GREMLIN Database
YCHO - Uncharacterized protein YchO
UniProt: P39165 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12405
Length: 464 (401)
Sequences: 337 (255)
Seq/√Len: 12.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_L318_L8.3191.00
222_E348_R6.0651.00
281_V284_V4.6191.00
256_R265_G4.2031.00
217_Q223_Q4.1311.00
158_S183_L3.9751.00
164_Q175_Y3.9320.99
431_V439_V3.6420.99
111_N336_N3.6300.99
187_L215_H3.6190.99
287_T303_G3.6040.99
210_P227_R3.5390.99
137_D334_Y3.3250.98
222_E350_R3.2810.98
313_P317_Q3.0530.97
286_V304_L3.0520.97
425_W448_L2.8930.96
148_G157_V2.7940.95
260_F293_G2.7880.94
148_G229_Y2.6950.93
171_W196_A2.6330.93
279_T323_V2.5520.91
74_N77_D2.5170.91
278_Y308_Y2.4780.90
393_I397_T2.4610.90
202_R331_G2.4030.89
155_G182_L2.3630.88
182_L225_M2.3500.87
433_D437_Q2.3310.87
398_P439_V2.2020.84
157_V187_L2.1830.83
413_P423_N2.1280.81
443_E446_L2.0950.80
413_P446_L2.0800.80
270_V294_E2.0480.79
150_T185_E2.0060.77
155_G223_Q2.0020.77
89_K291_K1.9650.76
210_P224_R1.9380.75
413_P425_W1.9210.74
216_E350_R1.8650.72
185_E215_H1.8590.71
415_W425_W1.8490.71
184_D187_L1.8210.70
229_Y253_F1.8190.70
66_F295_S1.7810.68
245_T396_L1.7670.67
150_T187_L1.7570.67
390_D408_W1.7530.67
397_T439_V1.6880.64
355_V398_P1.6840.63
290_H300_N1.6820.63
232_T248_S1.6760.63
179_Y188_Q1.6730.63
278_Y353_L1.6620.62
119_D302_L1.6600.62
132_F172_L1.6580.62
212_A215_H1.6530.62
159_N191_G1.6480.62
260_F266_Y1.6440.62
331_G335_D1.6360.61
167_A172_L1.6210.60
281_V438_R1.5930.59
352_T380_Y1.5860.59
401_Q407_G1.5740.58
136_Q266_Y1.5730.58
276_L295_S1.5640.58
366_P451_P1.5540.57
157_V185_E1.5440.57
390_D427_L1.5420.56
74_N78_T1.5410.56
313_P316_K1.5380.56
256_R346_E1.5340.56
423_N446_L1.5320.56
432_E438_R1.5140.55
119_D203_L1.5130.55
185_E350_R1.4930.54
185_E200_Y1.4880.54
122_G299_Q1.4840.53
150_T157_V1.4710.53
202_R335_D1.4700.53
200_Y429_V1.4560.52
178_F337_P1.4540.52
157_V287_T1.4310.51
368_E444_I1.4280.51
246_S289_Q1.4070.49
235_M245_T1.3980.49
229_Y336_N1.3960.49
429_V437_Q1.3880.48
190_A210_P1.3860.48
279_T285_T1.3850.48
346_E427_L1.3820.48
185_E218_T1.3810.48
413_P439_V1.3760.48
323_V331_G1.3740.48
148_G185_E1.3700.48
244_N327_Q1.3640.47
250_E259_L1.3560.47
143_T205_A1.3540.47
159_N340_N1.3530.47
95_S100_Q1.3520.47
130_S150_T1.3470.46
202_R234_R1.3460.46
437_Q446_L1.3400.46
200_Y328_S1.3380.46
240_Y357_L1.3370.46
393_I398_P1.3340.46
203_L315_K1.3230.45
212_A345_L1.3170.45
290_H396_L1.3070.44
159_N341_N1.2930.44
185_E346_E1.2870.43
352_T379_R1.2860.43
415_W439_V1.2860.43
60_A63_V1.2840.43
232_T235_M1.2840.43
250_E271_A1.2800.43
122_G270_V1.2760.43
439_V444_I1.2740.43
273_S347_Y1.2690.42
236_R278_Y1.2690.42
157_V229_Y1.2560.42
212_A258_D1.2530.42
249_L338_Q1.2510.41
187_L216_E1.2510.41
306_L320_A1.2440.41
170_N307_N1.2430.41
432_E446_L1.2410.41
207_F210_P1.2300.40
128_R179_Y1.2300.40
258_D263_G1.2220.40
289_Q301_N1.2080.39
148_G336_N1.2070.39
370_V375_Q1.2030.39
239_F263_G1.2000.39
390_D400_A1.1960.39
423_N431_V1.1810.38
220_T380_Y1.1780.38
413_P448_L1.1760.38
224_R346_E1.1620.37
156_L372_L1.1590.37
439_V446_L1.1580.37
66_F75_G1.1560.37
389_G427_L1.1540.37
115_D128_R1.1520.37
429_V439_V1.1470.36
142_L194_A1.1320.36
304_L329_L1.1300.36
232_T338_Q1.1260.35
259_L327_Q1.1250.35
188_Q196_A1.1250.35
415_W423_N1.1180.35
336_N355_V1.1110.35
378_S381_G1.1090.35
413_P438_R1.1030.34
310_F429_V1.1000.34
372_L444_I1.0990.34
308_Y313_P1.0970.34
388_Q441_S1.0930.34
97_Q101_H1.0880.34
143_T229_Y1.0860.34
119_D300_N1.0850.33
345_L404_S1.0840.33
231_L296_G1.0820.33
221_Q265_G1.0750.33
258_D262_S1.0710.33
164_Q258_D1.0690.33
191_G340_N1.0650.33
148_G181_N1.0580.32
110_G259_L1.0580.32
368_E427_L1.0570.32
252_Y271_A1.0550.32
136_Q225_M1.0540.32
220_T379_R1.0500.32
172_L331_G1.0440.32
221_Q244_N1.0410.31
81_Q88_G1.0390.31
250_E340_N1.0340.31
211_F224_R1.0330.31
275_G289_Q1.0320.31
381_G434_N1.0320.31
412_M446_L1.0270.31
122_G294_E1.0260.31
122_G291_K1.0240.31
289_Q300_N1.0220.31
303_G310_F1.0210.31
244_N252_Y1.0190.30
281_V308_Y1.0190.30
123_H328_S1.0170.30
106_L114_V1.0100.30
358_A372_L1.0080.30
119_D153_D1.0060.30
312_V317_Q0.9990.30
142_L331_G0.9960.29
135_L162_V0.9950.29
166_W451_P0.9940.29
288_A300_N0.9930.29
439_V442_N0.9920.29
406_E422_S0.9890.29
438_R441_S0.9870.29
183_L270_V0.9860.29
58_H61_E0.9800.29
389_G400_A0.9790.29
431_V446_L0.9700.28
140_R261_N0.9700.28
157_V196_A0.9670.28
385_L429_V0.9660.28
368_E409_T0.9630.28
427_L446_L0.9620.28
82_A85_F0.9570.28
170_N308_Y0.9560.28
182_L185_E0.9500.28
238_P387_W0.9500.28
160_V411_I0.9490.28
222_E338_Q0.9460.27
63_V68_E0.9420.27
244_N250_E0.9340.27
121_E234_R0.9320.27
405_A428_S0.9310.27
292_Q295_S0.9290.27
92_D218_T0.9280.27
55_G59_F0.9280.27
276_L284_V0.9280.27
79_G222_E0.9250.27
368_E411_I0.9240.26
246_S291_K0.9200.26
62_I71_M0.9160.26
96_Q212_A0.9160.26
80_E268_N0.9140.26
148_G341_N0.9130.26
67_G77_D0.9100.26
200_Y357_L0.9090.26
231_L363_D0.9040.26
181_N188_Q0.9040.26
258_D273_S0.8930.25
152_Q157_V0.8930.25
382_I397_T0.8890.25
116_V309_R0.8890.25
54_D59_F0.8890.25
53_H56_E0.8880.25
424_H447_T0.8860.25
235_M332_S0.8820.25
113_S128_R0.8820.25
203_L432_E0.8720.24
156_L328_S0.8700.24
429_V444_I0.8670.24
102_V109_W0.8670.24
67_G70_S0.8640.24
61_E315_K0.8640.24
147_L196_A0.8510.24
309_R312_V0.8470.24
288_A351_K0.8460.23
429_V432_E0.8460.23
226_A254_G0.8460.23
310_F412_M0.8430.23
132_F302_L0.8420.23
129_G284_V0.8400.23
178_F214_W0.8390.23
202_R329_L0.8390.23
259_L271_A0.8380.23
220_T352_T0.8380.23
63_V67_G0.8350.23
398_P431_V0.8340.23
204_S338_Q0.8330.23
185_E222_E0.8320.23
224_R227_R0.8310.23
148_G171_W0.8290.23
413_P441_S0.8280.23
169_G307_N0.8270.23
437_Q444_I0.8260.23
221_Q241_Q0.8240.23
432_E439_V0.8200.23
277_N285_T0.8190.22
252_Y259_L0.8160.22
104_S138_N0.8100.22
372_L389_G0.8070.22
310_F410_L0.8070.22
63_V71_M0.8060.22
427_L441_S0.8050.22
67_G288_A0.8050.22
240_Y335_D0.8050.22
232_T273_S0.8040.22
415_W446_L0.8000.22
358_A429_V0.7970.22
355_V444_I0.7940.22
250_E293_G0.7940.22
355_V431_V0.7930.22
231_L386_I0.7920.22
236_R243_L0.7910.21
245_T274_L0.7900.21
442_N451_P0.7890.21
57_K61_E0.7870.21
281_V359_T0.7810.21
289_Q302_L0.7810.21
173_V198_G0.7800.21
126_G308_Y0.7780.21
185_E229_Y0.7770.21
252_Y387_W0.7770.21
186_N215_H0.7760.21
291_K388_Q0.7760.21
452_F455_L0.7750.21
131_W440_S0.7740.21
312_V316_K0.7720.21
181_N430_V0.7680.21
117_K126_G0.7650.21
116_V260_F0.7650.21
278_Y408_W0.7630.21
294_E348_R0.7630.21
355_V393_I0.7600.20
278_Y313_P0.7590.20
189_R280_P0.7580.20
401_Q409_T0.7570.20
56_E60_A0.7560.20
117_K314_L0.7530.20
209_Q215_H0.7530.20
117_K218_T0.7500.20
148_G187_L0.7490.20
160_V297_E0.7480.20
438_R446_L0.7470.20
401_Q411_I0.7450.20
109_W112_A0.7420.20
315_K318_L0.7400.20
214_W347_Y0.7380.20
307_N383_R0.7370.20
204_S229_Y0.7350.20
214_W436_G0.7350.20
438_R444_I0.7340.20
276_L313_P0.7330.20
346_E353_L0.7310.19
263_G299_Q0.7280.19
176_N280_P0.7270.19
176_N189_R0.7270.19
256_R319_S0.7260.19
71_M80_E0.7260.19
127_S153_D0.7250.19
151_Q156_L0.7240.19
429_V442_N0.7240.19
111_N145_S0.7200.19
244_N340_N0.7190.19
279_T327_Q0.7190.19
361_P441_S0.7180.19
241_Q250_E0.7170.19
129_G149_L0.7120.19
116_V308_Y0.7110.19
353_L379_R0.7100.19
110_G275_G0.7090.19
358_A428_S0.7090.19
112_A197_W0.7080.19
432_E437_Q0.7040.19
393_I439_V0.7040.19
371_P374_L0.7030.19
187_L225_M0.7030.19
155_G343_P0.7020.19
263_G316_K0.7010.19
426_R445_T0.6990.18
116_V196_A0.6980.18
156_L216_E0.6970.18
129_G330_R0.6960.18
157_V289_Q0.6940.18
150_T229_Y0.6930.18
162_V253_F0.6930.18
81_Q356_F0.6930.18
160_V188_Q0.6910.18
148_G151_Q0.6910.18
212_A409_T0.6910.18
389_G416_Q0.6900.18
278_Y281_V0.6900.18
110_G197_W0.6900.18
376_I387_W0.6860.18
185_E212_A0.6830.18
288_A302_L0.6830.18
157_V218_T0.6820.18
167_A196_A0.6820.18
94_L194_A0.6820.18
75_G89_K0.6800.18
191_G327_Q0.6790.18
67_G74_N0.6780.18
87_L92_D0.6750.18
129_G190_A0.6750.18
261_N383_R0.6720.18
224_R425_W0.6720.18
442_N452_F0.6670.17
202_R233_A0.6670.17
156_L179_Y0.6660.17
385_L430_V0.6660.17
190_A328_S0.6660.17
160_V320_A0.6640.17
261_N273_S0.6640.17
90_V243_L0.6630.17
107_S393_I0.6600.17
246_S341_N0.6590.17
279_T331_G0.6580.17
96_Q295_S0.6580.17
244_N259_L0.6580.17
134_P163_G0.6570.17
259_L266_Y0.6560.17
132_F144_W0.6560.17
192_F216_E0.6550.17
246_S287_T0.6550.17
70_S76_L0.6540.17
353_L416_Q0.6530.17
156_L185_E0.6510.17
446_L451_P0.6490.17
425_W432_E0.6480.17
149_L235_M0.6460.17
125_T301_N0.6460.17
252_Y340_N0.6440.17
169_G302_L0.6440.17
236_R425_W0.6430.17
154_N290_H0.6420.17
159_N343_P0.6420.17
244_N266_Y0.6410.17
143_T164_Q0.6400.17
101_H129_G0.6400.17
182_L448_L0.6400.17
59_F192_F0.6390.17
163_G269_P0.6380.17
163_G347_Y0.6370.17
420_G437_Q0.6370.17
196_A292_Q0.6350.17
329_L332_S0.6340.17
246_S364_L0.6340.17
170_N268_N0.6320.16
75_G391_T0.6300.16
86_A260_F0.6300.16
376_I446_L0.6290.16
61_E236_R0.6270.16
195_E254_G0.6260.16
413_P419_E0.6260.16
150_T159_N0.6250.16
159_N334_Y0.6230.16
54_D192_F0.6230.16
245_T250_E0.6220.16
413_P431_V0.6200.16
74_N84_A0.6170.16
257_V346_E0.6170.16
373_K400_A0.6170.16
239_F378_S0.6150.16
316_K369_T0.6150.16
258_D299_Q0.6150.16
232_T347_Y0.6140.16
412_M448_L0.6110.16
183_L353_L0.6110.16
235_M319_S0.6110.16
162_V274_L0.6090.16
345_L350_R0.6080.16
113_S149_L0.6070.16
59_F66_F0.6070.16
261_N266_Y0.6060.16
220_T349_Q0.6060.16
164_Q236_R0.6060.16
306_L367_G0.6050.16
144_W244_N0.6050.16
112_A237_M0.6030.16
383_R434_N0.6030.16
244_N249_L0.6020.16
145_S211_F0.6000.16
57_K62_I0.5990.16
236_R308_Y0.5980.16
244_N323_V0.5980.16
324_A427_L0.5980.16
156_L268_N0.5960.15
188_Q286_V0.5950.15
94_L182_L0.5950.15
242_H271_A0.5940.15
200_Y252_Y0.5930.15
190_A229_Y0.5930.15
213_A367_G0.5930.15
240_Y323_V0.5920.15
170_N348_R0.5920.15
322_E377_R0.5920.15
197_W202_R0.5920.15
155_G184_D0.5910.15
67_G72_N0.5880.15
265_G346_E0.5880.15
103_E332_S0.5880.15
59_F63_V0.5870.15
187_L198_G0.5850.15
244_N265_G0.5830.15
147_L188_Q0.5810.15
245_T289_Q0.5810.15
94_L191_G0.5800.15
217_Q340_N0.5800.15
216_E318_L0.5800.15
156_L218_T0.5780.15
217_Q222_E0.5780.15
389_G397_T0.5780.15
261_N267_H0.5770.15
187_L223_Q0.5770.15
434_N455_L0.5760.15
353_L376_I0.5740.15
298_N383_R0.5740.15
328_S331_G0.5730.15
157_V216_E0.5730.15
102_V120_N0.5720.15
185_E216_E0.5720.15
128_R321_G0.5710.15
188_Q212_A0.5710.15
140_R234_R0.5710.15
58_H62_I0.5700.15
153_D340_N0.5680.15
370_V408_W0.5670.15
67_G71_M0.5660.15
147_L171_W0.5660.15
63_V69_T0.5650.15
179_Y255_D0.5630.15
110_G163_G0.5610.15
174_G208_Y0.5610.15
165_R208_Y0.5610.15
165_R174_G0.5610.15
165_R180_D0.5610.15
180_D208_Y0.5610.15
174_G180_D0.5610.15
264_T352_T0.5600.14
374_L400_A0.5590.14
331_G387_W0.5580.14
309_R334_Y0.5580.14
184_D215_H0.5570.14
150_T372_L0.5550.14
138_N141_Y0.5550.14
221_Q243_L0.5530.14
179_Y406_E0.5510.14
146_Q280_P0.5510.14
146_Q189_R0.5510.14
147_L185_E0.5510.14
185_E345_L0.5500.14
361_P397_T0.5490.14
220_T249_L0.5480.14
348_R389_G0.5470.14
350_R358_A0.5460.14
150_T184_D0.5460.14
310_F424_H0.5450.14
278_Y293_G0.5440.14
322_E367_G0.5440.14
74_N80_E0.5440.14
172_L340_N0.5440.14
390_D394_L0.5430.14
188_Q281_V0.5430.14
65_D160_V0.5430.14
181_N212_A0.5430.14
235_M377_R0.5420.14
150_T336_N0.5410.14
216_E222_E0.5390.14
236_R258_D0.5380.14
105_W210_P0.5360.14
412_M429_V0.5350.14
76_L81_Q0.5350.14
286_V315_K0.5340.14
189_R254_G0.5320.14
254_G280_P0.5320.14
234_R240_Y0.5310.14
102_V205_A0.5300.14
446_L450_E0.5290.14
144_W337_P0.5280.14
328_S372_L0.5260.14
415_W432_E0.5240.14
129_G342_L0.5240.14
60_A82_A0.5230.14
165_R193_G0.5230.14
180_D193_G0.5230.14
174_G193_G0.5230.14
193_G208_Y0.5230.14
153_D336_N0.5230.14
321_G344_T0.5230.14
199_E244_N0.5210.14
91_R95_S0.5210.14
154_N287_T0.5200.14
248_S296_G0.5200.14
114_V142_L0.5190.13
146_Q176_N0.5180.13
134_P144_W0.5180.13
72_N286_V0.5160.13
428_S441_S0.5160.13
265_G273_S0.5150.13
306_L382_I0.5140.13
191_G250_E0.5140.13
100_Q192_F0.5140.13
363_D406_E0.5110.13
415_W444_I0.5110.13
152_Q184_D0.5110.13
84_A145_S0.5110.13
161_G180_D0.5100.13
161_G165_R0.5100.13
161_G174_G0.5100.13
161_G208_Y0.5100.13
376_I381_G0.5100.13
362_W412_M0.5070.13
118_V147_L0.5060.13
156_L184_D0.5060.13
135_L242_H0.5060.13
78_T91_R0.5030.13
307_N334_Y0.5020.13
241_Q343_P0.5020.13
350_R452_F0.5020.13
144_W436_G0.5020.13
176_N254_G0.5020.13
233_A236_R0.5010.13
430_V445_T0.5010.13
103_E378_S0.5010.13
191_G259_L0.5000.13
250_E387_W0.5000.13
163_G254_G0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e1tA 1 0.5237 100 0.461 Contact Map
4e1sA 1 0.5172 100 0.469 Contact Map
3pddA 1 0.2198 95.4 0.961 Contact Map
2jmmA 1 0.3082 95.3 0.961 Contact Map
3qraA 1 0.3039 95.3 0.962 Contact Map
3pe9A 1 0.1918 95.1 0.962 Contact Map
1ormA 1 0.3017 94.3 0.963 Contact Map
1qjpA 1 0.2823 88.6 0.969 Contact Map
2x27X 1 0.3793 87.8 0.969 Contact Map
2k0lA 1 0.4138 86.8 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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