GREMLIN Database
EPMB - L-lysine 2,3-aminomutase
UniProt: P39280 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12473
Length: 342 (316)
Sequences: 1818 (1170)
Seq/√Len: 65.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_E67_N4.5531.00
207_E242_K4.0001.00
195_S222_L3.6821.00
152_A181_Q3.4231.00
176_D180_T3.2981.00
23_V60_I3.2861.00
229_A266_T3.2591.00
263_N266_T3.1501.00
172_D206_T2.8741.00
112_A157_L2.7591.00
264_A309_E2.7071.00
214_A245_R2.6721.00
145_Q149_E2.6361.00
189_K276_D2.3481.00
302_E305_Q2.3461.00
176_D215_R2.3171.00
25_D28_E2.2651.00
176_D212_C2.2511.00
262_D302_E2.2281.00
258_R262_D2.1871.00
182_L188_I2.1731.00
244_R278_G2.1571.00
32_L60_I2.1511.00
62_R233_D2.1461.00
112_A160_M2.1421.00
268_A313_L2.0851.00
126_Y227_N2.0441.00
240_M279_V2.0241.00
244_R250_L2.0141.00
106_H150_Y1.9921.00
74_R79_S1.9871.00
112_A151_V1.9841.00
224_N240_M1.9841.00
149_E153_A1.9681.00
60_I63_M1.8781.00
237_R277_A1.8641.00
258_R302_E1.8551.00
104_L112_A1.8441.00
157_L160_M1.8361.00
268_A310_L1.8311.00
59_F76_V1.8251.00
32_L57_R1.8111.00
36_D39_E1.8101.00
151_V188_I1.8091.00
70_D230_N1.8021.00
285_H323_A1.7801.00
145_Q181_Q1.7751.00
303_A322_L1.7281.00
232_V277_A1.6770.99
58_S233_D1.6660.99
287_L298_V1.6550.99
240_M277_A1.6410.99
289_K297_M1.6400.99
183_E217_T1.6370.99
116_V178_L1.6330.99
113_L163_S1.6290.99
300_D324_R1.6000.99
73_L77_L1.5970.99
224_N252_N1.5720.99
222_L248_V1.5710.99
168_L209_L1.5690.99
179_L212_C1.5620.99
158_D189_K1.5530.99
199_I226_I1.5370.99
63_M70_D1.5270.99
58_S203_A1.5200.99
110_N158_D1.5150.99
149_E152_A1.5090.99
157_L188_I1.5070.99
121_A197_L1.4980.99
326_I333_T1.4920.99
158_D272_N1.4670.98
237_R273_A1.4600.98
23_V29_L1.4600.98
23_V32_L1.4500.98
232_V274_L1.4470.98
213_F220_I1.4440.98
141_K177_W1.4400.98
311_L334_P1.4390.98
206_T210_V1.4280.98
168_L222_L1.4220.98
254_S267_L1.4180.98
264_A306_I1.4130.98
190_R317_Y1.4000.98
69_D74_R1.3980.98
267_L271_S1.3930.98
172_D204_R1.3900.98
223_V251_L1.3880.98
152_A184_A1.3840.98
102_P146_T1.3790.98
252_N279_V1.3730.98
28_E31_R1.3570.97
181_Q184_A1.3570.97
171_K174_E1.3460.97
151_V185_I1.3360.97
112_A150_Y1.3330.97
213_F248_V1.3290.97
27_D45_R1.3220.97
275_F318_L1.3020.97
82_E125_R1.2990.97
64_E230_N1.2960.96
30_L41_L1.2850.96
240_M250_L1.2840.96
290_V293_A1.2820.96
176_D208_A1.2780.96
210_V246_V1.2780.96
221_L249_T1.2550.96
145_Q177_W1.2550.96
183_E191_L1.2540.96
194_H285_H1.2470.96
286_V300_D1.2440.96
71_P230_N1.2340.95
176_D217_T1.2300.95
175_L193_I1.2290.95
300_D335_L1.2220.95
238_Q242_K1.2060.95
168_L175_L1.2050.95
106_H112_A1.2040.95
58_S62_R1.2000.95
74_R81_D1.1960.94
148_L152_A1.1940.94
254_S271_S1.1780.94
264_A267_L1.1740.94
252_N274_L1.1740.94
273_A276_D1.1730.94
75_Q196_R1.1710.94
226_I236_F1.1500.93
116_V170_A1.1400.93
229_A263_N1.1380.93
227_N257_L1.1380.93
190_R219_Q1.1320.93
243_L248_V1.1290.93
207_E211_E1.1250.92
168_L195_S1.1250.92
117_K169_M1.1220.92
155_P187_H1.1160.92
161_I194_H1.1160.92
175_L212_C1.1130.92
288_D325_E1.0830.91
196_R227_N1.0800.91
34_N65_K1.0750.91
126_Y225_H1.0730.91
102_P143_N1.0730.91
323_A334_P1.0700.90
269_N273_A1.0690.90
199_I224_N1.0680.90
22_V54_R1.0600.90
155_P186_P1.0600.90
221_L275_F1.0510.90
105_L327_G1.0440.89
232_V273_A1.0410.89
146_T149_E1.0390.89
274_L279_V1.0340.89
273_A277_A1.0320.89
267_L284_L1.0270.88
114_L147_A1.0260.88
23_V28_E1.0220.88
211_E214_A1.0210.88
154_H157_L1.0190.88
307_M311_L1.0150.88
85_I291_Q1.0140.88
122_V200_V1.0080.88
266_T306_I1.0020.87
50_L83_F0.9880.86
210_V242_K0.9850.86
92_D96_E0.9850.86
148_L188_I0.9840.86
123_N133_P0.9840.86
329_E333_T0.9800.86
245_R278_G0.9790.86
229_A269_N0.9790.86
224_N250_L0.9700.85
205_I243_L0.9670.85
104_L147_A0.9610.85
177_W181_Q0.9610.85
25_D32_L0.9600.85
226_I279_V0.9560.85
210_V243_L0.9550.85
272_N314_V0.9500.84
222_L243_L0.9490.84
148_L181_Q0.9440.84
168_L193_I0.9430.84
265_Q313_L0.9410.84
76_V122_V0.9400.84
213_F243_L0.9360.83
172_D209_L0.9320.83
99_S137_N0.9290.83
161_I285_H0.9280.83
167_P193_I0.9250.83
226_I232_V0.9240.83
125_R292_G0.9210.82
153_A156_E0.9170.82
28_E57_R0.9160.82
47_A83_F0.9120.82
232_V237_R0.9090.82
311_L321_K0.9080.81
110_N156_E0.9070.81
26_P30_L0.9040.81
150_Y154_H0.8970.81
168_L270_L0.8950.81
62_R236_F0.8940.80
58_S201_I0.8940.80
266_T269_N0.8920.80
55_V77_L0.8910.80
41_L45_R0.8890.80
236_F240_M0.8840.80
151_V157_L0.8790.79
214_A246_V0.8730.79
160_M188_I0.8730.79
183_E219_Q0.8710.79
190_R315_S0.8660.78
226_I274_L0.8640.78
198_P236_F0.8640.78
76_V126_Y0.8620.78
62_R230_N0.8610.78
268_A314_V0.8600.78
109_H313_L0.8580.78
42_L46_S0.8570.78
46_S80_Q0.8540.77
75_Q227_N0.8480.77
196_R199_I0.8460.77
238_Q241_A0.8430.76
190_R272_N0.8360.76
183_E218_L0.8320.75
106_H132_F0.8290.75
170_A174_E0.8200.74
241_A245_R0.8190.74
162_F182_L0.8170.74
147_A151_V0.8160.74
199_I252_N0.8060.73
198_P279_V0.8030.73
159_E251_L0.7990.72
82_E292_G0.7930.72
159_E194_H0.7920.72
180_T184_A0.7890.71
286_V335_L0.7870.71
123_N134_Y0.7870.71
229_A273_A0.7850.71
191_L218_L0.7850.71
232_V236_F0.7810.71
286_V322_L0.7810.71
287_L293_A0.7790.71
29_L77_L0.7780.70
208_A211_E0.7780.70
180_T212_C0.7760.70
207_E234_E0.7730.70
180_T217_T0.7700.70
301_D304_R0.7690.70
301_D305_Q0.7660.69
305_Q309_E0.7650.69
175_L179_L0.7630.69
327_G331_S0.7610.69
275_F317_Y0.7600.69
94_L288_D0.7570.68
42_L45_R0.7560.68
145_Q152_A0.7530.68
43_A46_S0.7480.67
169_M197_L0.7440.67
100_V150_Y0.7440.67
57_R61_D0.7410.67
86_A294_A0.7410.67
130_R133_P0.7390.66
168_L235_T0.7360.66
270_L274_L0.7350.66
183_E216_S0.7350.66
205_I224_N0.7330.66
151_V187_H0.7310.66
26_P41_L0.7300.66
152_A155_P0.7280.65
243_L250_L0.7280.65
148_L185_I0.7270.65
105_L113_L0.7260.65
115_L118_G0.7260.65
224_N279_V0.7260.65
256_L298_V0.7250.65
198_P240_M0.7220.65
208_A212_C0.7200.64
128_F163_S0.7190.64
27_D31_R0.7170.64
179_L193_I0.7120.64
120_C127_C0.7100.63
113_L288_D0.7100.63
195_S224_N0.7070.63
105_L288_D0.7070.63
124_C127_C0.7050.63
188_I220_I0.7040.63
206_T212_C0.7020.62
179_L183_E0.7020.62
128_F285_H0.7000.62
34_N38_E0.7000.62
252_N271_S0.7000.62
230_N269_N0.7000.62
81_D84_V0.6950.62
74_R259_D0.6940.62
24_T54_R0.6930.61
95_E101_V0.6930.61
120_C124_C0.6920.61
106_H288_D0.6910.61
72_L230_N0.6890.61
286_V298_V0.6890.61
297_M300_D0.6870.61
128_F288_D0.6870.61
286_V299_S0.6850.61
205_I239_A0.6820.60
307_M319_V0.6810.60
197_L205_I0.6780.60
304_R335_L0.6750.59
111_R288_D0.6710.59
162_F193_I0.6710.59
110_N315_S0.6700.59
251_L280_M0.6690.59
99_S102_P0.6680.59
141_K174_E0.6670.59
68_P71_P0.6660.58
67_N230_N0.6660.58
286_V303_A0.6650.58
172_D208_A0.6650.58
94_L98_H0.6650.58
122_V126_Y0.6570.57
326_I331_S0.6550.57
96_E100_V0.6540.57
180_T215_R0.6530.57
48_K83_F0.6490.56
74_R258_R0.6490.56
138_Q143_N0.6480.56
96_E131_H0.6480.56
204_R209_L0.6460.56
321_K334_P0.6450.56
300_D322_L0.6440.56
243_L246_V0.6440.56
256_L303_A0.6410.56
163_S288_D0.6390.55
78_T258_R0.6380.55
48_K53_L0.6380.55
153_A184_A0.6360.55
128_F325_E0.6350.55
214_A241_A0.6350.55
141_K173_H0.6340.55
113_L325_E0.6310.54
94_L106_H0.6310.54
145_Q148_L0.6290.54
34_N63_M0.6280.54
209_L212_C0.6280.54
94_L139_G0.6230.53
223_V317_Y0.6220.53
167_P170_A0.6190.53
203_A235_T0.6170.53
326_I329_E0.6150.53
49_K195_S0.6150.53
111_R320_P0.6140.52
131_H291_Q0.6130.52
179_L215_R0.6130.52
160_M182_L0.6110.52
24_T135_A0.6100.52
103_G147_A0.6100.52
131_H290_V0.6080.52
94_L163_S0.6060.51
62_R72_L0.6060.51
91_T291_Q0.6050.51
299_S302_E0.6040.51
190_R221_L0.6030.51
176_D179_L0.6010.51
210_V234_E0.6010.51
158_D315_S0.6000.51
162_F179_L0.6000.51
268_A272_N0.5990.51
234_E238_Q0.5970.50
292_G320_P0.5970.50
55_V76_V0.5950.50
116_V136_E0.5940.50
63_M230_N0.5940.50
21_D57_R0.5930.50
96_E99_S0.5920.50
321_K326_I0.5880.49
263_N302_E0.5880.49
125_R130_R0.5880.49
193_I220_I0.5860.49
260_V266_T0.5860.49
56_P201_I0.5850.49
105_L115_L0.5850.49
267_L306_I0.5850.49
94_L327_G0.5830.49
79_S260_V0.5800.48
249_T278_G0.5800.48
159_E287_L0.5770.48
140_N182_L0.5760.48
43_A80_Q0.5760.48
298_V303_A0.5760.48
114_L144_W0.5740.48
93_P284_L0.5730.48
215_R247_G0.5700.47
101_V147_A0.5690.47
82_E130_R0.5680.47
117_K170_A0.5650.47
111_R159_E0.5650.47
224_N244_R0.5640.47
316_G332_K0.5630.46
94_L325_E0.5610.46
62_R77_L0.5610.46
105_L128_F0.5600.46
67_N71_P0.5600.46
265_Q269_N0.5570.46
175_L209_L0.5560.46
256_L284_L0.5520.45
158_D318_L0.5510.45
283_Y316_G0.5510.45
35_I182_L0.5510.45
107_K288_D0.5500.45
94_L99_S0.5500.45
72_L168_L0.5480.45
285_H317_Y0.5480.45
63_M76_V0.5480.45
308_R312_T0.5480.45
104_L114_L0.5480.45
304_R308_R0.5470.45
123_N170_A0.5450.44
227_N256_L0.5450.44
81_D213_F0.5420.44
179_L217_T0.5420.44
159_E223_V0.5400.44
309_E312_T0.5390.44
300_D303_A0.5380.44
38_E41_L0.5370.43
212_C218_L0.5360.43
112_A154_H0.5360.43
59_F226_I0.5360.43
244_R249_T0.5350.43
148_L178_L0.5340.43
112_A147_A0.5330.43
228_H261_N0.5330.43
95_E98_H0.5330.43
126_Y252_N0.5330.43
45_R80_Q0.5310.43
103_G143_N0.5310.43
271_S274_L0.5290.42
103_G139_G0.5280.42
179_L213_F0.5280.42
200_V255_V0.5250.42
38_E146_T0.5240.42
100_V327_G0.5230.42
94_L128_F0.5230.42
144_W178_L0.5220.42
194_H223_V0.5220.42
130_R227_N0.5210.42
126_Y196_R0.5210.42
284_L295_H0.5200.41
59_F200_V0.5190.41
78_T272_N0.5180.41
311_L323_A0.5160.41
27_D152_A0.5160.41
220_I248_V0.5150.41
114_L178_L0.5150.41
310_L327_G0.5140.41
113_L128_F0.5140.41
176_D211_E0.5130.41
194_H251_L0.5130.41
111_R310_L0.5120.41
20_A173_H0.5120.41
289_K327_G0.5110.40
51_F130_R0.5110.40
33_L73_L0.5100.40
219_Q278_G0.5090.40
33_L60_I0.5060.40
103_G187_H0.5050.40
49_K142_R0.5050.40
162_F285_H0.5040.40
28_E32_L0.5040.40
46_S49_K0.5040.40
250_L254_S0.5030.40
163_S325_E0.5030.40
32_L42_L0.5020.39
54_R322_L0.5010.39
94_L297_M0.5010.39
38_E45_R0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a5hA 4 0.9942 100 0.43 Contact Map
3rfaA 1 0.8801 99.9 0.798 Contact Map
1tv8A 2 0.6784 99.7 0.855 Contact Map
2qgqA 1 0.6053 99.7 0.86 Contact Map
3c8fA 1 0.6433 99.6 0.865 Contact Map
4jc0A 1 0.8713 99.6 0.865 Contact Map
3iixA 1 0.7719 99.5 0.88 Contact Map
1oltA 1 0.7778 99.4 0.883 Contact Map
4wcxA 1 0.8538 99.4 0.885 Contact Map
1r30A 2 0.7222 99.4 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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