GREMLIN Database
ZNUA - High-affinity zinc uptake system protein ZnuA
UniProt: P39172 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12678
Length: 310 (283)
Sequences: 5728 (4560)
Seq/√Len: 271.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_R185_A4.0201.00
46_V169_S3.8751.00
43_A47_T3.8101.00
166_M173_L3.8101.00
46_V172_K3.7371.00
159_H177_L3.5201.00
190_Q297_S3.4111.00
147_S216_Q3.3521.00
188_E217_F3.2331.00
156_V181_E3.1381.00
170_R174_D2.8541.00
27_A48_E2.5881.00
41_A183_Q2.5651.00
152_R181_E2.5521.00
169_S173_L2.5401.00
166_M169_S2.5321.00
159_H163_V2.5161.00
163_V174_D2.4861.00
39_A79_V2.4571.00
155_A177_L2.3531.00
261_P265_E2.3491.00
36_G51_V2.1111.00
38_I151_A2.1081.00
188_E192_G2.0021.00
159_H174_D2.0001.00
194_E304_A1.9901.00
169_S172_K1.9891.00
202_G220_T1.9721.00
265_E269_R1.9591.00
163_V170_R1.9441.00
50_E71_R1.9221.00
177_L181_E1.9151.00
172_K176_N1.9081.00
39_A162_L1.8931.00
29_V75_A1.8921.00
39_A158_I1.8601.00
245_L271_T1.8551.00
36_G40_S1.8211.00
191_V300_A1.8061.00
109_D157_A1.7961.00
243_T247_E1.7851.00
25_D48_E1.7741.00
290_T294_E1.7291.00
244_Q248_Q1.6701.00
190_Q301_N1.6501.00
149_E216_Q1.6101.00
179_D183_Q1.6101.00
291_S294_E1.5671.00
155_A180_F1.5651.00
161_K164_E1.5591.00
105_A108_E1.5561.00
171_A175_A1.5531.00
183_Q293_S1.5491.00
79_V106_Q1.5401.00
239_H243_T1.5311.00
38_I180_F1.5231.00
68_D71_R1.5221.00
301_N305_S1.5051.00
43_A162_L1.4971.00
204_F245_L1.4931.00
77_L161_K1.4811.00
175_A179_D1.4731.00
150_I153_A1.4521.00
161_K165_L1.4471.00
77_L165_L1.4431.00
46_V166_M1.4381.00
202_G248_Q1.4371.00
190_Q194_E1.4241.00
27_A76_D1.4221.00
37_F41_A1.4121.00
213_F300_A1.3861.00
254_F306_C1.3821.00
185_A189_T1.3751.00
46_V176_N1.3671.00
174_D178_K1.3661.00
102_V164_E1.3561.00
149_E188_E1.3551.00
27_A50_E1.3541.00
178_K182_A1.3411.00
183_Q297_S1.3371.00
67_S70_K1.3361.00
194_E301_N1.3361.00
42_I177_L1.3351.00
191_V213_F1.3291.00
189_T193_N1.3161.00
26_A165_L1.3011.00
28_V162_L1.2991.00
153_A157_A1.2801.00
41_A180_F1.2681.00
186_S190_Q1.2641.00
106_Q154_T1.2631.00
144_L154_T1.2611.00
181_E185_A1.2551.00
30_A36_G1.2511.00
156_V159_H1.2291.00
70_K74_N1.2271.00
38_I155_A1.2191.00
28_V47_T1.2141.00
79_V104_I1.2081.00
237_R240_E1.2051.00
192_G196_A1.2041.00
80_W105_A1.1951.00
178_K181_E1.1911.00
102_V165_L1.1811.00
182_A186_S1.1791.00
297_S301_N1.1671.00
42_I155_A1.1651.00
191_V296_L1.1611.00
80_W89_M1.1571.00
171_A174_D1.1561.00
113_L215_K1.1491.00
298_Q302_Q1.1491.00
62_Y68_D1.1401.00
64_L88_F1.1321.00
214_E219_L1.1311.00
160_G163_V1.1281.00
44_D172_K1.1271.00
147_S150_I1.1241.00
41_A293_S1.1121.00
245_L273_V1.0981.00
242_R270_G1.0901.00
242_R267_V1.0841.00
233_P263_V1.0841.00
156_V160_G1.0821.00
35_V106_Q1.0791.00
200_G251_T1.0771.00
172_K175_A1.0731.00
182_A185_A1.0681.00
157_A161_K1.0611.00
60_H143_H1.0601.00
38_I158_I1.0541.00
176_N179_D1.0501.00
175_A178_K1.0501.00
222_L244_Q1.0411.00
210_Y278_L1.0381.00
37_F180_F1.0381.00
30_A51_V1.0371.00
141_N211_G1.0331.00
156_V177_L1.0111.00
153_A156_V1.0001.00
149_E152_R0.9981.00
8_L11_A0.9921.00
79_V158_I0.9911.00
30_A39_A0.9911.00
201_K218_G0.9901.00
26_A43_A0.9841.00
81_V154_T0.9811.00
198_L201_K0.9811.00
26_A47_T0.9701.00
28_V77_L0.9701.00
301_N304_A0.9651.00
46_V173_L0.9651.00
195_L300_A0.9631.00
241_I267_V0.9631.00
208_D223_G0.9621.00
183_Q186_S0.9591.00
110_V113_L0.9551.00
148_P184_L0.9521.00
192_G216_Q0.9511.00
150_I215_K0.9491.00
42_I173_L0.9491.00
11_A14_A0.9481.00
29_V52_L0.9481.00
290_T298_Q0.9461.00
179_D182_A0.9461.00
29_V71_R0.9411.00
29_V50_E0.9331.00
298_Q301_N0.9271.00
110_V150_I0.9261.00
203_Y214_E0.9231.00
202_G222_L0.9221.00
152_R156_V0.9001.00
151_A296_L0.8961.00
150_I154_T0.8931.00
242_R246_V0.8901.00
78_V89_M0.8881.00
104_I161_K0.8861.00
255_A275_M0.8851.00
158_I162_L0.8841.00
254_F278_L0.8821.00
279_D282_G0.8811.00
252_C276_G0.8741.00
253_V268_A0.8711.00
135_H138_G0.8691.00
188_E216_Q0.8671.00
43_A49_T0.8671.00
58_S61_D0.8661.00
83_P112_P0.8661.00
180_F184_L0.8611.00
148_P216_Q0.8511.00
35_V154_T0.8491.00
155_A181_E0.8441.00
159_H181_E0.8421.00
268_A272_S0.8381.00
28_V43_A0.8320.99
91_K94_S0.8300.99
205_V208_D0.8260.99
160_G164_E0.8250.99
7_L10_A0.8160.99
30_A49_T0.8160.99
240_E243_T0.8140.99
252_C306_C0.8100.99
160_G174_D0.8050.99
184_L187_T0.8050.99
193_N196_A0.8010.99
148_P296_L0.7980.99
157_A160_G0.7950.99
79_V161_K0.7950.99
93_V103_T0.7940.99
203_Y219_L0.7890.99
26_A76_D0.7860.99
205_V210_Y0.7850.99
37_F40_S0.7850.99
190_Q304_A0.7680.99
268_A275_M0.7650.99
300_A304_A0.7650.99
258_Q279_D0.7630.99
220_T248_Q0.7610.99
69_V92_P0.7500.99
279_D283_T0.7480.99
203_Y303_Y0.7480.99
38_I154_T0.7480.99
78_V93_V0.7460.99
292_Y296_L0.7430.99
203_Y221_P0.7400.99
28_V39_A0.7390.99
102_V161_K0.7360.99
234_G237_R0.7340.99
77_L104_I0.7310.99
156_V178_K0.7280.99
42_I176_N0.7260.99
240_E244_Q0.7240.99
39_A43_A0.7240.99
296_L300_A0.7240.99
149_E192_G0.7220.99
29_V72_L0.7220.99
41_A176_N0.7210.99
221_P224_H0.7170.98
43_A46_V0.7170.98
193_N197_P0.7140.98
30_A35_V0.7130.98
280_P285_I0.7130.98
243_T246_V0.7130.98
262_A265_E0.7130.98
190_Q300_A0.7120.98
185_A188_E0.7120.98
236_Q239_H0.7090.98
27_A74_N0.7080.98
214_E221_P0.7070.98
284_N287_L0.7050.98
174_D177_L0.7040.98
26_A166_M0.7040.98
80_W103_T0.7010.98
204_F241_I0.7010.98
106_Q157_A0.7010.98
186_S189_T0.6990.98
54_P57_A0.6980.98
107_L110_V0.6960.98
194_E198_L0.6940.98
197_P304_A0.6940.98
282_G287_L0.6910.98
163_V177_L0.6910.98
155_A159_H0.6850.98
83_P107_L0.6810.98
110_V153_A0.6800.98
281_L285_I0.6780.98
47_T162_L0.6770.98
294_E297_S0.6770.98
9_F12_L0.6740.98
28_V49_T0.6730.98
98_G101_Q0.6720.98
58_S229_P0.6720.98
26_A162_L0.6700.98
36_G49_T0.6700.98
276_G302_Q0.6680.98
76_D165_L0.6670.98
155_A184_L0.6660.98
6_T9_F0.6650.98
89_M93_V0.6650.98
195_L219_L0.6640.98
148_P188_E0.6630.97
151_A154_T0.6620.97
152_R184_L0.6620.97
190_Q193_N0.6620.97
279_D285_I0.6550.97
72_L92_P0.6510.97
183_Q291_S0.6490.97
206_F255_A0.6480.97
134_D137_H0.6470.97
278_L303_Y0.6430.97
52_L72_L0.6420.97
267_V271_T0.6400.97
8_L12_L0.6400.97
197_P200_G0.6390.97
264_V268_A0.6360.97
255_A277_T0.6330.97
35_V81_V0.6300.97
59_E258_Q0.6280.97
275_M278_L0.6230.96
67_S71_R0.6220.96
44_D179_D0.6200.96
151_A292_Y0.6160.96
83_P142_M0.6160.96
31_S80_W0.6150.96
255_A264_V0.6130.96
31_S86_E0.6130.96
281_L284_N0.6060.96
194_E197_P0.6060.96
42_I159_H0.6050.96
148_P293_S0.6010.96
163_V173_L0.6010.96
207_H256_E0.6010.96
136_H139_D0.6000.95
274_R305_S0.5990.95
41_A291_S0.5980.95
104_I158_I0.5970.95
159_H173_L0.5970.95
35_V79_V0.5960.95
253_V264_V0.5940.95
114_L117_S0.5940.95
81_V144_L0.5940.95
104_I157_A0.5920.95
107_L144_L0.5910.95
204_F250_A0.5890.95
245_L253_V0.5880.95
257_P279_D0.5880.95
144_L150_I0.5880.95
110_V157_A0.5880.95
152_R159_H0.5850.95
258_Q283_T0.5850.95
191_V195_L0.5840.95
20_A24_A0.5830.95
103_T106_Q0.5800.95
184_L292_Y0.5800.95
87_A90_Q0.5800.95
255_A259_F0.5800.95
78_V101_Q0.5790.95
112_P115_M0.5790.95
293_S296_L0.5780.94
110_V115_M0.5780.94
102_V106_Q0.5780.94
21_T24_A0.5770.94
81_V85_M0.5760.94
208_D228_N0.5750.94
102_V107_L0.5750.94
143_H207_H0.5740.94
194_E300_A0.5740.94
296_L299_L0.5730.94
238_L266_S0.5720.94
246_V272_S0.5710.94
213_F303_Y0.5700.94
192_G218_G0.5700.94
134_D138_G0.5700.94
198_L304_A0.5700.94
195_L198_L0.5680.94
213_F217_F0.5660.94
222_L241_I0.5660.94
302_Q305_S0.5620.94
111_K114_L0.5620.94
266_S269_R0.5610.94
22_Q25_D0.5600.94
205_V221_P0.5600.94
242_R271_T0.5580.93
147_S215_K0.5550.93
266_S270_G0.5530.93
222_L240_E0.5520.93
45_G172_K0.5510.93
42_I163_V0.5510.93
209_A256_E0.5510.93
219_L307_L0.5490.93
236_Q240_E0.5460.93
225_F231_I0.5440.93
270_G273_V0.5440.93
207_H225_F0.5430.92
32_L58_S0.5430.92
293_S297_S0.5400.92
72_L96_L0.5400.92
107_L112_P0.5400.92
226_T229_P0.5390.92
204_F244_Q0.5380.92
148_P191_V0.5370.92
117_S135_H0.5360.92
187_T293_S0.5330.92
90_Q94_S0.5300.92
33_K36_G0.5270.91
33_K37_F0.5250.91
146_L296_L0.5250.91
191_V217_F0.5230.91
61_D87_A0.5220.91
256_E259_F0.5220.91
113_L212_Y0.5200.91
10_A13_S0.5200.91
28_V79_V0.5180.91
268_A271_T0.5170.91
281_L295_F0.5150.90
69_V73_Q0.5150.90
141_N207_H0.5140.90
25_D43_A0.5130.90
34_P37_F0.5120.90
246_V270_G0.5110.90
148_P217_F0.5110.90
206_F259_F0.5080.90
206_F267_V0.5070.90
258_Q280_P0.5070.90
180_F293_S0.5060.90
106_Q161_K0.5060.90
114_L140_F0.5060.90
235_A239_H0.5060.90
7_L11_A0.5060.90
177_L180_F0.5050.90
189_T192_G0.5050.90
72_L78_V0.5050.90
66_P235_A0.5050.90
211_G215_K0.5050.90
59_E282_G0.5050.90
90_Q93_V0.5040.89
53_L59_E0.5030.89
80_W90_Q0.5030.89
23_A48_E0.5030.89
180_F183_Q0.5030.89
62_Y88_F0.5030.89
205_V214_E0.5000.89
93_V98_G0.5000.89
9_F17_W0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xrvA 1 0.8387 100 0.109 Contact Map
2o1eA 1 0.8484 100 0.114 Contact Map
2prsA 1 0.8484 100 0.124 Contact Map
4utoA 1 0.8645 100 0.141 Contact Map
3cx3A 1 0.8548 100 0.145 Contact Map
1pq4A 1 0.8387 100 0.153 Contact Map
1toaA 1 0.8613 100 0.162 Contact Map
3ujpA 4 0.8677 100 0.167 Contact Map
4nnoA 1 0.8677 100 0.168 Contact Map
4h0fA 1 0.8516 100 0.175 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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