GREMLIN Database
PRMB - 50S ribosomal protein L3 glutamine methyltransferase
UniProt: P39199 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12449
Length: 310 (268)
Sequences: 5467 (4227)
Seq/√Len: 258.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_R88_I4.8291.00
105_Y174_Q4.0201.00
96_K103_E3.7191.00
147_A161_A3.1681.00
190_S195_D2.7421.00
109_R167_D2.6701.00
166_P189_R2.5721.00
164_I229_L2.4911.00
69_T72_E2.3331.00
202_D253_A2.2841.00
176_I187_P2.2461.00
150_C205_V2.1871.00
102_H152_Y2.1871.00
137_L201_Y2.1651.00
234_G239_K2.1541.00
147_A159_V2.1471.00
289_G292_M2.1321.00
104_F149_A2.1241.00
46_V57_L2.1031.00
236_D242_R2.0911.00
285_N288_D2.0891.00
160_D201_Y2.0871.00
98_W103_E2.0751.00
100_C153_A2.0441.00
141_T172_A2.0261.00
260_C273_Y1.9981.00
107_D171_V1.9741.00
148_I181_L1.9641.00
56_P59_I1.9531.00
124_K259_I1.9481.00
160_D188_I1.9141.00
92_Y226_E1.8911.00
110_V143_S1.8801.00
252_L256_G1.8451.00
248_A258_L1.8451.00
80_V93_L1.8361.00
95_N105_Y1.8321.00
213_A232_A1.8191.00
135_H158_E1.8191.00
87_R221_N1.8091.00
63_M66_A1.7981.00
102_H149_A1.7981.00
102_H153_A1.7941.00
25_S68_L1.7811.00
116_P119_E1.7781.00
123_N284_D1.7771.00
105_Y178_E1.7591.00
125_F154_F1.6321.00
192_L240_L1.6271.00
51_P94_T1.5751.00
216_M232_A1.5651.00
49_V77_V1.5611.00
191_D243_R1.5581.00
245_L273_Y1.5551.00
267_V283_F1.5451.00
151_A159_V1.5421.00
193_F251_Y1.5391.00
151_A184_N1.5211.00
117_I146_I1.5191.00
91_A97_A1.5191.00
127_G257_V1.5121.00
55_L59_I1.5091.00
161_A185_V1.4991.00
59_I63_M1.4721.00
52_S80_V1.4711.00
29_A81_I1.4621.00
120_L259_I1.4481.00
191_D194_R1.4441.00
124_K203_L1.4401.00
271_E283_F1.4351.00
98_W101_G1.4331.00
228_E232_A1.4271.00
267_V288_D1.3941.00
88_I108_E1.3891.00
100_C122_N1.3881.00
169_L187_P1.3791.00
127_G259_I1.3741.00
212_D265_S1.3681.00
104_F145_C1.3521.00
241_T260_C1.3281.00
29_A77_V1.3281.00
42_W46_V1.3241.00
148_I176_I1.3231.00
141_T147_A1.3081.00
123_N126_A1.3021.00
124_K205_V1.2961.00
243_R247_N1.2931.00
109_R171_V1.2831.00
212_D215_D1.2781.00
139_M244_I1.2711.00
51_P80_V1.2631.00
40_N44_E1.2501.00
91_A112_V1.2491.00
104_F148_I1.2451.00
88_I93_L1.2421.00
51_P96_K1.2401.00
32_I85_N1.2361.00
154_F157_A1.2331.00
100_C149_A1.2311.00
68_L72_E1.2311.00
262_V267_V1.2191.00
238_L269_L1.2061.00
165_S229_L1.2021.00
200_Q253_A1.1971.00
106_V110_V1.1881.00
158_E186_I1.1881.00
215_D265_S1.1821.00
106_V171_V1.1821.00
136_I157_A1.1741.00
165_S168_A1.1721.00
103_E178_E1.1681.00
135_H199_V1.1641.00
58_D62_D1.1631.00
162_V190_S1.1551.00
264_N287_G1.1521.00
235_T242_R1.1511.00
247_N250_D1.1461.00
161_A187_P1.1391.00
121_I146_I1.1321.00
169_L189_R1.1251.00
148_I179_H1.1181.00
233_S241_T1.1121.00
32_I78_E1.0871.00
87_R222_E1.0731.00
128_L203_L1.0691.00
272_Q275_D1.0651.00
271_E274_P1.0631.00
28_S78_E1.0601.00
139_M192_L1.0571.00
121_I149_A1.0511.00
136_I150_C1.0451.00
162_V196_L1.0391.00
206_T260_C1.0361.00
73_K78_E1.0201.00
129_I154_F1.0141.00
82_R86_E1.0061.00
147_A151_A1.0031.00
152_Y181_L1.0021.00
172_A187_P1.0011.00
263_G266_M1.0001.00
48_L77_V0.9971.00
138_D147_A0.9901.00
192_L243_R0.9841.00
136_I159_V0.9771.00
135_H160_D0.9761.00
288_D292_M0.9741.00
267_V271_E0.9731.00
174_Q178_E0.9591.00
134_Q157_A0.9591.00
151_A185_V0.9581.00
216_M228_E0.9551.00
66_A72_E0.9541.00
176_I181_L0.9531.00
248_A278_F0.9481.00
43_D47_Q0.9471.00
233_S239_K0.9461.00
181_L184_N0.9431.00
193_F247_N0.9381.00
152_Y179_H0.9361.00
122_N126_A0.9361.00
141_T163_D0.9361.00
238_L242_R0.9291.00
52_S72_E0.9261.00
160_D186_I0.9261.00
125_F153_A0.9231.00
47_Q90_V0.9231.00
163_D169_L0.9211.00
289_G293_L0.9111.00
147_A185_V0.9101.00
44_E90_V0.9101.00
50_L53_L0.9091.00
186_I199_V0.9001.00
262_V291_F0.8961.00
233_S240_L0.8901.00
149_A153_A0.8891.00
283_F291_F0.8841.00
55_L63_M0.8831.00
259_I292_M0.8811.00
201_Y204_I0.8801.00
33_W81_I0.8781.00
77_V81_I0.8771.00
139_M193_F0.8761.00
274_P281_L0.8731.00
268_H272_Q0.8701.00
30_A42_W0.8701.00
110_V171_V0.8641.00
96_K178_E0.8631.00
246_G276_V0.8581.00
70_S73_K0.8550.99
140_C192_L0.8480.99
174_Q177_E0.8460.99
236_D239_K0.8440.99
135_H253_A0.8430.99
70_S74_H0.8370.99
121_I125_F0.8360.99
213_A216_M0.8360.99
138_D141_T0.8310.99
167_D170_A0.8300.99
245_L260_C0.8270.99
135_H201_Y0.8270.99
119_E290_V0.8250.99
32_I36_H0.8180.99
101_G153_A0.8180.99
173_E176_I0.8180.99
92_Y112_V0.8150.99
78_E82_R0.8130.99
173_E177_E0.8050.99
211_V231_L0.8040.99
101_G152_Y0.8010.99
92_Y109_R0.7980.99
216_M219_L0.7950.99
102_H179_H0.7890.99
136_I154_F0.7830.99
28_S32_I0.7800.99
128_L154_F0.7770.99
38_T41_P0.7740.99
288_D291_F0.7690.99
262_V270_M0.7680.99
127_G282_E0.7570.99
287_G292_M0.7560.99
123_N259_I0.7510.99
44_E84_V0.7500.99
240_L243_R0.7490.99
112_V226_E0.7480.99
107_D167_D0.7450.99
216_M233_S0.7420.99
160_D199_V0.7420.99
241_T262_V0.7360.98
148_I152_Y0.7350.98
48_L80_V0.7320.98
141_T161_A0.7290.98
72_E75_R0.7280.98
88_I225_H0.7260.98
273_Y291_F0.7160.98
107_D174_Q0.7160.98
165_S169_L0.7130.98
215_D264_N0.7100.98
188_I199_V0.7060.98
148_I185_V0.7040.98
239_K242_R0.7030.98
141_T187_P0.7000.98
40_N43_D0.6950.98
29_A33_W0.6950.98
38_T87_R0.6940.98
25_S77_V0.6910.98
121_I150_C0.6890.98
213_A235_T0.6880.98
159_V185_V0.6860.98
123_N290_V0.6840.98
123_N127_G0.6840.98
212_D216_M0.6830.98
75_R79_R0.6820.98
140_C240_L0.6810.98
197_P251_Y0.6800.97
249_A278_F0.6800.97
213_A233_S0.6790.97
271_E281_L0.6780.97
162_V188_I0.6760.97
133_P158_E0.6760.97
284_D292_M0.6750.97
170_A173_E0.6750.97
112_V230_G0.6750.97
137_L162_V0.6720.97
203_L257_V0.6710.97
262_V283_F0.6690.97
245_L270_M0.6550.97
95_N174_Q0.6530.97
137_L193_F0.6520.97
176_I185_V0.6520.97
221_N224_R0.6520.97
26_R49_V0.6460.97
244_I258_L0.6460.97
193_F196_L0.6450.97
84_V222_E0.6440.97
81_I85_N0.6440.97
119_E123_N0.6420.96
216_M224_R0.6410.96
212_D233_S0.6360.96
25_S73_K0.6320.96
55_L66_A0.6320.96
126_A284_D0.6310.96
136_I203_L0.6300.96
244_I248_A0.6300.96
124_K128_L0.6270.96
50_L55_L0.6260.96
214_E235_T0.6240.96
26_R29_A0.6240.96
82_R85_N0.6220.96
81_I84_V0.6210.96
166_P170_A0.6190.96
241_T270_M0.6160.96
243_R246_G0.6140.95
284_D290_V0.6130.95
137_L196_L0.6130.95
237_G266_M0.6120.95
204_I248_A0.6120.95
164_I189_R0.6120.95
137_L204_I0.6100.95
27_F31_N0.6080.95
59_I66_A0.6080.95
176_I179_H0.6060.95
47_Q94_T0.6010.95
96_K105_Y0.5990.95
173_E187_P0.5980.95
80_V84_V0.5960.95
25_S29_A0.5950.95
143_S171_V0.5940.95
140_C206_T0.5940.95
24_V28_S0.5930.95
219_L231_L0.5920.94
52_S75_R0.5920.94
229_L240_L0.5910.94
163_D172_A0.5900.94
145_C149_A0.5870.94
149_A152_Y0.5870.94
123_N292_M0.5870.94
45_A77_V0.5850.94
131_K134_Q0.5830.94
26_R30_A0.5820.94
34_Y42_W0.5810.94
106_V226_E0.5800.94
233_S236_D0.5800.94
266_M270_M0.5800.94
53_L72_E0.5790.94
150_C157_A0.5770.94
101_G104_F0.5750.94
109_R227_P0.5750.94
224_R232_A0.5740.94
47_Q98_W0.5740.94
59_I62_D0.5720.93
246_G249_A0.5720.93
151_A176_I0.5710.93
215_D263_G0.5700.93
134_Q156_D0.5690.93
27_F30_A0.5640.93
212_D263_G0.5630.93
190_S196_L0.5620.93
116_P290_V0.5590.93
206_T244_I0.5590.93
165_S171_V0.5580.93
192_L244_I0.5580.93
219_L233_S0.5580.93
139_M162_V0.5560.92
75_R80_V0.5550.92
150_C154_F0.5520.92
271_E291_F0.5520.92
107_D110_V0.5520.92
87_R220_P0.5510.92
273_Y293_L0.5500.92
213_A234_G0.5490.92
46_V61_E0.5480.92
104_F179_H0.5470.92
147_A187_P0.5470.92
48_L52_S0.5450.92
118_G121_I0.5450.92
31_N35_G0.5450.92
28_S81_I0.5450.92
33_W38_T0.5450.92
192_L247_N0.5420.91
48_L94_T0.5410.91
151_A181_L0.5410.91
270_M291_F0.5410.91
211_V223_Y0.5400.91
219_L232_A0.5380.91
274_P277_P0.5360.91
188_I195_D0.5360.91
283_F286_G0.5360.91
290_V293_L0.5350.91
151_A155_P0.5350.91
92_Y106_V0.5340.91
47_Q51_P0.5340.91
104_F181_L0.5330.91
30_A34_Y0.5290.90
204_I258_L0.5280.90
248_A252_L0.5270.90
257_V292_M0.5250.90
100_C152_Y0.5240.90
222_E225_H0.5240.90
204_I251_Y0.5240.90
287_G291_F0.5230.90
126_A129_I0.5190.90
99_F149_A0.5190.90
215_D218_D0.5180.90
38_T44_E0.5180.90
128_L157_A0.5180.90
98_W104_F0.5170.89
216_M220_P0.5170.89
86_E225_H0.5150.89
50_L57_L0.5150.89
133_P156_D0.5150.89
84_V93_L0.5110.89
262_V288_D0.5110.89
245_L293_L0.5090.89
287_G290_V0.5080.89
169_L173_E0.5080.89
137_L190_S0.5060.88
100_C104_F0.5030.88
120_L205_V0.5020.88
135_H202_D0.5020.88
224_R228_E0.5010.88
92_Y107_D0.5000.88
79_R82_R0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3tA 1 0.8774 100 0.436 Contact Map
1nv8A 1 0.8516 100 0.446 Contact Map
4dcmA 1 0.829 100 0.678 Contact Map
4dzrA 2 0.4806 100 0.682 Contact Map
3tm4A 1 0.8903 100 0.705 Contact Map
3c6kA 2 0.8355 100 0.707 Contact Map
1uwvA 1 0.8645 100 0.709 Contact Map
3evzA 1 0.6032 100 0.713 Contact Map
4mtlA 4 0.6355 100 0.726 Contact Map
1uirA 4 0.7419 100 0.739 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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