GREMLIN Database
YGGL - Uncharacterized protein YggL
UniProt: P38521 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12443
Length: 108 (104)
Sequences: 219 (127)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_N81_H4.3371.00
6_S16_D3.1020.97
44_D92_R2.9590.96
86_R90_E2.8210.94
6_S9_L2.3830.87
83_A87_K2.2790.85
28_R96_E2.2730.85
5_R9_L2.2590.84
68_L103_F2.2480.84
44_D91_E2.2320.84
45_F55_L2.0760.79
59_G88_W1.8110.68
57_F67_G1.7930.67
20_E106_W1.5960.58
45_F67_G1.5240.54
25_V81_H1.5190.54
8_R12_K1.5070.54
8_R11_K1.5070.54
6_S15_I1.4810.52
5_R16_D1.4670.52
87_K91_E1.3750.47
53_N84_I1.3690.47
27_W65_W1.3630.46
37_Q40_K1.3460.45
45_F57_F1.3430.45
58_D88_W1.3400.45
15_I87_K1.3320.45
7_R78_T1.3110.44
56_A103_F1.2920.43
68_L105_V1.2770.42
45_F85_V1.2690.41
23_F99_T1.2490.40
7_R18_F1.2370.40
26_A98_R1.2200.39
30_P95_D1.1760.37
70_C89_L1.1630.36
87_K98_R1.1610.36
27_W74_I1.1300.35
10_R16_D1.1260.35
77_C102_L1.1240.35
89_L107_W1.0800.33
48_E93_K1.0720.32
5_R22_G1.0690.32
72_Q75_G1.0580.32
19_Q106_W1.0500.31
3_K95_D1.0330.30
66_E97_V1.0240.30
43_D50_I1.0240.30
58_D62_Y1.0200.30
34_S37_Q1.0140.30
63_L94_L1.0070.29
42_V50_I1.0070.29
14_H73_E1.0030.29
20_E75_G1.0020.29
14_H74_I0.9920.29
24_S107_W0.9900.29
26_A90_E0.9810.28
14_H106_W0.9790.28
87_K90_E0.9660.28
71_M94_L0.9520.27
33_T84_I0.9490.27
29_F37_Q0.9450.27
56_A67_G0.9420.27
51_E96_E0.9320.26
69_I99_T0.9060.25
58_D105_V0.9050.25
77_C81_H0.8990.25
13_M41_T0.8910.25
28_R91_E0.8720.24
84_I95_D0.8700.24
9_L16_D0.8670.24
7_R48_E0.8660.24
15_I99_T0.8550.23
33_T63_L0.8510.23
4_N69_I0.8480.23
14_H52_P0.8390.23
54_K91_E0.8380.23
78_T101_E0.8240.22
37_Q93_K0.8150.22
5_R15_I0.8130.22
43_D46_I0.8040.22
73_E81_H0.7990.21
69_I80_E0.7950.21
40_K52_P0.7940.21
42_V79_E0.7910.21
24_S58_D0.7890.21
14_H94_L0.7860.21
21_L106_W0.7780.21
41_T74_I0.7740.21
40_K83_A0.7720.20
40_K79_E0.7700.20
6_S72_Q0.7680.20
86_R99_T0.7640.20
56_A60_S0.7560.20
88_W93_K0.7530.20
25_V45_F0.7520.20
75_G106_W0.7480.20
69_I96_E0.7470.20
50_I81_H0.7400.19
43_D61_G0.7370.19
44_D51_E0.7290.19
74_I106_W0.7210.19
83_A99_T0.7200.19
24_S71_M0.7200.19
21_L85_V0.7190.19
9_L24_S0.7140.19
29_F38_I0.7120.19
84_I99_T0.7070.18
6_S22_G0.6910.18
81_H84_I0.6900.18
24_S74_I0.6840.18
49_V53_N0.6840.18
72_Q77_C0.6830.18
8_R13_M0.6800.18
13_M45_F0.6740.17
46_I54_K0.6680.17
39_D98_R0.6660.17
49_V105_V0.6640.17
33_T93_K0.6590.17
14_H76_K0.6470.17
55_L69_I0.6450.17
87_K95_D0.6440.17
80_E97_V0.6320.16
74_I105_V0.6290.16
10_R17_E0.6270.16
29_F39_D0.6220.16
27_W45_F0.6180.16
6_S75_G0.6160.16
52_P106_W0.6140.16
42_V82_Q0.6120.16
32_G84_I0.6080.16
32_G69_I0.6070.15
4_N18_F0.6070.15
59_G106_W0.5950.15
37_Q64_A0.5940.15
7_R21_L0.5890.15
65_W74_I0.5810.15
36_E87_K0.5650.14
13_M76_K0.5630.14
46_I96_E0.5620.14
25_V59_G0.5590.14
22_G68_L0.5500.14
61_G94_L0.5440.14
21_L86_R0.5410.14
27_W68_L0.5400.14
14_H24_S0.5310.14
29_F35_E0.5230.13
53_N80_E0.5220.13
31_E100_S0.5210.13
68_L107_W0.5180.13
4_N13_M0.5170.13
24_S41_T0.5130.13
37_Q95_D0.5100.13
31_E36_E0.5030.13
74_I101_E0.5000.13
88_W106_W0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jr2A 2 0.9167 44.5 0.923 Contact Map
1f1jA 3 0.8704 40.3 0.925 Contact Map
4jj7A 1 0.8796 39.8 0.925 Contact Map
1m72A 2 0.9074 38.3 0.926 Contact Map
2nn3C 2 0.8889 35.5 0.927 Contact Map
3sirA 2 0.8704 32.7 0.929 Contact Map
2j32A 3 0.8704 32.2 0.929 Contact Map
3od5A 1 0.9074 30.8 0.93 Contact Map
4likA 1 0.9537 27.5 0.931 Contact Map
4m9rA 2 0.8981 27.3 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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