GREMLIN Database
IDNK - Thermosensitive gluconokinase
UniProt: P39208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12152
Length: 187 (162)
Sequences: 1905 (1368)
Seq/√Len: 107.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_A44_D4.2451.00
109_Y130_K4.0281.00
112_I133_F3.6351.00
107_G151_I3.2711.00
149_I158_V3.2701.00
62_E92_I3.1491.00
125_P128_L3.0911.00
139_P146_I3.0871.00
130_K134_E2.9931.00
106_D138_R2.8821.00
37_L64_L2.7171.00
33_D81_V2.6801.00
45_K56_D2.5931.00
39_P42_N2.4781.00
7_I102_F2.2731.00
116_M129_L2.2721.00
29_A77_T2.1641.00
64_L80_I2.1211.00
32_I37_L2.1111.00
26_L160_E2.0851.00
103_L162_C1.9921.00
104_W138_R1.9411.00
22_K155_I1.8101.00
104_W139_P1.7371.00
91_D94_R1.7061.00
154_D157_N1.6821.00
106_D148_R1.6761.00
18_L155_I1.6431.00
55_E58_L1.6381.00
32_I67_A1.6231.00
107_G112_I1.6091.00
19_I158_V1.5941.00
108_D111_T1.5661.00
58_L62_E1.5641.00
67_A78_G1.4861.00
17_T21_S1.4841.00
114_A118_R1.4731.00
58_L92_I1.4681.00
67_A70_S1.4641.00
20_G31_F1.4281.00
31_F81_V1.4201.00
13_G116_M1.4101.00
12_S129_L1.4021.00
153_H161_Q1.3661.00
109_Y133_F1.3541.00
153_H157_N1.3451.00
44_D48_Q1.3280.99
108_D152_N1.2940.99
111_T114_A1.2900.99
26_L163_R1.2770.99
37_L67_A1.2670.99
68_S80_I1.2380.99
43_I47_S1.2260.99
44_D47_S1.2250.99
87_K142_D1.2240.99
21_S25_A1.2180.99
6_F166_V1.2080.99
61_L89_Y1.1740.99
22_K159_T1.1610.99
5_S68_S1.1570.99
161_Q165_A1.1550.99
109_Y113_L1.1400.98
107_G111_T1.1310.98
8_L79_F1.1270.98
94_R102_F1.1090.98
153_H158_V1.1070.98
6_F103_L1.1060.98
68_S97_S1.0940.98
42_N63_R1.0910.98
113_L117_Q1.0890.98
58_L88_Q1.0770.98
88_Q135_A1.0270.97
147_V165_A1.0250.97
66_D70_S1.0020.96
30_K76_E0.9930.96
62_E95_K0.9790.96
65_N96_G0.9690.96
39_P63_R0.9380.95
65_N97_S0.9360.95
65_N69_Y0.9300.94
160_E164_Q0.9250.94
87_K91_D0.9220.94
21_S36_D0.9180.94
22_K156_A0.9090.94
87_K143_E0.9080.94
17_T34_G0.9030.94
112_I151_I0.8990.93
19_I155_I0.8950.93
33_D36_D0.8860.93
109_Y134_E0.8820.93
86_K135_A0.8780.93
116_M126_V0.8720.92
30_K77_T0.8610.92
11_V104_W0.8610.92
117_Q126_V0.8550.92
150_D158_V0.8530.92
149_I165_A0.8470.91
19_I159_T0.8430.91
113_L129_L0.8400.91
5_S78_G0.8390.91
64_L67_A0.8350.91
147_V162_C0.8290.90
43_I122_H0.8140.90
111_T152_N0.7960.88
11_V129_L0.7950.88
69_Y97_S0.7940.88
88_Q92_I0.7890.88
24_A79_F0.7850.88
42_N45_K0.7830.88
7_I68_S0.7760.87
20_G81_V0.7640.86
107_G129_L0.7640.86
112_I129_L0.7560.86
41_K44_D0.7530.86
26_L159_T0.7520.85
66_D69_Y0.7510.85
86_K89_Y0.7450.85
20_G71_L0.7430.85
22_K25_A0.7420.85
20_G24_A0.7390.84
19_I162_C0.7360.84
111_T151_I0.7290.84
70_S74_K0.7290.84
155_I159_T0.7240.83
103_L147_V0.7230.83
9_M136_L0.7150.82
30_K78_G0.7150.82
18_L22_K0.7140.82
106_D150_D0.7120.82
12_S128_L0.7120.82
86_K137_E0.7070.82
8_L162_C0.7060.82
14_S136_L0.7050.82
34_G80_I0.7030.81
151_I158_V0.7010.81
54_D86_K0.6980.81
54_D89_Y0.6890.80
47_S123_F0.6820.79
53_S58_L0.6790.79
129_L133_F0.6780.79
32_I78_G0.6770.79
87_K137_E0.6770.79
27_L163_R0.6760.79
105_L158_V0.6760.79
10_G16_K0.6710.78
24_A31_F0.6680.78
26_L167_L0.6680.78
9_M104_W0.6600.77
150_D153_H0.6570.77
30_K67_A0.6530.76
157_N160_E0.6520.76
149_I162_C0.6510.76
161_Q164_Q0.6510.76
6_F29_A0.6360.75
65_N95_K0.6350.74
93_L100_V0.6330.74
34_G37_L0.6330.74
110_E113_L0.6320.74
101_H144_Q0.6310.74
33_D64_L0.6310.74
32_I64_L0.6270.73
84_S93_L0.6270.73
10_G15_G0.6250.73
155_I158_V0.6160.72
61_L82_C0.6160.72
47_S50_I0.6160.72
11_V136_L0.6160.72
23_V159_T0.6150.72
39_P43_I0.6140.72
17_T123_F0.6130.72
104_W146_I0.6130.72
124_M131_S0.6120.72
99_H144_Q0.6120.72
94_R143_E0.6110.72
116_M133_F0.6090.71
7_I80_I0.6090.71
23_V155_I0.6080.71
65_N100_V0.6070.71
51_P131_S0.6020.70
50_I53_S0.6000.70
112_I116_M0.5990.70
8_L23_V0.5970.70
71_L76_E0.5960.70
14_S106_D0.5930.69
105_L151_I0.5910.69
56_D89_Y0.5850.68
62_E134_E0.5830.68
54_D61_L0.5820.68
116_M151_I0.5820.68
104_W148_R0.5800.68
65_N68_S0.5700.66
87_K141_A0.5660.66
67_A71_L0.5620.65
14_S112_I0.5610.65
12_S17_T0.5600.65
97_S100_V0.5590.65
42_N89_Y0.5590.65
103_L149_I0.5570.65
110_E114_A0.5560.64
82_C89_Y0.5550.64
114_A152_N0.5490.63
69_Y73_K0.5490.63
87_K146_I0.5480.63
38_H57_R0.5470.63
62_E76_E0.5460.63
23_V31_F0.5450.63
46_M57_R0.5440.63
157_N165_A0.5430.63
154_D158_V0.5420.62
127_A130_K0.5380.62
103_L165_A0.5370.62
38_H46_M0.5370.62
31_F79_F0.5350.61
65_N92_I0.5340.61
116_M124_M0.5300.61
5_S139_P0.5290.61
34_G74_K0.5270.60
71_L78_G0.5260.60
70_S75_N0.5240.60
12_S59_P0.5240.60
22_K26_L0.5240.60
8_L24_A0.5220.60
107_G150_D0.5210.59
14_S151_I0.5210.59
24_A159_T0.5210.59
39_P123_F0.5210.59
112_I125_P0.5190.59
94_R146_I0.5190.59
37_L78_G0.5180.59
66_D96_G0.5180.59
13_G16_K0.5160.59
47_S128_L0.5150.59
36_D120_A0.5150.59
19_I105_L0.5150.59
12_S47_S0.5120.58
23_V162_C0.5100.58
53_S86_K0.5100.58
23_V27_L0.5080.58
94_R100_V0.5060.57
35_D38_H0.5060.57
6_F101_H0.5030.57
46_M124_M0.5000.56
36_D43_I0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eunA 2 0.9144 100 0.629 Contact Map
1knqA 2 0.8984 100 0.634 Contact Map
3t61A 2 0.9251 99.9 0.655 Contact Map
2rhmA 2 0.8984 99.9 0.695 Contact Map
4rfvA 2 0.7112 99.9 0.698 Contact Map
4bzpA 2 0.8396 99.9 0.711 Contact Map
2gksA 2 0.877 99.8 0.712 Contact Map
1e6cA 1 0.8342 99.8 0.712 Contact Map
1m7gA 4 0.893 99.8 0.717 Contact Map
2yvuA 2 0.8556 99.8 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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