GREMLIN Database
YJDL - Probable dipeptide and tripeptide permease YjdL
UniProt: P39276 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12469
Length: 485 (459)
Sequences: 4666 (2912)
Seq/√Len: 135.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_A172_L4.4421.00
358_L383_L3.4861.00
67_L72_L3.4351.00
277_F387_A3.3771.00
310_F374_M3.3381.00
72_L77_A3.3101.00
43_D294_R3.1451.00
87_L108_I3.1211.00
347_F390_F3.0471.00
298_R304_E2.9761.00
453_E457_A2.9451.00
317_A382_A2.7191.00
33_L289_S2.6461.00
91_V105_A2.6441.00
67_L71_L2.6251.00
395_A412_Y2.5931.00
81_G115_L2.5841.00
72_L80_A2.5701.00
86_T178_F2.5571.00
91_V108_I2.5131.00
299_Q304_E2.4871.00
161_A308_A2.4831.00
378_I382_A2.4541.00
23_S89_H2.4261.00
351_L386_F2.4091.00
195_R200_K2.4061.00
17_Q21_Y2.3691.00
448_F451_M2.3271.00
292_I377_M2.3191.00
235_S238_L2.2991.00
340_R343_L2.2861.00
92_L105_A2.2771.00
83_L87_L2.2361.00
75_R188_H2.2141.00
350_L459_V2.2001.00
162_Q307_T2.1781.00
20_E117_K2.1551.00
231_E239_L2.1371.00
278_W392_D2.1151.00
79_I185_L2.0901.00
324_V328_L2.0671.00
239_L243_C2.0521.00
50_F285_G2.0411.00
313_V378_I2.0411.00
324_V327_W2.0391.00
358_L379_S2.0331.00
24_F54_A2.0251.00
93_G174_G2.0141.00
328_L332_E1.9941.00
321_A386_F1.9921.00
50_F286_S1.9801.00
17_Q20_E1.9781.00
61_P68_A1.9721.00
258_P262_R1.9681.00
139_F400_T1.9681.00
213_S217_V1.9661.00
32_I36_T1.9191.00
60_T63_L1.8781.00
43_D290_L1.8471.00
365_H368_A1.8451.00
124_L138_G1.7911.00
203_T206_K1.7681.00
239_L242_V1.7551.00
17_Q117_K1.7291.00
100_F104_L1.7191.00
85_M116_F1.6991.00
37_H166_W1.6891.00
41_F49_L1.6831.00
320_L324_V1.6711.00
88_G109_I1.6661.00
144_A319_M1.6611.00
314_N385_G1.6601.00
467_F471_F1.6411.00
188_H193_S1.6301.00
207_F211_V1.6011.00
210_P214_W1.6011.00
205_V208_A1.5981.00
350_L354_C1.5901.00
199_K202_L1.5841.00
251_A264_L1.5691.00
32_I290_L1.5671.00
460_A464_V1.5341.00
60_T110_I1.5331.00
33_L307_T1.5271.00
372_A376_V1.5261.00
208_A212_W1.5231.00
90_V174_G1.5221.00
151_I319_M1.4941.00
276_L458_C1.4891.00
450_Q454_W1.4851.00
121_S413_M1.4841.00
42_D45_H1.4791.00
355_G384_M1.4791.00
262_R474_S1.4741.00
461_I465_L1.4731.00
142_L146_G1.4631.00
231_E242_V1.4581.00
314_N318_V1.4571.00
165_G168_V1.4561.00
306_P309_L1.4491.00
205_V209_L1.4411.00
158_G308_A1.4411.00
298_R307_T1.4381.00
224_V227_T1.4371.00
223_P227_T1.4261.00
360_A454_W1.4151.00
18_I145_A1.4121.00
364_R368_A1.4091.00
274_G415_A1.4031.00
449_S453_E1.3951.00
192_Q195_R1.3901.00
279_V420_A1.3891.00
35_L50_F1.3851.00
105_A109_I1.3841.00
464_V468_A1.3821.00
363_A366_A1.3761.00
36_T290_L1.3751.00
240_A243_C1.3721.00
206_K210_P1.3641.00
468_A471_F1.3531.00
211_V215_L1.3491.00
360_A449_S1.3481.00
210_P213_S1.3451.00
354_C383_L1.3441.00
80_A83_L1.3391.00
234_W238_L1.3331.00
160_A164_Y1.3201.00
231_E235_S1.3191.00
468_A472_L1.3131.00
331_P335_G1.3111.00
168_V171_A1.3051.00
317_A385_G1.3001.00
346_A459_V1.2961.00
144_A322_G1.2941.00
88_G112_G1.2931.00
236_G239_L1.2921.00
99_T103_Y1.2891.00
281_A284_G1.2821.00
195_R198_D1.2821.00
86_T90_V1.2751.00
467_F470_R1.2751.00
456_L460_A1.2701.00
48_S429_Q1.2681.00
18_I148_I1.2681.00
292_I374_M1.2591.00
466_A470_R1.2561.00
26_G157_C1.2541.00
175_G179_I1.2521.00
235_S240_A1.2521.00
373_S376_V1.2511.00
231_E243_C1.2471.00
392_D396_I1.2451.00
327_W331_P1.2451.00
359_L380_G1.2431.00
12_Y187_G1.2431.00
113_Y117_K1.2381.00
362_D376_V1.2341.00
227_T231_E1.2241.00
209_L213_S1.2221.00
332_E337_S1.2221.00
214_W217_V1.2211.00
231_E234_W1.2181.00
143_Y388_E1.2171.00
21_Y117_K1.2151.00
72_L76_T1.2131.00
236_G240_A1.2101.00
147_N314_N1.2061.00
233_D236_G1.2061.00
295_F371_Q1.2031.00
198_D202_L1.1941.00
299_Q302_N1.1901.00
126_E400_T1.1870.99
32_I46_A1.1860.99
136_D397_A1.1860.99
406_G410_G1.1850.99
206_K257_F1.1830.99
353_A456_L1.1800.99
450_Q453_E1.1790.99
382_A386_F1.1690.99
235_S241_I1.1660.99
351_L387_A1.1640.99
158_G309_L1.1610.99
156_A172_L1.1590.99
237_Y241_I1.1550.99
318_V388_E1.1520.99
121_S142_L1.1470.99
339_L347_F1.1450.99
234_W240_A1.1450.99
303_I309_L1.1430.99
157_C160_A1.1430.99
345_F391_I1.1380.99
159_L164_Y1.1370.99
113_Y116_F1.1360.99
34_Y102_L1.1360.99
57_V60_T1.1330.99
64_G114_G1.1300.99
236_G243_C1.1280.99
431_T455_T1.1240.99
74_N126_E1.1240.99
256_K260_H1.1200.99
206_K211_V1.1140.99
201_A205_V1.1090.99
182_L186_S1.1080.99
207_F258_P1.1080.99
117_K413_M1.1060.99
231_E236_G1.1050.99
288_I380_G1.1040.99
86_T181_L1.0970.99
17_Q142_L1.0900.99
128_Y138_G1.0860.99
57_V110_I1.0850.99
19_W176_G1.0840.99
20_E25_Y1.0840.99
171_A175_G1.0830.99
196_S199_K1.0810.99
146_G413_M1.0810.99
21_Y24_F1.0780.99
353_A357_M1.0680.99
35_L102_L1.0680.99
229_L243_C1.0650.99
286_S428_A1.0650.99
88_G92_L1.0640.99
41_F99_T1.0630.99
235_S239_L1.0630.99
288_I381_L1.0510.99
41_F45_H1.0460.99
28_R50_F1.0460.99
311_Q315_A1.0380.99
150_S315_A1.0340.99
121_S409_T1.0330.99
146_G396_I1.0250.99
143_Y318_V1.0250.99
231_E240_A1.0210.98
207_F210_P1.0210.98
357_M452_G1.0200.98
155_I309_L1.0190.98
208_A211_V1.0160.98
354_C358_L1.0150.98
65_G406_G1.0150.98
333_S338_T1.0130.98
202_L206_K1.0060.98
298_R306_P1.0050.98
186_S189_R1.0050.98
124_L127_L1.0050.98
259_E262_R1.0050.98
193_S196_S1.0030.98
21_Y25_Y1.0010.98
226_F229_L0.9980.98
37_H162_Q0.9970.98
250_I253_M0.9960.98
45_H48_S0.9950.98
125_G400_T0.9940.98
348_G391_I0.9940.98
333_S336_N0.9930.98
85_M113_Y0.9870.98
67_L77_A0.9860.98
292_I296_V0.9770.98
17_Q116_F0.9760.98
223_P226_F0.9740.98
198_D201_A0.9730.98
253_M257_F0.9700.98
171_A174_G0.9690.98
206_K209_L0.9660.98
19_W120_I0.9640.98
346_A463_V0.9630.98
217_V243_C0.9610.98
318_V323_V0.9610.98
229_L232_N0.9580.98
201_A204_S0.9570.98
48_S425_G0.9570.98
297_N371_Q0.9560.98
65_G410_G0.9520.98
281_A385_G0.9510.98
232_N243_C0.9510.98
28_R282_Q0.9500.98
465_L469_T0.9460.98
58_Y117_K0.9420.97
284_G388_E0.9420.97
361_F365_H0.9410.97
284_G384_M0.9400.97
79_I82_A0.9400.97
143_Y147_N0.9400.97
221_L224_V0.9390.97
238_L243_C0.9360.97
206_K250_I0.9360.97
60_T114_G0.9340.97
238_L241_I0.9300.97
392_D412_Y0.9250.97
392_D395_A0.9230.97
198_D204_S0.9180.97
322_G393_P0.9180.97
322_G326_A0.9140.97
277_F318_V0.9130.97
51_S424_A0.9120.97
221_L226_F0.9090.97
47_I286_S0.9070.97
198_D214_W0.9060.97
325_L328_L0.8980.97
317_A378_I0.8980.97
121_S396_I0.8950.97
284_G381_L0.8920.96
6_Q10_I0.8900.96
195_R199_K0.8890.96
234_W237_Y0.8890.96
200_K206_K0.8880.96
430_Q434_S0.8870.96
58_Y413_M0.8850.96
204_S207_F0.8810.96
49_L103_Y0.8770.96
237_Y242_V0.8760.96
42_D46_A0.8740.96
270_L345_F0.8720.96
97_N101_S0.8720.96
228_L231_E0.8690.96
274_G412_Y0.8650.96
332_E339_L0.8580.96
353_A459_V0.8560.96
159_L163_W0.8490.95
225_F228_L0.8440.95
14_V145_A0.8410.95
36_T43_D0.8330.95
362_D372_A0.8280.95
33_L37_H0.8270.95
20_E177_M0.8270.95
66_W71_L0.8270.95
226_F231_E0.8270.95
137_G326_A0.8240.94
237_Y243_C0.8230.94
18_I146_G0.8220.94
84_L111_C0.8220.94
426_V430_Q0.8200.94
280_L455_T0.8140.94
56_L422_W0.8140.94
364_R450_Q0.8120.94
62_I410_G0.8110.94
19_W22_F0.8090.94
325_L386_F0.8070.94
116_F120_I0.8030.94
321_A389_L0.8030.94
129_D192_Q0.8020.94
281_A392_D0.8020.94
345_F395_A0.8010.94
446_R449_S0.8000.94
291_F296_V0.8000.94
305_V374_M0.7990.94
167_H171_A0.7980.93
199_K207_F0.7970.93
152_A155_I0.7940.93
330_S333_S0.7930.93
282_Q416_T0.7920.93
259_E474_S0.7910.93
296_V377_M0.7910.93
321_A324_V0.7900.93
87_L91_V0.7890.93
192_Q196_S0.7890.93
305_V309_L0.7870.93
335_G338_T0.7870.93
227_T230_L0.7860.93
197_M201_A0.7850.93
233_D238_L0.7840.93
230_L240_A0.7830.93
452_G455_T0.7820.93
388_E392_D0.7820.93
142_L388_E0.7810.93
32_I47_I0.7800.93
423_L426_V0.7750.92
142_L396_I0.7740.92
281_A314_N0.7740.92
280_L352_M0.7710.92
237_Y240_A0.7660.92
251_A255_I0.7650.92
211_V258_P0.7640.92
358_L380_G0.7570.92
20_E283_Q0.7550.91
121_S146_G0.7540.91
363_A367_A0.7540.91
162_Q308_A0.7530.91
207_F213_S0.7520.91
12_Y190_H0.7500.91
298_R374_M0.7500.91
77_A115_L0.7470.91
275_T420_A0.7450.91
202_L211_V0.7440.91
343_L346_A0.7430.91
282_Q421_N0.7430.91
125_G139_F0.7430.91
271_M399_I0.7400.91
273_V466_A0.7380.91
161_A165_G0.7380.91
57_V119_N0.7380.91
126_E405_S0.7380.91
225_F231_E0.7370.90
431_T435_Q0.7360.90
226_F230_L0.7330.90
184_F188_H0.7330.90
321_A382_A0.7320.90
17_Q146_G0.7320.90
201_A207_F0.7290.90
20_E24_F0.7290.90
41_F103_Y0.7280.90
79_I181_L0.7280.90
277_F391_I0.7280.90
279_V423_L0.7270.90
253_M256_K0.7250.90
452_G456_L0.7240.90
222_A225_F0.7230.90
79_I83_L0.7220.90
331_P334_R0.7210.89
291_F377_M0.7210.89
222_A226_F0.7190.89
227_T232_N0.7190.89
208_A223_P0.7180.89
47_I290_L0.7180.89
232_N236_G0.7150.89
397_A401_R0.7150.89
89_H177_M0.7140.89
93_G171_A0.7140.89
343_L463_V0.7130.89
230_L235_S0.7110.89
446_R453_E0.7090.89
285_G289_S0.7090.89
229_L239_L0.7090.89
154_P312_S0.7080.89
329_A338_T0.7070.89
194_T200_K0.7070.89
314_N388_E0.7060.89
54_A57_V0.7030.88
327_W330_S0.7020.88
69_D73_G0.7020.88
351_L383_L0.6980.88
250_I264_L0.6980.88
55_S422_W0.6970.88
420_A423_L0.6970.88
86_T174_G0.6970.88
332_E335_G0.6970.88
158_G161_A0.6960.88
280_L384_M0.6940.88
367_A450_Q0.6920.88
273_V462_I0.6920.88
233_D243_C0.6910.87
122_C409_T0.6900.87
29_A154_P0.6870.87
30_L169_G0.6860.87
232_N239_L0.6850.87
21_Y146_G0.6830.87
33_L36_T0.6820.87
218_M221_L0.6820.87
141_L144_A0.6800.87
151_I315_A0.6800.87
89_H174_G0.6780.86
34_Y326_A0.6780.86
446_R450_Q0.6770.86
296_V374_M0.6750.86
221_L225_F0.6740.86
211_V214_W0.6740.86
279_V427_V0.6730.86
90_V94_I0.6710.86
230_L234_W0.6710.86
357_M360_A0.6690.86
199_K214_W0.6680.86
161_A166_W0.6680.86
63_L420_A0.6680.86
7_P10_I0.6670.86
156_A159_L0.6660.85
235_S243_C0.6660.85
447_F451_M0.6650.85
14_V18_I0.6650.85
6_Q9_A0.6650.85
76_T80_A0.6640.85
64_G128_Y0.6640.85
197_M200_K0.6640.85
234_W242_V0.6620.85
147_N315_A0.6610.85
58_Y147_N0.6600.85
346_A350_L0.6570.85
229_L236_G0.6570.85
205_V212_W0.6560.85
360_A364_R0.6560.85
119_N173_A0.6550.85
182_L225_F0.6540.84
232_N240_A0.6540.84
362_D380_G0.6540.84
305_V368_A0.6520.84
8_R11_Y0.6520.84
193_S200_K0.6500.84
357_M457_A0.6490.84
369_D372_A0.6480.84
359_L362_D0.6440.84
206_K213_S0.6440.84
231_E238_L0.6430.83
118_S122_C0.6370.83
212_W215_L0.6360.83
24_F117_K0.6360.83
203_T210_P0.6360.83
313_V317_A0.6320.82
30_L35_L0.6310.82
208_A214_W0.6300.82
207_F214_W0.6300.82
120_I123_L0.6290.82
155_I312_S0.6280.82
254_M257_F0.6250.82
200_K207_F0.6240.82
248_Q251_A0.6230.81
284_G314_N0.6220.81
47_I431_T0.6220.81
224_V228_L0.6200.81
23_S113_Y0.6170.81
230_L233_D0.6160.81
276_L279_V0.6160.81
93_G181_L0.6160.81
234_W239_L0.6160.81
210_P218_M0.6150.81
360_A363_A0.6140.81
352_M355_G0.6140.81
277_F314_N0.6140.81
361_F364_R0.6130.80
270_L398_Q0.6120.80
204_S261_R0.6110.80
230_L238_L0.6110.80
250_I254_M0.6090.80
147_N388_E0.6080.80
148_I318_V0.6080.80
278_W281_A0.6070.80
260_H403_K0.6070.80
185_L188_H0.6070.80
23_S27_M0.6070.80
221_L231_E0.6070.80
21_Y26_G0.6060.80
192_Q199_K0.6060.80
159_L308_A0.6040.79
121_S392_D0.6040.79
245_I248_Q0.6030.79
459_V462_I0.6020.79
192_Q198_D0.6010.79
233_D239_L0.6010.79
424_A452_G0.6010.79
143_Y314_N0.6010.79
71_L92_L0.6010.79
199_K203_T0.5990.79
48_S52_A0.5980.79
140_S326_A0.5970.79
86_T144_A0.5950.78
35_L39_L0.5950.78
325_L389_L0.5930.78
144_A148_I0.5930.78
51_S425_G0.5920.78
143_Y311_Q0.5920.78
151_I316_I0.5910.78
348_G387_A0.5910.78
82_A177_M0.5900.78
116_F119_N0.5900.78
96_T99_T0.5890.78
126_E194_T0.5890.78
147_N150_S0.5880.78
164_Y306_P0.5870.77
17_Q26_G0.5870.77
238_L242_V0.5860.77
229_L234_W0.5860.77
179_I221_L0.5840.77
119_N406_G0.5840.77
12_Y183_I0.5840.77
471_F474_S0.5830.77
120_I146_G0.5830.77
217_V221_L0.5820.77
168_V173_A0.5820.77
111_C196_S0.5810.77
196_S204_S0.5800.77
232_N238_L0.5800.77
469_T473_F0.5800.77
56_L110_I0.5800.77
211_V237_Y0.5800.77
78_V406_G0.5790.77
403_K410_G0.5790.77
236_G241_I0.5780.76
203_T213_S0.5770.76
183_I191_F0.5760.76
305_V382_A0.5750.76
25_Y153_A0.5740.76
207_F261_R0.5740.76
11_Y15_A0.5740.76
147_N392_D0.5740.76
426_V429_Q0.5730.76
398_Q474_S0.5730.76
314_N384_M0.5710.76
48_S51_S0.5700.75
30_L43_D0.5700.75
235_S242_V0.5690.75
139_F270_L0.5680.75
78_V184_F0.5680.75
68_A73_G0.5680.75
246_A407_V0.5680.75
196_S200_K0.5670.75
95_D98_S0.5650.75
298_R310_F0.5650.75
214_W252_R0.5640.75
283_Q356_F0.5630.75
32_I289_S0.5620.74
342_W402_L0.5610.74
21_Y113_Y0.5610.74
85_M109_I0.5600.74
187_G190_H0.5590.74
284_G355_G0.5590.74
354_C357_M0.5580.74
209_L214_W0.5580.74
289_S311_Q0.5580.74
224_V233_D0.5570.74
224_V231_E0.5570.74
452_G459_V0.5540.73
109_I114_G0.5510.73
234_W243_C0.5510.73
388_E395_A0.5500.73
431_T447_F0.5490.73
8_R190_H0.5480.73
26_G73_G0.5480.73
343_L470_R0.5470.72
276_L387_A0.5470.72
59_V421_N0.5470.72
195_R202_L0.5460.72
53_Y57_V0.5450.72
430_Q433_E0.5450.72
144_A323_V0.5450.72
80_A185_L0.5440.72
449_S452_G0.5440.72
85_M89_H0.5430.72
283_Q287_T0.5430.72
19_W23_S0.5430.72
156_A160_A0.5420.72
62_I66_W0.5420.72
289_S381_L0.5420.72
214_W218_M0.5400.71
153_A424_A0.5400.71
303_I306_P0.5400.71
194_T204_S0.5390.71
459_V463_V0.5380.71
463_V467_F0.5380.71
348_G352_M0.5380.71
166_W170_F0.5360.71
64_G153_A0.5350.71
199_K204_S0.5340.71
227_T243_C0.5340.71
267_I452_G0.5330.70
248_Q252_R0.5330.70
21_Y177_M0.5320.70
116_F121_S0.5320.70
24_F28_R0.5310.70
116_F142_L0.5310.70
58_Y314_N0.5310.70
143_Y146_G0.5300.70
20_E26_G0.5300.70
281_A318_V0.5290.70
138_G400_T0.5270.70
291_F363_A0.5270.70
146_G152_A0.5250.69
278_W388_E0.5230.69
17_Q25_Y0.5230.69
350_L460_A0.5230.69
117_K146_G0.5220.69
232_N235_S0.5210.69
21_Y142_L0.5200.69
350_L463_V0.5190.68
16_I116_F0.5180.68
267_I399_I0.5180.68
230_L236_G0.5160.68
241_I250_I0.5150.68
9_A12_Y0.5140.68
244_L248_Q0.5140.68
161_A164_Y0.5130.68
194_T319_M0.5130.68
224_V229_L0.5110.67
321_A351_L0.5100.67
41_F102_L0.5100.67
154_P158_G0.5090.67
351_L390_F0.5090.67
341_V420_A0.5090.67
68_A78_V0.5070.67
198_D207_F0.5070.67
162_Q298_R0.5060.67
6_Q128_Y0.5060.67
186_S259_E0.5050.66
201_A210_P0.5050.66
147_N318_V0.5050.66
162_Q306_P0.5050.66
20_E116_F0.5040.66
206_K221_L0.5040.66
232_N237_Y0.5040.66
22_F155_I0.5020.66
405_S408_L0.5010.66
292_I310_F0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oh3A 2 0.9608 100 0.53 Contact Map
4uvmA 1 0.9629 100 0.537 Contact Map
4q65A 1 0.8907 100 0.59 Contact Map
4tphA 2 0.8928 100 0.634 Contact Map
4ikvA 1 0.9485 100 0.647 Contact Map
4xnjA 1 0.9258 100 0.67 Contact Map
4w6vA 1 0.934 100 0.746 Contact Map
3wdoA 1 0.8227 99.9 0.786 Contact Map
2cfqA 1 0.8351 99.9 0.789 Contact Map
4pypA 1 0.866 99.9 0.797 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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