247_A0.5971.00
465_S470_I0.5971.00
451_F457_V0.5961.00
361_P364_A0.5951.00
7_K11_I0.5951.00
97_I396_M0.5931.00
465_S469_M0.5931.00
475_F481_M0.5931.00
237_E424_P0.5921.00
343_T352_M0.5921.00
352_M364_A0.5891.00
272_L275_G0.5871.00
417_A420_D0.5861.00
422_D426_V0.5861.00
54_A223_I0.5851.00
233_T240_F0.5841.00
448_A455_Q0.5841.00
467_L474_V0.5831.00
400_S404_P0.5831.00
145_V325_T0.5831.00
446_T453_I0.5821.00
23_G26_N0.5821.00
61_G227_G0.5811.00
221_G224_E0.5811.00
285_V291_G0.5801.00
110_F141_W0.5791.00
464_D473_P0.5791.00
355_L358_M0.5781.00
235_N241_A0.5781.00
261_L264_V0.5781.00
14_I17_I0.5781.00
107_W110_F0.5771.00
336_L364_A0.5761.00
413_P438_T0.5751.00
337_K361_P0.5741.00
188_H193_I0.5741.00
281_N287_M0.5741.00
447_F455_Q0.5731.00
39_I46_A0.5731.00
79_V411_A0.5721.00
447_F454_I0.5691.00
240_F244_I0.5671.00
95_Y331_L0.5651.00
72_Y88_T0.5641.00
411_A415_F0.5631.00
271_V282_I0.5631.00
113_F318_L0.5601.00
281_N288_K0.5601.00
446_T451_F0.5601.00
432_L437_A0.5591.00
166_A170_L0.5581.00
150_S365_M0.5571.00
71_I224_E0.5571.00
22_F254_G0.5571.00
177_V309_G0.5561.00
232_K355_L0.5561.00
36_Y268_W0.5551.00
139_V377_L0.5541.00
232_K361_P0.5531.00
109_P320_M0.5531.00
271_V274_N0.5511.00
270_Q274_N0.5501.00
38_A259_I0.5491.00
39_I47_L0.5491.00
112_T317_G0.5491.00
446_T452_T0.5481.00
18_F21_V0.5481.00
237_E422_D0.5471.00
423_R427_I0.5451.00
143_I146_T0.5451.00
141_W328_F0.5441.00
250_V253_I0.5391.00
178_S182_L0.5381.00
281_N291_G0.5381.00
196_L201_P0.5351.00
11_I14_I0.5341.00
156_I333_Y0.5331.00
60_M78_S0.5331.00
459_E464_D0.5331.00
72_Y84_A0.5311.00
70_G227_G0.5311.00
177_V291_G0.5301.00
443_L451_F0.5291.00
155_K159_I0.5291.00
58_A62_A0.5291.00
436_I440_V0.5291.00
451_F459_E0.5281.00
38_A49_F0.5281.00
20_S225_A0.5281.00
87_G404_P0.5261.00
54_A58_A0.5261.00
427_I434_A0.5261.00
17_I21_V0.5261.00
454_I458_V0.5251.00
157_A329_F0.5251.00
190_A193_I0.5251.00
228_G334_S0.5251.00
335_P339_I0.5251.00
142_M373_T0.5241.00
464_D468_W0.5241.00
102_T328_F0.5241.00
152_G155_K0.5221.00
470_I481_M0.5201.00
164_G167_V0.5201.00
221_G397_A0.5191.00
90_M403_L0.5191.00
465_S473_P0.5191.00
20_S331_L0.5191.00
318_L322_L0.5181.00
188_H194_N0.5181.00
40_P209_M0.5171.00
391_N394_T0.5151.00
187_G191_Q0.5151.00
80_G84_A0.5151.00
153_I229_L0.5141.00
113_F317_G0.5111.00
146_T332_C0.5101.00
94_S97_I0.5091.00
468_W475_F0.5091.00
42_Y51_I0.5081.00
468_W479_L0.5081.00
6_K234_E0.5081.00
469_M476_F0.5071.00
448_A456_P0.5071.00
468_W474_V0.5061.00
367_M371_L0.5061.00
96_I368_Q0.5061.00
323_A326_G0.5051.00
466_T479_L0.5051.00
71_I228_G0.5051.00
60_M415_F0.5041.00
105_K109_P0.5031.00
90_M94_S0.5031.00
473_P476_F0.5031.00
161_A165_I0.5031.00
30_A259_I0.5021.00
453_I457_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.842 100 0.358 Contact Map
4djkA 2 0.866 100 0.386 Contact Map
3giaA 1 0.858 100 0.394 Contact Map
3dh4A 3 0.856 98.8 0.872 Contact Map
2xq2A 2 0.858 98.7 0.877 Contact Map
2jlnA 1 0.83 97.9 0.901 Contact Map
4wgvA 2 0.732 97.8 0.904 Contact Map
2a65A 2 0.892 97.7 0.906 Contact Map
4xp4A 1 0.904 97.2 0.913 Contact Map
4us3A 1 0.816 96.1 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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