GREMLIN Database
YEAD - Putative glucose-6-phosphate 1-epimerase
UniProt: P39173 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12679
Length: 294 (241)
Sequences: 2533 (1996)
Seq/√Len: 128.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_Q134_D3.8291.00
49_S57_E3.5511.00
128_K134_D3.2981.00
106_K120_E3.1471.00
123_Q128_K3.0001.00
41_A48_L2.7791.00
101_L124_S2.6581.00
120_E136_T2.4261.00
278_T281_K2.4221.00
120_E138_L2.4001.00
150_D282_P2.3281.00
32_D53_A2.3171.00
38_A50_W2.3061.00
42_L102_P2.2571.00
118_T140_H2.2551.00
136_T150_D2.2331.00
69_N100_N2.2201.00
98_A121_L2.2161.00
86_P94_A2.1751.00
38_A47_L2.0701.00
29_I117_L2.0681.00
32_D37_K2.0141.00
62_S70_G2.0081.00
79_V139_A2.0061.00
30_V39_S1.8941.00
40_F117_L1.8901.00
230_A290_R1.8641.00
109_H116_A1.8531.00
152_E157_F1.8441.00
134_D153_S1.8201.00
232_G290_R1.8101.00
189_N194_N1.8021.00
167_F220_I1.7401.00
116_A142_R1.7391.00
142_R146_T1.7321.00
36_V50_W1.7181.00
158_E276_K1.7131.00
159_T283_A1.7081.00
148_E284_H1.7081.00
122_T136_T1.6991.00
31_V143_V1.6851.00
206_R248_L1.6641.00
50_W291_V1.6441.00
37_K51_K1.6391.00
45_A119_F1.5991.00
156_E276_K1.5991.00
126_E129_K1.5801.00
149_I159_T1.5761.00
156_E278_T1.5761.00
118_T138_L1.5711.00
177_V180_L1.5611.00
217_C230_A1.5211.00
43_Q102_P1.5071.00
159_T277_V1.4861.00
196_L199_G1.4831.00
123_Q135_F1.4461.00
123_Q127_T1.4451.00
98_A137_L1.4161.00
116_A140_H1.4041.00
180_L184_F1.4011.00
104_T122_T1.3981.00
164_H267_E1.3941.00
146_T284_H1.3941.00
28_L39_S1.3901.00
219_V230_A1.3771.00
140_H148_E1.3611.00
104_T120_E1.3541.00
138_L150_D1.3421.00
30_V37_K1.3421.00
80_C162_A1.3371.00
51_K57_E1.3311.00
203_F207_T1.3171.00
97_F100_N1.3141.00
170_G225_L1.3121.00
83_W92_L1.3111.00
148_E282_P1.3001.00
83_W87_A1.2911.00
47_L141_F1.2871.00
162_A269_A1.2631.00
153_S157_F1.2621.00
35_Q145_K1.2491.00
239_V266_V1.2411.00
33_H115_V1.2401.00
244_P263_F1.2371.00
179_G184_F1.2331.00
136_T152_E1.2321.00
217_C232_G1.2281.00
107_S118_T1.2241.00
81_W149_I1.2241.00
127_T135_F1.2221.00
124_S127_T1.2160.99
58_V291_V1.2100.99
179_G182_D1.2080.99
137_L161_S1.2030.99
125_E129_K1.1990.99
57_E61_L1.1970.99
107_S116_A1.1930.99
84_F240_V1.1900.99
170_G224_A1.1900.99
175_V180_L1.1850.99
222_D225_L1.1790.99
271_A274_T1.1730.99
36_V143_V1.1720.99
97_F135_F1.1640.99
61_L168_N1.1560.99
105_L117_L1.1550.99
110_E115_V1.1410.99
199_G203_F1.1350.99
233_H239_V1.1330.99
232_G288_S1.1310.99
49_S61_L1.1210.99
109_H115_V1.1210.99
29_I42_L1.1170.99
220_I266_V1.1120.99
159_T285_L1.1030.99
231_V289_I1.1020.99
52_P55_E1.0830.99
48_L70_G1.0810.99
215_Q218_S1.0790.99
50_W59_L1.0790.99
39_S49_S1.0750.99
37_K53_A1.0740.99
106_K138_L1.0710.99
219_V228_I1.0650.99
131_W157_F1.0510.98
180_L185_I1.0490.98
245_G263_F1.0450.98
147_C161_S1.0430.98
222_D226_N1.0320.98
218_S239_V1.0260.98
138_L148_E1.0250.98
98_A103_W1.0210.98
95_H164_H1.0210.98
95_H267_E1.0170.98
101_L121_L1.0140.98
146_T286_A1.0120.98
175_V179_G1.0060.98
101_L126_E1.0050.98
85_G94_A0.9980.98
78_P267_E0.9960.98
189_N192_K0.9930.98
179_G186_D0.9920.98
186_D191_A0.9910.98
135_F157_F0.9910.98
185_I188_V0.9900.98
41_A46_H0.9840.98
182_D185_I0.9740.98
277_V281_K0.9630.97
134_D152_E0.9580.97
69_N94_A0.9500.97
270_Y273_E0.9320.97
243_N264_V0.9320.97
42_L119_F0.9270.97
222_D227_R0.9250.97
97_F121_L0.9250.97
79_V137_L0.9220.97
133_H157_F0.9200.96
61_L166_Y0.9050.96
179_G185_I0.9010.96
105_L119_F0.8980.96
268_T287_Q0.8940.96
159_T275_Q0.8910.96
236_H285_L0.8900.96
204_P207_T0.8890.96
231_V266_V0.8880.96
275_Q283_A0.8860.96
181_G184_F0.8830.96
121_L135_F0.8810.96
203_F264_V0.8650.95
186_D189_N0.8630.95
200_I205_D0.8590.95
31_V38_A0.8520.95
103_W139_A0.8490.95
163_L287_Q0.8440.94
170_G222_D0.8250.94
248_L262_T0.8240.94
181_G186_D0.8230.94
87_A92_L0.8210.93
173_A261_K0.8190.93
115_V142_R0.8120.93
58_V229_I0.8010.93
168_N262_T0.7920.92
167_F229_I0.7910.92
221_N228_I0.7900.92
46_H80_C0.7840.92
43_Q70_G0.7820.92
83_W160_T0.7780.92
60_W63_N0.7770.91
66_P262_T0.7670.91
94_A99_R0.7660.91
110_E116_A0.7620.91
36_V52_P0.7620.91
182_D215_Q0.7600.91
67_F70_G0.7560.90
83_W88_A0.7510.90
40_F119_F0.7490.90
161_S236_H0.7470.90
269_A274_T0.7460.90
59_L70_G0.7450.90
245_G248_L0.7440.90
46_H162_A0.7440.90
56_E227_R0.7390.89
123_Q152_E0.7320.89
106_K118_T0.7300.89
90_Q133_H0.7290.89
51_K54_G0.7280.89
220_I229_I0.7270.89
149_I161_S0.7240.88
233_H236_H0.7220.88
165_T287_Q0.7210.88
171_D228_I0.7210.88
147_C163_L0.7170.88
184_F188_V0.7170.88
31_V117_L0.7130.88
87_A160_T0.7130.88
177_V181_G0.7090.87
50_W81_W0.7090.87
131_W135_F0.7080.87
176_S180_L0.7030.87
184_F191_A0.7000.87
180_L186_D0.6990.87
79_V163_L0.6980.86
29_I119_F0.6970.86
122_T152_E0.6950.86
208_D240_V0.6890.86
43_Q69_N0.6880.86
188_V191_A0.6870.86
108_H117_L0.6810.85
101_L127_T0.6800.85
166_Y244_P0.6770.85
208_D211_Y0.6730.84
38_A48_L0.6720.84
81_W161_S0.6640.84
183_R193_E0.6590.83
32_D51_K0.6580.83
39_S51_K0.6570.83
125_E128_K0.6560.83
78_P164_H0.6550.83
99_R166_Y0.6550.83
169_V222_D0.6540.83
157_F277_V0.6530.83
124_S135_F0.6530.83
197_T200_I0.6520.83
86_P187_K0.6520.83
184_F189_N0.6510.82
178_S221_N0.6480.82
56_E225_L0.6470.82
80_C84_F0.6470.82
188_V192_K0.6410.81
208_D263_F0.6380.81
38_A143_V0.6380.81
177_V186_D0.6380.81
235_H283_A0.6370.81
81_W137_L0.6370.81
209_R240_V0.6330.81
50_W289_I0.6320.81
162_A165_T0.6280.80
177_V184_F0.6280.80
201_Q207_T0.6270.80
269_A273_E0.6260.80
87_A91_G0.6250.80
66_P71_V0.6220.79
166_Y240_V0.6220.79
80_C165_T0.6210.79
184_F190_D0.6200.79
58_V228_I0.6190.79
84_F243_N0.6180.79
171_D174_K0.6160.79
68_K100_N0.6160.79
211_Y240_V0.6160.79
85_G242_W0.6120.78
40_F141_F0.6110.78
83_W91_G0.6070.78
99_R267_E0.6040.77
220_I264_V0.6030.77
119_F141_F0.6020.77
216_D234_Q0.6020.77
71_V240_V0.6010.77
101_L130_F0.6000.77
247_A261_K0.5990.77
244_P247_A0.5980.77
33_H36_V0.5980.77
46_H84_F0.5960.77
199_G207_T0.5860.75
181_G185_I0.5850.75
128_K135_F0.5840.75
187_K210_V0.5830.75
216_D219_V0.5790.74
205_D246_P0.5790.74
185_I192_K0.5760.74
52_P58_V0.5740.74
60_W64_N0.5730.74
231_V287_Q0.5720.74
186_D190_D0.5660.73
183_R190_D0.5640.73
199_G205_D0.5620.72
200_I203_F0.5600.72
149_I157_F0.5600.72
140_H146_T0.5580.72
41_A45_A0.5580.72
97_F131_W0.5550.71
79_V98_A0.5530.71
248_L261_K0.5510.71
149_I277_V0.5490.71
180_L183_R0.5490.71
165_T211_Y0.5490.71
137_L147_C0.5480.70
207_T245_G0.5460.70
62_S69_N0.5460.70
203_F206_R0.5440.70
29_I105_L0.5430.70
121_L137_L0.5430.70
83_W274_T0.5430.70
38_A117_L0.5420.70
172_I245_G0.5410.69
176_S182_D0.5400.69
205_D243_N0.5390.69
56_E168_N0.5380.69
161_S270_Y0.5360.69
28_L48_L0.5360.69
39_S48_L0.5350.69
276_K279_K0.5350.69
29_I40_F0.5340.68
236_H270_Y0.5340.68
162_A268_T0.5310.68
93_P100_N0.5290.68
269_A272_S0.5280.68
99_R164_H0.5260.67
85_G99_R0.5260.67
84_F103_W0.5250.67
179_G188_V0.5250.67
184_F187_K0.5240.67
46_H100_N0.5230.67
52_P227_R0.5230.67
105_L108_H0.5200.66
184_F209_R0.5190.66
176_S179_G0.5180.66
29_I38_A0.5170.66
246_P263_F0.5170.66
234_Q286_A0.5160.66
176_S200_I0.5160.66
81_W160_T0.5150.66
247_A262_T0.5140.66
134_D154_H0.5140.66
94_A263_F0.5140.66
222_D228_I0.5130.65
178_S183_R0.5120.65
51_K55_E0.5120.65
38_A52_P0.5100.65
270_Y274_T0.5100.65
182_D188_V0.5090.65
180_L188_V0.5080.65
160_T285_L0.5070.65
236_H283_A0.5050.64
151_L279_K0.5050.64
103_W137_L0.5040.64
132_P135_F0.5020.64
177_V203_F0.5020.64
84_F166_Y0.5020.64
84_F265_C0.5010.64
46_H139_A0.5010.64
106_K136_T0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2htaA 1 0.9762 100 0.345 Contact Map
2cirA 1 0.915 100 0.36 Contact Map
1jovA 1 0.9048 100 0.388 Contact Map
3k25A 1 0.8878 100 0.465 Contact Map
3dcdA 1 0.8299 100 0.482 Contact Map
3q1nA 1 0.8299 100 0.486 Contact Map
3os7A 2 0.9116 100 0.499 Contact Map
3mwxA 1 0.9014 100 0.511 Contact Map
3nreA 1 0.8299 100 0.523 Contact Map
4rnlA 1 0.949 100 0.526 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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