GREMLIN Database
USPG - Universal stress protein G
UniProt: P39177 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12683
Length: 142 (130)
Sequences: 20074 (16285)
Seq/√Len: 1428.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_H87_H3.0751.00
6_I106_A2.7451.00
4_T35_H2.7051.00
94_R129_S2.6291.00
33_V85_K2.5931.00
23_H139_L2.5231.00
4_T33_V2.4111.00
87_H100_L2.3421.00
108_V139_L2.3081.00
91_G96_E2.1121.00
74_V86_Q2.0091.00
35_H85_K1.9611.00
111_I130_V1.9381.00
109_V136_L1.9381.00
35_H106_A1.9261.00
89_R96_E1.8491.00
128_S132_R1.8101.00
33_V83_R1.7601.00
35_H100_L1.7521.00
8_P111_I1.7271.00
7_M24_A1.7231.00
101_A109_V1.7131.00
22_R76_H1.7081.00
4_T107_D1.6791.00
39_V96_E1.6481.00
37_L100_L1.6231.00
74_V78_T1.5791.00
96_E99_E1.5361.00
8_P97_V1.5011.00
102_E135_N1.4641.00
109_V134_A1.4561.00
63_Q67_Q1.4131.00
27_L30_D1.4081.00
38_H66_A1.3861.00
18_D76_H1.3651.00
7_M21_V1.3421.00
24_A28_A1.3411.00
89_R100_L1.3321.00
67_Q71_Q1.3151.00
32_G107_D1.3151.00
98_N133_H1.3131.00
129_S133_H1.3011.00
101_A135_N1.2681.00
93_V126_N1.2591.00
109_V130_V1.2221.00
71_Q74_V1.1871.00
134_A138_V1.1771.00
37_L89_R1.1681.00
59_E63_Q1.1641.00
100_L106_A1.1281.00
118_I122_L1.0911.00
39_V93_V1.0841.00
73_M77_F1.0791.00
69_R73_M1.0601.00
4_T106_A1.0591.00
113_S140_V1.0571.00
111_I127_A1.0371.00
11_V38_H1.0351.00
17_S20_A1.0291.00
64_H68_E1.0261.00
5_I108_V1.0071.00
101_A136_L1.0051.00
18_D72_T1.0031.00
71_Q75_S0.9871.00
62_L65_E0.9811.00
29_Q80_D0.9451.00
30_D107_D0.9411.00
69_R72_T0.9371.00
37_L97_V0.9361.00
101_A106_A0.9241.00
120_T128_S0.9211.00
60_E64_H0.9211.00
66_A70_L0.9161.00
98_N101_A0.9151.00
9_V73_M0.9151.00
36_L84_I0.9111.00
65_E69_R0.9111.00
25_E82_S0.9111.00
12_F17_S0.9021.00
21_V73_M0.9021.00
131_I140_V0.9011.00
23_H26_F0.8991.00
23_H27_L0.8971.00
21_V36_L0.8971.00
66_A88_V0.8901.00
71_Q86_Q0.8851.00
40_L90_F0.8841.00
70_L86_Q0.8831.00
66_A69_R0.8681.00
113_S127_A0.8681.00
24_A34_I0.8581.00
28_A34_I0.8411.00
40_L88_V0.8391.00
8_P112_G0.8371.00
72_T76_H0.8311.00
76_H79_I0.8271.00
98_N134_A0.8251.00
9_V36_L0.8251.00
72_T75_S0.8241.00
62_L66_A0.8211.00
23_H137_P0.8151.00
24_A110_V0.8151.00
7_M34_I0.8051.00
18_D22_R0.8051.00
25_E77_F0.8041.00
6_I100_L0.7971.00
73_M76_H0.7961.00
117_S120_T0.7871.00
23_H141_V0.7871.00
9_V20_A0.7761.00
92_S95_D0.7761.00
38_H69_R0.7741.00
98_N130_V0.7711.00
127_A140_V0.7691.00
39_V91_G0.7681.00
6_I37_L0.7671.00
19_K22_R0.7661.00
9_V21_V0.7631.00
6_I109_V0.7611.00
65_E68_E0.7611.00
110_V139_L0.7561.00
36_L73_M0.7481.00
57_R60_E0.7451.00
75_S79_I0.7451.00
75_S78_T0.7401.00
21_V25_E0.7361.00
94_R126_N0.7281.00
56_R60_E0.7251.00
29_Q81_P0.7181.00
28_A32_G0.7151.00
9_V18_D0.7151.00
61_H64_H0.7131.00
96_E100_L0.7121.00
105_G136_L0.7081.00
117_S121_H0.7071.00
97_V130_V0.7051.00
91_G99_E0.6981.00
68_E72_T0.6971.00
111_I140_V0.6961.00
25_E80_D0.6801.00
25_E29_Q0.6791.00
7_M20_A0.6731.00
61_H65_E0.6591.00
36_L77_F0.6591.00
60_E63_Q0.6591.00
67_Q86_Q0.6491.00
77_F84_I0.6431.00
94_R98_N0.6411.00
123_L127_A0.6401.00
56_R59_E0.6351.00
118_I121_H0.6321.00
70_L74_V0.6321.00
64_H67_Q0.6301.00
40_L66_A0.6291.00
113_S122_L0.6281.00
9_V17_S0.6251.00
74_V77_F0.6251.00
24_A32_G0.6241.00
11_V69_R0.6151.00
59_E90_F0.6101.00
94_R130_V0.6091.00
14_M19_K0.6061.00
110_V141_V0.6051.00
5_I28_A0.6041.00
57_R61_H0.6001.00
11_V73_M0.5991.00
26_F29_Q0.5951.00
68_E71_Q0.5941.00
74_V84_I0.5871.00
55_V58_F0.5861.00
5_I110_V0.5801.00
95_D99_E0.5691.00
18_D73_M0.5691.00
37_L96_E0.5651.00
63_Q90_F0.5641.00
102_E136_L0.5581.00
130_V138_V0.5581.00
20_A110_V0.5541.00
27_L139_L0.5491.00
13_E18_D0.5471.00
112_G141_V0.5441.00
114_R127_A0.5431.00
76_H80_D0.5371.00
27_L110_V0.5371.00
98_N129_S0.5301.00
97_V126_N0.5291.00
10_D17_S0.5291.00
94_R133_H0.5271.00
131_I138_V0.5251.00
44_A47_S0.5251.00
58_F61_H0.5201.00
25_E76_H0.5161.00
39_V89_R0.5071.00
27_L32_G0.5011.00
36_L86_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ahwA 4 0.9859 99.9 0.154 Contact Map
3hgmA 2 0.9789 99.9 0.168 Contact Map
3s3tA 4 0.9789 99.9 0.169 Contact Map
1mjhA 2 0.9437 99.9 0.178 Contact Map
2gm3A 2 0.8662 99.9 0.179 Contact Map
4wnyA 2 0.8803 99.9 0.18 Contact Map
1tq8A 4 0.8451 99.9 0.187 Contact Map
2dumA 2 0.9507 99.9 0.19 Contact Map
3fg9A 3 0.9648 99.9 0.195 Contact Map
3fdxA 2 0.8873 99.9 0.207 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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