YEAD - ECOLI - GREMLIN Contacts

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YEAD - Putative glucose-6-phosphate 1-epimerase

UniProt:	P39173	Sequences: MIKKIFALPVIEQISPVLSRRKLDELDLIVVDHPQVKASFALQGAHLLSWKPAGEEEVLWLSNNTPFKNGVAIRGGVPVCWPWFGPAAQQGLPAHGFARNLPWTLKSHHEDADGVALTFELTQSEETKKFWPHDFTLLAHFRVGKTCEIDLESHGEFETTSALHTYFNVGDIAKVSVSGLGDRFIDKVNDAKENVLTDGIQTFPDRTDRVYLNPQDCSVINDEALNRIIAVGHQHHLNVVGWNPGPALSISMGDMPDDGYKTFVCVETAYASETQKVTKEKPAHLAQSIRVAKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12679
Length:	294 (241)
Sequences:	2533 (1996)
Seq/√Len:	128.6

ECOLI - YEAD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
123_Q	134_D	3.829	1.00
49_S	57_E	3.551	1.00
128_K	134_D	3.298	1.00
106_K	120_E	3.147	1.00
123_Q	128_K	3.000	1.00
41_A	48_L	2.779	1.00
101_L	124_S	2.658	1.00
120_E	136_T	2.426	1.00
278_T	281_K	2.422	1.00
120_E	138_L	2.400	1.00
150_D	282_P	2.328	1.00
32_D	53_A	2.317	1.00
38_A	50_W	2.306	1.00
42_L	102_P	2.257	1.00
118_T	140_H	2.255	1.00
136_T	150_D	2.233	1.00
69_N	100_N	2.220	1.00
98_A	121_L	2.216	1.00
86_P	94_A	2.175	1.00
38_A	47_L	2.070	1.00
29_I	117_L	2.068	1.00
32_D	37_K	2.014	1.00
62_S	70_G	2.008	1.00
79_V	139_A	2.006	1.00
30_V	39_S	1.894	1.00
40_F	117_L	1.890	1.00
230_A	290_R	1.864	1.00
109_H	116_A	1.853	1.00
152_E	157_F	1.844	1.00
134_D	153_S	1.820	1.00
232_G	290_R	1.810	1.00
189_N	194_N	1.802	1.00
167_F	220_I	1.740	1.00
116_A	142_R	1.739	1.00
142_R	146_T	1.732	1.00
36_V	50_W	1.718	1.00
158_E	276_K	1.713	1.00
159_T	283_A	1.708	1.00
148_E	284_H	1.708	1.00
122_T	136_T	1.699	1.00
31_V	143_V	1.685	1.00
206_R	248_L	1.664	1.00
50_W	291_V	1.644	1.00
37_K	51_K	1.639	1.00
45_A	119_F	1.599	1.00
156_E	276_K	1.599	1.00
126_E	129_K	1.580	1.00
149_I	159_T	1.576	1.00
156_E	278_T	1.576	1.00
118_T	138_L	1.571	1.00
177_V	180_L	1.561	1.00
217_C	230_A	1.521	1.00
43_Q	102_P	1.507	1.00
159_T	277_V	1.486	1.00
196_L	199_G	1.483	1.00
123_Q	135_F	1.446	1.00
123_Q	127_T	1.445	1.00
98_A	137_L	1.416	1.00
116_A	140_H	1.404	1.00
180_L	184_F	1.401	1.00
104_T	122_T	1.398	1.00
164_H	267_E	1.394	1.00
146_T	284_H	1.394	1.00
28_L	39_S	1.390	1.00
219_V	230_A	1.377	1.00
140_H	148_E	1.361	1.00
104_T	120_E	1.354	1.00
138_L	150_D	1.342	1.00
30_V	37_K	1.342	1.00
80_C	162_A	1.337	1.00
51_K	57_E	1.331	1.00
203_F	207_T	1.317	1.00
97_F	100_N	1.314	1.00
170_G	225_L	1.312	1.00
83_W	92_L	1.311	1.00
148_E	282_P	1.300	1.00
83_W	87_A	1.291	1.00
47_L	141_F	1.287	1.00
162_A	269_A	1.263	1.00
153_S	157_F	1.262	1.00
35_Q	145_K	1.249	1.00
239_V	266_V	1.241	1.00
33_H	115_V	1.240	1.00
244_P	263_F	1.237	1.00
179_G	184_F	1.233	1.00
136_T	152_E	1.232	1.00
217_C	232_G	1.228	1.00
107_S	118_T	1.224	1.00
81_W	149_I	1.224	1.00
127_T	135_F	1.222	1.00
124_S	127_T	1.216	0.99
58_V	291_V	1.210	0.99
179_G	182_D	1.208	0.99
137_L	161_S	1.203	0.99
125_E	129_K	1.199	0.99
57_E	61_L	1.197	0.99
107_S	116_A	1.193	0.99
84_F	240_V	1.190	0.99
170_G	224_A	1.190	0.99
175_V	180_L	1.185	0.99
222_D	225_L	1.179	0.99
271_A	274_T	1.173	0.99
36_V	143_V	1.172	0.99
97_F	135_F	1.164	0.99
61_L	168_N	1.156	0.99
105_L	117_L	1.155	0.99
110_E	115_V	1.141	0.99
199_G	203_F	1.135	0.99
233_H	239_V	1.133	0.99
232_G	288_S	1.131	0.99
49_S	61_L	1.121	0.99
109_H	115_V	1.121	0.99
29_I	42_L	1.117	0.99
220_I	266_V	1.112	0.99
159_T	285_L	1.103	0.99
231_V	289_I	1.102	0.99
52_P	55_E	1.083	0.99
48_L	70_G	1.081	0.99
215_Q	218_S	1.079	0.99
50_W	59_L	1.079	0.99
39_S	49_S	1.075	0.99
37_K	53_A	1.074	0.99
106_K	138_L	1.071	0.99
219_V	228_I	1.065	0.99
131_W	157_F	1.051	0.98
180_L	185_I	1.049	0.98
245_G	263_F	1.045	0.98
147_C	161_S	1.043	0.98
222_D	226_N	1.032	0.98
218_S	239_V	1.026	0.98
138_L	148_E	1.025	0.98
98_A	103_W	1.021	0.98
95_H	164_H	1.021	0.98
95_H	267_E	1.017	0.98
101_L	121_L	1.014	0.98
146_T	286_A	1.012	0.98
175_V	179_G	1.006	0.98
101_L	126_E	1.005	0.98
85_G	94_A	0.998	0.98
78_P	267_E	0.996	0.98
189_N	192_K	0.993	0.98
179_G	186_D	0.992	0.98
186_D	191_A	0.991	0.98
135_F	157_F	0.991	0.98
185_I	188_V	0.990	0.98
41_A	46_H	0.984	0.98
182_D	185_I	0.974	0.98
277_V	281_K	0.963	0.97
134_D	152_E	0.958	0.97
69_N	94_A	0.950	0.97
270_Y	273_E	0.932	0.97
243_N	264_V	0.932	0.97
42_L	119_F	0.927	0.97
222_D	227_R	0.925	0.97
97_F	121_L	0.925	0.97
79_V	137_L	0.922	0.97
133_H	157_F	0.920	0.96
61_L	166_Y	0.905	0.96
179_G	185_I	0.901	0.96
105_L	119_F	0.898	0.96
268_T	287_Q	0.894	0.96
159_T	275_Q	0.891	0.96
236_H	285_L	0.890	0.96
204_P	207_T	0.889	0.96
231_V	266_V	0.888	0.96
275_Q	283_A	0.886	0.96
181_G	184_F	0.883	0.96
121_L	135_F	0.881	0.96
203_F	264_V	0.865	0.95
186_D	189_N	0.863	0.95
200_I	205_D	0.859	0.95
31_V	38_A	0.852	0.95
103_W	139_A	0.849	0.95
163_L	287_Q	0.844	0.94
170_G	222_D	0.825	0.94
248_L	262_T	0.824	0.94
181_G	186_D	0.823	0.94
87_A	92_L	0.821	0.93
173_A	261_K	0.819	0.93
115_V	142_R	0.812	0.93
58_V	229_I	0.801	0.93
168_N	262_T	0.792	0.92
167_F	229_I	0.791	0.92
221_N	228_I	0.790	0.92
46_H	80_C	0.784	0.92
43_Q	70_G	0.782	0.92
83_W	160_T	0.778	0.92
60_W	63_N	0.777	0.91
66_P	262_T	0.767	0.91
94_A	99_R	0.766	0.91
110_E	116_A	0.762	0.91
36_V	52_P	0.762	0.91
182_D	215_Q	0.760	0.91
67_F	70_G	0.756	0.90
83_W	88_A	0.751	0.90
40_F	119_F	0.749	0.90
161_S	236_H	0.747	0.90
269_A	274_T	0.746	0.90
59_L	70_G	0.745	0.90
245_G	248_L	0.744	0.90
46_H	162_A	0.744	0.90
56_E	227_R	0.739	0.89
123_Q	152_E	0.732	0.89
106_K	118_T	0.730	0.89
90_Q	133_H	0.729	0.89
51_K	54_G	0.728	0.89
220_I	229_I	0.727	0.89
149_I	161_S	0.724	0.88
233_H	236_H	0.722	0.88
165_T	287_Q	0.721	0.88
171_D	228_I	0.721	0.88
147_C	163_L	0.717	0.88
184_F	188_V	0.717	0.88
31_V	117_L	0.713	0.88
87_A	160_T	0.713	0.88
177_V	181_G	0.709	0.87
50_W	81_W	0.709	0.87
131_W	135_F	0.708	0.87
176_S	180_L	0.703	0.87
184_F	191_A	0.700	0.87
180_L	186_D	0.699	0.87
79_V	163_L	0.698	0.86
29_I	119_F	0.697	0.86
122_T	152_E	0.695	0.86
208_D	240_V	0.689	0.86
43_Q	69_N	0.688	0.86
188_V	191_A	0.687	0.86
108_H	117_L	0.681	0.85
101_L	127_T	0.680	0.85
166_Y	244_P	0.677	0.85
208_D	211_Y	0.673	0.84
38_A	48_L	0.672	0.84
81_W	161_S	0.664	0.84
183_R	193_E	0.659	0.83
32_D	51_K	0.658	0.83
39_S	51_K	0.657	0.83
125_E	128_K	0.656	0.83
78_P	164_H	0.655	0.83
99_R	166_Y	0.655	0.83
169_V	222_D	0.654	0.83
157_F	277_V	0.653	0.83
124_S	135_F	0.653	0.83
197_T	200_I	0.652	0.83
86_P	187_K	0.652	0.83
184_F	189_N	0.651	0.82
178_S	221_N	0.648	0.82
56_E	225_L	0.647	0.82
80_C	84_F	0.647	0.82
188_V	192_K	0.641	0.81
208_D	263_F	0.638	0.81
38_A	143_V	0.638	0.81
177_V	186_D	0.638	0.81
235_H	283_A	0.637	0.81
81_W	137_L	0.637	0.81
209_R	240_V	0.633	0.81
50_W	289_I	0.632	0.81
162_A	165_T	0.628	0.80
177_V	184_F	0.628	0.80
201_Q	207_T	0.627	0.80
269_A	273_E	0.626	0.80
87_A	91_G	0.625	0.80
66_P	71_V	0.622	0.79
166_Y	240_V	0.622	0.79
80_C	165_T	0.621	0.79
184_F	190_D	0.620	0.79
58_V	228_I	0.619	0.79
84_F	243_N	0.618	0.79
171_D	174_K	0.616	0.79
68_K	100_N	0.616	0.79
211_Y	240_V	0.616	0.79
85_G	242_W	0.612	0.78
40_F	141_F	0.611	0.78
83_W	91_G	0.607	0.78
99_R	267_E	0.604	0.77
220_I	264_V	0.603	0.77
119_F	141_F	0.602	0.77
216_D	234_Q	0.602	0.77
71_V	240_V	0.601	0.77
101_L	130_F	0.600	0.77
247_A	261_K	0.599	0.77
244_P	247_A	0.598	0.77
33_H	36_V	0.598	0.77
46_H	84_F	0.596	0.77
199_G	207_T	0.586	0.75
181_G	185_I	0.585	0.75
128_K	135_F	0.584	0.75
187_K	210_V	0.583	0.75
216_D	219_V	0.579	0.74
205_D	246_P	0.579	0.74
185_I	192_K	0.576	0.74
52_P	58_V	0.574	0.74
60_W	64_N	0.573	0.74
231_V	287_Q	0.572	0.74
186_D	190_D	0.566	0.73
183_R	190_D	0.564	0.73
199_G	205_D	0.562	0.72
200_I	203_F	0.560	0.72
149_I	157_F	0.560	0.72
140_H	146_T	0.558	0.72
41_A	45_A	0.558	0.72
97_F	131_W	0.555	0.71
79_V	98_A	0.553	0.71
248_L	261_K	0.551	0.71
149_I	277_V	0.549	0.71
180_L	183_R	0.549	0.71
165_T	211_Y	0.549	0.71
137_L	147_C	0.548	0.70
207_T	245_G	0.546	0.70
62_S	69_N	0.546	0.70
203_F	206_R	0.544	0.70
29_I	105_L	0.543	0.70
121_L	137_L	0.543	0.70
83_W	274_T	0.543	0.70
38_A	117_L	0.542	0.70
172_I	245_G	0.541	0.69
176_S	182_D	0.540	0.69
205_D	243_N	0.539	0.69
56_E	168_N	0.538	0.69
161_S	270_Y	0.536	0.69
28_L	48_L	0.536	0.69
39_S	48_L	0.535	0.69
276_K	279_K	0.535	0.69
29_I	40_F	0.534	0.68
236_H	270_Y	0.534	0.68
162_A	268_T	0.531	0.68
93_P	100_N	0.529	0.68
269_A	272_S	0.528	0.68
99_R	164_H	0.526	0.67
85_G	99_R	0.526	0.67
84_F	103_W	0.525	0.67
179_G	188_V	0.525	0.67
184_F	187_K	0.524	0.67
46_H	100_N	0.523	0.67
52_P	227_R	0.523	0.67
105_L	108_H	0.520	0.66
184_F	209_R	0.519	0.66
176_S	179_G	0.518	0.66
29_I	38_A	0.517	0.66
246_P	263_F	0.517	0.66
234_Q	286_A	0.516	0.66
176_S	200_I	0.516	0.66
81_W	160_T	0.515	0.66
247_A	262_T	0.514	0.66
134_D	154_H	0.514	0.66
94_A	263_F	0.514	0.66
222_D	228_I	0.513	0.65
178_S	183_R	0.512	0.65
51_K	55_E	0.512	0.65
38_A	52_P	0.510	0.65
270_Y	274_T	0.510	0.65
182_D	188_V	0.509	0.65
180_L	188_V	0.508	0.65
160_T	285_L	0.507	0.65
236_H	283_A	0.505	0.64
151_L	279_K	0.505	0.64
103_W	137_L	0.504	0.64
132_P	135_F	0.502	0.64
177_V	203_F	0.502	0.64
84_F	166_Y	0.502	0.64
84_F	265_C	0.501	0.64
46_H	139_A	0.501	0.64
106_K	136_T	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2htaA	1	0.9762	100	0.345	Contact Map
2cirA	1	0.915	100	0.36	Contact Map
1jovA	1	0.9048	100	0.388	Contact Map
3k25A	1	0.8878	100	0.465	Contact Map
3dcdA	1	0.8299	100	0.482	Contact Map
3q1nA	1	0.8299	100	0.486	Contact Map
3os7A	2	0.9116	100	0.499	Contact Map
3mwxA	1	0.9014	100	0.511	Contact Map
3nreA	1	0.8299	100	0.523	Contact Map
4rnlA	1	0.949	100	0.526	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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