ZNUA - ECOLI - GREMLIN Contacts

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ZNUA - High-affinity zinc uptake system protein ZnuA

UniProt:	P39172	Sequences: MLHKKTLLFAALSAALWGGATQAADAAVVASLKPVGFIASAIADGVTETEVLLPDGASEHDYSLRPSDVKRLQNADLVVWVGPEMEAFMQKPVSKLPGAKQVTIAQLEDVKPLLMKSIHGDDDDHDHAEKSDEDHHHGDFNMHLWLSPEIARATAVAIHGKLVELMPQSRAKLDANLKDFEAQLASTETQVGNELAPLKGKGYFVFHDAYGYFEKQFGLTPLGHFTVNPEIQPGAQRLHEIRTQLVEQKATCVFAEPQFRPAVVESVARGTSVRMGTLDPLGTNIKLGKTSYSEFLSQLANQYASCLKGD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12678
Length:	310 (283)
Sequences:	5728 (4560)
Seq/√Len:	271.1

ECOLI - ZNUA
BACSU - ZNUA MNTA
HALSA - Q9HHR6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
152_R	185_A	4.020	1.00
46_V	169_S	3.875	1.00
43_A	47_T	3.810	1.00
166_M	173_L	3.810	1.00
46_V	172_K	3.737	1.00
159_H	177_L	3.520	1.00
190_Q	297_S	3.411	1.00
147_S	216_Q	3.352	1.00
188_E	217_F	3.233	1.00
156_V	181_E	3.138	1.00
170_R	174_D	2.854	1.00
27_A	48_E	2.588	1.00
41_A	183_Q	2.565	1.00
152_R	181_E	2.552	1.00
169_S	173_L	2.540	1.00
166_M	169_S	2.532	1.00
159_H	163_V	2.516	1.00
163_V	174_D	2.486	1.00
39_A	79_V	2.457	1.00
155_A	177_L	2.353	1.00
261_P	265_E	2.349	1.00
36_G	51_V	2.111	1.00
38_I	151_A	2.108	1.00
188_E	192_G	2.002	1.00
159_H	174_D	2.000	1.00
194_E	304_A	1.990	1.00
169_S	172_K	1.989	1.00
202_G	220_T	1.972	1.00
265_E	269_R	1.959	1.00
163_V	170_R	1.944	1.00
50_E	71_R	1.922	1.00
177_L	181_E	1.915	1.00
172_K	176_N	1.908	1.00
39_A	162_L	1.893	1.00
29_V	75_A	1.892	1.00
39_A	158_I	1.860	1.00
245_L	271_T	1.855	1.00
36_G	40_S	1.821	1.00
191_V	300_A	1.806	1.00
109_D	157_A	1.796	1.00
243_T	247_E	1.785	1.00
25_D	48_E	1.774	1.00
290_T	294_E	1.729	1.00
244_Q	248_Q	1.670	1.00
190_Q	301_N	1.650	1.00
149_E	216_Q	1.610	1.00
179_D	183_Q	1.610	1.00
291_S	294_E	1.567	1.00
155_A	180_F	1.565	1.00
161_K	164_E	1.559	1.00
105_A	108_E	1.556	1.00
171_A	175_A	1.553	1.00
183_Q	293_S	1.549	1.00
79_V	106_Q	1.540	1.00
239_H	243_T	1.531	1.00
38_I	180_F	1.523	1.00
68_D	71_R	1.522	1.00
301_N	305_S	1.505	1.00
43_A	162_L	1.497	1.00
204_F	245_L	1.493	1.00
77_L	161_K	1.481	1.00
175_A	179_D	1.473	1.00
150_I	153_A	1.452	1.00
161_K	165_L	1.447	1.00
77_L	165_L	1.443	1.00
46_V	166_M	1.438	1.00
202_G	248_Q	1.437	1.00
190_Q	194_E	1.424	1.00
27_A	76_D	1.422	1.00
37_F	41_A	1.412	1.00
213_F	300_A	1.386	1.00
254_F	306_C	1.382	1.00
185_A	189_T	1.375	1.00
46_V	176_N	1.367	1.00
174_D	178_K	1.366	1.00
102_V	164_E	1.356	1.00
149_E	188_E	1.355	1.00
27_A	50_E	1.354	1.00
178_K	182_A	1.341	1.00
183_Q	297_S	1.337	1.00
67_S	70_K	1.336	1.00
194_E	301_N	1.336	1.00
42_I	177_L	1.335	1.00
191_V	213_F	1.329	1.00
189_T	193_N	1.316	1.00
26_A	165_L	1.301	1.00
28_V	162_L	1.299	1.00
153_A	157_A	1.280	1.00
41_A	180_F	1.268	1.00
186_S	190_Q	1.264	1.00
106_Q	154_T	1.263	1.00
144_L	154_T	1.261	1.00
181_E	185_A	1.255	1.00
30_A	36_G	1.251	1.00
156_V	159_H	1.229	1.00
70_K	74_N	1.227	1.00
38_I	155_A	1.219	1.00
28_V	47_T	1.214	1.00
79_V	104_I	1.208	1.00
237_R	240_E	1.205	1.00
192_G	196_A	1.204	1.00
80_W	105_A	1.195	1.00
178_K	181_E	1.191	1.00
102_V	165_L	1.181	1.00
182_A	186_S	1.179	1.00
297_S	301_N	1.167	1.00
42_I	155_A	1.165	1.00
191_V	296_L	1.161	1.00
80_W	89_M	1.157	1.00
171_A	174_D	1.156	1.00
113_L	215_K	1.149	1.00
298_Q	302_Q	1.149	1.00
62_Y	68_D	1.140	1.00
64_L	88_F	1.132	1.00
214_E	219_L	1.131	1.00
160_G	163_V	1.128	1.00
44_D	172_K	1.127	1.00
147_S	150_I	1.124	1.00
41_A	293_S	1.112	1.00
245_L	273_V	1.098	1.00
242_R	270_G	1.090	1.00
242_R	267_V	1.084	1.00
233_P	263_V	1.084	1.00
156_V	160_G	1.082	1.00
35_V	106_Q	1.079	1.00
200_G	251_T	1.077	1.00
172_K	175_A	1.073	1.00
182_A	185_A	1.068	1.00
157_A	161_K	1.061	1.00
60_H	143_H	1.060	1.00
38_I	158_I	1.054	1.00
176_N	179_D	1.050	1.00
175_A	178_K	1.050	1.00
222_L	244_Q	1.041	1.00
210_Y	278_L	1.038	1.00
37_F	180_F	1.038	1.00
30_A	51_V	1.037	1.00
141_N	211_G	1.033	1.00
156_V	177_L	1.011	1.00
153_A	156_V	1.000	1.00
149_E	152_R	0.998	1.00
8_L	11_A	0.992	1.00
79_V	158_I	0.991	1.00
30_A	39_A	0.991	1.00
201_K	218_G	0.990	1.00
26_A	43_A	0.984	1.00
81_V	154_T	0.981	1.00
198_L	201_K	0.981	1.00
26_A	47_T	0.970	1.00
28_V	77_L	0.970	1.00
301_N	304_A	0.965	1.00
46_V	173_L	0.965	1.00
195_L	300_A	0.963	1.00
241_I	267_V	0.963	1.00
208_D	223_G	0.962	1.00
183_Q	186_S	0.959	1.00
110_V	113_L	0.955	1.00
148_P	184_L	0.952	1.00
192_G	216_Q	0.951	1.00
150_I	215_K	0.949	1.00
42_I	173_L	0.949	1.00
11_A	14_A	0.948	1.00
29_V	52_L	0.948	1.00
290_T	298_Q	0.946	1.00
179_D	182_A	0.946	1.00
29_V	71_R	0.941	1.00
29_V	50_E	0.933	1.00
298_Q	301_N	0.927	1.00
110_V	150_I	0.926	1.00
203_Y	214_E	0.923	1.00
202_G	222_L	0.922	1.00
152_R	156_V	0.900	1.00
151_A	296_L	0.896	1.00
150_I	154_T	0.893	1.00
242_R	246_V	0.890	1.00
78_V	89_M	0.888	1.00
104_I	161_K	0.886	1.00
255_A	275_M	0.885	1.00
158_I	162_L	0.884	1.00
254_F	278_L	0.882	1.00
279_D	282_G	0.881	1.00
252_C	276_G	0.874	1.00
253_V	268_A	0.871	1.00
135_H	138_G	0.869	1.00
188_E	216_Q	0.867	1.00
43_A	49_T	0.867	1.00
58_S	61_D	0.866	1.00
83_P	112_P	0.866	1.00
180_F	184_L	0.861	1.00
148_P	216_Q	0.851	1.00
35_V	154_T	0.849	1.00
155_A	181_E	0.844	1.00
159_H	181_E	0.842	1.00
268_A	272_S	0.838	1.00
28_V	43_A	0.832	0.99
91_K	94_S	0.830	0.99
205_V	208_D	0.826	0.99
160_G	164_E	0.825	0.99
7_L	10_A	0.816	0.99
30_A	49_T	0.816	0.99
240_E	243_T	0.814	0.99
252_C	306_C	0.810	0.99
160_G	174_D	0.805	0.99
184_L	187_T	0.805	0.99
193_N	196_A	0.801	0.99
148_P	296_L	0.798	0.99
157_A	160_G	0.795	0.99
79_V	161_K	0.795	0.99
93_V	103_T	0.794	0.99
203_Y	219_L	0.789	0.99
26_A	76_D	0.786	0.99
205_V	210_Y	0.785	0.99
37_F	40_S	0.785	0.99
190_Q	304_A	0.768	0.99
268_A	275_M	0.765	0.99
300_A	304_A	0.765	0.99
258_Q	279_D	0.763	0.99
220_T	248_Q	0.761	0.99
69_V	92_P	0.750	0.99
279_D	283_T	0.748	0.99
203_Y	303_Y	0.748	0.99
38_I	154_T	0.748	0.99
78_V	93_V	0.746	0.99
292_Y	296_L	0.743	0.99
203_Y	221_P	0.740	0.99
28_V	39_A	0.739	0.99
102_V	161_K	0.736	0.99
234_G	237_R	0.734	0.99
77_L	104_I	0.731	0.99
156_V	178_K	0.728	0.99
42_I	176_N	0.726	0.99
240_E	244_Q	0.724	0.99
39_A	43_A	0.724	0.99
296_L	300_A	0.724	0.99
149_E	192_G	0.722	0.99
29_V	72_L	0.722	0.99
41_A	176_N	0.721	0.99
221_P	224_H	0.717	0.98
43_A	46_V	0.717	0.98
193_N	197_P	0.714	0.98
30_A	35_V	0.713	0.98
280_P	285_I	0.713	0.98
243_T	246_V	0.713	0.98
262_A	265_E	0.713	0.98
190_Q	300_A	0.712	0.98
185_A	188_E	0.712	0.98
236_Q	239_H	0.709	0.98
27_A	74_N	0.708	0.98
214_E	221_P	0.707	0.98
284_N	287_L	0.705	0.98
174_D	177_L	0.704	0.98
26_A	166_M	0.704	0.98
80_W	103_T	0.701	0.98
204_F	241_I	0.701	0.98
106_Q	157_A	0.701	0.98
186_S	189_T	0.699	0.98
54_P	57_A	0.698	0.98
107_L	110_V	0.696	0.98
194_E	198_L	0.694	0.98
197_P	304_A	0.694	0.98
282_G	287_L	0.691	0.98
163_V	177_L	0.691	0.98
155_A	159_H	0.685	0.98
83_P	107_L	0.681	0.98
110_V	153_A	0.680	0.98
281_L	285_I	0.678	0.98
47_T	162_L	0.677	0.98
294_E	297_S	0.677	0.98
9_F	12_L	0.674	0.98
28_V	49_T	0.673	0.98
98_G	101_Q	0.672	0.98
58_S	229_P	0.672	0.98
26_A	162_L	0.670	0.98
36_G	49_T	0.670	0.98
276_G	302_Q	0.668	0.98
76_D	165_L	0.667	0.98
155_A	184_L	0.666	0.98
6_T	9_F	0.665	0.98
89_M	93_V	0.665	0.98
195_L	219_L	0.664	0.98
148_P	188_E	0.663	0.97
151_A	154_T	0.662	0.97
152_R	184_L	0.662	0.97
190_Q	193_N	0.662	0.97
279_D	285_I	0.655	0.97
72_L	92_P	0.651	0.97
183_Q	291_S	0.649	0.97
206_F	255_A	0.648	0.97
134_D	137_H	0.647	0.97
278_L	303_Y	0.643	0.97
52_L	72_L	0.642	0.97
267_V	271_T	0.640	0.97
8_L	12_L	0.640	0.97
197_P	200_G	0.639	0.97
264_V	268_A	0.636	0.97
255_A	277_T	0.633	0.97
35_V	81_V	0.630	0.97
59_E	258_Q	0.628	0.97
275_M	278_L	0.623	0.96
67_S	71_R	0.622	0.96
44_D	179_D	0.620	0.96
151_A	292_Y	0.616	0.96
83_P	142_M	0.616	0.96
31_S	80_W	0.615	0.96
255_A	264_V	0.613	0.96
31_S	86_E	0.613	0.96
281_L	284_N	0.606	0.96
194_E	197_P	0.606	0.96
42_I	159_H	0.605	0.96
148_P	293_S	0.601	0.96
163_V	173_L	0.601	0.96
207_H	256_E	0.601	0.96
136_H	139_D	0.600	0.95
274_R	305_S	0.599	0.95
41_A	291_S	0.598	0.95
104_I	158_I	0.597	0.95
159_H	173_L	0.597	0.95
35_V	79_V	0.596	0.95
253_V	264_V	0.594	0.95
114_L	117_S	0.594	0.95
81_V	144_L	0.594	0.95
104_I	157_A	0.592	0.95
107_L	144_L	0.591	0.95
204_F	250_A	0.589	0.95
245_L	253_V	0.588	0.95
257_P	279_D	0.588	0.95
144_L	150_I	0.588	0.95
110_V	157_A	0.588	0.95
152_R	159_H	0.585	0.95
258_Q	283_T	0.585	0.95
191_V	195_L	0.584	0.95
20_A	24_A	0.583	0.95
103_T	106_Q	0.580	0.95
184_L	292_Y	0.580	0.95
87_A	90_Q	0.580	0.95
255_A	259_F	0.580	0.95
78_V	101_Q	0.579	0.95
112_P	115_M	0.579	0.95
293_S	296_L	0.578	0.94
110_V	115_M	0.578	0.94
102_V	106_Q	0.578	0.94
21_T	24_A	0.577	0.94
81_V	85_M	0.576	0.94
208_D	228_N	0.575	0.94
102_V	107_L	0.575	0.94
143_H	207_H	0.574	0.94
194_E	300_A	0.574	0.94
296_L	299_L	0.573	0.94
238_L	266_S	0.572	0.94
246_V	272_S	0.571	0.94
213_F	303_Y	0.570	0.94
192_G	218_G	0.570	0.94
134_D	138_G	0.570	0.94
198_L	304_A	0.570	0.94
195_L	198_L	0.568	0.94
213_F	217_F	0.566	0.94
222_L	241_I	0.566	0.94
302_Q	305_S	0.562	0.94
111_K	114_L	0.562	0.94
266_S	269_R	0.561	0.94
22_Q	25_D	0.560	0.94
205_V	221_P	0.560	0.94
242_R	271_T	0.558	0.93
147_S	215_K	0.555	0.93
266_S	270_G	0.553	0.93
222_L	240_E	0.552	0.93
45_G	172_K	0.551	0.93
42_I	163_V	0.551	0.93
209_A	256_E	0.551	0.93
219_L	307_L	0.549	0.93
236_Q	240_E	0.546	0.93
225_F	231_I	0.544	0.93
270_G	273_V	0.544	0.93
207_H	225_F	0.543	0.92
32_L	58_S	0.543	0.92
293_S	297_S	0.540	0.92
72_L	96_L	0.540	0.92
107_L	112_P	0.540	0.92
226_T	229_P	0.539	0.92
204_F	244_Q	0.538	0.92
148_P	191_V	0.537	0.92
117_S	135_H	0.536	0.92
187_T	293_S	0.533	0.92
90_Q	94_S	0.530	0.92
33_K	36_G	0.527	0.91
33_K	37_F	0.525	0.91
146_L	296_L	0.525	0.91
191_V	217_F	0.523	0.91
61_D	87_A	0.522	0.91
256_E	259_F	0.522	0.91
113_L	212_Y	0.520	0.91
10_A	13_S	0.520	0.91
28_V	79_V	0.518	0.91
268_A	271_T	0.517	0.91
281_L	295_F	0.515	0.90
69_V	73_Q	0.515	0.90
141_N	207_H	0.514	0.90
25_D	43_A	0.513	0.90
34_P	37_F	0.512	0.90
246_V	270_G	0.511	0.90
148_P	217_F	0.511	0.90
206_F	259_F	0.508	0.90
206_F	267_V	0.507	0.90
258_Q	280_P	0.507	0.90
180_F	293_S	0.506	0.90
106_Q	161_K	0.506	0.90
114_L	140_F	0.506	0.90
235_A	239_H	0.506	0.90
7_L	11_A	0.506	0.90
177_L	180_F	0.505	0.90
189_T	192_G	0.505	0.90
72_L	78_V	0.505	0.90
66_P	235_A	0.505	0.90
211_G	215_K	0.505	0.90
59_E	282_G	0.505	0.90
90_Q	93_V	0.504	0.89
53_L	59_E	0.503	0.89
80_W	90_Q	0.503	0.89
23_A	48_E	0.503	0.89
180_F	183_Q	0.503	0.89
62_Y	88_F	0.503	0.89
205_V	214_E	0.500	0.89
93_V	98_G	0.500	0.89
9_F	17_W	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xrvA	1	0.8387	100	0.109	Contact Map
2o1eA	1	0.8484	100	0.114	Contact Map
2prsA	1	0.8484	100	0.124	Contact Map
4utoA	1	0.8645	100	0.141	Contact Map
3cx3A	1	0.8548	100	0.145	Contact Map
1pq4A	1	0.8387	100	0.153	Contact Map
1toaA	1	0.8613	100	0.162	Contact Map
3ujpA	4	0.8677	100	0.167	Contact Map
4nnoA	1	0.8677	100	0.168	Contact Map
4h0fA	1	0.8516	100	0.175	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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