EPMB - ECOLI - GREMLIN Contacts

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EPMB - L-lysine 2,3-aminomutase

UniProt:	P39280	Sequences: MAHIVTLNTPSREDWLTQLADVVTDPDELLRLLNIDAEEKLLAGRSAKKLFALRVPRSFIDRMEKGNPDDPLLRQVLTSQDEFVIAPGFSTDPLEEQHSVVPGLLHKYHNRALLLVKGGCAVNCRYCFRRHFPYAENQGNKRNWQTALEYVAAHPELDEMIFSGGDPLMAKDHELDWLLTQLEAIPHIKRLRIHSRLPIVIPARITEALVECFARSTLQILLVNHINHANEVDETFRQAMAKLRRVGVTLLNQSVLLRDVNDNAQTLANLSNALFDAGVMPYYLHVLDKVQGAAHFMVSDDEARQIMRELLTLVSGYLVPKLAREIGGEPSKTPLDLQLRQQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12473
Length:	342 (316)
Sequences:	1818 (1170)
Seq/√Len:	65.8

ECOLI - EPMB
BACSU - KAMA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_E	67_N	4.553	1.00
207_E	242_K	4.000	1.00
195_S	222_L	3.682	1.00
152_A	181_Q	3.423	1.00
176_D	180_T	3.298	1.00
23_V	60_I	3.286	1.00
229_A	266_T	3.259	1.00
263_N	266_T	3.150	1.00
172_D	206_T	2.874	1.00
112_A	157_L	2.759	1.00
264_A	309_E	2.707	1.00
214_A	245_R	2.672	1.00
145_Q	149_E	2.636	1.00
189_K	276_D	2.348	1.00
302_E	305_Q	2.346	1.00
176_D	215_R	2.317	1.00
25_D	28_E	2.265	1.00
176_D	212_C	2.251	1.00
262_D	302_E	2.228	1.00
258_R	262_D	2.187	1.00
182_L	188_I	2.173	1.00
244_R	278_G	2.157	1.00
32_L	60_I	2.151	1.00
62_R	233_D	2.146	1.00
112_A	160_M	2.142	1.00
268_A	313_L	2.085	1.00
126_Y	227_N	2.044	1.00
240_M	279_V	2.024	1.00
244_R	250_L	2.014	1.00
106_H	150_Y	1.992	1.00
74_R	79_S	1.987	1.00
112_A	151_V	1.984	1.00
224_N	240_M	1.984	1.00
149_E	153_A	1.968	1.00
60_I	63_M	1.878	1.00
237_R	277_A	1.864	1.00
258_R	302_E	1.855	1.00
104_L	112_A	1.844	1.00
157_L	160_M	1.836	1.00
268_A	310_L	1.831	1.00
59_F	76_V	1.825	1.00
32_L	57_R	1.811	1.00
36_D	39_E	1.810	1.00
151_V	188_I	1.809	1.00
70_D	230_N	1.802	1.00
285_H	323_A	1.780	1.00
145_Q	181_Q	1.775	1.00
303_A	322_L	1.728	1.00
232_V	277_A	1.677	0.99
58_S	233_D	1.666	0.99
287_L	298_V	1.655	0.99
240_M	277_A	1.641	0.99
289_K	297_M	1.640	0.99
183_E	217_T	1.637	0.99
116_V	178_L	1.633	0.99
113_L	163_S	1.629	0.99
300_D	324_R	1.600	0.99
73_L	77_L	1.597	0.99
224_N	252_N	1.572	0.99
222_L	248_V	1.571	0.99
168_L	209_L	1.569	0.99
179_L	212_C	1.562	0.99
158_D	189_K	1.553	0.99
199_I	226_I	1.537	0.99
63_M	70_D	1.527	0.99
58_S	203_A	1.520	0.99
110_N	158_D	1.515	0.99
149_E	152_A	1.509	0.99
157_L	188_I	1.507	0.99
121_A	197_L	1.498	0.99
326_I	333_T	1.492	0.99
158_D	272_N	1.467	0.98
237_R	273_A	1.460	0.98
23_V	29_L	1.460	0.98
23_V	32_L	1.450	0.98
232_V	274_L	1.447	0.98
213_F	220_I	1.444	0.98
141_K	177_W	1.440	0.98
311_L	334_P	1.439	0.98
206_T	210_V	1.428	0.98
168_L	222_L	1.422	0.98
254_S	267_L	1.418	0.98
264_A	306_I	1.413	0.98
190_R	317_Y	1.400	0.98
69_D	74_R	1.398	0.98
267_L	271_S	1.393	0.98
172_D	204_R	1.390	0.98
223_V	251_L	1.388	0.98
152_A	184_A	1.384	0.98
102_P	146_T	1.379	0.98
252_N	279_V	1.373	0.98
28_E	31_R	1.357	0.97
181_Q	184_A	1.357	0.97
171_K	174_E	1.346	0.97
151_V	185_I	1.336	0.97
112_A	150_Y	1.333	0.97
213_F	248_V	1.329	0.97
27_D	45_R	1.322	0.97
275_F	318_L	1.302	0.97
82_E	125_R	1.299	0.97
64_E	230_N	1.296	0.96
30_L	41_L	1.285	0.96
240_M	250_L	1.284	0.96
290_V	293_A	1.282	0.96
176_D	208_A	1.278	0.96
210_V	246_V	1.278	0.96
221_L	249_T	1.255	0.96
145_Q	177_W	1.255	0.96
183_E	191_L	1.254	0.96
194_H	285_H	1.247	0.96
286_V	300_D	1.244	0.96
71_P	230_N	1.234	0.95
176_D	217_T	1.230	0.95
175_L	193_I	1.229	0.95
300_D	335_L	1.222	0.95
238_Q	242_K	1.206	0.95
168_L	175_L	1.205	0.95
106_H	112_A	1.204	0.95
58_S	62_R	1.200	0.95
74_R	81_D	1.196	0.94
148_L	152_A	1.194	0.94
254_S	271_S	1.178	0.94
264_A	267_L	1.174	0.94
252_N	274_L	1.174	0.94
273_A	276_D	1.173	0.94
75_Q	196_R	1.171	0.94
226_I	236_F	1.150	0.93
116_V	170_A	1.140	0.93
229_A	263_N	1.138	0.93
227_N	257_L	1.138	0.93
190_R	219_Q	1.132	0.93
243_L	248_V	1.129	0.93
207_E	211_E	1.125	0.92
168_L	195_S	1.125	0.92
117_K	169_M	1.122	0.92
155_P	187_H	1.116	0.92
161_I	194_H	1.116	0.92
175_L	212_C	1.113	0.92
288_D	325_E	1.083	0.91
196_R	227_N	1.080	0.91
34_N	65_K	1.075	0.91
126_Y	225_H	1.073	0.91
102_P	143_N	1.073	0.91
323_A	334_P	1.070	0.90
269_N	273_A	1.069	0.90
199_I	224_N	1.068	0.90
22_V	54_R	1.060	0.90
155_P	186_P	1.060	0.90
221_L	275_F	1.051	0.90
105_L	327_G	1.044	0.89
232_V	273_A	1.041	0.89
146_T	149_E	1.039	0.89
274_L	279_V	1.034	0.89
273_A	277_A	1.032	0.89
267_L	284_L	1.027	0.88
114_L	147_A	1.026	0.88
23_V	28_E	1.022	0.88
211_E	214_A	1.021	0.88
154_H	157_L	1.019	0.88
307_M	311_L	1.015	0.88
85_I	291_Q	1.014	0.88
122_V	200_V	1.008	0.88
266_T	306_I	1.002	0.87
50_L	83_F	0.988	0.86
210_V	242_K	0.985	0.86
92_D	96_E	0.985	0.86
148_L	188_I	0.984	0.86
123_N	133_P	0.984	0.86
329_E	333_T	0.980	0.86
245_R	278_G	0.979	0.86
229_A	269_N	0.979	0.86
224_N	250_L	0.970	0.85
205_I	243_L	0.967	0.85
104_L	147_A	0.961	0.85
177_W	181_Q	0.961	0.85
25_D	32_L	0.960	0.85
226_I	279_V	0.956	0.85
210_V	243_L	0.955	0.85
272_N	314_V	0.950	0.84
222_L	243_L	0.949	0.84
148_L	181_Q	0.944	0.84
168_L	193_I	0.943	0.84
265_Q	313_L	0.941	0.84
76_V	122_V	0.940	0.84
213_F	243_L	0.936	0.83
172_D	209_L	0.932	0.83
99_S	137_N	0.929	0.83
161_I	285_H	0.928	0.83
167_P	193_I	0.925	0.83
226_I	232_V	0.924	0.83
125_R	292_G	0.921	0.82
153_A	156_E	0.917	0.82
28_E	57_R	0.916	0.82
47_A	83_F	0.912	0.82
232_V	237_R	0.909	0.82
311_L	321_K	0.908	0.81
110_N	156_E	0.907	0.81
26_P	30_L	0.904	0.81
150_Y	154_H	0.897	0.81
168_L	270_L	0.895	0.81
62_R	236_F	0.894	0.80
58_S	201_I	0.894	0.80
266_T	269_N	0.892	0.80
55_V	77_L	0.891	0.80
41_L	45_R	0.889	0.80
236_F	240_M	0.884	0.80
151_V	157_L	0.879	0.79
214_A	246_V	0.873	0.79
160_M	188_I	0.873	0.79
183_E	219_Q	0.871	0.79
190_R	315_S	0.866	0.78
226_I	274_L	0.864	0.78
198_P	236_F	0.864	0.78
76_V	126_Y	0.862	0.78
62_R	230_N	0.861	0.78
268_A	314_V	0.860	0.78
109_H	313_L	0.858	0.78
42_L	46_S	0.857	0.78
46_S	80_Q	0.854	0.77
75_Q	227_N	0.848	0.77
196_R	199_I	0.846	0.77
238_Q	241_A	0.843	0.76
190_R	272_N	0.836	0.76
183_E	218_L	0.832	0.75
106_H	132_F	0.829	0.75
170_A	174_E	0.820	0.74
241_A	245_R	0.819	0.74
162_F	182_L	0.817	0.74
147_A	151_V	0.816	0.74
199_I	252_N	0.806	0.73
198_P	279_V	0.803	0.73
159_E	251_L	0.799	0.72
82_E	292_G	0.793	0.72
159_E	194_H	0.792	0.72
180_T	184_A	0.789	0.71
286_V	335_L	0.787	0.71
123_N	134_Y	0.787	0.71
229_A	273_A	0.785	0.71
191_L	218_L	0.785	0.71
232_V	236_F	0.781	0.71
286_V	322_L	0.781	0.71
287_L	293_A	0.779	0.71
29_L	77_L	0.778	0.70
208_A	211_E	0.778	0.70
180_T	212_C	0.776	0.70
207_E	234_E	0.773	0.70
180_T	217_T	0.770	0.70
301_D	304_R	0.769	0.70
301_D	305_Q	0.766	0.69
305_Q	309_E	0.765	0.69
175_L	179_L	0.763	0.69
327_G	331_S	0.761	0.69
275_F	317_Y	0.760	0.69
94_L	288_D	0.757	0.68
42_L	45_R	0.756	0.68
145_Q	152_A	0.753	0.68
43_A	46_S	0.748	0.67
169_M	197_L	0.744	0.67
100_V	150_Y	0.744	0.67
57_R	61_D	0.741	0.67
86_A	294_A	0.741	0.67
130_R	133_P	0.739	0.66
168_L	235_T	0.736	0.66
270_L	274_L	0.735	0.66
183_E	216_S	0.735	0.66
205_I	224_N	0.733	0.66
151_V	187_H	0.731	0.66
26_P	41_L	0.730	0.66
152_A	155_P	0.728	0.65
243_L	250_L	0.728	0.65
148_L	185_I	0.727	0.65
105_L	113_L	0.726	0.65
115_L	118_G	0.726	0.65
224_N	279_V	0.726	0.65
256_L	298_V	0.725	0.65
198_P	240_M	0.722	0.65
208_A	212_C	0.720	0.64
128_F	163_S	0.719	0.64
27_D	31_R	0.717	0.64
179_L	193_I	0.712	0.64
120_C	127_C	0.710	0.63
113_L	288_D	0.710	0.63
195_S	224_N	0.707	0.63
105_L	288_D	0.707	0.63
124_C	127_C	0.705	0.63
188_I	220_I	0.704	0.63
206_T	212_C	0.702	0.62
179_L	183_E	0.702	0.62
128_F	285_H	0.700	0.62
34_N	38_E	0.700	0.62
252_N	271_S	0.700	0.62
230_N	269_N	0.700	0.62
81_D	84_V	0.695	0.62
74_R	259_D	0.694	0.62
24_T	54_R	0.693	0.61
95_E	101_V	0.693	0.61
120_C	124_C	0.692	0.61
106_H	288_D	0.691	0.61
72_L	230_N	0.689	0.61
286_V	298_V	0.689	0.61
297_M	300_D	0.687	0.61
128_F	288_D	0.687	0.61
286_V	299_S	0.685	0.61
205_I	239_A	0.682	0.60
307_M	319_V	0.681	0.60
197_L	205_I	0.678	0.60
304_R	335_L	0.675	0.59
111_R	288_D	0.671	0.59
162_F	193_I	0.671	0.59
110_N	315_S	0.670	0.59
251_L	280_M	0.669	0.59
99_S	102_P	0.668	0.59
141_K	174_E	0.667	0.59
68_P	71_P	0.666	0.58
67_N	230_N	0.666	0.58
286_V	303_A	0.665	0.58
172_D	208_A	0.665	0.58
94_L	98_H	0.665	0.58
122_V	126_Y	0.657	0.57
326_I	331_S	0.655	0.57
96_E	100_V	0.654	0.57
180_T	215_R	0.653	0.57
48_K	83_F	0.649	0.56
74_R	258_R	0.649	0.56
138_Q	143_N	0.648	0.56
96_E	131_H	0.648	0.56
204_R	209_L	0.646	0.56
321_K	334_P	0.645	0.56
300_D	322_L	0.644	0.56
243_L	246_V	0.644	0.56
256_L	303_A	0.641	0.56
163_S	288_D	0.639	0.55
78_T	258_R	0.638	0.55
48_K	53_L	0.638	0.55
153_A	184_A	0.636	0.55
128_F	325_E	0.635	0.55
214_A	241_A	0.635	0.55
141_K	173_H	0.634	0.55
113_L	325_E	0.631	0.54
94_L	106_H	0.631	0.54
145_Q	148_L	0.629	0.54
34_N	63_M	0.628	0.54
209_L	212_C	0.628	0.54
94_L	139_G	0.623	0.53
223_V	317_Y	0.622	0.53
167_P	170_A	0.619	0.53
203_A	235_T	0.617	0.53
326_I	329_E	0.615	0.53
49_K	195_S	0.615	0.53
111_R	320_P	0.614	0.52
131_H	291_Q	0.613	0.52
179_L	215_R	0.613	0.52
160_M	182_L	0.611	0.52
24_T	135_A	0.610	0.52
103_G	147_A	0.610	0.52
131_H	290_V	0.608	0.52
94_L	163_S	0.606	0.51
62_R	72_L	0.606	0.51
91_T	291_Q	0.605	0.51
299_S	302_E	0.604	0.51
190_R	221_L	0.603	0.51
176_D	179_L	0.601	0.51
210_V	234_E	0.601	0.51
158_D	315_S	0.600	0.51
162_F	179_L	0.600	0.51
268_A	272_N	0.599	0.51
234_E	238_Q	0.597	0.50
292_G	320_P	0.597	0.50
55_V	76_V	0.595	0.50
116_V	136_E	0.594	0.50
63_M	230_N	0.594	0.50
21_D	57_R	0.593	0.50
96_E	99_S	0.592	0.50
321_K	326_I	0.588	0.49
263_N	302_E	0.588	0.49
125_R	130_R	0.588	0.49
193_I	220_I	0.586	0.49
260_V	266_T	0.586	0.49
56_P	201_I	0.585	0.49
105_L	115_L	0.585	0.49
267_L	306_I	0.585	0.49
94_L	327_G	0.583	0.49
79_S	260_V	0.580	0.48
249_T	278_G	0.580	0.48
159_E	287_L	0.577	0.48
140_N	182_L	0.576	0.48
43_A	80_Q	0.576	0.48
298_V	303_A	0.576	0.48
114_L	144_W	0.574	0.48
93_P	284_L	0.573	0.48
215_R	247_G	0.570	0.47
101_V	147_A	0.569	0.47
82_E	130_R	0.568	0.47
117_K	170_A	0.565	0.47
111_R	159_E	0.565	0.47
224_N	244_R	0.564	0.47
316_G	332_K	0.563	0.46
94_L	325_E	0.561	0.46
62_R	77_L	0.561	0.46
105_L	128_F	0.560	0.46
67_N	71_P	0.560	0.46
265_Q	269_N	0.557	0.46
175_L	209_L	0.556	0.46
256_L	284_L	0.552	0.45
158_D	318_L	0.551	0.45
283_Y	316_G	0.551	0.45
35_I	182_L	0.551	0.45
107_K	288_D	0.550	0.45
94_L	99_S	0.550	0.45
72_L	168_L	0.548	0.45
285_H	317_Y	0.548	0.45
63_M	76_V	0.548	0.45
308_R	312_T	0.548	0.45
104_L	114_L	0.548	0.45
304_R	308_R	0.547	0.45
123_N	170_A	0.545	0.44
227_N	256_L	0.545	0.44
81_D	213_F	0.542	0.44
179_L	217_T	0.542	0.44
159_E	223_V	0.540	0.44
309_E	312_T	0.539	0.44
300_D	303_A	0.538	0.44
38_E	41_L	0.537	0.43
212_C	218_L	0.536	0.43
112_A	154_H	0.536	0.43
59_F	226_I	0.536	0.43
244_R	249_T	0.535	0.43
148_L	178_L	0.534	0.43
112_A	147_A	0.533	0.43
228_H	261_N	0.533	0.43
95_E	98_H	0.533	0.43
126_Y	252_N	0.533	0.43
45_R	80_Q	0.531	0.43
103_G	143_N	0.531	0.43
271_S	274_L	0.529	0.42
103_G	139_G	0.528	0.42
179_L	213_F	0.528	0.42
200_V	255_V	0.525	0.42
38_E	146_T	0.524	0.42
100_V	327_G	0.523	0.42
94_L	128_F	0.523	0.42
144_W	178_L	0.522	0.42
194_H	223_V	0.522	0.42
130_R	227_N	0.521	0.42
126_Y	196_R	0.521	0.42
284_L	295_H	0.520	0.41
59_F	200_V	0.519	0.41
78_T	272_N	0.518	0.41
311_L	323_A	0.516	0.41
27_D	152_A	0.516	0.41
220_I	248_V	0.515	0.41
114_L	178_L	0.515	0.41
310_L	327_G	0.514	0.41
113_L	128_F	0.514	0.41
176_D	211_E	0.513	0.41
194_H	251_L	0.513	0.41
111_R	310_L	0.512	0.41
20_A	173_H	0.512	0.41
289_K	327_G	0.511	0.40
51_F	130_R	0.511	0.40
33_L	73_L	0.510	0.40
219_Q	278_G	0.509	0.40
33_L	60_I	0.506	0.40
103_G	187_H	0.505	0.40
49_K	142_R	0.505	0.40
162_F	285_H	0.504	0.40
28_E	32_L	0.504	0.40
46_S	49_K	0.504	0.40
250_L	254_S	0.503	0.40
163_S	325_E	0.503	0.40
32_L	42_L	0.502	0.39
54_R	322_L	0.501	0.39
94_L	297_M	0.501	0.39
38_E	45_R	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2a5hA	4	0.9942	100	0.43	Contact Map
3rfaA	1	0.8801	99.9	0.798	Contact Map
1tv8A	2	0.6784	99.7	0.855	Contact Map
2qgqA	1	0.6053	99.7	0.86	Contact Map
3c8fA	1	0.6433	99.6	0.865	Contact Map
4jc0A	1	0.8713	99.6	0.865	Contact Map
3iixA	1	0.7719	99.5	0.88	Contact Map
1oltA	1	0.7778	99.4	0.883	Contact Map
4wcxA	1	0.8538	99.4	0.885	Contact Map
1r30A	2	0.7222	99.4	0.885	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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