GREMLIN Database
NFNB - Oxygen-insensitive NAD(P)H nitroreductase
UniProt: P38489 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20151
Length: 217 (198)
Sequences: 7049 (5454)
Seq/√Len: 387.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_D20_K4.5481.00
29_Q157_L4.0391.00
24_P52_S3.1011.00
24_P28_E2.9071.00
23_T26_Q2.8021.00
20_K193_H2.7661.00
48_F146_N2.6421.00
160_D194_H2.4721.00
30_I154_V2.4281.00
173_D185_S2.3861.00
54_E58_A2.3291.00
59_R175_E2.2551.00
159_L193_H2.2531.00
32_T35_Q2.2321.00
147_V187_V2.0651.00
26_Q159_L1.9731.00
56_G59_R1.9381.00
15_A195_S1.8931.00
33_L153_G1.8681.00
151_L163_P1.8351.00
26_Q157_L1.8201.00
63_S171_I1.8021.00
8_L36_Y1.7851.00
63_S175_E1.7701.00
210_Q214_L1.7531.00
3_I6_V1.6671.00
155_A160_D1.6631.00
61_A76_L1.6591.00
60_V172_L1.6511.00
154_V191_V1.6371.00
5_S9_K1.6301.00
9_K155_A1.6071.00
208_L212_I1.6031.00
17_D195_S1.5961.00
16_F190_P1.5851.00
34_L150_F1.5531.00
171_I174_A1.5521.00
194_H197_E1.5501.00
30_I159_L1.5441.00
3_I7_A1.5211.00
28_E211_N1.5211.00
151_L161_A1.5081.00
147_V189_V1.4781.00
179_K182_G1.4561.00
47_H183_Y1.4401.00
154_V161_A1.4301.00
73_R77_D1.4291.00
56_G175_E1.4241.00
12_S162_V1.4231.00
110_T114_K1.4141.00
53_T56_G1.4121.00
151_L189_V1.4041.00
30_I150_F1.4031.00
35_Q213_T1.3991.00
58_A62_K1.3351.00
141_K144_Y1.3261.00
30_I191_V1.3221.00
120_G124_F1.3151.00
16_F162_V1.3121.00
159_L191_V1.3081.00
143_V186_L1.3001.00
145_L148_G1.2831.00
168_D171_I1.2781.00
22_L159_L1.2761.00
141_K165_E1.2641.00
7_A149_N1.2531.00
33_L157_L1.2491.00
54_E57_K1.2441.00
4_I157_L1.2391.00
31_K214_L1.2251.00
4_I8_L1.2091.00
97_L212_I1.2071.00
171_I175_E1.2041.00
48_F82_V1.2031.00
59_R62_K1.1991.00
21_K52_S1.1951.00
55_E58_A1.1931.00
103_D106_G1.1911.00
4_I33_L1.1861.00
118_D121_R1.1771.00
114_K118_D1.1611.00
116_A119_K1.1501.00
27_A191_V1.1461.00
26_Q29_Q1.1441.00
73_R76_L1.1441.00
8_L32_T1.1101.00
37_S149_N1.1041.00
98_V102_E1.1031.00
101_Q105_D1.0961.00
117_N120_G1.0931.00
22_L193_H1.0821.00
102_E105_D1.0771.00
150_F191_V1.0681.00
119_K122_K1.0631.00
28_E210_Q1.0341.00
22_L26_Q1.0331.00
89_A92_D1.0251.00
4_I29_Q1.0251.00
28_E32_T1.0251.00
29_Q33_L1.0081.00
161_A191_V1.0021.00
150_F189_V1.0001.00
26_Q193_H0.9831.00
118_D122_K0.9821.00
116_A120_G0.9751.00
136_A184_T0.9741.00
178_L181_K0.9721.00
93_V97_L0.9701.00
78_A81_V0.9681.00
149_N152_L0.9671.00
99_V102_E0.9631.00
34_L48_F0.9581.00
170_A174_A0.9521.00
82_V150_F0.9521.00
98_V103_D0.9481.00
77_D80_H0.9471.00
72_E76_L0.9451.00
99_V103_D0.9441.00
101_Q104_A0.9371.00
25_E28_E0.9361.00
40_S165_E0.9251.00
87_K93_V0.9201.00
3_I156_A0.9101.00
71_N74_K0.9101.00
6_V156_A0.9081.00
98_V101_Q0.9071.00
161_A189_V0.9061.00
15_A196_V0.9021.00
23_T193_H0.9011.00
78_A82_V0.8981.00
30_I157_L0.8971.00
121_R124_F0.8961.00
97_L100_D0.8941.00
5_S8_L0.8831.00
138_W165_E0.8701.00
100_D104_A0.8671.00
31_K50_V0.8621.00
50_V214_L0.8621.00
137_E141_K0.8581.00
31_K34_L0.8571.00
96_K100_D0.8551.00
122_K125_A0.8471.00
118_D124_F0.8471.00
140_A186_L0.8431.00
13_T198_D0.8431.00
115_A119_K0.8391.00
84_F150_F0.8361.00
87_K90_M0.8321.00
58_A61_A0.8301.00
21_K54_E0.8271.00
76_L79_S0.8141.00
146_N213_T0.8131.00
162_V190_P0.8091.00
117_N121_R0.8081.00
29_Q32_T0.8051.00
49_I183_Y0.7991.00
173_D184_T0.7991.00
172_L175_E0.7951.00
32_T210_Q0.7931.00
39_S46_W0.7911.00
137_E140_A0.7841.00
64_A188_V0.7831.00
49_I176_F0.7821.00
40_S138_W0.7781.00
169_A185_S0.7721.00
102_E106_G0.7681.00
55_E59_R0.7681.00
14_K74_K0.7671.00
3_I152_L0.7631.00
59_R63_S0.7601.00
51_A56_G0.7511.00
113_A116_A0.7481.00
131_D134_D0.7471.00
99_V104_A0.7451.00
13_T194_H0.7451.00
58_A76_L0.7441.00
88_T91_D0.7431.00
113_A120_G0.7411.00
121_R125_A0.7361.00
209_P212_I0.7341.00
27_A50_V0.7301.00
85_C183_Y0.7281.00
172_L185_S0.7271.00
27_A31_K0.7231.00
75_M78_A0.7231.00
98_V106_G0.7221.00
150_F161_A0.7171.00
163_P187_V0.7121.00
141_K186_L0.7081.00
153_G156_A0.7071.00
7_A33_L0.7031.00
111_P114_K0.7001.00
100_D103_D0.6991.00
90_M93_V0.6981.00
22_L25_E0.6971.00
114_K117_N0.6940.99
88_T92_D0.6920.99
178_L183_Y0.6890.99
25_E29_Q0.6800.99
178_L185_S0.6790.99
17_D193_H0.6770.99
84_F88_T0.6760.99
194_H198_D0.6750.99
99_V105_D0.6730.99
57_K61_A0.6600.99
117_N123_F0.6600.99
95_L98_V0.6560.99
111_P115_A0.6560.99
95_L102_E0.6500.99
123_F126_D0.6490.99
120_G123_F0.6480.99
140_A144_Y0.6470.99
119_K123_F0.6440.99
164_I190_P0.6430.99
72_E75_M0.6430.99
74_K77_D0.6430.99
27_A80_H0.6430.99
15_A198_D0.6410.99
148_G152_L0.6390.99
145_L149_N0.6360.99
88_T184_T0.6340.99
63_S172_L0.6310.99
119_K124_F0.6280.99
170_A173_D0.6230.99
84_F87_K0.6220.99
103_D110_T0.6170.99
142_Q165_E0.6120.99
48_F84_F0.6090.99
39_S45_P0.6070.99
87_K91_D0.6050.99
169_A173_D0.6040.99
122_K126_D0.6030.99
78_A83_V0.6030.99
81_V190_P0.6020.99
51_A176_F0.6010.99
95_L99_V0.6000.99
46_W213_T0.5980.98
83_V188_V0.5970.98
22_L27_A0.5950.98
61_A72_E0.5950.98
49_I85_C0.5940.98
140_A184_T0.5910.98
4_I156_A0.5900.98
147_V151_L0.5860.98
7_A156_A0.5840.98
113_A118_D0.5840.98
17_D196_V0.5790.98
35_Q48_F0.5770.98
115_A118_D0.5770.98
75_M81_V0.5770.98
113_A119_K0.5760.98
77_D81_V0.5730.98
64_A75_M0.5680.98
31_K213_T0.5660.98
141_K187_V0.5640.98
6_V158_G0.5640.98
50_V80_H0.5610.98
138_W141_K0.5590.98
97_L101_Q0.5570.98
115_A121_R0.5530.98
173_D178_L0.5510.97
64_A172_L0.5500.97
83_V86_A0.5470.97
11_H204_P0.5450.97
23_T159_L0.5450.97
74_K78_A0.5420.97
60_V176_F0.5420.97
30_I153_G0.5410.97
179_K183_Y0.5390.97
46_W143_V0.5390.97
114_K119_K0.5370.97
150_F153_G0.5340.97
80_H84_F0.5330.97
195_S198_D0.5330.97
23_T28_E0.5320.97
103_D108_F0.5310.97
27_A52_S0.5290.97
110_T113_A0.5290.97
75_M79_S0.5270.97
36_Y204_P0.5260.97
30_I34_L0.5250.97
89_A182_G0.5250.97
56_G176_F0.5230.97
40_S142_Q0.5210.96
172_L188_V0.5190.96
12_S163_P0.5160.96
6_V152_L0.5150.96
118_D123_F0.5150.96
7_A36_Y0.5110.96
56_G60_V0.5090.96
79_S83_V0.5070.96
13_T16_F0.5060.96
113_A122_K0.5030.96
89_A93_V0.5030.96
152_L156_A0.5010.96
167_F188_V0.5000.96
30_I33_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3of4A 3 0.9539 100 0.196 Contact Map
1icrA 2 0.9908 100 0.197 Contact Map
3bemA 2 0.9447 100 0.202 Contact Map
3gagA 4 0.9309 100 0.202 Contact Map
3ge6A 2 0.9401 100 0.206 Contact Map
4qlxA 2 0.9447 100 0.207 Contact Map
1vfrA 2 0.9677 100 0.217 Contact Map
3gbhA 3 0.9447 100 0.218 Contact Map
1noxA 2 0.9124 100 0.223 Contact Map
2h0uA 2 0.8571 100 0.225 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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