GREMLIN Database
YFCC - Uncharacterized protein YfcC
UniProt: P39263 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12607
Length: 506 (442)
Sequences: 2112 (1517)
Seq/√Len: 72.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_I492_M4.7711.00
348_E351_R3.7971.00
128_R348_E3.5021.00
20_V339_V3.4761.00
487_G491_I3.3581.00
159_S236_W3.2791.00
302_W307_N3.1421.00
495_V499_G3.0591.00
116_M360_V3.0541.00
282_F285_G2.9781.00
284_F288_L2.9501.00
278_E282_F2.7231.00
155_F247_T2.7181.00
434_D440_R2.6901.00
282_F286_D2.6511.00
27_I31_L2.6411.00
483_A487_G2.6241.00
152_P248_M2.6001.00
475_F479_L2.5591.00
257_N260_L2.5291.00
159_S240_T2.4731.00
498_I502_L2.4561.00
326_G342_M2.4371.00
281_P285_G2.4221.00
278_E285_G2.4061.00
338_T341_T2.3971.00
116_M353_M2.3481.00
227_S441_Q2.3221.00
324_V328_I2.2581.00
245_I249_V2.1801.00
278_E284_F2.1681.00
396_D399_V2.1621.00
243_G489_L2.1611.00
412_N454_S2.1281.00
42_D66_R2.0941.00
128_R341_T2.0931.00
28_L32_A2.0611.00
24_F28_L2.0481.00
235_V496_V2.0371.00
93_M320_T2.0261.00
296_V321_M2.0211.00
285_G289_V2.0201.00
433_G443_T2.0201.00
410_V414_F2.0001.00
281_P286_D1.9611.00
191_T255_K1.9611.00
162_G170_E1.9461.00
289_V329_G1.9421.00
153_A240_T1.9201.00
290_L294_T1.9171.00
124_G349_G1.8931.00
398_A498_I1.8691.00
249_V253_R1.8591.00
302_W306_V1.8321.00
259_L264_H1.8241.00
408_Q425_T1.8091.00
234_V496_V1.8051.00
412_N451_D1.7941.00
281_P284_F1.7811.00
237_V241_L1.7761.00
233_I237_V1.7741.00
402_W494_S1.7431.00
121_G346_F1.7281.00
153_A244_L1.7271.00
36_V41_F1.7251.00
26_A369_L1.7191.00
37_P81_Q1.7141.00
246_F488_L1.7131.00
279_Q282_F1.7101.00
412_N421_Q1.7091.00
92_L369_L1.7081.00
404_M429_L1.6911.00
285_G336_G1.6871.00
194_L481_V1.6591.00
38_V70_N1.6551.00
43_S382_N1.6531.00
32_A36_V1.6511.00
291_I295_A1.6461.00
401_A442_V1.6441.00
43_S386_N1.6411.00
151_I185_L1.6390.99
241_L245_I1.6260.99
41_F386_N1.6080.99
402_W498_I1.5850.99
32_A35_V1.5800.99
29_T370_V1.5790.99
305_I308_A1.5760.99
213_C418_G1.5750.99
402_W406_L1.5690.99
409_A454_S1.5630.99
34_W38_V1.5600.99
13_W16_P1.5600.99
229_S233_I1.5540.99
221_A441_Q1.5470.99
252_S256_K1.5430.99
91_G95_F1.5430.99
282_F289_V1.5420.99
499_G503_M1.5170.99
329_G337_M1.5160.99
36_V380_V1.5130.99
323_L327_I1.5080.99
288_L291_I1.5060.99
240_T244_L1.5060.99
439_N442_V1.5020.99
242_I488_L1.5000.99
350_A354_I1.4990.99
491_I495_V1.4960.99
179_A193_V1.4940.99
278_E281_P1.4860.99
451_D455_H1.4640.99
125_I319_F1.4620.99
173_A176_I1.4220.99
40_M379_S1.4170.99
278_E286_D1.4130.98
246_F250_Y1.3940.98
405_L494_S1.3690.98
30_S92_L1.3680.98
285_G288_L1.3650.98
408_Q421_Q1.3640.98
99_G365_G1.3620.98
17_D343_A1.3620.98
421_Q425_T1.3600.98
418_G451_D1.3590.98
163_A208_W1.3570.98
299_W302_W1.3530.98
389_A435_L1.3490.98
247_T485_L1.3430.98
288_L328_I1.3420.98
156_I240_T1.3370.98
409_A490_F1.3370.98
191_T252_S1.3320.98
280_R284_F1.3280.98
417_S420_G1.3240.98
286_D289_V1.3230.98
288_L292_V1.3220.98
98_E372_N1.3220.98
235_V449_F1.3210.98
301_I305_I1.3130.98
204_F418_G1.3080.97
321_M324_V1.3060.97
231_L235_V1.3050.97
295_A299_W1.3020.97
131_T290_L1.3010.97
23_F27_I1.2950.97
267_D271_R1.2950.97
236_W240_T1.2900.97
287_W290_L1.2870.97
129_T329_G1.2860.97
279_Q284_F1.2830.97
134_N286_D1.2770.97
190_I481_V1.2710.97
202_I243_G1.2640.97
235_V493_S1.2380.96
298_V302_W1.2360.96
34_W81_Q1.2290.96
451_D454_S1.2240.96
189_S267_D1.2230.96
324_V327_I1.2170.96
406_L410_V1.2090.96
71_E80_V1.2060.96
95_F98_E1.2050.96
474_D477_N1.2020.96
315_A319_F1.1960.96
125_I322_G1.1950.96
202_I239_A1.1940.96
279_Q285_G1.1920.96
161_G208_W1.1870.96
138_A142_H1.1800.95
292_V324_V1.1770.95
19_L362_F1.1750.95
406_L490_F1.1740.95
188_D191_T1.1540.95
265_E477_N1.1500.95
36_V39_G1.1500.95
292_V296_V1.1380.94
222_G430_A1.1370.94
162_G171_A1.1290.94
182_M195_V1.1280.94
287_W291_I1.1270.94
278_E289_V1.1200.94
129_T336_G1.1170.94
350_A358_L1.1160.94
17_D355_A1.1130.94
282_F290_L1.1120.94
128_R345_S1.1100.94
33_T373_G1.1090.94
284_F289_V1.1080.94
282_F308_A1.1060.93
295_A298_V1.1040.93
221_A434_D1.1030.93
277_V282_F1.1020.93
156_I195_V1.0940.93
401_A497_V1.0920.93
282_F287_W1.0890.93
218_Q223_V1.0860.93
190_I262_R1.0860.93
19_L343_A1.0850.93
140_I174_F1.0800.93
152_P244_L1.0790.93
182_M192_T1.0740.92
457_I486_L1.0720.92
26_A365_G1.0720.92
327_I336_G1.0700.92
277_V285_G1.0680.92
156_I244_L1.0670.92
187_Y248_M1.0670.92
101_T108_T1.0620.92
405_L490_F1.0620.92
248_M252_S1.0610.92
19_L355_A1.0580.92
415_V424_L1.0580.92
204_F451_D1.0560.92
155_F178_I1.0550.92
412_N450_G1.0510.92
100_L114_M1.0510.92
336_G345_S1.0500.92
282_F305_I1.0370.91
163_A236_W1.0360.91
215_V225_V1.0350.91
143_T450_G1.0330.91
286_D290_L1.0310.91
223_V441_Q1.0270.91
170_E212_F1.0240.91
198_I243_G1.0210.90
275_A278_E1.0200.90
221_A440_R1.0160.90
277_V281_P1.0130.90
14_A340_N1.0090.90
166_G213_C1.0080.90
212_F215_V1.0070.90
96_P369_L1.0060.90
442_V497_V1.0060.90
91_G372_N1.0010.90
198_I482_G1.0010.90
62_P65_F0.9970.89
194_L482_G0.9960.89
450_G454_S0.9950.89
390_N393_S0.9940.89
353_M356_P0.9910.89
191_T251_A0.9890.89
499_G502_L0.9880.89
17_D340_N0.9870.89
187_Y255_K0.9830.89
221_A430_A0.9760.88
124_G345_S0.9760.88
194_L247_T0.9740.88
304_V308_A0.9670.88
463_S470_V0.9670.88
30_S34_W0.9640.88
24_F27_I0.9620.88
187_Y252_S0.9560.87
34_W37_P0.9550.87
26_A92_L0.9540.87
134_N278_E0.9540.87
388_I407_F0.9500.87
278_E305_I0.9490.87
282_F288_L0.9470.87
281_P303_G0.9430.87
445_L500_A0.9280.86
282_F303_G0.9260.86
297_M300_V0.9260.86
80_V373_G0.9230.85
67_I70_N0.9210.85
401_A438_V0.9200.85
108_T364_K0.9200.85
322_G342_M0.9190.85
160_L164_V0.9180.85
280_R286_D0.9120.85
303_G308_A0.9110.85
453_F493_S0.9080.84
34_W373_G0.9050.84
281_P308_A0.9040.84
20_V340_N0.9040.84
453_F490_F0.9030.84
128_R352_M0.9030.84
245_I488_L0.8980.84
201_Q456_I0.8970.84
279_Q286_D0.8960.84
350_A353_M0.8880.83
369_L373_G0.8880.83
10_T13_W0.8870.83
446_A497_V0.8870.83
277_V284_F0.8860.83
398_A502_L0.8860.83
462_A466_A0.8830.83
241_L244_L0.8810.83
492_M496_V0.8800.82
204_F213_C0.8740.82
442_V500_A0.8740.82
96_P361_G0.8700.82
281_P288_L0.8680.82
373_G382_N0.8670.82
281_P295_A0.8670.82
283_T286_D0.8660.81
280_R287_W0.8620.81
21_I24_F0.8590.81
162_G204_F0.8550.81
430_A440_R0.8550.81
320_T324_V0.8530.80
363_A417_S0.8490.80
337_M345_S0.8490.80
166_G212_F0.8470.80
96_P312_P0.8440.80
109_A364_K0.8440.80
190_I194_L0.8430.80
168_G463_S0.8420.80
418_G421_Q0.8410.80
302_W308_A0.8390.79
188_D254_V0.8390.79
264_H267_D0.8380.79
202_I489_L0.8360.79
338_T342_M0.8360.79
208_W233_I0.8340.79
179_A470_V0.8320.79
289_V292_V0.8320.79
230_G234_V0.8280.78
178_I182_M0.8270.78
223_V227_S0.8230.78
171_A175_A0.8220.78
344_S351_R0.8220.78
289_V321_M0.8200.78
152_P187_Y0.8190.78
143_T154_L0.8190.78
322_G326_G0.8150.77
284_F328_I0.8130.77
144_R150_F0.8120.77
401_A446_A0.8120.77
171_A200_T0.8110.77
94_N98_E0.8100.77
171_A201_Q0.8080.77
389_A432_L0.8050.77
244_L248_M0.8050.77
292_V328_I0.8040.76
168_G204_F0.8040.76
100_L357_A0.8030.76
206_S239_A0.8020.76
189_S263_V0.8010.76
193_V471_C0.7980.76
289_V305_I0.7950.76
292_V320_T0.7950.76
138_A283_T0.7870.75
267_D270_F0.7870.75
221_A227_S0.7850.75
117_L120_G0.7820.74
156_I159_S0.7820.74
193_V473_V0.7800.74
285_G303_G0.7780.74
30_S81_Q0.7720.73
238_I496_V0.7680.73
196_T199_A0.7680.73
231_L500_A0.7660.73
41_F383_T0.7650.73
157_L240_T0.7620.72
129_T327_I0.7600.72
182_M247_T0.7550.72
453_F486_L0.7550.72
44_Q62_P0.7530.72
212_F232_R0.7520.71
294_T298_V0.7510.71
284_F295_A0.7480.71
455_H471_C0.7450.71
35_V151_I0.7450.71
421_Q451_D0.7440.71
159_S163_A0.7420.70
310_F313_E0.7400.70
386_N390_N0.7400.70
140_I183_V0.7390.70
442_V445_L0.7390.70
234_V241_L0.7350.70
71_E379_S0.7330.70
252_S255_K0.7320.69
212_F216_V0.7310.69
201_Q461_S0.7310.69
239_A489_L0.7310.69
411_F415_V0.7300.69
409_A412_N0.7300.69
414_F458_Y0.7300.69
29_T373_G0.7270.69
29_T380_V0.7260.69
21_I101_T0.7250.69
235_V365_G0.7230.68
29_T369_L0.7220.68
492_M495_V0.7200.68
256_K260_L0.7200.68
81_Q91_G0.7180.68
351_R354_I0.7170.68
405_L497_V0.7150.68
125_I129_T0.7150.68
303_G307_N0.7130.67
238_I492_M0.7120.67
218_Q227_S0.7110.67
426_M433_G0.7110.67
215_V232_R0.7100.67
159_S400_A0.7100.67
157_L161_G0.7090.67
386_N389_A0.7070.67
285_G307_N0.7070.67
482_G486_L0.7050.67
169_E212_F0.7030.66
135_G328_I0.7030.66
282_F307_N0.7030.66
309_W313_E0.7020.66
179_A192_T0.7010.66
203_G206_S0.7000.66
281_P307_N0.7000.66
458_Y463_S0.6990.66
385_L432_L0.6980.66
195_V243_G0.6970.66
416_T461_S0.6950.65
284_F305_I0.6940.65
373_G380_V0.6930.65
31_L35_V0.6910.65
385_L424_L0.6910.65
36_V383_T0.6900.65
348_E352_M0.6900.65
285_G295_A0.6870.65
115_F170_E0.6860.64
117_L121_G0.6850.64
213_C217_A0.6850.64
284_F287_W0.6840.64
215_V226_L0.6820.64
162_G200_T0.6770.63
251_A254_V0.6770.63
342_M345_S0.6770.63
285_G305_I0.6750.63
285_G328_I0.6750.63
17_D20_V0.6730.63
164_V209_M0.6710.63
413_F458_Y0.6690.62
451_D458_Y0.6690.62
45_E63_H0.6670.62
155_F243_G0.6660.62
411_F425_T0.6650.62
100_L113_I0.6640.62
189_S192_T0.6640.62
392_I436_V0.6640.62
40_M43_S0.6610.62
70_N80_V0.6610.62
395_L399_V0.6600.61
217_A426_M0.6600.61
162_G212_F0.6580.61
30_S80_V0.6560.61
354_I359_L0.6560.61
176_I195_V0.6560.61
208_W236_W0.6540.61
281_P292_V0.6530.61
111_G417_S0.6530.61
35_V499_G0.6530.61
18_T175_A0.6520.61
195_V247_T0.6510.60
429_L443_T0.6500.60
278_E308_A0.6500.60
292_V295_A0.6480.60
449_F496_V0.6470.60
285_G308_A0.6470.60
26_A29_T0.6440.60
487_G490_F0.6410.59
397_N438_V0.6410.59
116_M177_I0.6410.59
275_A281_P0.6380.59
292_V303_G0.6380.59
27_I92_L0.6370.59
188_D261_S0.6370.59
346_F350_A0.6350.58
291_I298_V0.6350.58
118_V212_F0.6340.58
419_S427_P0.6340.58
285_G291_I0.6330.58
370_V380_V0.6330.58
344_S348_E0.6330.58
116_M356_P0.6320.58
10_T14_A0.6300.58
156_I236_W0.6300.58
311_I484_T0.6290.58
284_F291_I0.6290.58
279_Q288_L0.6280.58
160_L163_A0.6280.58
170_E200_T0.6280.58
388_I392_I0.6250.57
426_M444_V0.6250.57
174_F196_T0.6230.57
483_A486_L0.6220.57
197_Y456_I0.6200.57
125_I298_V0.6190.57
413_F454_S0.6190.57
100_L361_G0.6180.56
327_I338_T0.6170.56
286_D307_N0.6160.56
385_L388_I0.6150.56
165_F171_A0.6150.56
457_I483_A0.6140.56
232_R445_L0.6140.56
101_T110_V0.6120.56
94_N251_A0.6120.56
125_I177_I0.6110.56
297_M301_I0.6100.55
363_A420_G0.6080.55
399_V438_V0.6070.55
163_A211_P0.6070.55
357_A361_G0.6060.55
15_M476_R0.6060.55
461_S465_M0.6030.55
19_L418_G0.6030.55
253_R260_L0.6020.55
155_F244_L0.6020.55
403_F406_L0.6020.55
32_A384_I0.6020.55
30_S64_S0.6020.55
151_I449_F0.6010.54
11_R14_A0.6000.54
443_T446_A0.5990.54
91_G94_N0.5970.54
20_V24_F0.5970.54
380_V383_T0.5960.54
18_T463_S0.5950.54
180_P183_V0.5950.54
31_L406_L0.5930.53
283_T287_W0.5930.53
418_G447_F0.5930.53
135_G157_L0.5920.53
391_A394_G0.5920.53
249_V252_S0.5910.53
170_E207_S0.5910.53
433_G436_V0.5900.53
284_F307_N0.5900.53
188_D250_Y0.5890.53
213_C451_D0.5890.53
315_A497_V0.5850.52
214_V217_A0.5840.52
204_F455_H0.5830.52
98_E101_T0.5830.52
281_P287_W0.5820.52
285_G329_G0.5810.52
384_I414_F0.5790.52
399_V498_I0.5790.52
151_I251_A0.5780.52
219_G424_L0.5750.51
282_F291_I0.5750.51
118_V346_F0.5750.51
430_A434_D0.5750.51
116_M121_G0.5750.51
396_D438_V0.5750.51
135_G290_L0.5740.51
219_G314_I0.5740.51
341_T345_S0.5730.51
17_D344_S0.5720.51
23_F95_F0.5700.51
464_L468_L0.5700.51
204_F314_I0.5700.51
323_L342_M0.5690.50
488_L491_I0.5680.50
139_L384_I0.5670.50
202_I456_I0.5670.50
212_F217_A0.5660.50
92_L314_I0.5660.50
387_S435_L0.5660.50
250_Y261_S0.5650.50
152_P197_Y0.5640.50
205_A418_G0.5640.50
127_M133_D0.5620.50
40_M66_R0.5600.49
387_S391_A0.5580.49
263_V266_S0.5570.49
239_A243_G0.5550.49
291_I406_L0.5550.49
126_V325_I0.5550.49
292_V305_I0.5540.49
389_A436_V0.5530.48
266_S474_D0.5530.48
101_T113_I0.5530.48
181_L185_L0.5530.48
326_G337_M0.5520.48
135_G174_F0.5520.48
139_L157_L0.5510.48
35_V298_V0.5510.48
222_G225_V0.5510.48
166_G210_N0.5490.48
132_I492_M0.5490.48
117_L354_I0.5490.48
146_N150_F0.5490.48
130_G134_N0.5480.48
21_I343_A0.5480.48
191_T254_V0.5480.48
124_G312_P0.5470.48
210_N226_L0.5470.48
161_G170_E0.5470.48
191_T263_V0.5470.48
132_I177_I0.5460.48
191_T247_T0.5460.48
175_A356_P0.5450.47
163_A207_S0.5450.47
380_V384_I0.5440.47
39_G383_T0.5440.47
329_G336_G0.5440.47
63_H386_N0.5430.47
457_I492_M0.5430.47
293_L297_M0.5430.47
346_F358_L0.5410.47
190_I471_C0.5410.47
31_L487_G0.5400.47
282_F292_V0.5400.47
234_V499_G0.5380.47
351_R496_V0.5360.46
473_V477_N0.5360.46
120_G346_F0.5340.46
198_I247_T0.5340.46
297_M307_N0.5330.46
192_T466_A0.5330.46
440_R477_N0.5330.46
404_M443_T0.5320.46
33_T225_V0.5320.46
295_A308_A0.5310.46
282_F302_W0.5300.46
120_G358_L0.5290.46
356_P420_G0.5290.46
278_E288_L0.5290.46
340_N344_S0.5270.45
68_L307_N0.5260.45
187_Y448_Q0.5260.45
400_A433_G0.5250.45
38_V382_N0.5250.45
268_R272_E0.5250.45
388_I432_L0.5240.45
464_L475_F0.5230.45
163_A400_A0.5220.45
258_P261_S0.5220.45
265_E495_V0.5200.44
227_S353_M0.5190.44
70_N373_G0.5190.44
45_E62_P0.5180.44
234_V503_M0.5180.44
449_F497_V0.5170.44
180_P385_L0.5170.44
387_S390_N0.5150.44
38_V44_Q0.5150.44
286_D291_I0.5140.44
463_S466_A0.5140.44
191_T250_Y0.5140.44
251_A481_V0.5100.43
301_I304_V0.5100.43
63_H66_R0.5100.43
97_F312_P0.5100.43
359_L465_M0.5100.43
162_G424_L0.5100.43
172_V197_Y0.5090.43
181_L411_F0.5090.43
338_T344_S0.5090.43
239_A493_S0.5080.43
447_F451_D0.5070.43
296_V406_L0.5060.43
461_S464_L0.5060.43
161_G301_I0.5060.43
152_P165_F0.5050.43
36_V387_S0.5050.43
196_T464_L0.5050.43
286_D292_V0.5040.43
156_I247_T0.5040.43
128_R337_M0.5030.42
388_I411_F0.5030.42
437_G487_G0.5020.42
418_G461_S0.5020.42
239_A242_I0.5010.42
405_L493_S0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0cA 3 0.8636 100 0.491 Contact Map
4r1iA 2 0.8972 100 0.508 Contact Map
4f35D 2 0.834 100 0.791 Contact Map
3giaA 1 0.415 78.4 0.966 Contact Map
1pw4A 1 0.4012 54.7 0.971 Contact Map
4xnjA 1 0.7589 54.1 0.971 Contact Map
3qnqA 2 0.4783 53.7 0.971 Contact Map
4j05A 3 0.3953 43.7 0.973 Contact Map
3d31C 2 0.3992 42.5 0.973 Contact Map
4djkA 2 0.4269 41.6 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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