GREMLIN Database
UXUB - D-mannonate oxidoreductase
UniProt: P39160 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20248
Length: 486 (452)
Sequences: 2412 (1681)
Seq/√Len: 79.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_H92_K4.1371.00
320_N480_R3.8321.00
58_V111_I3.4501.00
42_T273_W3.1161.00
473_Q482_C3.0411.00
328_F352_T2.9801.00
241_A247_Y2.9511.00
23_S56_C2.9461.00
311_Y320_N2.9371.00
234_P237_L2.8461.00
109_E171_L2.7441.00
99_E114_A2.6771.00
117_R120_T2.6741.00
44_H92_K2.6621.00
56_C114_A2.6621.00
262_I278_A2.6001.00
196_K200_L2.5851.00
204_Q215_E2.5731.00
25_I42_T2.5411.00
193_H222_C2.3791.00
317_T323_Y2.3761.00
329_A333_Q2.2901.00
82_A91_L2.2671.00
304_Y374_G2.2231.00
21_L54_G2.2191.00
387_R456_D2.2141.00
113_N175_K2.2111.00
219_T267_V2.1411.00
121_A270_R2.1001.00
389_H394_G2.0881.00
180_F218_V2.0841.00
365_H369_Q2.0811.00
324_R359_S2.0771.00
203_A214_I2.0691.00
26_V120_T2.0621.00
332_M351_A2.0541.00
160_S163_G2.0291.00
199_V220_F2.0201.00
238_Q242_D1.9951.00
301_F402_G1.9891.00
115_M168_A1.9581.00
403_V463_F1.9551.00
99_E110_G1.9481.00
41_Y258_R1.9481.00
307_Y420_I1.9451.00
34_H38_Q1.9381.00
106_D110_G1.9301.00
272_D275_K1.9261.00
73_K77_L1.9201.00
182_V195_A1.9141.00
167_E171_L1.8891.00
109_E113_N1.8871.00
273_W278_A1.8731.00
170_R174_E1.8701.00
474_L482_C1.8481.00
54_G98_K1.8431.00
466_A470_A1.8371.00
305_L405_G1.8361.00
134_A198_A1.8361.00
60_L164_Y1.8231.00
78_L93_I1.8231.00
173_R209_Q1.8161.00
298_S327_A1.7861.00
23_S120_T1.7861.00
336_A351_A1.7831.00
301_F330_L1.7521.00
305_L401_L1.7501.00
294_M351_A1.7401.00
324_R328_F1.7401.00
315_A319_T1.7381.00
56_C99_E1.7331.00
171_L175_K1.7311.00
40_L81_V1.7241.00
23_S99_E1.7211.00
212_A216_E1.7201.00
183_M262_I1.7121.00
219_T265_N1.6921.00
43_H47_E1.6901.00
83_E254_C1.6881.00
190_E193_H1.6791.00
70_E74_K1.6691.00
167_E170_R1.6691.00
386_V403_V1.6651.00
26_V58_V1.6561.00
181_T267_V1.6501.00
101_L111_I1.6371.00
294_M331_M1.6271.00
22_E119_Q1.6271.00
170_R206_R1.6181.00
57_E97_M1.6161.00
81_V94_I1.6061.00
234_P238_Q1.5871.00
314_I370_I1.5791.00
306_G317_T1.5791.00
407_M446_L1.5661.00
461_A465_G1.5640.99
239_E243_Q1.5630.99
298_S331_M1.5600.99
23_S98_K1.5350.99
458_P464_V1.5350.99
115_M180_F1.5340.99
312_E316_D1.5320.99
165_I199_V1.5310.99
135_D138_S1.5310.99
25_I55_I1.5150.99
190_E285_V1.5130.99
204_Q211_A1.5120.99
150_H154_N1.5120.99
346_D349_A1.5080.99
386_V463_F1.5040.99
116_A171_L1.5000.99
325_K329_A1.4910.99
56_C120_T1.4880.99
24_R121_A1.4810.99
166_V214_I1.4770.99
388_L391_Q1.4560.99
209_Q212_A1.4290.99
110_G113_N1.4240.99
179_A218_V1.4240.99
444_K464_V1.4160.99
355_I359_S1.4140.99
200_L215_E1.4100.99
401_L482_C1.4010.99
42_T55_I1.3940.99
305_L474_L1.3890.99
414_D418_N1.3860.99
127_V161_A1.3850.99
17_D20_R1.3850.99
123_V180_F1.3760.99
116_A167_E1.3730.99
112_L171_L1.3730.99
322_A480_R1.3600.99
450_S459_Q1.3600.99
80_T93_I1.3570.99
303_A371_A1.3540.99
140_Q201_G1.3460.98
448_G458_P1.3400.98
329_A398_H1.3330.98
400_A467_V1.3250.98
140_Q197_V1.3170.98
281_V286_P1.3130.98
46_L51_S1.3120.98
312_E366_R1.3040.98
396_W400_A1.3040.98
39_A55_I1.3010.98
408_R471_Y1.2990.98
169_L172_R1.2850.98
472_Q476_E1.2840.98
62_P66_R1.2750.98
214_I220_F1.2710.98
408_R475_C1.2610.98
314_I367_T1.2500.98
211_A214_I1.2500.98
232_A237_L1.2420.97
69_I73_K1.2390.97
328_F332_M1.2370.97
314_I317_T1.2320.97
294_M354_L1.2300.97
166_V203_A1.2280.97
80_T91_L1.2230.97
44_H48_S1.2220.97
431_Q435_A1.2160.97
349_A353_L1.2130.97
112_L167_E1.2090.97
84_K236_T1.2070.97
309_G323_Y1.2000.97
84_K89_T1.1990.97
154_N157_A1.1970.97
301_F326_A1.1950.97
125_L161_A1.1940.97
450_S456_D1.1940.97
178_K268_N1.1920.97
150_H159_K1.1910.97
204_Q212_A1.1900.97
208_P212_A1.1890.97
180_F267_V1.1840.97
232_A251_A1.1810.96
17_D21_L1.1800.96
204_Q208_P1.1800.96
397_R466_A1.1770.96
283_D286_P1.1740.96
113_N116_A1.1720.96
473_Q477_R1.1700.96
167_E206_R1.1660.96
89_T243_Q1.1640.96
294_M336_A1.1580.96
368_W409_Y1.1530.96
411_Q434_N1.1430.96
307_Y409_Y1.1380.96
130_K376_Q1.1360.96
336_A347_L1.1340.96
477_R481_E1.1310.96
332_M352_T1.1290.95
170_R207_D1.1270.95
456_D459_Q1.1250.95
302_L323_Y1.1160.95
293_R388_L1.1160.95
30_C97_M1.1090.95
289_M340_S1.0970.95
390_L460_N1.0960.95
16_W43_H1.0940.95
77_L100_A1.0910.95
464_V468_T1.0910.95
28_L115_M1.0870.94
30_C57_E1.0860.94
318_V324_R1.0810.94
387_R454_A1.0760.94
378_L402_G1.0760.94
444_K448_G1.0750.94
152_L202_L1.0710.94
318_V355_I1.0710.94
28_L161_A1.0630.94
40_L92_K1.0620.94
300_S377_K1.0610.94
182_V220_F1.0590.94
66_R70_E1.0570.94
197_V201_G1.0530.93
200_L211_A1.0430.93
75_Q248_D1.0420.93
426_M429_E1.0420.93
183_M223_T1.0390.93
401_L474_L1.0360.93
121_A269_G1.0320.93
75_Q78_L1.0320.93
428_A432_K1.0310.93
26_V123_V1.0310.93
432_K435_A1.0290.93
307_Y368_W1.0270.93
335_Q399_L1.0230.92
40_L94_I1.0210.92
212_A215_E1.0140.92
141_L201_G1.0120.92
429_E451_G1.0120.92
314_I327_A1.0090.92
347_L351_A1.0090.92
227_R254_C1.0090.92
315_A364_R1.0020.92
385_P399_L0.9980.91
78_L95_G0.9930.91
48_S275_K0.9910.91
331_M355_I0.9900.91
313_T316_D0.9880.91
307_Y367_T0.9830.91
400_A463_F0.9790.91
40_L44_H0.9780.91
168_A172_R0.9770.91
232_A252_I0.9750.90
166_V199_V0.9710.90
318_V327_A0.9690.90
429_E449_L0.9680.90
408_R415_E0.9670.90
330_L399_L0.9630.90
38_Q124_S0.9600.90
193_H196_K0.9590.90
270_R274_D0.9580.90
26_V168_A0.9530.89
368_W420_I0.9510.89
160_S172_R0.9510.89
41_Y276_V0.9480.89
444_K468_T0.9470.89
366_R369_Q0.9410.89
42_T278_A0.9410.89
449_L452_I0.9390.89
388_L392_N0.9370.89
466_A469_A0.9360.89
33_F185_C0.9350.89
77_L99_E0.9350.89
331_M351_A0.9340.88
91_L244_L0.9300.88
442_R448_G0.9290.88
313_T364_R0.9280.88
309_G320_N0.9270.88
375_S406_W0.9240.88
161_A169_L0.9210.88
108_C164_Y0.9210.88
396_W462_D0.9190.88
222_C263_E0.9180.88
149_K153_E0.9160.88
47_E92_K0.9120.87
86_A361_P0.9110.87
376_Q426_M0.9110.87
123_V182_V0.9090.87
23_S114_A0.9070.87
44_H258_R0.9050.87
166_V169_L0.9020.87
429_E432_K0.8980.86
316_D319_T0.8970.86
353_L356_E0.8950.86
365_H381_R0.8940.86
372_M423_V0.8910.86
375_S452_I0.8900.86
403_V467_V0.8900.86
114_A117_R0.8900.86
83_E90_E0.8870.86
273_W280_F0.8840.86
383_L386_V0.8730.85
382_L402_G0.8730.85
409_Y422_V0.8730.85
25_I122_I0.8710.85
331_M354_L0.8680.85
162_I168_A0.8660.84
69_I105_I0.8650.84
240_I244_L0.8610.84
433_I449_L0.8590.84
113_N171_L0.8560.84
124_S223_T0.8530.84
194_V197_V0.8520.83
130_K381_R0.8510.83
74_K249_P0.8500.83
134_A194_V0.8420.83
122_I270_R0.8410.83
333_Q398_H0.8410.83
305_L323_Y0.8390.82
326_A398_H0.8360.82
71_N249_P0.8350.82
24_R53_W0.8350.82
365_H370_I0.8350.82
161_A164_Y0.8340.82
213_W217_N0.8330.82
59_N68_L0.8320.82
474_L479_A0.8290.82
386_V400_A0.8280.82
28_L168_A0.8250.81
38_Q185_C0.8230.81
302_L367_T0.8230.81
440_A468_T0.8230.81
328_F351_A0.8200.81
45_L276_V0.8140.81
408_R412_G0.8120.80
290_M345_T0.8080.80
328_F355_I0.8080.80
203_A211_A0.8080.80
59_N102_H0.8070.80
200_L214_I0.8060.80
237_L241_A0.8050.80
80_T246_V0.8040.80
352_T355_I0.8040.80
125_L184_S0.8020.80
181_T266_F0.8000.79
373_D425_P0.7990.79
335_Q385_P0.7980.79
42_T45_L0.7960.79
441_D444_K0.7960.79
332_M336_A0.7960.79
182_V218_V0.7950.79
169_L213_W0.7940.79
294_M335_Q0.7930.79
115_M123_V0.7930.79
85_G256_P0.7920.79
72_L77_L0.7900.79
469_A473_Q0.7880.78
330_L335_Q0.7870.78
334_E398_H0.7850.78
161_A166_V0.7840.78
34_H39_A0.7800.78
239_E242_D0.7740.77
307_Y312_E0.7740.77
162_I172_R0.7730.77
43_H96_S0.7730.77
69_I100_A0.7730.77
163_G202_L0.7720.77
160_S168_A0.7720.77
173_R207_D0.7720.77
124_S183_M0.7710.77
383_L403_V0.7710.77
349_A352_T0.7690.77
274_D280_F0.7690.77
50_D275_K0.7670.76
181_T270_R0.7640.76
30_C60_L0.7610.76
166_V170_R0.7590.76
173_R210_L0.7580.76
478_G482_C0.7580.76
44_H276_V0.7580.76
298_S358_F0.7580.76
165_I195_A0.7570.76
422_V427_L0.7560.75
33_F38_Q0.7560.75
274_D278_A0.7550.75
23_S54_G0.7550.75
266_F270_R0.7520.75
293_R338_T0.7520.75
304_Y409_Y0.7510.75
181_T221_P0.7480.75
322_A483_V0.7480.75
22_E52_D0.7470.75
300_S374_G0.7450.74
166_V202_L0.7430.74
23_S119_Q0.7410.74
55_I96_S0.7390.74
407_M467_V0.7390.74
30_C59_N0.7380.74
83_E88_S0.7380.74
348_N352_T0.7330.73
160_S169_L0.7330.73
67_V71_N0.7320.73
400_A466_A0.7310.73
103_P164_Y0.7300.73
102_H105_I0.7300.73
207_D211_A0.7290.73
169_L173_R0.7290.73
447_L463_F0.7280.73
150_H153_E0.7280.73
44_H47_E0.7270.73
118_P177_L0.7270.73
203_A210_L0.7240.72
89_T362_S0.7240.72
257_F260_W0.7240.72
50_D272_D0.7220.72
124_S260_W0.7220.72
375_S424_D0.7210.72
124_S185_C0.7210.72
59_N100_A0.7210.72
429_E433_I0.7200.72
368_W423_V0.7170.72
309_G322_A0.7150.71
26_V115_M0.7130.71
290_M347_L0.7110.71
116_A168_A0.7100.71
306_G367_T0.7080.71
168_A180_F0.7080.71
314_I377_K0.7070.70
40_L258_R0.7060.70
316_D367_T0.7060.70
67_V70_E0.7060.70
180_F203_A0.7060.70
24_R46_L0.7040.70
448_G464_V0.7030.70
56_C98_K0.6960.69
289_M388_L0.6960.69
300_S304_Y0.6950.69
169_L182_V0.6940.69
436_Q445_A0.6940.69
415_E479_A0.6940.69
166_V172_R0.6940.69
310_G320_N0.6920.69
84_K227_R0.6910.69
428_A431_Q0.6890.68
230_P350_Y0.6880.68
237_L251_A0.6860.68
386_V399_L0.6860.68
157_A172_R0.6850.68
311_Y316_D0.6850.68
333_Q395_S0.6820.68
334_E389_H0.6810.68
75_Q80_T0.6800.67
479_A483_V0.6790.67
201_G205_A0.6780.67
130_K373_D0.6750.67
294_M298_S0.6750.67
185_C257_F0.6750.67
177_L180_F0.6730.67
284_V288_E0.6710.66
236_T239_E0.6690.66
73_K99_E0.6670.66
133_C160_S0.6670.66
321_P325_K0.6660.66
390_L462_D0.6640.66
154_N159_K0.6640.66
196_K215_E0.6630.66
397_R469_A0.6630.66
171_L174_E0.6620.65
322_A325_K0.6610.65
390_L396_W0.6580.65
338_T385_P0.6580.65
18_H21_L0.6570.65
238_Q241_A0.6570.65
198_A201_G0.6560.65
99_E113_N0.6540.64
224_M284_V0.6530.64
160_S164_Y0.6530.64
230_P260_W0.6520.64
168_A173_R0.6520.64
338_T389_H0.6510.64
136_A140_Q0.6510.64
93_I246_V0.6510.64
465_G469_A0.6500.64
384_D388_L0.6490.64
163_G172_R0.6490.64
286_P339_L0.6470.64
59_N69_I0.6470.64
236_T253_A0.6460.64
306_G311_Y0.6460.64
376_Q380_Q0.6460.64
151_D163_G0.6450.63
446_L452_I0.6430.63
75_Q79_Y0.6420.63
108_C111_I0.6390.63
390_L463_F0.6390.63
301_F335_Q0.6380.63
410_T420_I0.6380.63
212_A459_Q0.6380.63
101_L110_G0.6370.62
323_Y483_V0.6370.62
405_G479_A0.6350.62
62_P67_V0.6330.62
177_L217_N0.6320.62
479_A482_C0.6320.62
300_S372_M0.6320.62
104_E108_C0.6300.62
311_Y409_Y0.6280.61
310_G414_D0.6250.61
259_Q350_Y0.6250.61
162_I202_L0.6250.61
434_N442_R0.6230.61
411_Q475_C0.6220.61
72_L250_C0.6220.61
376_Q381_R0.6180.60
379_P454_A0.6170.60
219_T268_N0.6170.60
71_N250_C0.6170.60
79_Y227_R0.6150.60
385_P388_L0.6120.59
125_L165_I0.6120.59
309_G480_R0.6100.59
229_V363_L0.6090.59
474_L478_G0.6090.59
118_P178_K0.6080.59
51_S54_G0.6080.59
183_M273_W0.6070.59
81_V363_L0.6060.59
183_M278_A0.6060.59
444_K461_A0.6050.58
112_L164_Y0.6040.58
334_E399_L0.6010.58
58_V101_L0.6000.58
141_L198_A0.5990.58
352_T356_E0.5980.58
40_L386_V0.5960.57
163_G167_E0.5950.57
401_L470_A0.5950.57
33_F37_H0.5940.57
61_M127_V0.5940.57
48_S276_V0.5940.57
403_V453_F0.5940.57
59_N62_P0.5930.57
75_Q81_V0.5920.57
62_P68_L0.5920.57
396_W460_N0.5910.57
341_M345_T0.5910.57
34_H37_H0.5910.57
85_G362_S0.5910.57
401_L479_A0.5900.57
180_F268_N0.5880.56
343_E348_N0.5870.56
162_I199_V0.5870.56
302_L317_T0.5870.56
293_R385_P0.5860.56
410_T422_V0.5860.56
313_T363_L0.5860.56
189_R297_G0.5850.56
150_H155_P0.5850.56
412_G415_E0.5850.56
158_P167_E0.5850.56
330_L398_H0.5850.56
304_Y317_T0.5840.56
396_W466_A0.5840.56
70_E105_I0.5840.56
18_H95_G0.5830.56
413_V417_G0.5820.56
16_W95_G0.5820.56
168_A174_E0.5800.55
334_E383_L0.5800.55
440_A472_Q0.5790.55
193_H448_G0.5790.55
389_H396_W0.5770.55
462_D466_A0.5770.55
233_T236_T0.5770.55
77_L81_V0.5760.55
478_G481_E0.5750.55
189_R288_E0.5720.54
454_A458_P0.5720.54
44_H321_P0.5710.54
30_C100_A0.5700.54
305_L479_A0.5680.54
130_K369_Q0.5680.54
28_L111_I0.5670.54
235_E238_Q0.5670.54
156_T159_K0.5670.54
162_I169_L0.5650.53
129_E372_M0.5620.53
232_A250_C0.5600.53
175_K178_K0.5600.53
200_L363_L0.5590.53
16_W19_S0.5580.53
300_S370_I0.5580.53
38_Q260_W0.5570.52
117_R177_L0.5560.52
413_V418_N0.5550.52
30_C61_M0.5530.52
412_G418_N0.5510.52
384_D387_R0.5500.51
46_L96_S0.5500.51
407_M453_F0.5490.51
378_L382_L0.5490.51
134_A139_G0.5480.51
85_G361_P0.5480.51
427_L431_Q0.5470.51
227_R258_R0.5450.51
112_L116_A0.5440.51
292_L381_R0.5430.51
81_V256_P0.5430.51
161_A172_R0.5420.50
26_V114_A0.5420.50
194_V198_A0.5410.50
43_H95_G0.5410.50
210_L214_I0.5370.50
185_C350_Y0.5360.50
273_W361_P0.5360.50
45_L50_D0.5350.50
408_R474_L0.5340.49
84_K254_C0.5330.49
129_E373_D0.5330.49
229_V365_H0.5320.49
72_L97_M0.5310.49
24_R51_S0.5310.49
471_Y474_L0.5310.49
477_R482_C0.5300.49
45_L51_S0.5300.49
156_T167_E0.5300.49
387_R391_Q0.5300.49
134_A205_A0.5290.49
166_V173_R0.5290.49
341_M346_D0.5280.49
193_H265_N0.5280.49
122_I273_W0.5270.49
221_P264_D0.5250.48
83_E87_E0.5240.48
48_S459_Q0.5240.48
126_T288_E0.5230.48
161_A199_V0.5230.48
162_I166_V0.5220.48
229_V244_L0.5210.48
305_L402_G0.5210.48
367_T371_A0.5210.48
45_L275_K0.5200.48
323_Y479_A0.5200.48
178_K219_T0.5190.47
375_S430_F0.5190.47
265_N282_A0.5170.47
170_R173_R0.5170.47
75_Q84_K0.5170.47
120_T164_Y0.5160.47
22_E51_S0.5160.47
157_A169_L0.5140.47
381_R467_V0.5130.47
16_W21_L0.5130.47
121_A180_F0.5120.47
228_I360_N0.5120.47
83_E258_R0.5120.47
130_K425_P0.5120.47
471_Y475_C0.5110.46
32_A369_Q0.5110.46
120_T180_F0.5100.46
181_T219_T0.5100.46
230_P252_I0.5100.46
342_P345_T0.5090.46
61_M67_V0.5070.46
443_V468_T0.5070.46
297_G382_L0.5070.46
42_T280_F0.5060.46
431_Q448_G0.5060.46
208_P412_G0.5060.46
219_T266_F0.5050.46
382_L399_L0.5050.46
312_E364_R0.5050.46
367_T370_I0.5050.46
305_L378_L0.5050.46
300_S369_Q0.5040.46
81_V254_C0.5040.46
21_L95_G0.5040.46
61_M102_H0.5030.45
199_V214_I0.5020.45
422_V431_Q0.5020.45
98_K120_T0.5010.45
341_M363_L0.5000.45
33_F254_C0.5000.45
165_I182_V0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lj8A 1 0.9918 100 0.083 Contact Map
4im7A 1 0.9856 100 0.085 Contact Map
3h2zA 2 0.7613 100 0.376 Contact Map
3wfiA 2 0.6193 80.2 0.97 Contact Map
3hn2A 2 0.6111 78.3 0.971 Contact Map
2ew2A 2 0.6276 75.1 0.972 Contact Map
3i83A 2 0.6317 67.9 0.973 Contact Map
2qytA 1 0.572 53.4 0.975 Contact Map
1z9bA 1 0.1749 43.9 0.977 Contact Map
3hwrA 2 0.607 43.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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