GREMLIN Database
INSN2 - Transposase InsN for insertion sequence element IS911B
UniProt: P39212 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40014
Length: 100 (87)
Sequences: 579 (373)
Seq/√Len: 39.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_E83_R6.1461.00
85_K90_E4.4421.00
86_L89_I3.8691.00
78_E81_K2.4881.00
89_I93_N2.4201.00
71_P80_R2.1950.99
36_T39_D2.1710.99
26_S51_M1.9700.99
35_Y40_A1.9680.99
28_Q32_D1.6560.96
52_T56_K1.5210.94
79_I82_L1.5000.93
27_A58_L1.4880.93
53_R57_Q1.4530.92
79_I83_R1.4450.92
18_F23_K1.4370.92
27_A55_V1.4360.92
69_A73_T1.4050.91
88_R92_E1.3330.89
81_K85_K1.3100.88
37_V52_T1.3000.87
91_M94_E1.2950.87
85_K88_R1.2940.87
32_D62_R1.2570.85
26_S44_M1.2550.85
42_K45_D1.2180.84
78_E86_L1.2080.83
72_I75_E1.2080.83
67_P73_T1.1930.82
75_E79_I1.1730.81
29_L44_M1.1530.80
71_P77_I1.1420.79
29_L40_A1.1390.79
90_E94_E1.1270.79
35_Y59_R1.1260.78
30_V40_A1.1200.78
82_L86_L1.1120.78
48_L52_T1.0940.76
39_D43_A1.0850.76
38_A42_K1.0830.76
27_A62_R1.0670.75
47_G50_T1.0650.74
87_Q94_E1.0040.70
87_Q91_M1.0020.70
14_K17_N1.0000.70
61_E64_G0.9870.69
29_L35_Y0.9730.68
69_A77_I0.9700.67
51_M54_W0.9690.67
20_A24_R0.9360.64
28_Q80_R0.9110.62
69_A72_I0.9100.62
29_L33_Q0.9010.61
50_T53_R0.8950.61
58_L62_R0.8560.58
67_P71_P0.8550.57
73_T76_Q0.8480.57
31_V62_R0.8470.57
21_E51_M0.8440.56
67_P80_R0.8420.56
37_V48_L0.8200.54
30_V96_L0.8040.53
46_V55_V0.8010.53
89_I92_E0.7990.52
64_G73_T0.7800.51
86_L93_N0.7790.51
47_G57_Q0.7790.51
67_P75_E0.7730.50
18_F22_F0.7680.50
61_E65_K0.7550.48
25_E29_L0.7520.48
49_S57_Q0.7500.48
42_K56_K0.7480.48
66_T71_P0.7400.47
70_S77_I0.7230.45
30_V41_A0.7190.45
76_Q79_I0.7110.44
86_L90_E0.7070.44
14_K94_E0.6910.43
19_S25_E0.6840.42
20_A70_S0.6800.42
87_Q90_E0.6780.41
76_Q96_L0.6770.41
26_S52_T0.6700.41
33_Q40_A0.6680.40
70_S74_P0.6620.40
13_M45_D0.6610.40
40_A46_V0.6550.39
18_F50_T0.6490.39
77_I81_K0.6400.38
45_D65_K0.6360.38
71_P75_E0.6330.37
66_T70_S0.6200.36
22_F26_S0.6200.36
66_T80_R0.6180.36
38_A49_S0.6080.35
60_D65_K0.5990.35
58_L81_K0.5950.34
56_K60_D0.5920.34
62_R65_K0.5900.34
27_A31_V0.5900.34
67_P74_P0.5850.33
73_T80_R0.5830.33
72_I77_I0.5720.32
20_A33_Q0.5700.32
38_A52_T0.5650.32
57_Q62_R0.5640.32
91_M95_I0.5630.32
44_M51_M0.5590.31
72_I76_Q0.5510.31
47_G53_R0.5490.31
25_E31_V0.5480.30
24_R73_T0.5480.30
19_S28_Q0.5450.30
37_V53_R0.5440.30
42_K48_L0.5340.29
36_T49_S0.5340.29
39_D87_Q0.5330.29
54_W97_K0.5310.29
17_N87_Q0.5250.29
28_Q43_A0.5240.29
79_I94_E0.5220.28
92_E96_L0.5210.28
17_N56_K0.5210.28
71_P76_Q0.5190.28
69_A74_P0.5160.28
51_M93_N0.5150.28
67_P92_E0.5140.28
23_K70_S0.5040.27
34_K81_K0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rn7A 1 0.87 99.8 0.443 Contact Map
2jn6A 1 0.88 99.8 0.466 Contact Map
1hlvA 1 0.88 99 0.656 Contact Map
2oa4A 1 0.85 98.9 0.669 Contact Map
2ao9A 7 0.66 98.8 0.681 Contact Map
2gloA 1 0.56 98.7 0.691 Contact Map
2k27A 1 0.98 98.6 0.708 Contact Map
2jrtA 1 0.8 98.5 0.712 Contact Map
2elhA 1 0.82 98.5 0.713 Contact Map
1u78A 1 0.81 98.5 0.718 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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