GREMLIN Database
ALSB - D-allose-binding periplasmic protein
UniProt: P39265 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12458
Length: 311 (282)
Sequences: 38359 (28602)
Seq/√Len: 1703.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_V180_E3.4731.00
154_A218_K3.3561.00
85_G283_M2.7871.00
154_A245_L2.6971.00
144_G247_V2.6941.00
175_R179_T2.6731.00
251_G269_A2.6291.00
131_A286_A2.5271.00
142_A184_K2.3561.00
204_L237_N2.3111.00
49_E52_T2.2871.00
208_T238_A2.2491.00
149_I185_A2.2021.00
146_S181_A2.1961.00
142_A181_A2.1581.00
49_E281_K2.1541.00
142_A180_E2.1441.00
208_T234_A2.1431.00
139_A143_K2.0941.00
278_T281_K2.0831.00
50_A280_L2.0291.00
49_E277_A1.9941.00
140_V249_T1.9921.00
138_V176_N1.9861.00
141_G145_A1.9811.00
148_I219_A1.9751.00
45_G276_G1.9271.00
203_A230_G1.9201.00
190_L193_S1.9061.00
146_S150_D1.8581.00
145_A178_A1.8511.00
269_A302_K1.8091.00
141_G221_Y1.8081.00
28_A83_Y1.8081.00
212_Q238_A1.7911.00
160_A217_I1.7901.00
235_V244_V1.7881.00
48_D273_A1.7571.00
222_C231_V1.7501.00
142_A146_S1.7461.00
161_I223_A1.7461.00
204_L234_A1.7411.00
207_A231_V1.7101.00
271_N274_D1.7011.00
113_L279_G1.6941.00
146_S185_A1.6851.00
49_E53_L1.6681.00
278_T297_K1.6361.00
143_K301_F1.6331.00
234_A238_A1.6251.00
45_G273_A1.6151.00
240_K243_K1.6091.00
264_M307_I1.6031.00
139_A142_A1.6031.00
176_N180_E1.5961.00
158_E216_N1.5911.00
147_F150_D1.5591.00
260_E263_Q1.5581.00
147_F305_D1.5361.00
149_I181_A1.5341.00
53_L284_V1.5301.00
247_V266_A1.5051.00
234_A237_N1.5041.00
187_Q192_A1.5031.00
158_E189_K1.4911.00
274_D278_T1.4871.00
173_A176_N1.4801.00
179_T183_K1.4621.00
204_L233_Q1.4581.00
158_E218_K1.4381.00
136_D139_A1.4291.00
236_A263_Q1.4151.00
49_E280_L1.4051.00
274_D277_A1.4001.00
235_V240_K1.3891.00
251_G306_S1.3851.00
25_A84_K1.3821.00
197_D202_K1.3721.00
204_L208_T1.3651.00
236_A260_E1.3631.00
140_V301_F1.3621.00
141_G177_G1.3561.00
181_A184_K1.3521.00
145_A149_I1.3391.00
160_A210_V1.3351.00
208_T237_N1.3251.00
145_A181_A1.3211.00
194_Q209_N1.3191.00
145_A177_G1.3171.00
87_A279_G1.2981.00
207_A235_V1.2961.00
138_V142_A1.2931.00
50_A57_V1.2921.00
177_G181_A1.2801.00
281_K285_D1.2771.00
25_A55_V1.2771.00
208_T212_Q1.2671.00
28_A78_L1.2631.00
143_K146_S1.2601.00
76_E102_R1.2571.00
60_F74_L1.2531.00
207_A220_I1.2501.00
27_Y50_A1.2461.00
101_A105_K1.2441.00
60_F78_L1.2191.00
46_I280_L1.2111.00
154_A219_A1.2061.00
189_K192_A1.2021.00
273_A277_A1.1941.00
26_E56_S1.1821.00
178_A182_F1.1731.00
29_V46_I1.1731.00
232_A246_V1.1711.00
230_G234_A1.1651.00
26_E58_D1.1571.00
157_G218_K1.1451.00
47_E51_K1.1421.00
138_V177_G1.1401.00
161_I175_R1.1401.00
138_V173_A1.1341.00
209_N213_R1.1311.00
199_D202_K1.1271.00
53_L281_K1.1261.00
201_I205_D1.1211.00
13_V16_M1.1191.00
158_E191_V1.1131.00
206_V209_N1.1081.00
29_V57_V1.0931.00
46_I87_A1.0911.00
214_N217_I1.0901.00
180_E184_K1.0881.00
285_D291_K1.0871.00
159_V182_F1.0831.00
15_L18_S1.0811.00
285_D290_G1.0781.00
146_S184_K1.0781.00
144_G221_Y1.0741.00
178_A221_Y1.0691.00
162_I231_V1.0681.00
278_T282_L1.0681.00
200_R233_Q1.0661.00
220_I231_V1.0631.00
276_G280_L1.0601.00
225_D267_T1.0541.00
172_E176_N1.0531.00
282_L297_K1.0501.00
158_E215_P1.0491.00
176_N179_T1.0401.00
147_F266_A1.0351.00
222_C227_M1.0321.00
51_K70_S1.0311.00
225_D248_G1.0311.00
205_D209_N1.0291.00
277_A281_K1.0171.00
55_V284_V1.0151.00
202_K205_D1.0101.00
181_A185_A1.0071.00
43_K47_E1.0041.00
203_A207_A1.0011.00
70_S73_Q0.9921.00
150_D185_A0.9811.00
72_L76_E0.9811.00
283_M287_E0.9801.00
13_V19_T0.9771.00
169_A173_A0.9761.00
76_E80_N0.9761.00
179_T190_L0.9731.00
159_V219_A0.9711.00
97_V101_A0.9701.00
222_C228_A0.9651.00
16_M19_T0.9641.00
166_A195_P0.9641.00
12_L17_L0.9631.00
139_A300_E0.9621.00
144_G268_V0.9601.00
278_T299_P0.9581.00
145_A182_F0.9561.00
52_T277_A0.9541.00
67_D70_S0.9421.00
131_A282_L0.9411.00
302_K305_D0.9361.00
44_K48_D0.9361.00
207_A211_L0.9341.00
149_I157_G0.9261.00
164_G198_W0.9251.00
87_A283_M0.9141.00
188_I192_A0.9131.00
225_D251_G0.9131.00
194_Q206_V0.9051.00
271_N302_K0.8971.00
38_F272_P0.8861.00
240_K244_V0.8861.00
220_I244_V0.8801.00
48_D277_A0.8781.00
46_I276_G0.8761.00
14_G17_L0.8731.00
132_F296_D0.8731.00
137_N174_R0.8721.00
205_D208_T0.8701.00
27_Y87_A0.8671.00
269_A304_V0.8651.00
136_D298_A0.8641.00
160_A220_I0.8621.00
167_G172_E0.8601.00
48_D52_T0.8601.00
282_L285_D0.8591.00
43_K59_I0.8571.00
211_L234_A0.8571.00
135_T271_N0.8541.00
228_A248_G0.8511.00
163_E175_R0.8491.00
235_V246_V0.8471.00
42_M113_L0.8471.00
73_Q76_E0.8441.00
202_K206_V0.8411.00
280_L284_V0.8271.00
85_G287_E0.8251.00
135_T270_Q0.8251.00
26_E81_K0.8241.00
180_E183_K0.8241.00
58_D83_Y0.8221.00
187_Q193_S0.8121.00
133_V282_L0.8091.00
134_T298_A0.8081.00
29_V43_K0.8081.00
248_G267_T0.8051.00
271_N299_P0.8031.00
196_A227_M0.7991.00
134_T296_D0.7951.00
148_I247_V0.7941.00
65_E70_S0.7911.00
135_T301_F0.7871.00
58_D81_K0.7871.00
211_L238_A0.7871.00
147_F303_L0.7871.00
102_R105_K0.7831.00
11_T80_N0.7831.00
161_I221_Y0.7801.00
46_I57_V0.7791.00
139_A301_F0.7761.00
116_K296_D0.7741.00
10_G16_M0.7741.00
250_D270_Q0.7701.00
44_K47_E0.7681.00
70_S74_L0.7661.00
45_G277_A0.7651.00
207_A234_A0.7651.00
45_G49_E0.7641.00
131_A295_L0.7611.00
24_A84_K0.7611.00
173_A177_G0.7611.00
30_V74_L0.7551.00
216_N240_K0.7551.00
32_K39_W0.7551.00
149_I188_I0.7541.00
41_D273_A0.7531.00
136_D300_E0.7511.00
233_Q236_A0.7461.00
162_I222_C0.7411.00
187_Q190_L0.7401.00
85_G111_V0.7391.00
104_W130_E0.7381.00
28_A86_I0.7361.00
207_A210_V0.7361.00
251_G304_V0.7361.00
218_K245_L0.7291.00
87_A113_L0.7241.00
209_N212_Q0.7151.00
225_D228_A0.7131.00
142_A177_G0.7101.00
47_E57_V0.7051.00
143_K268_V0.7031.00
27_Y280_L0.7001.00
11_T15_L0.6881.00
99_P102_R0.6871.00
198_W223_A0.6841.00
266_A303_L0.6801.00
101_A104_W0.6791.00
251_G255_A0.6781.00
188_I193_S0.6781.00
79_S106_K0.6761.00
112_N117_I0.6761.00
23_A84_K0.6741.00
260_E264_M0.6741.00
224_N250_D0.6691.00
6_K9_S0.6691.00
111_V286_A0.6691.00
232_A259_V0.6681.00
103_A110_L0.6671.00
171_G198_W0.6641.00
114_D170_S0.6631.00
213_R217_I0.6621.00
36_N226_T0.6601.00
203_A206_V0.6601.00
221_Y247_V0.6601.00
11_T76_E0.6581.00
72_L99_P0.6571.00
229_M254_E0.6561.00
161_I178_A0.6521.00
149_I182_F0.6491.00
69_Q73_Q0.6471.00
255_A267_T0.6461.00
213_R216_N0.6461.00
258_M263_Q0.6451.00
233_Q237_N0.6441.00
200_R254_E0.6441.00
104_W129_V0.6421.00
196_A202_K0.6421.00
85_G279_G0.6411.00
79_S108_I0.6401.00
148_I221_Y0.6351.00
264_M306_S0.6341.00
233_Q264_M0.6331.00
159_V218_K0.6291.00
112_N132_F0.6261.00
221_Y249_T0.6261.00
75_F86_I0.6261.00
164_G171_G0.6251.00
68_F72_L0.6221.00
114_D137_N0.6221.00
224_N227_M0.6221.00
235_V238_A0.6201.00
232_A236_A0.6171.00
273_A276_G0.6141.00
41_D272_P0.6141.00
112_N130_E0.6121.00
182_F190_L0.6101.00
55_V84_K0.6091.00
143_K147_F0.6081.00
225_D252_I0.6051.00
50_A55_V0.6031.00
207_A230_G0.5991.00
111_V283_M0.5981.00
137_N170_S0.5971.00
147_F247_V0.5951.00
86_I108_I0.5941.00
289_S292_V0.5931.00
154_A157_G0.5921.00
39_W89_A0.5891.00
119_M128_N0.5891.00
104_W110_L0.5891.00
42_M272_P0.5861.00
55_V287_E0.5831.00
194_Q213_R0.5831.00
200_R230_G0.5821.00
17_L21_A0.5801.00
137_N173_A0.5801.00
111_V133_V0.5781.00
201_I204_L0.5771.00
73_Q77_D0.5761.00
116_K132_F0.5761.00
222_C248_G0.5721.00
27_Y85_G0.5721.00
38_F42_M0.5721.00
60_F77_D0.5711.00
98_M101_A0.5711.00
159_V178_A0.5701.00
110_L130_E0.5661.00
45_G272_P0.5661.00
27_Y55_V0.5661.00
198_W227_M0.5651.00
236_A241_T0.5631.00
206_V210_V0.5611.00
174_R270_Q0.5611.00
131_A294_P0.5601.00
27_Y287_E0.5591.00
257_K260_E0.5581.00
144_G219_A0.5571.00
158_E217_I0.5571.00
145_A185_A0.5561.00
134_T137_N0.5561.00
44_K273_A0.5551.00
114_D275_I0.5551.00
109_Y287_E0.5541.00
24_A56_S0.5531.00
77_D80_N0.5531.00
249_T270_Q0.5501.00
78_L83_Y0.5461.00
168_N171_G0.5461.00
142_A145_A0.5451.00
111_V282_L0.5451.00
111_V279_G0.5451.00
74_L77_D0.5451.00
18_S21_A0.5411.00
47_E63_P0.5401.00
282_L286_A0.5391.00
229_M252_I0.5371.00
102_R106_K0.5361.00
171_G223_A0.5351.00
233_Q260_E0.5331.00
10_G14_G0.5311.00
189_K193_S0.5311.00
158_E214_N0.5311.00
50_A284_V0.5301.00
194_Q210_V0.5291.00
98_M102_R0.5291.00
69_Q72_L0.5281.00
268_V301_F0.5271.00
219_A245_L0.5251.00
14_G18_S0.5211.00
211_L235_V0.5201.00
285_D289_S0.5201.00
204_L230_G0.5191.00
204_L207_A0.5191.00
15_L19_T0.5181.00
232_A265_T0.5141.00
231_V235_V0.5141.00
255_A264_M0.5141.00
225_D255_A0.5131.00
72_L102_R0.5121.00
285_D295_L0.5101.00
26_E84_K0.5091.00
298_A301_F0.5081.00
182_F188_I0.5061.00
275_I299_P0.5061.00
79_S82_N0.5041.00
135_T140_V0.5031.00
37_P226_T0.5031.00
178_A190_L0.5031.00
207_A222_C0.5021.00
278_T285_D0.5011.00
162_I206_V0.5001.00
200_R226_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.926 100 0.126 Contact Map
3huuA 2 0.8424 100 0.135 Contact Map
1qpzA 2 0.9389 100 0.136 Contact Map
3dbiA 2 0.8714 100 0.14 Contact Map
2iksA 2 0.8746 100 0.14 Contact Map
4o5aA 2 0.8521 100 0.141 Contact Map
2o20A 2 0.8714 100 0.143 Contact Map
3bilA 2 0.8167 100 0.144 Contact Map
3e3mA 2 0.8457 100 0.149 Contact Map
3kjxA 2 0.9389 100 0.151 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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