GREMLIN Database
UXUR - Uxu operon transcriptional regulator
UniProt: P39161 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20249
Length: 257 (207)
Sequences: 23156 (16963)
Seq/√Len: 1179.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_R209_I3.7461.00
111_E217_K3.3531.00
212_D215_A2.9361.00
133_E202_K2.7961.00
21_L26_P2.7541.00
28_N31_E2.7121.00
21_L42_M2.4371.00
104_L108_N2.3941.00
36_E47_R2.2651.00
124_K154_A2.2601.00
97_E162_S2.1771.00
15_G56_M2.1091.00
103_Q225_E2.1041.00
64_E74_L2.0511.00
19_R60_K2.0171.00
115_L213_A1.9871.00
100_Q112_F1.9551.00
14_V45_V1.9451.00
122_I209_I1.8821.00
121_D160_H1.8411.00
157_E165_V1.8301.00
207_A215_A1.7771.00
154_A157_E1.7691.00
14_V43_L1.7681.00
65_V71_I1.7521.00
17_M21_L1.7441.00
107_S221_W1.7131.00
118_T121_D1.7011.00
129_L205_L1.6791.00
111_E213_A1.6641.00
200_D226_N1.6401.00
108_N111_E1.6121.00
140_A143_S1.6061.00
101_A167_L1.6011.00
215_A219_A1.5921.00
217_K221_W1.5841.00
107_S217_K1.5771.00
20_D24_K1.5611.00
203_Q219_A1.5181.00
8_Q16_A1.4991.00
66_R69_A1.4641.00
166_E170_Q1.4571.00
131_L147_G1.4481.00
152_H201_H1.4321.00
121_D158_A1.4301.00
156_A168_F1.4261.00
110_A216_A1.4191.00
153_L169_R1.4181.00
163_M174_W1.4141.00
103_Q221_W1.4121.00
126_R205_L1.4111.00
128_A147_G1.4111.00
15_G60_K1.4021.00
206_A210_K1.3971.00
133_E198_L1.3871.00
210_K215_A1.3351.00
103_Q228_K1.3291.00
213_A217_K1.3251.00
37_R41_E1.3181.00
117_A122_I1.3141.00
97_E163_M1.3061.00
202_K206_A1.2901.00
129_L202_K1.2591.00
131_L150_Q1.2521.00
127_Q131_L1.2441.00
38_E42_M1.2351.00
32_R72_Y1.2171.00
39_I50_V1.2111.00
126_R130_Q1.2071.00
13_E17_M1.2031.00
128_A154_A1.2001.00
66_R72_Y1.1991.00
218_L222_Q1.1821.00
96_F232_L1.1771.00
103_Q107_S1.1761.00
221_W225_E1.1761.00
96_F228_K1.1701.00
153_L157_E1.1581.00
17_M43_L1.1521.00
150_Q154_A1.1521.00
200_D223_H1.1461.00
21_L43_L1.1441.00
117_A121_D1.1411.00
107_S111_E1.1371.00
17_M20_D1.1341.00
102_R106_E1.1291.00
117_A211_K1.1211.00
215_A218_L1.1151.00
117_A158_A1.1141.00
110_A220_M1.1081.00
27_Y73_V1.1041.00
111_E214_R1.1021.00
122_I205_L1.1001.00
155_I208_L1.1001.00
58_E65_V1.0931.00
206_A209_I1.0751.00
143_S146_S1.0721.00
110_A114_A1.0711.00
97_E161_N1.0691.00
129_L133_E1.0631.00
147_G150_Q1.0631.00
109_I156_A1.0581.00
129_L132_E1.0571.00
205_L209_I1.0561.00
154_A158_A1.0551.00
148_D152_H1.0551.00
228_K232_L1.0481.00
126_R202_K1.0411.00
128_A150_Q1.0371.00
122_I211_K1.0321.00
100_Q161_N1.0191.00
124_K157_E1.0181.00
58_E63_V1.0151.00
64_E72_Y1.0141.00
167_L170_Q1.0081.00
130_Q133_E1.0031.00
124_K127_Q1.0011.00
52_E55_I0.9941.00
152_H223_H0.9881.00
207_A212_D0.9791.00
108_N217_K0.9771.00
21_L27_Y0.9731.00
112_F116_Q0.9701.00
114_A213_A0.9691.00
36_E51_R0.9571.00
201_H223_H0.9541.00
22_I73_V0.9531.00
8_Q13_E0.9531.00
151_F205_L0.9431.00
199_G203_Q0.9421.00
203_Q222_Q0.9421.00
203_Q215_A0.9311.00
146_S150_Q0.9261.00
124_K128_A0.9261.00
106_E152_H0.9231.00
56_M59_I0.9171.00
123_V127_Q0.9171.00
54_L71_I0.9161.00
159_T165_V0.9131.00
11_Y56_M0.9091.00
116_Q160_H0.9051.00
114_A208_L0.8981.00
66_R70_G0.8951.00
108_N112_F0.8941.00
203_Q206_A0.8891.00
165_V169_R0.8841.00
204_I220_M0.8841.00
122_I126_R0.8831.00
63_V71_I0.8781.00
15_G19_R0.8771.00
128_A131_L0.8771.00
214_R218_L0.8751.00
94_G163_M0.8721.00
32_R70_G0.8601.00
69_A72_Y0.8541.00
134_R138_S0.8541.00
40_A50_V0.8491.00
19_R23_I0.8471.00
102_R224_L0.8411.00
135_E143_S0.8381.00
93_A160_H0.8371.00
214_R217_K0.8351.00
101_A163_M0.8321.00
126_R206_A0.8231.00
19_R62_L0.8221.00
131_L134_R0.8211.00
198_L202_K0.8181.00
114_A211_K0.8171.00
93_A97_E0.8151.00
113_A158_A0.8151.00
130_Q134_R0.8141.00
153_L172_W0.8141.00
55_I58_E0.8071.00
148_D201_H0.8071.00
121_D124_K0.8071.00
38_E41_E0.8071.00
119_R123_V0.8041.00
10_P13_E0.8031.00
203_Q207_A0.8011.00
204_I219_A0.7971.00
46_T49_V0.7931.00
125_M154_A0.7891.00
119_R211_K0.7871.00
163_M167_L0.7851.00
132_E144_S0.7801.00
114_A216_A0.7771.00
35_P38_E0.7751.00
54_L63_V0.7741.00
117_A208_L0.7691.00
163_M166_E0.7681.00
12_Q56_M0.7671.00
9_R12_Q0.7671.00
207_A219_A0.7591.00
55_I65_V0.7541.00
112_F115_L0.7541.00
100_Q228_K0.7511.00
10_P49_V0.7471.00
195_K199_G0.7451.00
111_E115_L0.7411.00
125_M205_L0.7351.00
100_Q116_Q0.7321.00
225_E229_Q0.7321.00
101_A164_L0.7311.00
130_Q202_K0.7291.00
39_I54_L0.7291.00
219_A222_Q0.7221.00
99_L227_V0.7211.00
112_F161_N0.7161.00
204_I216_A0.7151.00
133_E137_A0.7111.00
149_M176_E0.7041.00
45_V50_V0.7021.00
131_L143_S0.7021.00
101_A109_I0.7001.00
123_V209_I0.6881.00
127_Q130_Q0.6841.00
34_P38_E0.6841.00
218_L221_W0.6841.00
122_I208_L0.6821.00
113_A117_A0.6821.00
222_Q226_N0.6811.00
123_V126_R0.6791.00
11_Y15_G0.6771.00
56_M60_K0.6761.00
225_E228_K0.6751.00
143_S147_G0.6721.00
135_E147_G0.6691.00
26_P42_M0.6691.00
129_L198_L0.6661.00
153_L165_V0.6621.00
204_I223_H0.6591.00
8_Q12_Q0.6581.00
124_K150_Q0.6551.00
226_N230_R0.6551.00
149_M172_W0.6501.00
131_L135_E0.6491.00
150_Q153_L0.6401.00
27_Y31_E0.6401.00
100_Q108_N0.6371.00
121_D154_A0.6371.00
94_G162_S0.6341.00
49_V53_A0.6321.00
121_D157_E0.6311.00
200_D203_Q0.6281.00
113_A159_T0.6261.00
104_L164_L0.6241.00
180_M183_Q0.6211.00
68_G71_I0.6181.00
77_S94_G0.6141.00
135_E140_A0.6131.00
21_L25_T0.6101.00
109_I159_T0.6101.00
29_P75_D0.6091.00
110_A213_A0.6051.00
103_Q224_L0.5981.00
107_S220_M0.5981.00
144_S197_W0.5951.00
101_A105_L0.5941.00
107_S213_A0.5801.00
132_E198_L0.5781.00
43_L50_V0.5761.00
109_I164_L0.5741.00
166_E174_W0.5741.00
30_G75_D0.5711.00
11_Y52_E0.5671.00
72_Y75_D0.5661.00
106_E201_H0.5651.00
33_L63_V0.5621.00
125_M158_A0.5621.00
37_R40_A0.5591.00
134_R137_A0.5581.00
120_E124_K0.5571.00
113_A155_I0.5571.00
93_A162_S0.5541.00
96_F100_Q0.5531.00
111_E221_W0.5531.00
110_A155_I0.5521.00
55_I59_I0.5491.00
229_Q232_L0.5471.00
104_L107_S0.5471.00
18_I39_I0.5471.00
156_A172_W0.5401.00
108_N164_L0.5391.00
204_I207_A0.5381.00
112_F159_T0.5371.00
106_E224_L0.5361.00
125_M128_A0.5331.00
226_N229_Q0.5331.00
229_Q233_E0.5311.00
23_I62_L0.5301.00
222_Q225_E0.5301.00
21_L24_K0.5271.00
166_E169_R0.5241.00
149_M153_L0.5211.00
193_Y196_E0.5211.00
41_E44_D0.5161.00
199_G202_K0.5161.00
119_R122_I0.5161.00
105_L168_F0.5151.00
27_Y33_L0.5131.00
133_E199_G0.5121.00
208_L216_A0.5111.00
27_Y42_M0.5101.00
94_G97_E0.5101.00
100_Q103_Q0.5101.00
162_S165_V0.5081.00
107_S110_A0.5061.00
119_R209_I0.5061.00
192_L195_K0.5051.00
34_P37_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hs5A 1 0.8054 100 0.213 Contact Map
4p96A 2 0.93 100 0.217 Contact Map
3c7jA 4 0.856 100 0.219 Contact Map
3ihuA 1 0.7938 100 0.223 Contact Map
4p9fA 1 0.821 100 0.224 Contact Map
3sxyA 2 0.7782 100 0.225 Contact Map
2di3A 2 0.8716 100 0.24 Contact Map
1hw1A 2 0.8599 100 0.259 Contact Map
3ic7A 2 0.4319 99.9 0.546 Contact Map
3by6A 2 0.4708 99.9 0.557 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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