GREMLIN Database
TORR - TorCAD operon transcriptional regulatory protein TorR
UniProt: P38684 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12615
Length: 230 (200)
Sequences: 71226 (51077)
Seq/√Len: 3611.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_Q31_V3.6191.00
15_Q33_A3.1031.00
19_Q31_V2.9391.00
8_V38_L2.6361.00
36_A58_D2.5501.00
34_S58_D2.5151.00
30_S47_V2.5011.00
35_G59_E2.4951.00
43_Q71_R2.3881.00
39_R67_A2.3801.00
59_E67_A2.3261.00
4_H30_S2.0881.00
4_H28_T2.0751.00
19_Q23_T2.0181.00
21_Y106_L1.9651.00
88_R108_E1.9581.00
197_R200_D1.9431.00
32_T41_I1.9231.00
161_A164_E1.9031.00
52_L64_L1.8691.00
25_E110_V1.8291.00
33_A37_G1.8261.00
55_N82_R1.8011.00
65_T76_I1.7861.00
179_R200_D1.7781.00
85_R105_E1.7611.00
34_S37_G1.7531.00
78_L91_G1.7351.00
6_V32_T1.6701.00
78_L96_A1.6621.00
60_N63_M1.6561.00
69_R97_D1.6211.00
30_S41_I1.5961.00
67_A71_R1.5661.00
167_V171_T1.5461.00
59_E63_M1.5401.00
202_L205_R1.5231.00
67_A70_E1.5021.00
168_A185_M1.4961.00
41_I45_Q1.4961.00
35_G64_L1.4911.00
136_R141_C1.4851.00
3_H117_L1.4831.00
22_F113_V1.4521.00
139_G152_D1.4451.00
65_T78_L1.4251.00
39_R64_L1.4241.00
30_S45_Q1.4161.00
82_R87_D1.4021.00
54_I78_L1.3961.00
98_D112_R1.3921.00
41_I44_N1.3911.00
162_E209_K1.3831.00
52_L65_T1.3791.00
63_M66_R1.3691.00
49_L113_V1.3661.00
42_M68_L1.3651.00
77_I116_L1.3591.00
50_I74_V1.3541.00
148_T155_P1.3461.00
177_L185_M1.3401.00
9_E15_Q1.3401.00
36_A59_E1.3091.00
97_D119_R1.2931.00
10_D53_D1.2851.00
8_V56_L1.2641.00
178_S181_R1.2611.00
54_I62_L1.2541.00
93_E114_K1.2531.00
168_A172_N1.2381.00
41_I47_V1.2331.00
12_P33_A1.2261.00
39_R59_E1.2221.00
40_E44_N1.2211.00
66_R94_M1.2111.00
32_T38_L1.2061.00
37_G40_E1.1891.00
6_V38_L1.1721.00
84_D87_D1.1631.00
27_Y114_K1.1571.00
36_A40_E1.1541.00
141_C150_E1.1421.00
4_H45_Q1.1381.00
143_N146_R1.1261.00
37_G41_I1.1221.00
66_R90_V1.1151.00
6_V47_V1.1111.00
97_D116_L1.1091.00
142_L170_V1.1071.00
168_A177_L1.1021.00
62_L90_V1.0931.00
201_V204_R1.0901.00
26_G114_K1.0781.00
25_E114_K1.0761.00
85_R89_I1.0751.00
161_A187_S1.0461.00
49_L117_L1.0321.00
5_I27_Y1.0311.00
181_R185_M1.0301.00
198_T202_L1.0251.00
3_H27_Y1.0221.00
110_V114_K1.0211.00
62_L91_G1.0211.00
38_L42_M1.0181.00
62_L94_M1.0061.00
38_L64_L1.0011.00
8_V50_I0.9961.00
197_R201_V0.9931.00
108_E111_V0.9921.00
52_L76_I0.9901.00
6_V41_I0.9861.00
144_V167_V0.9801.00
164_E167_V0.9791.00
86_I90_V0.9781.00
163_Y167_V0.9741.00
90_V94_M0.9731.00
180_E196_L0.9681.00
18_L79_V0.9641.00
6_V42_M0.9631.00
111_V115_N0.9421.00
50_I68_L0.9411.00
147_H164_E0.9371.00
168_A182_L0.9341.00
13_V17_R0.9271.00
203_I207_R0.9251.00
7_I29_V0.9241.00
54_I60_N0.9241.00
39_R43_Q0.9211.00
7_I18_L0.9211.00
56_L64_L0.9181.00
116_L119_R0.9091.00
16_A31_V0.9051.00
89_I93_E0.9031.00
63_M67_A0.9011.00
8_V32_T0.8991.00
19_Q29_V0.8991.00
52_L78_L0.8921.00
12_P15_Q0.8911.00
12_P16_A0.8911.00
32_T37_G0.8841.00
88_R101_T0.8831.00
142_L163_Y0.8831.00
150_E155_P0.8791.00
85_R88_R0.8761.00
27_Y110_V0.8751.00
40_E43_Q0.8751.00
65_T94_M0.8711.00
51_L109_L0.8691.00
65_T96_A0.8651.00
205_R208_H0.8641.00
196_L200_D0.8611.00
18_L109_L0.8591.00
90_V93_E0.8501.00
197_R204_R0.8501.00
92_L112_R0.8491.00
77_I112_R0.8421.00
177_L181_R0.8361.00
50_I76_I0.8361.00
4_H47_V0.8331.00
20_S24_Q0.8321.00
83_S101_T0.8311.00
51_L79_V0.8291.00
89_I107_R0.8231.00
204_R208_H0.8201.00
159_T209_K0.8121.00
68_L72_S0.8061.00
160_R164_E0.8011.00
54_I87_D0.7951.00
64_L68_L0.7941.00
55_N81_G0.7921.00
180_E184_R0.7841.00
108_E112_R0.7831.00
3_H121_D0.7791.00
59_E64_L0.7781.00
54_I82_R0.7761.00
42_M74_V0.7761.00
214_L217_T0.7751.00
16_A19_Q0.7751.00
66_R70_E0.7731.00
86_I107_R0.7701.00
106_L110_V0.7631.00
75_G97_D0.7551.00
115_N118_W0.7521.00
77_I98_D0.7481.00
207_R212_A0.7471.00
42_M47_V0.7381.00
171_T185_M0.7371.00
39_R42_M0.7351.00
35_G58_D0.7341.00
35_G39_R0.7321.00
7_I19_Q0.7291.00
200_D203_I0.7231.00
136_R139_G0.7181.00
142_L149_L0.7151.00
9_E56_L0.7141.00
85_R107_R0.7101.00
150_E153_G0.7061.00
104_L109_L0.7051.00
87_D90_V0.7041.00
179_R196_L0.7031.00
7_I31_V0.6991.00
16_A20_S0.6971.00
115_N120_I0.6941.00
136_R140_Y0.6911.00
147_H163_Y0.6881.00
8_V64_L0.6881.00
91_G96_A0.6851.00
151_R213_D0.6841.00
4_H48_D0.6801.00
14_T104_L0.6781.00
43_Q67_A0.6781.00
93_E111_V0.6771.00
168_A171_T0.6771.00
79_V104_L0.6751.00
139_G151_R0.6751.00
17_R21_Y0.6741.00
181_R184_R0.6741.00
144_V171_T0.6721.00
42_M50_I0.6701.00
11_E14_T0.6681.00
105_E108_E0.6661.00
137_F140_Y0.6641.00
194_P199_V0.6621.00
169_F203_I0.6611.00
151_R211_S0.6591.00
201_V205_R0.6421.00
80_T88_R0.6421.00
120_I124_R0.6351.00
22_F27_Y0.6321.00
88_R105_E0.6271.00
142_L167_V0.6261.00
107_R111_V0.6221.00
117_L120_I0.6191.00
69_R74_V0.6181.00
73_T122_L0.6171.00
183_L187_S0.6161.00
11_E81_G0.6141.00
75_G117_L0.6131.00
140_Y151_R0.6121.00
21_Y110_V0.6101.00
73_T123_A0.6081.00
3_H48_D0.6061.00
68_L76_I0.6031.00
211_S214_L0.5991.00
15_Q19_Q0.5991.00
51_L77_I0.5971.00
62_L87_D0.5961.00
5_I22_F0.5951.00
51_L113_V0.5951.00
135_Y144_V0.5941.00
143_N148_T0.5891.00
54_I91_G0.5891.00
23_T28_T0.5851.00
5_I49_L0.5841.00
23_T29_V0.5781.00
171_T177_L0.5731.00
39_R71_R0.5711.00
112_R116_L0.5691.00
42_M64_L0.5681.00
52_L56_L0.5681.00
65_T69_R0.5661.00
69_R75_G0.5641.00
165_M169_F0.5641.00
135_Y170_V0.5551.00
10_D80_T0.5551.00
81_G103_P0.5551.00
184_R187_S0.5551.00
5_I113_V0.5551.00
98_D115_N0.5531.00
162_E205_R0.5501.00
104_L108_E0.5501.00
149_L156_I0.5481.00
151_R154_E0.5421.00
91_G99_Y0.5411.00
89_I92_L0.5411.00
42_M72_S0.5401.00
7_I15_Q0.5351.00
179_R183_L0.5351.00
46_S72_S0.5341.00
141_C153_G0.5331.00
8_V35_G0.5311.00
151_R212_A0.5301.00
86_I89_I0.5231.00
161_A202_L0.5211.00
195_D198_T0.5201.00
53_D102_K0.5171.00
42_M71_R0.5171.00
35_G56_L0.5131.00
11_E103_P0.5131.00
83_S103_P0.5111.00
14_T17_R0.5101.00
17_R20_S0.5091.00
34_S56_L0.5091.00
27_Y117_L0.5061.00
8_V52_L0.5041.00
111_V114_K0.5041.00
113_V117_L0.5011.00
75_G120_I0.5011.00
172_N185_M0.5011.00
135_Y138_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gwrA 1 0.9478 100 0.203 Contact Map
4b09A 2 0.9043 100 0.218 Contact Map
2oqrA 2 0.9609 100 0.219 Contact Map
3r0jA 2 0.9435 100 0.226 Contact Map
1ys7A 2 0.9652 100 0.228 Contact Map
4kfcA 2 0.9522 100 0.228 Contact Map
1kgsA 1 0.9304 100 0.229 Contact Map
1p2fA 1 0.9174 100 0.267 Contact Map
3q9sA 1 0.8913 100 0.277 Contact Map
2hqrA 2 0.9261 100 0.279 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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