GREMLIN Database
YJEH - Inner membrane protein YjeH
UniProt: P39277 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12470
Length: 418 (398)
Sequences: 24499 (15910)
Seq/√Len: 797.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_W323_L4.3951.00
305_Y317_N4.3621.00
364_K368_G3.3331.00
49_I229_G3.1821.00
308_R317_N3.1111.00
215_R219_R3.0111.00
9_G211_K2.9401.00
210_F216_D2.7691.00
73_A300_H2.7021.00
212_N215_R2.6481.00
298_A307_A2.6351.00
310_S316_N2.5891.00
89_G297_Q2.5821.00
127_L327_V2.4891.00
61_I366_L2.4241.00
305_Y308_R2.4221.00
14_I223_I2.3981.00
266_G270_I2.3171.00
356_L378_G2.2811.00
209_E292_R2.2711.00
208_S299_Q2.2661.00
10_L223_I2.2661.00
77_G85_E2.2521.00
10_L216_D2.1561.00
135_Y139_R2.1451.00
295_W299_Q2.1421.00
320_N324_G2.1271.00
257_K260_V2.0941.00
405_L409_R2.0681.00
13_G210_F2.0661.00
127_L330_T2.0601.00
10_L14_I2.0561.00
166_G238_V2.0551.00
138_T316_N2.0421.00
169_K172_N2.0421.00
142_S146_N2.0351.00
134_W319_L2.0321.00
126_E330_T2.0171.00
247_E261_Q2.0111.00
375_V379_L2.0071.00
80_F364_K2.0001.00
397_I401_G1.9971.00
131_A327_V1.9941.00
359_M377_G1.9901.00
93_L322_V1.9791.00
58_V359_M1.9731.00
219_R223_I1.9621.00
9_G12_Q1.9381.00
153_G157_A1.9041.00
50_I54_P1.8841.00
301_N304_H1.8751.00
77_G82_S1.8681.00
306_L321_A1.8471.00
244_A247_E1.8171.00
33_A41_S1.8071.00
80_F360_L1.7861.00
90_W403_W1.7771.00
44_A189_A1.7501.00
257_K261_Q1.7231.00
212_N216_D1.7161.00
364_K367_Q1.7121.00
383_L387_M1.7031.00
12_Q149_T1.6921.00
137_G284_N1.6891.00
76_V88_T1.6871.00
131_A323_L1.6811.00
104_L283_L1.6681.00
404_L408_K1.6671.00
379_L383_L1.6511.00
372_L376_V1.6481.00
222_M226_L1.6411.00
157_A161_A1.6411.00
310_S314_I1.6401.00
88_T357_L1.6251.00
130_L326_C1.6181.00
138_T320_N1.6121.00
17_L224_G1.5971.00
121_Q124_L1.5951.00
100_L326_C1.5851.00
40_N186_L1.5751.00
226_L230_L1.5541.00
393_L397_I1.5511.00
14_I227_L1.5381.00
398_M402_L1.5221.00
104_L130_L1.5131.00
111_G125_A1.5071.00
399_L403_W1.4951.00
81_G84_L1.4881.00
8_L12_Q1.4831.00
206_L288_Q1.4711.00
294_V318_A1.4681.00
295_W309_L1.4651.00
134_W320_N1.4501.00
170_P173_I1.4501.00
156_V160_V1.4381.00
389_G392_S1.4361.00
269_W273_V1.4271.00
317_N321_A1.4211.00
290_F322_V1.4151.00
158_L274_I1.4011.00
5_K313_H1.3971.00
212_N219_R1.3951.00
304_H307_A1.3951.00
127_L131_A1.3951.00
76_V357_L1.3861.00
48_L193_M1.3781.00
80_F84_L1.3771.00
374_A377_G1.3741.00
168_I241_H1.3701.00
213_P218_P1.3701.00
69_A208_S1.3651.00
107_A276_Y1.3551.00
56_A225_L1.3551.00
360_L378_G1.3541.00
260_V268_L1.3441.00
367_Q370_Y1.3441.00
12_Q145_A1.3421.00
304_H308_R1.3411.00
395_A398_M1.3371.00
291_A319_L1.3311.00
56_A221_L1.3291.00
381_C384_L1.3281.00
401_G405_L1.3241.00
168_I173_I1.3141.00
51_L380_L1.3121.00
8_L13_G1.3101.00
230_L234_G1.3081.00
66_Y78_M1.3061.00
55_I359_M1.3031.00
175_F178_P1.3021.00
61_I64_R1.3001.00
308_R316_N1.2931.00
372_L375_V1.2901.00
107_A129_T1.2851.00
360_L364_K1.2841.00
130_L323_L1.2771.00
403_W406_L1.2711.00
163_W234_G1.2701.00
366_L370_Y1.2561.00
162_I166_G1.2561.00
79_A361_A1.2531.00
216_D219_R1.2511.00
57_I222_M1.2421.00
74_H78_M1.2411.00
263_F267_A1.2401.00
374_A381_C1.2361.00
21_L228_A1.2361.00
133_V283_L1.2301.00
394_Y398_M1.2181.00
377_G380_L1.2171.00
28_A106_I1.2161.00
396_L400_A1.2121.00
392_S396_L1.2111.00
10_L219_R1.2081.00
393_L396_L1.1961.00
86_R90_W1.1961.00
294_V302_P1.1921.00
42_L237_V1.1851.00
8_L145_A1.1781.00
50_I376_V1.1751.00
54_P376_V1.1701.00
123_L127_L1.1631.00
93_L294_V1.1571.00
251_A257_K1.1501.00
391_K395_A1.1501.00
103_A282_S1.1461.00
161_A165_A1.1451.00
398_M401_G1.1421.00
382_V386_A1.1421.00
169_K173_I1.1411.00
251_A254_S1.1411.00
317_N320_N1.1321.00
68_S74_H1.1321.00
374_A380_L1.1271.00
260_V265_V1.1251.00
211_K216_D1.1211.00
11_A15_G1.1161.00
182_E185_G1.1151.00
174_P178_P1.1131.00
377_G381_C1.1091.00
374_A378_G1.1081.00
136_I147_L1.1021.00
76_V84_L1.1021.00
166_G242_F1.1021.00
245_Y248_K1.1001.00
374_A386_A1.1001.00
7_E211_K1.0961.00
299_Q307_A1.0951.00
356_L382_V1.0931.00
59_F72_V1.0871.00
80_F83_R1.0841.00
17_L203_F1.0821.00
124_L128_G1.0811.00
309_L313_H1.0731.00
148_Q284_N1.0731.00
168_I172_N1.0721.00
402_L405_L1.0721.00
108_A125_A1.0711.00
63_G75_F1.0651.00
34_A41_S1.0641.00
324_G328_V1.0611.00
390_W394_Y1.0601.00
46_P233_W1.0551.00
16_L206_L1.0471.00
18_S227_L1.0471.00
131_A135_Y1.0461.00
394_Y397_I1.0401.00
167_D170_P1.0351.00
65_H370_Y1.0251.00
111_G115_F1.0251.00
73_A296_S1.0121.00
392_S395_A1.0091.00
397_I400_A1.0041.00
58_V374_A1.0031.00
134_W138_T1.0031.00
13_G220_A1.0001.00
198_V351_F0.9931.00
128_G132_L0.9921.00
147_L151_I0.9911.00
383_L386_A0.9901.00
381_C385_L0.9901.00
78_M369_R0.9871.00
390_W393_L0.9861.00
160_V164_W0.9821.00
146_N150_V0.9691.00
393_L398_M0.9681.00
374_A384_L0.9621.00
174_P177_A0.9571.00
244_A261_Q0.9511.00
392_S397_I0.9471.00
18_S228_A0.9451.00
207_A217_F0.9451.00
138_T310_S0.9421.00
380_L383_L0.9391.00
397_I406_L0.9371.00
68_S78_M0.9321.00
163_W238_V0.9301.00
42_L240_L0.9271.00
138_T314_I0.9271.00
132_L280_F0.9241.00
162_I259_V0.9231.00
70_G73_A0.9201.00
391_K394_Y0.9181.00
384_L387_M0.9161.00
188_A192_V0.9161.00
237_V241_H0.9161.00
133_V284_N0.9121.00
253_A257_K0.9091.00
108_A126_E0.9091.00
151_I281_A0.9061.00
141_A288_Q0.9051.00
183_L186_L0.9021.00
356_L360_L0.9001.00
377_G386_A0.8991.00
201_E205_H0.8961.00
392_S398_M0.8951.00
378_G381_C0.8891.00
49_I197_F0.8881.00
265_V269_W0.8831.00
242_F258_I0.8821.00
77_G300_H0.8811.00
102_A195_W0.8811.00
392_S406_L0.8801.00
403_W407_P0.8781.00
388_V393_L0.8701.00
102_A344_I0.8681.00
287_I323_L0.8661.00
229_G233_W0.8621.00
115_F118_H0.8611.00
168_I171_A0.8611.00
70_G74_H0.8601.00
90_W302_P0.8591.00
380_L384_L0.8591.00
43_W186_L0.8581.00
223_I227_L0.8551.00
107_A279_C0.8531.00
397_I403_W0.8521.00
392_S399_L0.8511.00
402_L406_L0.8491.00
308_R311_S0.8441.00
396_L403_W0.8381.00
302_P306_L0.8371.00
118_H121_Q0.8341.00
177_A181_I0.8321.00
388_V392_S0.8301.00
378_G382_V0.8291.00
390_W397_I0.8271.00
22_L25_G0.8231.00
76_V361_A0.8171.00
306_L317_N0.8171.00
377_G387_M0.8161.00
15_G149_T0.8151.00
53_F57_I0.8101.00
111_G276_Y0.8101.00
405_L408_K0.8091.00
346_Y350_I0.8031.00
396_L405_L0.7951.00
12_Q146_N0.7951.00
146_N149_T0.7941.00
323_L327_V0.7941.00
112_Q122_L0.7941.00
264_G267_A0.7931.00
316_N320_N0.7921.00
54_P58_V0.7911.00
363_C367_Q0.7901.00
406_L409_R0.7881.00
176_P181_I0.7881.00
202_A289_S0.7871.00
7_E142_S0.7871.00
123_L330_T0.7871.00
62_L362_G0.7871.00
10_L220_A0.7851.00
83_R404_L0.7831.00
155_I278_A0.7821.00
84_L357_L0.7811.00
33_A37_A0.7811.00
125_A128_G0.7811.00
156_V231_V0.7801.00
135_Y138_T0.7801.00
167_D171_A0.7791.00
362_G366_L0.7771.00
11_A149_T0.7751.00
107_A280_F0.7741.00
46_P50_I0.7681.00
198_V355_Y0.7671.00
374_A385_L0.7661.00
391_K405_L0.7631.00
108_A122_L0.7631.00
388_V391_K0.7621.00
99_G347_A0.7621.00
212_N218_P0.7621.00
375_V386_A0.7611.00
83_R87_V0.7601.00
11_A146_N0.7591.00
183_L187_F0.7581.00
324_G327_V0.7541.00
292_R295_W0.7511.00
377_G384_L0.7481.00
363_C375_V0.7411.00
175_F180_N0.7401.00
73_A77_G0.7371.00
392_S405_L0.7361.00
145_A149_T0.7351.00
396_L406_L0.7351.00
14_I220_A0.7341.00
397_I409_R0.7331.00
365_L370_Y0.7321.00
62_L75_F0.7321.00
61_I65_H0.7291.00
187_F383_L0.7281.00
393_L399_L0.7281.00
130_L330_T0.7261.00
53_F222_M0.7261.00
26_V235_C0.7261.00
311_S316_N0.7251.00
133_V287_I0.7231.00
388_V399_L0.7221.00
238_V241_H0.7191.00
234_G238_V0.7181.00
137_G319_L0.7181.00
349_G396_L0.7171.00
21_L224_G0.7141.00
247_E250_A0.7131.00
392_S403_W0.7111.00
218_P221_L0.7111.00
372_L380_L0.7101.00
400_A404_L0.7071.00
393_L404_L0.7011.00
388_V397_I0.6981.00
139_R143_S0.6951.00
92_F96_I0.6861.00
133_V280_F0.6861.00
7_E141_A0.6851.00
399_L406_L0.6811.00
22_L155_I0.6801.00
391_K396_L0.6801.00
287_I291_A0.6791.00
43_W47_V0.6781.00
266_G269_W0.6771.00
69_A295_W0.6771.00
41_S236_T0.6761.00
365_L369_R0.6761.00
235_C255_L0.6761.00
111_G129_T0.6741.00
361_A365_L0.6731.00
397_I404_L0.6731.00
97_P325_C0.6731.00
177_A180_N0.6721.00
73_A89_G0.6721.00
208_S295_W0.6711.00
105_Q343_L0.6691.00
123_L126_E0.6691.00
79_A364_K0.6691.00
98_V346_Y0.6661.00
398_M405_L0.6661.00
291_A318_A0.6641.00
399_L405_L0.6631.00
137_G288_Q0.6631.00
378_G387_M0.6631.00
315_P318_A0.6621.00
127_L331_L0.6611.00
389_G397_I0.6561.00
310_S313_H0.6521.00
60_A64_R0.6491.00
91_L354_I0.6471.00
79_A365_L0.6471.00
43_W46_P0.6451.00
185_G188_A0.6441.00
42_L233_W0.6421.00
19_T152_A0.6401.00
80_F361_A0.6371.00
401_G404_L0.6371.00
101_P343_L0.6351.00
163_W235_C0.6331.00
56_A200_L0.6331.00
298_A306_L0.6331.00
379_L382_V0.6311.00
52_V200_L0.6311.00
385_L393_L0.6311.00
95_V351_F0.6311.00
367_Q371_R0.6301.00
227_L231_V0.6301.00
368_G371_R0.6301.00
103_A106_I0.6301.00
305_Y321_A0.6301.00
176_P180_N0.6281.00
141_A206_L0.6261.00
204_A221_L0.6261.00
101_P329_S0.6241.00
145_A284_N0.6241.00
113_A272_C0.6241.00
389_G396_L0.6231.00
178_P246_G0.6221.00
377_G383_L0.6221.00
59_F358_C0.6221.00
30_P236_T0.6191.00
42_L46_P0.6191.00
395_A406_L0.6181.00
306_L318_A0.6181.00
167_D172_N0.6181.00
143_S146_N0.6181.00
395_A405_L0.6181.00
63_G217_F0.6161.00
393_L403_W0.6121.00
39_N240_L0.6111.00
373_L381_C0.6111.00
140_G143_S0.6091.00
294_V321_A0.6081.00
138_T319_L0.6081.00
14_I17_L0.6071.00
339_N342_A0.6071.00
389_G399_L0.6061.00
129_T283_L0.6041.00
131_A134_W0.6031.00
391_K404_L0.6021.00
381_C387_M0.5991.00
373_L387_M0.5981.00
112_Q116_G0.5971.00
96_I286_Y0.5951.00
134_W287_I0.5951.00
108_A111_G0.5951.00
157_A160_V0.5951.00
375_V380_L0.5951.00
389_G395_A0.5941.00
259_V267_A0.5941.00
47_V190_L0.5941.00
209_E309_L0.5921.00
130_L327_V0.5921.00
23_G232_Y0.5911.00
63_G204_A0.5901.00
400_A403_W0.5891.00
374_A387_M0.5891.00
375_V385_L0.5881.00
392_S407_P0.5881.00
382_V385_L0.5881.00
45_W196_C0.5881.00
373_L376_V0.5861.00
223_I226_L0.5861.00
350_I354_I0.5851.00
394_Y399_L0.5851.00
235_C239_V0.5851.00
254_S259_V0.5851.00
278_A281_A0.5851.00
312_R316_N0.5841.00
18_S21_L0.5841.00
7_E11_A0.5821.00
375_V378_G0.5801.00
110_F275_G0.5801.00
48_L194_F0.5791.00
20_S285_I0.5791.00
20_S286_Y0.5781.00
389_G393_L0.5781.00
99_G102_A0.5771.00
376_V380_L0.5751.00
72_V201_E0.5731.00
114_M272_C0.5731.00
377_G385_L0.5701.00
154_L158_L0.5701.00
397_I405_L0.5691.00
91_L353_M0.5661.00
22_L231_V0.5651.00
62_L79_A0.5651.00
359_M378_G0.5641.00
198_V201_E0.5621.00
165_A263_F0.5611.00
273_V277_L0.5611.00
246_G250_A0.5601.00
213_P216_D0.5591.00
389_G406_L0.5591.00
399_L402_L0.5561.00
72_V205_H0.5561.00
32_L341_D0.5561.00
394_Y403_W0.5541.00
114_M273_V0.5541.00
104_L108_A0.5531.00
209_E315_P0.5531.00
144_S288_Q0.5531.00
152_A155_I0.5521.00
11_A14_I0.5521.00
13_G206_L0.5501.00
400_A405_L0.5491.00
205_H289_S0.5491.00
26_V30_P0.5481.00
217_F221_L0.5451.00
215_R218_P0.5451.00
328_V331_L0.5451.00
22_L27_F0.5451.00
290_F294_V0.5451.00
341_D344_I0.5451.00
54_P373_L0.5441.00
173_I240_L0.5431.00
26_V29_V0.5431.00
18_S152_A0.5411.00
395_A400_A0.5391.00
380_L387_M0.5391.00
292_R309_L0.5381.00
340_L344_I0.5371.00
393_L408_K0.5361.00
373_L380_L0.5361.00
56_A60_A0.5361.00
149_T153_G0.5351.00
81_G85_E0.5351.00
321_A325_C0.5351.00
227_L230_L0.5341.00
143_S147_L0.5341.00
29_V344_I0.5331.00
375_V381_C0.5331.00
253_A256_P0.5331.00
174_P180_N0.5321.00
97_P322_V0.5321.00
71_G204_A0.5311.00
110_F256_P0.5301.00
375_V387_M0.5301.00
196_C232_Y0.5281.00
399_L407_P0.5271.00
99_G103_A0.5271.00
73_A85_E0.5261.00
55_I201_E0.5251.00
396_L402_L0.5251.00
391_K398_M0.5251.00
148_Q155_I0.5241.00
103_A283_L0.5241.00
292_R315_P0.5241.00
97_P329_S0.5231.00
113_A116_G0.5221.00
150_V153_G0.5201.00
6_Q211_K0.5191.00
101_P326_C0.5181.00
394_Y407_P0.5181.00
210_F220_A0.5171.00
154_L274_I0.5161.00
395_A404_L0.5161.00
259_V264_G0.5151.00
36_V188_A0.5131.00
132_L136_I0.5121.00
404_L407_P0.5121.00
287_I319_L0.5111.00
139_R312_R0.5111.00
20_S202_A0.5101.00
9_G142_S0.5101.00
174_P179_G0.5091.00
39_N245_Y0.5071.00
395_A401_G0.5071.00
393_L405_L0.5051.00
104_L107_A0.5041.00
128_G131_A0.5041.00
316_N319_L0.5031.00
173_I241_H0.5031.00
45_W236_T0.5031.00
109_G122_L0.5021.00
391_K403_W0.5021.00
17_L21_L0.5021.00
227_L234_G0.5011.00
239_V255_L0.5011.00
48_L197_F0.5001.00
60_A221_L0.5001.00
210_F217_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9641 100 0.248 Contact Map
3giaA 1 0.9785 100 0.319 Contact Map
4djkA 2 0.933 100 0.352 Contact Map
3dh4A 3 0.9545 98.8 0.855 Contact Map
2xq2A 2 0.9545 98.7 0.859 Contact Map
2jlnA 1 0.9402 98.5 0.867 Contact Map
4wgvA 2 0.8565 98.2 0.88 Contact Map
2a65A 2 0.9569 96.5 0.91 Contact Map
4us3A 1 0.9139 95.1 0.919 Contact Map
4xp4A 1 0.9593 95 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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