GREMLIN Database
ERFK - Probable L,D-transpeptidase ErfK/SrfK
UniProt: P39176 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12682
Length: 310 (289)
Sequences: 560 (348)
Seq/√Len: 20.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_T231_I4.9781.00
137_T185_G4.7301.00
141_R183_Y4.5621.00
104_E236_K4.2751.00
128_G204_S4.2151.00
157_E205_Q3.9221.00
152_P156_R3.7331.00
108_Y236_K3.4641.00
177_M189_A3.3791.00
104_E108_Y3.0300.99
247_L288_A2.9410.99
120_F217_Y2.6200.98
88_L119_V2.5990.98
129_R205_Q2.5540.98
123_G204_S2.4500.97
155_R167_A2.4210.97
149_T171_A2.3650.96
212_N216_K2.2810.96
89_I238_T2.2590.95
239_T245_N2.2480.95
55_A64_M2.2470.95
93_T110_Y2.2470.95
183_Y189_A2.2120.95
149_T168_F2.1900.95
64_M82_L2.1010.93
102_V184_I2.0670.93
156_R160_K2.0610.93
158_Y163_E2.0590.92
147_T171_A2.0410.92
199_I203_V2.0090.92
198_G203_V2.0020.91
248_E299_P1.9920.91
159_A164_S1.9880.91
139_V182_I1.9450.90
181_A215_I1.8920.89
127_A204_S1.8890.89
32_R238_T1.8790.88
55_A213_D1.8590.88
154_T205_Q1.8530.88
209_R236_K1.8520.88
19_S34_V1.8460.88
108_Y231_I1.8100.87
122_I208_I1.7830.86
72_D75_L1.7500.85
45_H77_K1.7410.84
145_A179_L1.7350.84
60_G198_G1.7350.84
40_V57_Y1.6980.83
151_T154_T1.6920.82
181_A189_A1.6740.82
55_A196_N1.6680.82
33_L89_I1.6410.80
100_V208_I1.6300.80
247_L302_I1.6100.79
153_N205_Q1.5990.79
14_F18_T1.5780.78
72_D197_F1.5510.76
285_V288_A1.5420.76
54_A64_M1.5410.76
136_V227_R1.5230.75
247_L291_A1.5150.75
283_V288_A1.4930.74
232_D253_L1.4750.73
45_H78_S1.4710.72
123_G128_G1.4530.72
126_Q157_E1.4360.71
129_R134_N1.4310.70
153_N187_L1.4230.70
150_P155_R1.4120.69
42_V45_H1.4070.69
13_L20_L1.3970.68
136_V229_Q1.3900.68
288_A302_I1.3780.67
151_T187_L1.3760.67
60_G72_D1.3750.67
9_S14_F1.3740.67
190_I210_L1.3590.66
51_E211_R1.3520.66
248_E295_R1.3420.65
180_Y220_D1.3120.63
120_F189_A1.3020.63
129_R157_E1.2980.63
71_A76_P1.2980.63
93_T233_Q1.2960.62
55_A211_R1.2830.62
196_N199_I1.2700.61
102_V230_I1.2570.60
200_G228_V1.2440.59
73_V128_G1.2370.59
96_K113_D1.2230.58
198_G201_L1.2180.58
34_V88_L1.2130.57
145_A225_G1.2070.57
85_P106_R1.2060.57
75_L197_F1.2050.57
33_L87_Q1.2010.56
98_I139_V1.1990.56
60_G69_P1.1980.56
45_H177_M1.1850.55
184_I189_A1.1840.55
239_T243_G1.1790.55
244_S301_Q1.1760.55
9_S15_A1.1570.54
71_A80_S1.1510.53
150_P209_R1.1470.53
249_V291_A1.1460.53
81_Q110_Y1.1390.52
52_T74_F1.1310.52
143_Q224_V1.1260.52
235_V285_V1.1240.51
50_L64_M1.1230.51
182_I216_K1.1220.51
216_K220_D1.1200.51
150_P188_Y1.1180.51
131_T208_I1.1140.51
184_I188_Y1.1070.50
289_N292_L1.1040.50
179_L212_N1.1040.50
160_K168_F1.1030.50
51_E55_A1.1020.50
150_P236_K1.0910.49
63_N201_L1.0860.49
10_F159_A1.0760.48
89_I260_Y1.0700.48
138_T224_V1.0650.48
33_L246_W1.0610.47
224_V284_D1.0610.47
290_A294_R1.0560.47
63_N238_T1.0490.47
107_L194_N1.0400.46
42_V77_K1.0390.46
105_M204_S1.0380.46
70_G300_V1.0360.46
250_H299_P1.0320.45
104_E209_R1.0310.45
37_S122_I1.0310.45
32_R65_L1.0250.45
113_D139_V1.0210.45
223_P226_T1.0110.44
182_I246_W1.0100.44
92_D233_Q0.9980.43
54_A211_R0.9940.43
184_I212_N0.9930.43
203_V299_P0.9840.42
63_N302_I0.9780.42
125_G297_G0.9760.42
159_A300_V0.9760.42
27_P253_L0.9710.41
236_K248_E0.9710.41
105_M143_Q0.9690.41
158_Y197_F0.9680.41
42_V78_S0.9630.41
71_A103_A0.9620.41
95_R189_A0.9620.41
284_D290_A0.9560.41
66_E251_E0.9500.40
28_P144_E0.9410.40
124_I128_G0.9400.40
9_S17_H0.9330.39
138_T225_G0.9310.39
125_G209_R0.9300.39
49_P74_F0.9290.39
291_A300_V0.9250.39
84_I230_I0.9240.39
15_A18_T0.9180.38
125_G188_Y0.9140.38
34_V263_D0.9080.38
33_L238_T0.9040.37
158_Y195_A0.9000.37
250_H295_R0.8990.37
42_V79_G0.8950.37
174_D216_K0.8940.37
67_A85_P0.8910.36
19_S28_P0.8910.36
39_T81_Q0.8890.36
167_A284_D0.8830.36
77_K80_S0.8800.36
61_L140_E0.8770.36
152_P167_A0.8770.36
84_I219_F0.8760.36
73_V302_I0.8730.35
34_V180_Y0.8700.35
53_F221_N0.8680.35
134_N196_N0.8650.35
28_P95_R0.8610.35
61_L73_V0.8590.35
102_V145_A0.8590.35
62_S73_V0.8550.34
53_F154_T0.8510.34
48_Q177_M0.8370.33
110_Y270_V0.8360.33
73_V123_G0.8310.33
129_R187_L0.8280.33
26_L111_P0.8250.33
38_F86_Q0.8220.32
199_I249_V0.8210.32
99_V170_P0.8210.32
137_T253_L0.8200.32
132_P162_G0.8160.32
108_Y210_L0.8160.32
107_L243_G0.8120.32
109_Y226_T0.8090.32
143_Q183_Y0.8060.31
60_G106_R0.8060.31
248_E297_G0.8050.31
192_G218_L0.7980.31
131_T196_N0.7970.31
156_R283_V0.7960.31
156_R291_A0.7930.31
136_V225_G0.7920.31
9_S224_V0.7910.31
103_A266_V0.7900.31
165_L184_I0.7850.30
105_M205_Q0.7810.30
276_A287_R0.7810.30
110_Y118_E0.7790.30
31_S199_I0.7770.30
17_H20_L0.7760.30
49_P78_S0.7730.30
147_T168_F0.7710.30
91_P175_N0.7700.29
145_A180_Y0.7690.29
90_L117_V0.7660.29
140_E183_Y0.7620.29
134_N212_N0.7610.29
169_V230_I0.7610.29
232_D252_P0.7550.29
155_R165_L0.7550.29
167_A223_P0.7540.29
30_G37_S0.7510.28
10_F18_T0.7500.28
98_I222_V0.7480.28
186_R230_I0.7460.28
71_A75_L0.7440.28
62_S102_V0.7430.28
12_L15_A0.7310.27
177_M199_I0.7260.27
69_P210_L0.7180.27
90_L199_I0.7160.27
12_L20_L0.7150.27
10_F16_S0.7140.27
90_L97_G0.7140.27
157_E203_V0.7120.26
130_E194_N0.7120.26
100_V230_I0.7120.26
49_P126_Q0.7110.26
105_M183_Y0.7110.26
168_F171_A0.7070.26
170_P209_R0.7060.26
58_G283_V0.7030.26
34_V224_V0.6990.26
27_P111_P0.6990.26
60_G85_P0.6960.26
180_Y215_I0.6960.26
155_R209_R0.6900.25
23_T40_V0.6890.25
210_L288_A0.6880.25
26_L94_V0.6840.25
238_T255_R0.6830.25
67_A183_Y0.6800.25
39_T292_L0.6780.25
15_A159_A0.6770.25
110_Y231_I0.6750.25
250_H297_G0.6720.24
131_T216_K0.6720.24
118_E217_Y0.6710.24
63_N158_Y0.6600.24
29_E95_R0.6600.24
52_T163_E0.6570.24
110_Y185_G0.6560.24
249_V301_Q0.6540.24
235_V275_R0.6540.24
61_L192_G0.6520.23
11_A16_S0.6520.23
17_H21_A0.6510.23
199_I204_S0.6510.23
216_K253_L0.6480.23
123_G127_A0.6480.23
104_E150_P0.6480.23
189_A201_L0.6460.23
102_V194_N0.6450.23
68_N97_G0.6450.23
161_R174_D0.6450.23
59_Q65_L0.6440.23
269_P272_P0.6440.23
153_N157_E0.6420.23
182_I219_F0.6400.23
150_P197_F0.6390.23
113_D219_F0.6380.23
54_A199_I0.6370.23
159_A169_V0.6360.23
10_F17_H0.6360.23
180_Y216_K0.6340.23
126_Q129_R0.6320.23
100_V263_D0.6300.22
33_L42_V0.6290.22
59_Q64_M0.6290.22
43_P110_Y0.6270.22
76_P85_P0.6270.22
104_E248_E0.6250.22
15_A19_S0.6240.22
133_R138_T0.6240.22
33_L80_S0.6220.22
13_L17_H0.6210.22
31_S241_P0.6160.22
249_V292_L0.6140.22
86_Q156_R0.6130.22
202_R243_G0.6110.22
172_G176_P0.6110.22
32_R122_I0.6100.22
249_V273_S0.6080.21
158_Y164_S0.6070.21
22_V86_Q0.6040.21
141_R187_L0.6040.21
49_P177_M0.6030.21
204_S254_S0.6030.21
51_E74_F0.6030.21
142_K226_T0.6030.21
62_S105_M0.6010.21
202_R232_D0.6010.21
12_L16_S0.6000.21
34_V119_V0.5980.21
10_F275_R0.5970.21
184_I208_I0.5930.21
48_Q284_D0.5920.21
195_A203_V0.5920.21
138_T227_R0.5910.21
18_T56_Q0.5910.21
73_V204_S0.5900.21
48_Q285_V0.5900.21
41_T287_R0.5890.21
264_R274_L0.5830.20
144_E237_Y0.5830.20
151_T186_R0.5830.20
106_R200_G0.5800.20
14_F17_H0.5780.20
243_G254_S0.5760.20
158_Y198_G0.5750.20
235_V249_V0.5740.20
150_P210_L0.5730.20
158_Y165_L0.5720.20
61_L198_G0.5720.20
63_N119_V0.5700.20
62_S196_N0.5690.20
74_F129_R0.5680.20
49_P52_T0.5670.20
143_Q230_I0.5670.20
139_V145_A0.5660.20
58_G230_I0.5660.20
84_I250_H0.5650.20
165_L203_V0.5640.20
90_L111_P0.5640.20
138_T296_S0.5630.20
173_P225_G0.5630.20
95_R150_P0.5610.19
125_G184_I0.5610.19
165_L248_E0.5600.19
199_I213_D0.5600.19
165_L299_P0.5570.19
140_E153_N0.5560.19
108_Y150_P0.5560.19
32_R95_R0.5530.19
203_V291_A0.5520.19
90_L110_Y0.5510.19
114_S141_R0.5490.19
66_E75_L0.5490.19
73_V84_I0.5480.19
166_P189_A0.5460.19
39_T164_S0.5460.19
67_A226_T0.5460.19
18_T302_I0.5450.19
49_P59_Q0.5440.19
44_D77_K0.5430.19
131_T193_T0.5420.19
107_L202_R0.5410.19
217_Y221_N0.5400.19
12_L17_H0.5390.19
224_V293_Q0.5380.19
195_A295_R0.5380.19
270_V275_R0.5370.18
84_I217_Y0.5370.18
157_E296_S0.5360.18
155_R236_K0.5340.18
270_V292_L0.5340.18
142_K234_P0.5330.18
53_F199_I0.5320.18
101_N125_G0.5310.18
55_A134_N0.5310.18
193_T212_N0.5300.18
210_L215_I0.5290.18
245_N287_R0.5280.18
100_V218_L0.5280.18
196_N212_N0.5270.18
239_T281_Q0.5270.18
100_V130_E0.5250.18
84_I197_F0.5250.18
89_I116_T0.5250.18
26_L117_V0.5240.18
142_K218_L0.5230.18
188_Y297_G0.5220.18
140_E184_I0.5220.18
103_A192_G0.5210.18
105_M155_R0.5210.18
162_G201_L0.5200.18
101_N297_G0.5200.18
10_F272_P0.5180.18
222_V226_T0.5180.18
25_P113_D0.5150.18
9_S13_L0.5140.18
16_S20_L0.5140.18
105_M189_A0.5130.18
55_A212_N0.5130.18
31_S103_A0.5120.18
126_Q245_N0.5120.18
211_R233_Q0.5100.17
90_L152_P0.5080.17
94_V111_P0.5080.17
45_H74_F0.5050.17
121_P243_G0.5050.17
70_G76_P0.5050.17
26_L288_A0.5040.17
182_I215_I0.5030.17
123_G192_G0.5030.17
293_Q302_I0.5030.17
273_S277_F0.5020.17
104_E215_I0.5020.17
40_V89_I0.5020.17
142_K224_V0.5020.17
139_V258_A0.5020.17
151_T177_M0.5010.17
125_G215_I0.5010.17
13_L274_L0.5000.17
121_P214_D0.5000.17
90_L109_Y0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lzhA 1 0.8871 100 0.399 Contact Map
4xvoA 1 0.6323 100 0.662 Contact Map
4jmnA 1 0.6323 100 0.664 Contact Map
4a1kA 2 0.529 100 0.681 Contact Map
4k73A 1 0.6065 100 0.737 Contact Map
3vypA 1 0.7387 100 0.751 Contact Map
1zatA 1 0.6645 100 0.761 Contact Map
4qtfA 2 0.7581 100 0.762 Contact Map
5bmqA 3 0.5871 100 0.767 Contact Map
4xxtA 1 0.5903 100 0.779 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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