GREMLIN Database
AG43 - Antigen 43
UniProt: P39180 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12686
Length: 1039 (840)
Sequences: 266 (247)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
888_Q919_R5.8961.00
915_A966_T5.6791.00
890_Q919_R5.2471.00
797_Y826_G5.1511.00
749_Q781_D5.0231.00
855_S903_D4.7720.99
781_D828_Y4.7110.99
963_V993_T4.4120.99
839_W874_G3.9460.98
1012_G1034_T3.9250.98
636_G688_Y3.8780.97
751_G919_R3.6790.96
749_Q779_E3.5140.95
870_S919_R3.4740.95
777_R919_R3.4420.95
751_G830_N3.3890.94
751_G841_D3.3410.94
751_G890_Q3.2830.93
734_Q749_Q3.1920.92
903_D992_G3.1320.91
496_G528_T3.0530.90
830_N839_W3.0330.90
563_W569_A3.0140.89
888_Q903_D3.0130.89
830_N841_D2.9000.87
841_D890_Q2.8650.87
781_D795_G2.8630.87
777_R872_E2.7250.84
751_G777_R2.7000.83
777_R888_Q2.6520.82
958_W998_Q2.6250.81
841_D919_R2.5790.80
777_R839_W2.5720.80
734_Q781_D2.5400.79
698_W890_Q2.5320.79
751_G872_E2.4980.78
839_W890_Q2.4720.77
839_W872_E2.4460.76
777_R1012_G2.4340.76
777_R890_Q2.3560.73
870_S890_Q2.3480.73
830_N890_Q2.3460.73
401_D404_A2.3180.72
818_V853_A2.3150.72
1009_I1037_V2.3150.72
496_G502_V2.2920.71
160_E163_I2.2870.71
795_G828_Y2.2820.71
842_I852_K2.2720.71
189_N192_A2.2530.70
734_Q751_G2.2370.69
830_N872_E2.2310.69
638_T690_L2.2200.69
918_V967_F2.2180.69
1015_A1029_Y2.2170.69
528_T544_T2.2130.69
839_W919_R2.2120.68
214_T218_K2.1620.67
999_A1015_A2.1570.66
874_G1000_G2.1380.66
751_G888_Q2.1100.65
636_G841_D2.1050.64
800_A839_W2.0970.64
490_G512_V2.0820.64
751_G870_S2.0480.62
769_S915_A2.0460.62
870_S888_Q2.0430.62
885_L922_F2.0340.62
289_V347_G2.0280.61
747_S998_Q2.0270.61
753_L775_F2.0270.61
749_Q828_Y2.0270.61
891_Y1036_N2.0080.61
874_G919_R2.0050.60
837_G919_R1.9980.60
561_A568_N1.9800.59
874_G958_W1.9770.59
841_D874_G1.9630.59
238_G243_V1.9500.58
259_V297_V1.9360.58
779_E887_P1.9240.57
957_W976_G1.9170.57
186_T189_N1.9110.57
772_S819_R1.9090.57
690_L698_W1.9050.56
795_G887_P1.9040.56
806_D863_R1.9030.56
864_G898_L1.8790.55
604_L611_I1.8750.55
453_T466_T1.8740.55
477_G517_G1.8690.55
898_L903_D1.8630.55
473_T480_L1.8620.55
700_L781_D1.8430.54
713_Y903_D1.8400.54
919_R958_W1.8390.54
638_T898_L1.8290.53
548_G563_W1.8100.52
797_Y819_R1.8010.52
960_Q998_Q1.7900.52
439_G443_A1.7870.51
888_Q958_W1.7830.51
749_Q1020_S1.7720.51
818_V918_V1.7710.51
713_Y901_G1.7610.50
958_W1000_G1.7600.50
720_A801_G1.7510.50
1020_S1028_G1.7480.50
494_K517_G1.7460.50
514_L536_T1.7410.49
751_G839_W1.7330.49
734_Q874_G1.7330.49
841_D870_S1.7300.49
209_G220_G1.7210.49
887_P921_G1.7120.48
274_G293_G1.7040.48
775_F872_E1.6910.47
736_G751_G1.6910.47
777_R870_S1.6800.47
659_I777_R1.6750.47
919_R962_S1.6650.46
504_N547_N1.6610.46
893_W1036_N1.6520.46
797_Y901_G1.6440.45
423_F492_V1.6300.45
510_K538_L1.6290.45
841_D851_M1.6130.44
349_L1034_T1.6090.44
149_T152_N1.6040.44
847_T866_G1.6040.44
998_Q1016_G1.5920.43
597_A614_R1.5840.43
325_I329_G1.5840.43
830_N919_R1.5800.43
428_G536_T1.5800.43
509_Q512_V1.5750.42
958_W1034_T1.5730.42
282_G306_V1.5700.42
965_R993_T1.5590.42
998_Q1002_E1.5560.42
502_V553_T1.5430.41
507_L540_L1.5420.41
919_R923_R1.5410.41
143_Q148_N1.5390.41
288_T473_T1.5380.41
872_E923_R1.5380.41
563_W566_P1.5360.41
606_G609_G1.5340.41
888_Q962_S1.5310.41
713_Y860_F1.5280.41
894_Q915_A1.5250.40
171_D193_E1.5250.40
492_V501_T1.5220.40
751_G874_G1.5220.40
160_E168_V1.5190.40
838_L847_T1.5160.40
420_G428_G1.5040.40
903_D923_R1.4990.39
901_G1029_Y1.4950.39
713_Y961_P1.4920.39
517_G520_T1.4850.39
845_Q855_S1.4830.39
734_Q1000_G1.4830.39
849_H853_A1.4810.39
724_D894_Q1.4750.38
822_A860_F1.4730.38
843_V870_S1.4720.38
232_T381_M1.4710.38
886_E919_R1.4710.38
759_G769_S1.4700.38
217_N220_G1.4700.38
708_A853_A1.4690.38
696_E703_E1.4610.38
419_K428_G1.4540.38
837_G855_S1.4510.37
998_Q1012_G1.4510.37
698_W839_W1.4500.37
568_N575_V1.4480.37
186_T191_G1.4460.37
171_D188_V1.4450.37
734_Q779_E1.4450.37
640_L661_V1.4410.37
646_G667_G1.4380.37
851_M864_G1.4360.37
470_D484_G1.4330.37
677_Q714_A1.4330.37
351_V438_G1.4320.37
872_E890_Q1.4310.37
826_G1031_G1.4290.37
853_A1014_Q1.4260.36
185_D191_G1.4260.36
565_I631_G1.4230.36
797_Y1016_G1.4180.36
347_G408_G1.4090.36
713_Y962_S1.4090.36
147_V150_T1.4060.36
872_E919_R1.4050.36
903_D919_R1.4020.36
875_L1020_S1.4020.36
340_N343_L1.4010.35
270_V284_A1.4010.35
777_R830_N1.3870.35
925_G992_G1.3690.34
646_G826_G1.3660.34
508_T514_L1.3650.34
478_D481_L1.3640.34
918_V994_S1.3620.34
749_Q775_F1.3610.34
171_D176_V1.3580.34
540_L562_T1.3560.34
188_V193_E1.3520.34
837_G890_Q1.3520.34
136_A142_L1.3490.34
923_R1001_L1.3450.33
322_V335_E1.3450.33
698_W870_S1.3420.33
148_N151_L1.3350.33
734_Q777_R1.3340.33
238_G348_R1.3320.33
837_G841_D1.3310.33
340_N346_G1.3260.33
839_W846_G1.3220.32
845_Q919_R1.3180.32
611_I628_V1.3160.32
504_N512_V1.3150.32
154_G164_A1.3140.32
816_G1012_G1.3080.32
860_F901_G1.3080.32
781_D872_E1.3040.32
888_Q901_G1.3000.32
458_A487_T1.3000.32
840_A864_G1.2940.31
416_M419_K1.2940.31
797_Y828_Y1.2940.31
625_D890_Q1.2920.31
777_R841_D1.2910.31
469_N540_L1.2890.31
462_L477_G1.2880.31
434_T437_N1.2860.31
714_A846_G1.2840.31
775_F956_N1.2840.31
636_G662_V1.2800.31
911_G1033_A1.2800.31
667_G837_G1.2770.31
253_N407_I1.2760.31
724_D860_F1.2760.31
799_A824_S1.2750.31
842_I885_L1.2750.31
257_Q297_V1.2750.31
1001_L1014_Q1.2720.31
148_N154_G1.2710.31
830_N888_Q1.2670.30
891_Y1005_V1.2670.30
713_Y888_Q1.2650.30
313_A316_T1.2620.30
178_K181_T1.2600.30
349_L542_G1.2580.30
658_G686_F1.2570.30
855_S905_A1.2560.30
828_Y901_G1.2540.30
507_L517_G1.2490.30
510_K583_Q1.2470.30
548_G555_V1.2440.30
188_V192_A1.2440.30
239_G403_K1.2440.30
444_R540_L1.2410.30
799_A847_T1.2410.30
958_W1015_A1.2400.30
971_G976_G1.2350.29
490_G496_G1.2330.29
161_G169_I1.2330.29
161_G175_Q1.2310.29
724_D1020_S1.2280.29
751_G996_D1.2250.29
189_N219_N1.2240.29
667_G690_L1.2170.29
846_G864_G1.2160.29
625_D870_S1.2130.29
544_T563_W1.2130.29
825_L1023_G1.2070.28
799_A1036_N1.2060.28
870_S885_L1.2020.28
917_H966_T1.1970.28
443_A446_G1.1960.28
683_A688_Y1.1950.28
698_W837_G1.1940.28
212_V218_K1.1900.28
749_Q872_E1.1890.28
223_I227_E1.1880.28
839_W965_R1.1850.28
148_N190_T1.1840.28
354_G439_G1.1820.28
842_I886_E1.1820.28
636_G919_R1.1810.27
490_G494_K1.1810.27
963_V967_F1.1800.27
864_G1028_G1.1790.27
769_S966_T1.1760.27
502_V540_L1.1740.27
439_G496_G1.1730.27
178_K198_A1.1730.27
625_D675_F1.1720.27
638_T919_R1.1700.27
312_G318_T1.1690.27
159_H162_A1.1690.27
843_V993_T1.1660.27
890_Q958_W1.1640.27
720_A959_V1.1620.27
915_A925_G1.1620.27
625_D841_D1.1610.27
574_V584_I1.1580.27
870_S996_D1.1580.27
749_Q921_G1.1580.27
1010_T1035_L1.1570.27
186_T193_E1.1560.27
582_G589_T1.1560.27
748_I800_A1.1550.27
161_G166_G1.1530.27
584_I624_A1.1520.27
606_G866_G1.1470.26
651_G685_A1.1460.26
480_L499_T1.1440.26
715_S831_L1.1380.26
903_D975_V1.1370.26
967_F993_T1.1350.26
824_S843_V1.1330.26
710_V888_Q1.1330.26
797_Y1031_G1.1320.26
491_S517_G1.1310.26
841_D872_E1.1300.26
166_G171_D1.1290.26
527_T604_L1.1280.26
393_A609_G1.1270.26
675_F998_Q1.1260.26
749_Q851_M1.1250.26
893_W967_F1.1250.26
504_N608_N1.1180.25
470_D522_N1.1170.25
919_R1017_Y1.1170.25
720_A956_N1.1160.25
884_M925_G1.1120.25
168_V171_D1.1100.25
419_K423_F1.1100.25
478_D488_G1.1090.25
638_T903_D1.1070.25
784_R824_S1.1070.25
654_T684_G1.1020.25
822_A962_S1.1000.25
872_E965_R1.0980.25
777_R996_D1.0980.25
635_T696_E1.0970.25
350_D557_L1.0970.25
998_Q1014_Q1.0970.25
166_G173_G1.0960.25
862_A1012_G1.0960.25
284_A661_V1.0930.25
769_S891_Y1.0890.24
472_L555_V1.0860.24
826_G866_G1.0850.24
781_D874_G1.0820.24
300_G303_A1.0810.24
394_A608_N1.0810.24
698_W919_R1.0790.24
885_L924_L1.0770.24
698_W841_D1.0770.24
752_H872_E1.0700.24
637_K818_V1.0680.24
625_D698_W1.0670.24
394_A503_S1.0650.24
204_G276_Q1.0600.24
654_T659_I1.0590.24
749_Q918_V1.0590.24
677_Q698_W1.0580.24
780_G845_Q1.0560.23
379_V425_L1.0520.23
417_L427_A1.0490.23
604_L618_D1.0480.23
514_L563_W1.0460.23
841_D888_Q1.0400.23
757_N903_D1.0390.23
872_E888_Q1.0380.23
455_N459_I1.0370.23
853_A995_L1.0360.23
822_A872_E1.0360.23
915_A992_G1.0340.23
597_A601_V1.0330.23
919_R996_D1.0330.23
864_G924_L1.0320.23
266_S271_N1.0310.23
751_G994_S1.0280.23
797_Y886_E1.0270.23
213_R321_T1.0270.23
326_N329_G1.0260.23
181_T191_G1.0260.23
688_Y698_W1.0250.23
775_F822_A1.0250.23
153_G158_M1.0240.23
148_N162_A1.0210.22
797_Y894_Q1.0160.22
918_V1012_G1.0160.22
613_L631_G1.0140.22
781_D901_G1.0140.22
474_I502_V1.0130.22
851_M855_S1.0050.22
966_T994_S1.0030.22
976_G988_P1.0000.22
152_N156_Q0.9980.22
636_G903_D0.9950.22
751_G845_Q0.9950.22
644_N684_G0.9920.22
155_E161_G0.9910.22
842_I871_L0.9910.22
625_D888_Q0.9890.21
599_L824_S0.9870.21
142_L156_Q0.9860.21
423_F426_N0.9850.21
396_S581_A0.9840.21
699_Y901_G0.9830.21
841_D849_H0.9810.21
738_N843_V0.9800.21
571_V899_D0.9790.21
167_T170_N0.9780.21
777_R860_F0.9770.21
142_L149_T0.9770.21
799_A818_V0.9730.21
498_G519_L0.9720.21
410_G413_D0.9710.21
890_Q996_D0.9710.21
768_E881_D0.9700.21
430_T474_I0.9700.21
849_H891_Y0.9700.21
157_W162_A0.9690.21
504_N1015_A0.9680.21
749_Q916_Q0.9660.21
346_G420_G0.9650.21
280_N312_G0.9650.21
282_G310_Q0.9630.21
918_V964_I0.9610.21
749_Q803_S0.9600.21
890_Q962_S0.9600.21
472_L487_T0.9580.21
287_T290_N0.9560.21
747_S780_G0.9560.21
961_P997_L0.9560.21
147_V151_L0.9550.21
700_L849_H0.9550.21
872_E1012_G0.9520.20
905_A976_G0.9510.20
622_N626_R0.9510.20
397_G496_G0.9500.20
625_D699_Y0.9480.20
425_L509_Q0.9480.20
724_D827_G0.9470.20
957_W994_S0.9460.20
738_N889_L0.9460.20
797_Y898_L0.9450.20
710_V713_Y0.9430.20
166_G190_T0.9430.20
874_G888_Q0.9420.20
167_T191_G0.9370.20
422_S425_L0.9360.20
164_A168_V0.9360.20
898_L901_G0.9340.20
609_G871_L0.9340.20
295_L368_L0.9340.20
734_Q841_D0.9340.20
136_A147_V0.9330.20
886_E890_Q0.9330.20
777_R837_G0.9330.20
387_L472_L0.9320.20
576_D599_L0.9320.20
807_V816_G0.9310.20
190_T193_E0.9280.20
994_S1012_G0.9280.20
879_I883_L0.9270.20
794_A915_A0.9270.20
841_D958_W0.9270.20
473_T477_G0.9260.20
713_Y919_R0.9260.20
720_A973_M0.9260.20
759_G775_F0.9240.20
555_V561_A0.9240.20
711_P831_L0.9230.20
377_T861_R0.9230.20
916_Q968_S0.9210.20
240_D423_F0.9210.20
795_G1000_G0.9200.20
826_G862_A0.9190.20
1012_G1032_Q0.9190.20
645_A925_G0.9190.20
536_T542_G0.9190.20
755_H797_Y0.9180.20
278_V307_T0.9160.19
493_E512_V0.9160.19
209_G212_V0.9160.19
903_D962_S0.9160.19
839_W888_Q0.9160.19
348_R353_T0.9150.19
797_Y888_Q0.9150.19
638_T713_Y0.9130.19
712_L807_V0.9130.19
383_N821_D0.9120.19
898_L923_R0.9110.19
314_L504_N0.9110.19
152_N164_A0.9100.19
466_T470_D0.9100.19
797_Y1029_Y0.9100.19
286_N290_N0.9090.19
171_D175_Q0.9090.19
206_F221_R0.9080.19
345_N350_D0.9080.19
417_L425_L0.9070.19
862_A901_G0.9070.19
890_Q903_D0.9060.19
714_A719_Q0.9050.19
829_L845_Q0.9050.19
625_D636_G0.9020.19
1012_G1026_A0.9020.19
218_K255_G0.9000.19
839_W1012_G0.8990.19
957_W971_G0.8990.19
958_W1014_Q0.8990.19
162_A168_V0.8990.19
143_Q150_T0.8980.19
557_L573_S0.8970.19
864_G876_P0.8970.19
457_G472_L0.8960.19
1014_Q1030_N0.8960.19
662_V688_Y0.8960.19
920_A1001_L0.8940.19
482_Q519_L0.8930.19
606_G837_G0.8910.19
439_G461_T0.8910.19
724_D728_A0.8900.19
847_T926_S0.8900.19
479_A490_G0.8890.19
440_L448_L0.8880.19
189_N200_N0.8880.19
839_W958_W0.8880.19
403_K406_S0.8870.19
843_V862_A0.8860.19
915_A998_Q0.8860.19
886_E903_D0.8850.19
903_D1019_H0.8840.19
809_D843_V0.8840.19
563_W586_F0.8840.19
771_G865_W0.8830.19
853_A965_R0.8820.19
903_D958_W0.8810.19
150_T156_Q0.8800.19
281_G486_L0.8800.19
563_W574_V0.8790.19
877_F1004_R0.8780.18
247_A257_Q0.8770.18
470_D487_T0.8750.18
822_A874_G0.8750.18
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733_H845_Q0.5480.11
167_T174_W0.5480.11
709_E713_Y0.5480.11
769_S901_G0.5470.11
638_T923_R0.5460.11
747_S1031_G0.5460.11
541_T581_A0.5450.11
434_T441_F0.5450.11
169_I173_G0.5450.11
142_L147_V0.5440.11
345_N370_V0.5430.11
169_I209_G0.5430.11
738_N823_G0.5420.11
481_L498_G0.5420.11
826_G854_S0.5410.11
778_L966_T0.5410.11
915_A967_F0.5410.11
514_L519_L0.5400.11
281_G519_L0.5400.11
410_G492_V0.5400.11
419_K430_T0.5390.11
489_N574_V0.5390.11
450_G470_D0.5380.11
731_R885_L0.5380.11
750_G885_L0.5380.11
777_R962_S0.5370.11
492_V495_S0.5370.11
917_H1004_R0.5360.11
295_L569_A0.5340.11
450_G498_G0.5340.11
515_N1007_E0.5340.11
1006_R1009_I0.5330.11
824_S847_T0.5330.11
839_W1014_Q0.5330.11
862_A1020_S0.5330.11
183_A186_T0.5320.11
474_I518_T0.5320.11
228_G324_G0.5320.11
831_L894_Q0.5310.11
903_D1020_S0.5310.11
818_V845_Q0.5300.11
402_G405_F0.5290.11
292_K319_A0.5290.11
347_G511_A0.5280.11
214_T219_N0.5280.11
734_Q994_S0.5280.11
747_S966_T0.5270.11
410_G582_G0.5270.11
499_T510_K0.5260.11
474_I495_S0.5260.11
543_S556_T0.5260.11
752_H774_G0.5260.11
883_L994_S0.5260.11
716_M725_R0.5250.11
278_V318_T0.5250.11
581_A631_G0.5250.11
207_V220_G0.5240.11
532_A538_L0.5240.11
903_D991_N0.5230.11
259_V295_L0.5230.11
601_V624_A0.5230.11
174_W177_V0.5220.11
684_G734_Q0.5220.11
379_V410_G0.5210.11
415_L428_G0.5210.11
158_M164_A0.5210.11
188_V932_F0.5210.11
488_G528_T0.5210.11
214_T220_G0.5210.11
169_I175_Q0.5200.11
230_A242_T0.5200.11
485_S532_A0.5200.11
480_L514_L0.5190.11
751_G805_V0.5180.11
170_N177_V0.5170.11
901_G998_Q0.5170.11
920_A952_E0.5170.11
343_L393_A0.5170.11
686_F837_G0.5170.11
155_E162_A0.5170.11
926_S998_Q0.5170.11
278_V425_L0.5160.11
803_S816_G0.5160.11
830_N961_P0.5160.11
903_D1029_Y0.5150.11
884_M995_L0.5150.11
845_Q903_D0.5140.11
844_A1037_V0.5140.11
580_H603_N0.5140.11
816_G967_F0.5130.11
836_S1026_A0.5130.11
858_N888_Q0.5130.11
713_Y890_Q0.5130.11
631_G894_Q0.5120.11
486_L526_V0.5120.11
636_G1000_G0.5120.11
387_L395_V0.5120.11
152_N158_M0.5120.11
167_T497_S0.5120.11
565_I889_L0.5110.11
245_G690_L0.5110.11
462_L465_K0.5110.11
818_V847_T0.5110.11
338_A346_G0.5110.11
414_A467_V0.5100.11
747_S1012_G0.5090.11
179_P189_N0.5090.11
659_I693_D0.5090.11
773_Y896_L0.5090.11
490_G514_L0.5080.11
599_L636_G0.5080.11
673_G1020_S0.5080.11
660_Q665_I0.5080.11
839_W891_Y0.5080.11
707_R961_P0.5080.11
781_D822_A0.5080.11
374_G404_A0.5070.11
569_A572_Q0.5070.11
193_E200_N0.5050.11
864_G893_W0.5050.11
143_Q147_V0.5050.11
174_W191_G0.5050.11
497_S514_L0.5050.11
994_S998_Q0.5050.11
894_Q971_G0.5040.11
166_G169_I0.5030.11
482_Q502_V0.5020.11
869_G920_A0.5020.11
466_T778_L0.5020.11
278_V488_G0.5010.11
452_T460_L0.5010.11
781_D866_G0.5010.11
209_G240_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4meeA 1 0.2772 100 0.619 Contact Map
3aehA 1 0.2618 100 0.736 Contact Map
3sltA 1 0.2859 100 0.736 Contact Map
3qq2A 2 0.2348 100 0.741 Contact Map
1uynX 1 0.2522 100 0.763 Contact Map
3kvnX 1 0.4639 100 0.785 Contact Map
4kh3A 1 0.4726 100 0.787 Contact Map
3h09A 1 0.5958 99.9 0.85 Contact Map
3syjA 2 0.6015 99.9 0.864 Contact Map
1dabA 5 0.4254 99.9 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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