GREMLIN Database
CHAC - Glutathione-specific gamma-glutamylcyclotransferase
UniProt: P39163 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12403
Length: 231 (180)
Sequences: 839 (564)
Seq/√Len: 42.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_L213_V4.7251.00
65_E110_R4.7221.00
175_I189_L3.5111.00
197_I207_N2.9451.00
81_R163_E2.7661.00
193_E207_N2.6881.00
82_L95_M2.6861.00
207_N210_L2.3531.00
187_Q191_S2.3211.00
78_F189_L2.2761.00
85_G182_L2.0640.99
60_A122_L2.0430.99
175_I185_N2.0370.99
78_F175_I2.0320.99
212_S215_K2.0080.99
124_W128_M1.9880.99
48_W110_R1.9820.99
124_W153_F1.9680.99
69_G138_C1.9080.99
196_L206_L1.9040.99
80_L97_A1.8830.99
193_E210_L1.8660.99
210_L214_K1.8530.98
94_R192_L1.8450.98
94_R166_T1.8430.98
129_I161_E1.7570.98
66_S107_V1.7470.98
197_I210_L1.7410.98
163_E166_T1.7160.97
49_I123_L1.6250.96
168_A209_L1.6010.96
46_P110_R1.5750.96
46_P113_E1.5430.95
91_Q177_A1.5400.95
179_S184_T1.5270.95
174_L178_A1.4940.94
208_D212_S1.4820.94
70_T105_T1.4540.93
80_L132_C1.4400.93
190_F210_L1.4380.93
186_A190_F1.4300.93
128_M135_P1.3920.92
172_A175_I1.3860.92
80_L155_M1.3730.91
82_L85_G1.3680.91
68_T105_T1.3680.91
84_A128_M1.3610.91
56_M195_E1.3550.91
212_S216_L1.3490.90
168_A208_D1.3320.90
124_W135_P1.3260.90
99_K157_P1.3250.90
75_H102_G1.3240.90
142_L146_R1.3010.89
99_K162_Y1.2900.88
78_F172_A1.2780.88
51_G109_Y1.2750.88
80_L159_H1.2750.88
82_L182_L1.2530.87
169_Q212_S1.2490.87
48_W65_E1.2460.86
59_P150_A1.2350.86
78_F96_L1.2180.85
207_N214_K1.2060.85
185_N192_L1.2050.85
124_W131_G1.1740.83
192_L206_L1.1700.83
81_R174_L1.1670.83
79_C97_A1.1650.82
171_I205_G1.1540.82
134_L154_I1.1510.82
140_L150_A1.1470.81
190_F217_L1.1470.81
85_G119_E1.1390.81
176_A213_V1.1320.81
104_T192_L1.1260.80
124_W133_Y1.1220.80
85_G122_L1.1150.80
48_W108_A1.1120.79
153_F182_L1.0900.78
51_G85_G1.0780.77
173_P216_L1.0700.77
84_A182_L1.0590.76
56_M196_L1.0590.76
186_A217_L1.0550.76
173_P177_A1.0510.75
85_G185_N1.0490.75
190_F214_K1.0430.75
119_E124_W1.0420.75
59_P157_P1.0420.75
176_A186_A1.0250.74
209_L212_S1.0240.73
47_V116_L1.0180.73
123_L164_S1.0140.73
51_G123_L1.0080.72
129_I199_L1.0060.72
63_F109_Y1.0020.72
167_R170_V1.0000.72
82_L119_E0.9890.71
62_E115_T0.9860.71
166_T171_I0.9830.70
64_T112_P0.9820.70
46_P116_L0.9820.70
202_Q212_S0.9670.69
176_A189_L0.9650.69
64_T110_R0.9650.69
62_E111_L0.9520.68
47_V151_I0.9510.68
128_M133_Y0.9470.67
75_H169_Q0.9420.67
166_T192_L0.9350.66
63_F66_S0.9240.66
59_P111_L0.9230.65
157_P162_Y0.9170.65
134_L156_D0.9140.65
111_L119_E0.9130.65
84_A157_P0.9110.64
142_L148_V0.9080.64
72_V105_T0.9060.64
128_M182_L0.8930.63
87_G95_M0.8900.63
130_T159_H0.8880.62
58_N96_L0.8860.62
171_I174_L0.8860.62
95_M124_W0.8780.62
172_A213_V0.8750.61
81_R166_T0.8600.60
69_G140_L0.8530.59
84_A130_T0.8420.58
209_L213_V0.8390.58
58_N109_Y0.8360.58
191_S194_Q0.8360.58
69_G105_T0.8350.58
94_R125_K0.8330.57
85_G95_M0.8310.57
38_L41_R0.8300.57
50_F57_W0.8290.57
172_A176_A0.8240.57
155_M182_L0.8080.55
108_A140_L0.8050.55
85_G131_G0.8040.55
73_G206_L0.7890.53
40_C90_H0.7860.53
67_C146_R0.7790.52
128_M153_F0.7750.52
193_E206_L0.7740.52
95_M130_T0.7710.52
168_A211_V0.7650.51
69_G206_L0.7620.51
63_F143_D0.7610.51
80_L185_N0.7580.50
119_E122_L0.7580.50
190_F193_E0.7570.50
138_C152_V0.7560.50
75_H187_Q0.7540.50
67_C110_R0.7510.50
171_I209_L0.7440.49
82_L128_M0.7390.49
191_S195_E0.7370.49
51_G107_V0.7270.48
109_Y148_V0.7230.47
88_T109_Y0.7180.47
142_L145_G0.7170.47
58_N119_E0.7100.46
88_T181_P0.7040.45
78_F182_L0.7040.45
60_A119_E0.6960.45
189_L209_L0.6960.45
101_G151_I0.6960.45
91_Q178_A0.6880.44
68_T88_T0.6880.44
85_G159_H0.6870.44
172_A216_L0.6790.43
124_W130_T0.6700.42
97_A192_L0.6700.42
140_L147_T0.6690.42
70_T211_V0.6680.42
94_R104_T0.6670.42
104_T196_L0.6560.41
43_D211_V0.6540.41
47_V120_L0.6510.41
56_M158_R0.6500.40
194_Q198_K0.6420.40
129_I133_Y0.6410.40
54_S126_R0.6280.38
131_G159_H0.6260.38
104_T152_V0.6250.38
73_G101_G0.6240.38
45_G113_E0.6230.38
177_A212_S0.6180.38
213_V217_L0.6160.37
51_G63_F0.6150.37
124_W182_L0.6140.37
74_W186_A0.6140.37
131_G205_G0.6130.37
68_T190_F0.6090.37
142_L147_T0.6090.37
97_A185_N0.6070.37
178_A214_K0.6050.36
84_A181_P0.6050.36
101_G104_T0.6040.36
39_A42_P0.6030.36
96_L159_H0.6030.36
130_T205_G0.5980.36
80_L167_R0.5960.36
57_W178_A0.5900.35
48_W67_C0.5880.35
84_A119_E0.5880.35
56_M119_E0.5860.35
83_T161_E0.5840.35
56_M203_D0.5830.35
132_C155_M0.5810.34
56_M187_Q0.5800.34
61_L119_E0.5800.34
72_V139_Q0.5800.34
96_L140_L0.5770.34
63_F199_L0.5760.34
115_T118_Q0.5730.34
71_L97_A0.5730.34
202_Q207_N0.5710.34
130_T185_N0.5700.33
148_V206_L0.5670.33
195_E199_L0.5660.33
70_T103_R0.5650.33
119_E182_L0.5640.33
116_L198_K0.5630.33
85_G151_I0.5620.33
190_F213_V0.5620.33
139_Q147_T0.5610.33
78_F176_A0.5590.33
108_A150_A0.5590.33
168_A171_I0.5580.32
166_T174_L0.5570.32
170_V173_P0.5560.32
125_K128_M0.5550.32
118_Q121_T0.5550.32
55_L59_P0.5520.32
82_L125_K0.5500.32
141_D144_D0.5500.32
177_A194_Q0.5460.31
139_Q204_D0.5440.31
104_T138_C0.5430.31
94_R185_N0.5420.31
69_G150_A0.5400.31
94_R171_I0.5360.31
49_I179_S0.5330.30
83_T129_I0.5330.30
71_L152_V0.5320.30
74_W162_Y0.5290.30
60_A116_L0.5260.30
50_F106_G0.5220.30
69_G196_L0.5220.30
48_W196_L0.5200.29
95_M182_L0.5200.29
184_T187_Q0.5190.29
99_K165_D0.5190.29
100_E214_K0.5160.29
146_R204_D0.5150.29
159_H175_I0.5140.29
85_G181_P0.5110.29
51_G197_I0.5090.29
59_P122_L0.5080.28
182_L185_N0.5080.28
112_P143_D0.5060.28
88_T104_T0.5020.28
60_A85_G0.5020.28
171_I175_I0.5020.28
57_W161_E0.5020.28
77_A130_T0.5010.28
86_R126_R0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cryA 2 0.7013 100 0.607 Contact Map
2qikA 1 0.7749 100 0.618 Contact Map
3judA 1 0.5844 99.8 0.755 Contact Map
2jqvA 1 0.6797 99.8 0.763 Contact Map
2g0qA 1 0.6104 99.6 0.794 Contact Map
1xhsA 1 0.4675 98.1 0.89 Contact Map
1v30A 1 0.4892 97.9 0.896 Contact Map
1vkbA 1 0.5671 97 0.911 Contact Map
4issA 2 0.7359 84.2 0.942 Contact Map
4gysA 2 0.1861 79.5 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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