GREMLIN Database
XNI - Flap endonuclease Xni
UniProt: P38506 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12372
Length: 251 (242)
Sequences: 4422 (2675)
Seq/√Len: 171.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_N209_A4.3121.00
150_D153_F3.9161.00
108_A234_L3.1251.00
216_K220_T3.0271.00
221_H224_M2.9371.00
62_R230_D2.8541.00
183_A221_H2.7921.00
222_K226_F2.7671.00
115_T135_S2.6831.00
161_Q164_Q2.5871.00
85_R97_S2.4251.00
89_E95_C2.3961.00
215_R219_E2.3921.00
4_H120_Q2.3621.00
204_Y226_F2.3571.00
155_D161_Q2.2531.00
213_K216_K2.1631.00
213_K217_K2.1381.00
204_Y222_K2.1101.00
199_S202_G2.1031.00
112_V236_T1.9951.00
10_A47_A1.9891.00
201_E226_F1.9721.00
202_G205_E1.9631.00
136_P151_A1.9421.00
243_N246_Q1.9411.00
30_Q87_A1.8771.00
35_Q39_H1.8581.00
168_Y194_L1.8561.00
151_A163_Q1.8371.00
107_A123_I1.7961.00
73_M78_H1.7411.00
202_G206_N1.7221.00
179_V232_A1.7171.00
152_P156_K1.7151.00
204_Y207_L1.7091.00
201_E229_R1.6991.00
212_E215_R1.6941.00
185_I214_W1.6651.00
86_A89_E1.6551.00
182_V225_A1.6531.00
56_S61_Q1.6381.00
168_Y172_A1.6281.00
207_L219_E1.6081.00
230_D235_Q1.5831.00
53_N99_S1.5361.00
152_P155_D1.5281.00
51_D99_S1.4961.00
182_V218_L1.4951.00
192_Q196_E1.4631.00
4_H122_T1.4481.00
120_Q137_T1.4381.00
112_V116_Q1.4361.00
184_G217_K1.4201.00
111_A138_L1.4111.00
134_L154_I1.4111.00
196_E209_A1.4101.00
160_V191_T1.4021.00
125_S130_Y1.3991.00
53_N56_S1.3841.00
167_D229_R1.3811.00
36_L124_V1.3631.00
131_C140_I1.3571.00
153_F156_K1.3571.00
229_R233_R1.3551.00
44_H119_H1.3511.00
172_A187_P1.3491.00
151_A155_D1.3451.00
210_V218_L1.3361.00
17_I76_E1.3341.00
108_A236_T1.3281.00
75_E78_H1.3241.00
166_P233_R1.3181.00
14_I84_L1.3141.00
61_Q100_G1.3121.00
204_Y218_L1.3011.00
115_T138_L1.2921.00
139_R148_W1.2861.00
191_T195_V1.2771.00
16_R32_A1.2721.00
48_V106_L1.2551.00
6_L124_V1.2441.00
101_N235_Q1.2321.00
207_L215_R1.2201.00
69_G178_K1.2151.00
57_G60_H1.2121.00
63_L231_I1.2121.00
201_E205_E1.1991.00
56_S60_H1.1931.00
170_G232_A1.1911.00
197_F210_V1.1771.00
75_E79_D1.1741.00
62_R227_L1.1681.00
21_Q24_P1.1541.00
134_L140_I1.1541.00
217_K220_T1.1451.00
179_V228_C1.1381.00
212_E216_K1.1361.00
98_T106_L1.1281.00
128_K169_W1.1271.00
193_L203_I1.1251.00
197_F206_N1.1241.00
164_Q198_Q1.1231.00
183_A224_M1.1191.00
171_L189_S1.1181.00
109_T238_L1.1181.00
111_A121_A1.1101.00
33_L93_V1.1041.00
49_F95_C1.0951.00
204_Y225_A1.0931.00
114_V121_A1.0921.00
154_I160_V1.0771.00
216_K219_E1.0751.00
115_T137_T1.0741.00
113_K117_A1.0741.00
235_Q238_L1.0721.00
101_N238_L1.0711.00
197_F209_A1.0510.99
149_L153_F1.0340.99
147_R157_E1.0320.99
120_Q139_R1.0300.99
5_L114_V1.0240.99
51_D97_S1.0180.99
46_V247_L1.0170.99
6_L36_L1.0120.99
168_Y187_P1.0100.99
159_G195_V0.9900.99
52_E56_S0.9860.99
25_C80_E0.9820.99
217_K221_H0.9800.99
82_P86_A0.9790.99
27_E31_H0.9610.99
101_N239_H0.9610.99
6_L45_A0.9540.99
187_P191_T0.9510.99
14_I77_L0.9490.99
18_H71_P0.9470.99
147_R153_F0.9340.99
121_A138_L0.9300.99
107_A130_Y0.9230.99
112_V115_T0.9210.99
30_Q84_L0.9200.99
29_C88_F0.9170.99
112_V135_S0.9080.99
30_Q34_D0.9070.98
40_S148_W0.9040.98
153_F157_E0.9000.98
5_L247_L0.8970.98
198_Q202_G0.8950.98
8_V47_A0.8940.98
18_H74_P0.8930.98
155_D195_V0.8890.98
53_N60_H0.8870.98
26_V83_A0.8850.98
207_L218_L0.8830.98
26_V84_L0.8830.98
168_Y191_T0.8810.98
83_A86_A0.8780.98
130_Y234_L0.8760.98
160_V164_Q0.8760.98
242_G247_L0.8740.98
51_D56_S0.8710.98
5_L119_H0.8660.98
219_E222_K0.8660.98
180_P228_C0.8650.98
131_C149_L0.8620.98
228_C232_A0.8600.98
76_E79_D0.8590.98
166_P232_A0.8580.98
224_M227_L0.8530.98
114_V118_G0.8510.98
170_G225_A0.8510.98
200_L225_A0.8490.98
122_T141_R0.8430.98
96_W247_L0.8430.98
63_L180_P0.8420.98
40_S122_T0.8350.97
25_C84_L0.8340.97
6_L122_T0.8320.97
226_F229_R0.8280.97
63_L227_L0.8230.97
141_R148_W0.8220.97
117_A245_Q0.8210.97
114_V119_H0.8130.97
185_I193_L0.8130.97
68_A178_K0.8110.97
164_Q194_L0.8030.97
131_C142_D0.8030.97
131_C134_L0.8000.97
192_Q214_W0.7930.97
81_M85_R0.7900.96
160_V168_Y0.7850.96
4_H40_S0.7840.96
185_I189_S0.7830.96
29_C84_L0.7830.96
6_L40_S0.7830.96
151_A161_Q0.7820.96
47_A88_F0.7790.96
196_E211_A0.7780.96
5_L121_A0.7690.96
171_L218_L0.7690.96
233_R236_T0.7670.96
223_E226_F0.7660.96
189_S214_W0.7630.96
154_I165_L0.7620.96
170_G228_C0.7600.96
210_V215_R0.7590.96
210_V214_W0.7590.96
160_V165_L0.7580.95
7_I110_L0.7510.95
193_L214_W0.7470.95
149_L157_E0.7460.95
222_K225_A0.7450.95
40_S141_R0.7430.95
203_I210_V0.7410.95
189_S192_Q0.7390.95
8_V13_L0.7380.95
225_A228_C0.7320.95
34_D91_R0.7290.94
207_L222_K0.7280.94
184_G213_K0.7270.94
79_D82_P0.7270.94
65_D68_A0.7240.94
139_R150_D0.7230.94
47_A93_V0.7230.94
48_V110_L0.7190.94
226_F230_D0.7170.94
7_I121_A0.7150.94
58_W235_Q0.7130.94
158_F165_L0.7130.94
12_N143_Y0.7100.94
122_T148_W0.7090.94
122_T139_R0.7090.94
115_T121_A0.7070.93
37_I45_A0.7020.93
211_A214_W0.7020.93
182_V221_H0.7000.93
214_W217_K0.7000.93
124_V141_R0.6980.93
154_I157_E0.6960.93
45_A93_V0.6940.93
17_I21_Q0.6850.92
52_E78_H0.6790.92
160_V195_V0.6790.92
161_Q198_Q0.6770.92
208_D219_E0.6740.92
165_L169_W0.6720.92
165_L232_A0.6720.92
128_K142_D0.6670.91
20_V28_T0.6640.91
7_I107_A0.6640.91
96_W110_L0.6610.91
51_D106_L0.6550.91
4_H43_T0.6530.90
32_A143_Y0.6480.90
170_G200_L0.6470.90
98_T239_H0.6470.90
221_H225_A0.6460.90
118_G121_A0.6460.90
21_Q28_T0.6450.90
182_V217_K0.6430.90
129_G177_S0.6430.90
168_Y190_A0.6420.90
170_G229_R0.6390.90
121_A137_T0.6380.89
171_L200_L0.6340.89
166_P170_G0.6330.89
200_L226_F0.6310.89
56_S100_G0.6290.89
164_Q199_S0.6270.89
194_L198_Q0.6260.89
135_S138_L0.6250.88
20_V23_S0.6220.88
94_P246_Q0.6210.88
20_V24_P0.6200.88
166_P229_R0.6200.88
12_N126_T0.6090.87
10_A14_I0.6080.87
203_I206_N0.6070.87
151_A162_P0.6070.87
169_W176_S0.6040.87
142_D145_Q0.6010.86
49_F97_S0.6010.86
142_D169_W0.6010.86
73_M77_L0.5980.86
11_L81_M0.5960.86
58_W101_N0.5960.86
26_V87_A0.5920.86
227_L230_D0.5920.86
139_R151_A0.5910.86
154_I191_T0.5910.86
12_N125_S0.5900.85
7_I123_I0.5890.85
11_L49_F0.5880.85
174_I177_S0.5880.85
113_K243_N0.5860.85
154_I158_F0.5860.85
113_K116_Q0.5850.85
7_I46_V0.5820.85
200_L203_I0.5800.85
203_I207_L0.5770.84
112_V138_L0.5770.84
164_Q167_D0.5750.84
22_G76_E0.5740.84
171_L203_I0.5710.84
46_V96_W0.5700.83
142_D149_L0.5690.83
183_A217_K0.5690.83
32_A35_Q0.5680.83
230_D233_R0.5670.83
134_L151_A0.5650.83
166_P234_L0.5640.83
205_E226_F0.5620.83
60_H176_S0.5600.82
207_L210_V0.5600.82
111_A115_T0.5590.82
98_T101_N0.5580.82
88_F91_R0.5540.82
88_F93_V0.5530.82
72_P78_H0.5520.82
98_T238_L0.5520.82
212_E219_E0.5520.82
111_A236_T0.5490.81
13_L143_Y0.5490.81
199_S205_E0.5480.81
96_W106_L0.5440.81
165_L168_Y0.5440.81
208_D215_R0.5420.80
49_F85_R0.5390.80
30_Q33_L0.5380.80
17_I22_G0.5370.80
8_V124_V0.5340.79
206_N210_V0.5320.79
4_H119_H0.5320.79
5_L46_V0.5310.79
166_P169_W0.5300.79
13_L130_Y0.5300.79
159_G191_T0.5300.79
183_A220_T0.5300.79
17_I80_E0.5290.79
194_L199_S0.5290.79
155_D159_G0.5280.79
218_L225_A0.5280.79
34_D38_M0.5270.78
131_C165_L0.5250.78
30_Q91_R0.5240.78
192_Q195_V0.5240.78
171_L182_V0.5200.78
82_P85_R0.5180.77
172_A194_L0.5170.77
57_G61_Q0.5150.77
134_L153_F0.5140.77
175_S187_P0.5110.76
14_I81_M0.5110.76
220_T224_M0.5080.76
164_Q168_Y0.5070.76
72_P75_E0.5050.76
135_S236_T0.5050.76
111_A114_V0.5040.75
13_L124_V0.5020.75
27_E178_K0.5010.75
42_P45_A0.5000.75
4_H44_H0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zdbA 1 0.9801 100 0.186 Contact Map
1bgxT 1 0.9761 100 0.193 Contact Map
1exnA 1 0.9801 100 0.219 Contact Map
3h7iA 1 0.9402 100 0.293 Contact Map
4q0wA 1 0.9363 100 0.39 Contact Map
2izoA 1 0.7331 100 0.413 Contact Map
1rxwA 1 0.8566 100 0.424 Contact Map
3oryA 3 0.8924 100 0.426 Contact Map
4wa8A 1 0.8247 100 0.447 Contact Map
3q8kA 1 0.9203 100 0.452 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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