GREMLIN Database
DEGQ - Periplasmic pH-dependent serine endoprotease DegQ
UniProt: P39099 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12612
Length: 455 (391)
Sequences: 2760 (1914)
Seq/√Len: 96.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_N224_E6.9451.00
47_E163_R6.2241.00
345_L354_V5.9281.00
316_S344_G5.8321.00
98_N101_K4.1741.00
117_I131_L4.1541.00
318_N335_T4.0091.00
158_D161_K3.6651.00
108_N134_S3.6461.00
209_I243_G3.5981.00
344_G351_P3.4541.00
130_K146_Q3.3081.00
155_A224_E3.3071.00
342_K353_E3.2141.00
294_V308_V3.1831.00
162_L226_I3.1611.00
340_K355_E3.0401.00
52_A153_Q2.9771.00
142_L259_I2.8841.00
129_A143_L2.8721.00
424_S427_E2.7601.00
186_V203_I2.7551.00
158_D249_N2.7071.00
160_D249_N2.6051.00
105_L251_A2.5921.00
342_K355_E2.5731.00
95_V225_L2.5671.00
345_L352_L2.5291.00
105_L255_A2.4451.00
340_K357_T2.4291.00
96_I121_L2.3141.00
300_G304_A2.3091.00
316_S321_P2.3021.00
95_V217_A2.2761.00
127_F145_I2.2481.00
217_A225_L2.2381.00
70_E73_K2.2201.00
43_A163_R2.2061.00
308_V345_L2.0971.00
315_T346_L2.0761.00
294_V314_I2.0581.00
59_E116_K2.0401.00
116_K128_D2.0381.00
162_L186_V2.0291.00
316_S319_G2.0221.00
49_V154_I2.0121.00
103_Y132_I2.0021.00
41_S166_D2.0021.00
104_V145_I1.9811.00
299_P304_A1.9711.00
43_A166_D1.9231.00
305_K359_D1.9111.00
46_L181_A1.8971.00
272_K296_E1.8441.00
344_G353_E1.8431.00
269_L356_V1.8211.00
118_S126_E1.8051.00
308_V343_L1.7991.00
97_I255_A1.7851.00
167_F183_S1.7841.00
315_T351_P1.7771.00
71_E75_F1.7751.00
71_E74_K1.7691.00
74_K77_G1.7301.00
154_I219_L1.6801.00
256_Q260_D1.6781.00
308_V354_V1.6711.00
427_E431_V1.6691.00
56_V119_I1.6581.00
156_I248_S1.6571.00
42_L167_F1.6201.00
173_N178_G1.6121.00
130_K144_Q1.6081.00
44_P163_R1.6021.00
154_I225_L1.5951.00
73_K77_G1.5871.00
256_Q259_I1.5761.00
96_I151_L1.5571.00
168_A186_V1.5471.00
100_S150_K1.5431.00
335_T358_L1.5381.00
417_V428_M1.5351.00
252_R256_Q1.5301.00
394_I408_L1.5271.00
72_F75_F1.4981.00
159_S249_N1.4981.00
156_I252_R1.4891.00
265_K360_T1.4761.00
72_F76_F1.4651.00
235_P240_V1.4561.00
211_R235_P1.4441.00
147_N151_L1.4411.00
317_L335_T1.4341.00
317_L332_I1.4321.00
276_M286_L1.4311.00
103_Y142_L1.4271.00
103_Y259_I1.4241.00
52_A154_I1.4090.99
71_E77_G1.4090.99
269_L358_L1.3780.99
315_T344_G1.3780.99
312_D347_R1.3760.99
49_V219_L1.3730.99
271_I292_A1.3510.99
255_A259_I1.3470.99
422_V427_E1.3240.99
71_E79_D1.3080.99
423_N427_E1.3060.99
273_G325_F1.3040.99
417_V422_V1.2780.99
70_E74_K1.2780.99
95_V228_I1.2740.99
290_R321_P1.2670.99
95_V219_L1.2600.99
341_V358_L1.2490.99
228_I251_A1.2480.99
194_L197_E1.2470.99
173_N231_A1.2380.99
302_G359_D1.2320.99
275_E325_F1.2290.99
168_A226_I1.2270.99
45_M169_V1.2160.98
234_A237_G1.1960.98
108_N112_N1.1890.98
103_Y144_Q1.1780.98
101_K144_Q1.1750.98
140_I228_I1.1740.98
133_G258_L1.1700.98
71_E76_F1.1680.98
346_L351_P1.1660.98
169_V221_L1.1630.98
162_L203_I1.1600.98
109_H214_S1.1600.98
112_N136_D1.1560.98
49_V171_V1.1540.98
374_A383_G1.1480.98
267_G358_L1.1480.98
306_A356_V1.1470.98
336_E339_T1.1460.98
104_V143_L1.1450.98
92_G110_V1.1410.98
261_F265_K1.1380.98
42_L183_S1.1350.98
58_V117_I1.1320.98
427_E430_K1.1300.98
102_G144_Q1.1270.98
41_S44_P1.1250.97
109_H139_D1.1240.97
196_L200_E1.1200.97
46_L50_L1.1130.97
162_L189_L1.1090.97
277_S280_I1.1060.97
276_M289_Q1.1040.97
207_A243_G1.0880.97
140_I246_I1.0870.97
430_K434_A1.0810.97
138_S266_R1.0800.97
46_L171_V1.0700.97
268_L362_T1.0640.96
120_Q126_E1.0610.96
335_T339_T1.0510.96
323_N327_E1.0490.96
45_M219_L1.0440.96
254_L258_L1.0420.96
138_S254_L1.0380.96
205_T218_L1.0210.96
177_L180_T1.0150.95
274_T280_I1.0140.95
118_S128_D1.0140.95
257_Q261_F1.0080.95
147_N150_K1.0050.95
420_D434_A1.0040.95
60_G88_F1.0040.95
123_D127_F1.0010.95
187_S204_Q0.9990.95
420_D431_V0.9990.95
164_V189_L0.9970.95
58_V115_Q0.9950.95
422_V431_V0.9910.95
59_E87_P0.9880.95
290_R323_N0.9840.95
263_E360_T0.9820.94
318_N342_K0.9760.94
400_G404_A0.9750.94
38_P41_S0.9720.94
121_L127_F0.9720.94
117_I143_L0.9660.94
56_V90_G0.9620.94
268_L302_G0.9620.94
309_K347_R0.9610.94
61_T115_Q0.9590.94
347_R352_L0.9590.94
95_V154_I0.9530.94
296_E310_A0.9420.93
309_K348_N0.9360.93
199_L333_A0.9340.93
392_I422_V0.9310.93
429_R433_A0.9210.92
55_S90_G0.9200.92
139_D214_S0.9190.92
132_I144_Q0.9180.92
156_I251_A0.9170.92
107_N110_V0.9130.92
274_T295_S0.9120.92
425_I428_M0.9100.92
319_G342_K0.9100.92
280_I283_A0.9090.92
58_V91_L0.9050.92
114_A117_I0.9010.92
320_K331_R0.9010.92
57_R120_Q0.8860.91
35_D38_P0.8850.91
69_P73_K0.8800.91
63_S85_A0.8780.90
52_A152_T0.8770.90
426_A429_R0.8760.90
42_L46_L0.8760.90
390_K423_N0.8760.90
46_L169_V0.8700.90
169_V183_S0.8620.90
94_G104_V0.8600.90
350_K355_E0.8580.89
98_N144_Q0.8550.89
330_S334_T0.8490.89
95_V167_F0.8470.89
293_F311_G0.8470.89
179_Q219_L0.8440.89
108_N136_D0.8380.88
157_A162_L0.8370.88
189_L203_I0.8370.88
422_V428_M0.8330.88
280_I284_F0.8290.88
234_A239_S0.8270.88
431_V434_A0.8250.88
420_D427_E0.8250.88
166_D220_N0.8230.87
428_M432_L0.8230.87
194_L198_G0.8180.87
70_E75_F0.8170.87
175_F232_I0.8160.87
140_I248_S0.8130.87
127_F147_N0.8130.87
297_V307_G0.8110.87
51_P152_T0.8100.87
111_I134_S0.8040.86
251_A255_A0.8020.86
212_G215_G0.8010.86
392_I424_S0.8010.86
107_N229_N0.7980.86
146_Q149_S0.7970.86
267_G337_P0.7960.86
105_L248_S0.7930.85
170_A229_N0.7930.85
156_I255_A0.7910.85
426_A430_K0.7870.85
317_L341_V0.7870.85
391_G394_I0.7870.85
268_L298_L0.7850.85
385_L389_G0.7850.85
272_K298_L0.7810.84
239_S243_G0.7790.84
403_A407_G0.7760.84
140_I243_G0.7750.84
402_P406_A0.7740.84
167_F177_L0.7700.84
181_A185_I0.7690.84
236_G239_S0.7670.83
218_L245_A0.7660.83
98_N153_Q0.7620.83
46_L167_F0.7600.83
111_I143_L0.7600.83
50_L122_N0.7590.83
54_V104_V0.7590.83
186_V226_I0.7580.83
96_I145_I0.7570.83
343_L354_V0.7550.82
55_S91_L0.7540.82
360_T363_S0.7540.82
54_V94_G0.7530.82
157_A248_S0.7510.82
285_N288_V0.7490.82
260_D263_E0.7480.82
61_T85_A0.7470.82
202_F232_I0.7460.82
324_S327_E0.7440.82
131_L134_S0.7420.81
190_G201_N0.7410.81
197_E200_E0.7400.81
272_K295_S0.7350.81
106_T109_H0.7340.81
34_A37_A0.7330.81
82_D345_L0.7320.80
209_I213_N0.7270.80
396_E410_K0.7270.80
83_Q86_Q0.7260.80
210_N213_N0.7250.80
230_T246_I0.7230.80
107_N214_S0.7200.79
193_G196_L0.7200.79
267_G333_A0.7190.79
204_Q210_N0.7150.79
399_K404_A0.7110.79
200_E225_L0.7110.79
109_H212_G0.7050.78
50_L179_Q0.7050.78
297_V310_A0.7040.78
107_N212_G0.7000.77
186_V430_K0.6970.77
305_K424_S0.6960.77
249_N252_R0.6960.77
338_G354_V0.6950.77
139_D184_G0.6950.77
173_N230_T0.6930.77
121_L125_R0.6930.77
248_S251_A0.6930.77
100_S153_Q0.6920.77
304_A307_G0.6880.76
416_G419_R0.6870.76
318_N355_E0.6820.76
257_Q264_I0.6810.75
57_R91_L0.6800.75
59_E89_E0.6790.75
284_F313_I0.6770.75
36_Q39_L0.6770.75
58_V90_G0.6760.75
275_E324_S0.6750.75
327_E331_R0.6730.75
104_V151_L0.6710.74
60_G115_Q0.6710.74
175_F240_V0.6700.74
178_G217_A0.6680.74
95_V329_R0.6640.74
180_T253_T0.6640.74
301_S304_A0.6630.74
161_K222_N0.6620.73
89_E143_L0.6620.73
135_D266_R0.6600.73
273_G328_L0.6590.73
202_F230_T0.6580.73
277_S281_A0.6560.73
273_G292_A0.6550.73
64_Q85_A0.6530.72
49_V225_L0.6510.72
274_T293_F0.6510.72
131_L143_L0.6510.72
109_H184_G0.6500.72
70_E77_G0.6470.72
156_I225_L0.6460.72
45_M48_K0.6450.71
248_S252_R0.6420.71
233_L239_S0.6420.71
200_E231_A0.6380.71
142_L255_A0.6360.70
182_T188_A0.6360.70
279_D282_K0.6350.70
298_L301_S0.6350.70
44_P47_E0.6340.70
316_S351_P0.6340.70
139_D212_G0.6330.70
392_I425_I0.6310.70
385_L388_G0.6310.70
73_K79_D0.6270.69
187_S210_N0.6270.69
163_R166_D0.6270.69
166_D179_Q0.6270.69
158_D252_R0.6270.69
122_N179_Q0.6250.69
109_H247_P0.6250.69
410_K416_G0.6250.69
420_D430_K0.6240.69
106_T139_D0.6230.69
401_S404_A0.6230.69
135_D138_S0.6220.69
232_I240_V0.6210.69
82_D85_A0.6210.69
404_A410_K0.6210.69
286_L289_Q0.6200.69
400_G403_A0.6190.68
156_I162_L0.6180.68
170_A218_L0.6180.68
58_V88_F0.6160.68
198_G296_E0.6130.68
196_L231_A0.6130.68
278_A282_K0.6120.68
428_M431_V0.6120.68
317_L343_L0.6120.68
317_L331_R0.6110.67
385_L396_E0.6110.67
98_N259_I0.6100.67
137_Q198_G0.6090.67
96_I104_V0.6080.67
74_K79_D0.6070.67
177_L230_T0.6060.67
69_P75_F0.6050.67
106_T184_G0.6040.66
100_S152_T0.6030.66
213_N216_G0.6030.66
33_V37_A0.6030.66
424_S428_M0.6020.66
64_Q77_G0.6000.66
254_L359_D0.6000.66
347_R354_V0.6000.66
205_T208_S0.5990.66
64_Q84_P0.5990.66
317_L328_L0.5990.66
62_A86_Q0.5990.66
124_G201_N0.5970.66
32_Q35_D0.5960.65
133_G262_G0.5950.65
200_E219_L0.5950.65
175_F239_S0.5950.65
200_E250_M0.5940.65
305_K357_T0.5940.65
271_I325_F0.5940.65
392_I428_M0.5940.65
202_F231_A0.5920.65
40_P45_M0.5910.65
35_D222_N0.5900.65
407_G422_V0.5900.65
145_I148_P0.5890.65
108_N185_I0.5890.65
318_N339_T0.5890.65
106_T212_G0.5880.64
95_V200_E0.5870.64
205_T210_N0.5870.64
275_E326_A0.5870.64
57_R126_E0.5870.64
102_G151_L0.5850.64
318_N331_R0.5830.64
288_V346_L0.5820.64
97_I142_L0.5820.64
393_K396_E0.5810.64
106_T141_A0.5800.63
343_L356_V0.5790.63
257_Q260_D0.5790.63
55_S176_G0.5780.63
184_G212_G0.5770.63
204_Q244_F0.5750.63
392_I395_D0.5740.63
425_I429_R0.5740.63
165_G191_R0.5720.62
419_R436_P0.5720.62
135_D191_R0.5710.62
33_V36_Q0.5710.62
133_G142_L0.5700.62
170_A213_N0.5690.62
281_A285_N0.5680.62
138_S250_M0.5680.62
430_K433_A0.5680.62
189_L211_R0.5670.62
395_D406_A0.5670.62
92_G216_G0.5670.62
384_Q387_D0.5660.62
188_A231_A0.5660.62
184_G204_Q0.5650.61
403_A412_D0.5640.61
37_A40_P0.5630.61
399_K436_P0.5630.61
346_L349_G0.5600.61
184_G214_S0.5600.61
261_F264_I0.5550.60
108_N179_Q0.5540.60
206_D210_N0.5530.60
56_V129_A0.5530.60
335_T341_V0.5530.60
205_T245_A0.5530.60
273_G322_L0.5530.60
416_G422_V0.5520.60
390_K421_R0.5520.60
139_D247_P0.5520.60
332_I335_T0.5520.60
276_M290_R0.5510.59
309_K350_K0.5510.59
109_H213_N0.5510.59
270_G307_G0.5510.59
211_R240_V0.5500.59
303_S306_A0.5490.59
41_S163_R0.5490.59
171_V181_A0.5490.59
399_K415_I0.5480.59
397_V404_A0.5480.59
70_E79_D0.5480.59
97_I337_P0.5480.59
270_G302_G0.5470.59
41_S178_G0.5470.59
390_K413_V0.5460.59
98_N337_P0.5450.59
189_L330_S0.5440.58
142_L258_L0.5440.58
399_K410_K0.5440.58
109_H204_Q0.5440.58
322_L327_E0.5430.58
199_L329_R0.5430.58
403_A406_A0.5430.58
131_L341_V0.5410.58
416_G428_M0.5410.58
253_T334_T0.5410.58
46_L189_L0.5400.58
55_S242_I0.5390.58
191_R244_F0.5390.58
294_V354_V0.5390.58
384_Q388_G0.5390.58
166_D239_S0.5370.58
395_D405_Q0.5370.58
408_L412_D0.5370.58
250_M329_R0.5360.57
107_N213_N0.5360.57
174_P210_N0.5350.57
421_R430_K0.5350.57
335_T343_L0.5320.57
210_N214_S0.5320.57
176_G212_G0.5310.57
387_D393_K0.5310.57
173_N217_A0.5300.57
173_N244_F0.5300.57
40_P221_L0.5300.57
342_K352_L0.5290.56
385_L415_I0.5290.56
203_I218_L0.5290.56
320_K423_N0.5270.56
264_I267_G0.5270.56
167_F221_L0.5270.56
391_G413_V0.5270.56
267_G332_I0.5260.56
175_F233_L0.5260.56
125_R149_S0.5260.56
239_S242_I0.5250.56
235_P238_G0.5250.56
111_I274_T0.5250.56
386_K423_N0.5240.56
56_V171_V0.5240.56
180_T191_R0.5240.56
343_L347_R0.5240.56
366_A369_E0.5240.56
384_Q413_V0.5230.56
385_L413_V0.5230.56
139_D215_G0.5220.55
207_A212_G0.5220.55
325_F329_R0.5220.55
77_G80_L0.5210.55
33_V48_K0.5210.55
174_P244_F0.5200.55
394_I407_G0.5200.55
117_I150_K0.5200.55
112_N134_S0.5190.55
167_F225_L0.5190.55
399_K409_Q0.5190.55
107_N139_D0.5190.55
390_K417_V0.5180.55
57_R118_S0.5180.55
104_V310_A0.5180.55
345_L353_E0.5170.55
43_A221_L0.5170.55
33_V38_P0.5160.55
237_G240_V0.5160.55
101_K132_I0.5150.54
369_E373_P0.5150.54
164_V230_T0.5150.54
429_R435_K0.5140.54
287_D351_P0.5140.54
201_N242_I0.5140.54
48_K51_P0.5140.54
286_L346_L0.5130.54
37_A309_K0.5130.54
304_A337_P0.5120.54
197_E317_L0.5120.54
35_D39_L0.5100.54
384_Q421_R0.5090.54
232_I239_S0.5090.54
410_K437_A0.5080.53
126_E346_L0.5080.53
385_L431_V0.5080.53
290_R351_P0.5070.53
62_A340_K0.5070.53
292_A322_L0.5070.53
374_A413_V0.5060.53
32_Q36_Q0.5060.53
387_D428_M0.5060.53
215_G247_P0.5060.53
204_Q212_G0.5060.53
107_N207_A0.5050.53
157_A189_L0.5040.53
409_Q412_D0.5040.53
417_V429_R0.5040.53
185_I241_G0.5020.53
254_L330_S0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ky9A 5 0.8725 100 0.323 Contact Map
3pv2A 6 0.8374 100 0.345 Contact Map
4a8cA 5 0.8681 100 0.356 Contact Map
4flnA 5 0.8505 100 0.434 Contact Map
3stjA 6 0.6593 100 0.453 Contact Map
1lcyA 3 0.6374 100 0.522 Contact Map
4ic6A 4 0.6967 100 0.526 Contact Map
3qo6A 5 0.6923 100 0.528 Contact Map
4ri0A 3 0.6703 100 0.534 Contact Map
1te0A 6 0.6923 100 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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