FADK - ECOLI - GREMLIN Contacts

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FADK - Short-chain-fatty-acid--CoA ligase

UniProt:	P38135	Sequences: MKVTLTFNEQRRAAYRQQGLWGDASLADYWQQTARAMPDKIAVVDNHGASYTYSALDHAASCLANWMLAKGIESGDRIAFQLPGWCEFTVIYLACLKIGAVSVPLLPSWREAELVWVLNKCQAKMFFAPTLFKQTRPVDLILPLQNQLPQLQQIVGVDKLAPATSSLSLSQIIADNTSLTTAITTHGDELAAVLFTSGTEGLPKGVMLTHNNILASERAYCARLNLTWQDVFMMPAPLGHATGFLHGVTAPFLIGARSVLLDIFTPDACLALLEQQRCTCMLGATPFVYDLLNVLEKQPADLSALRFFLCGGTTIPKKVARECQQRGIKLLSVYGSTESSPHAVVNLDDPLSRFMHTDGYAAAGVEIKVVDDARKTLPPGCEGEEASRGPNVFMGYFDEPELTARALDEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMSDERLGERSCAYVVLKAPHHSLSLEEVVAFFSRKRVAKYKYPEHIVVIEKLPRTTSGKIQKFLLRKDIMRRLTQDVCEEIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12357
Length:	548 (491)
Sequences:	71531 (51650)
Seq/√Len:	2330.9

ECOLI - FADK LCFA ACSA ENTF AAS ENTE PRPE CAIC MENE PAAK
BACSU - DHBE PPSE SRFAC LCFA ACSA YNGI LCFB YDAB PPSB YTCI MENE PPSC DLTA YHFT DHBF PKSJ PPSD SRFAA PKSN SRFAB PPSA
HALSA - Q9HRY8 Q9HSM3 Q9HNK0 Q9HQU8 Q9HQ43 Q9HQN8
SULSO - Q97UX8 Q97UW7 Q97VU7 Q97VT6 Q97YK9 Q97U22 Q97WQ0 Q97WQ9 Q97WK0 Q97XW4 Q97UF6 Q97V27 Q97WS5 Q980E4 Q97X52 Q97XW5 Q97VJ6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
190_L	207_M	4.046	1.00
385_E	419_C	3.460	1.00
120_K	195_F	3.101	1.00
366_E	388_R	3.017	1.00
456_H	498_F	2.964	1.00
399_E	402_L	2.938	1.00
72_I	100_A	2.935	1.00
61_S	97_K	2.895	1.00
76_D	124_K	2.811	1.00
209_T	394_M	2.792	1.00
79_A	123_A	2.722	1.00
57_D	97_K	2.666	1.00
420_R	428_K	2.638	1.00
77_R	103_V	2.530	1.00
44_V	257_R	2.482	1.00
438_V	443_N	2.473	1.00
384_E	414_Y	2.445	1.00
41_I	50_S	2.425	1.00
231_V	257_R	2.391	1.00
461_D	520_R	2.373	1.00
122_Q	398_D	2.371	1.00
371_D	375_K	2.342	1.00
453_L	478_A	2.314	1.00
382_E	418_L	2.300	1.00
37_M	40_K	2.271	1.00
454_L	462_A	2.264	1.00
370_V	386_A	2.252	1.00
66_W	70_K	2.243	1.00
31_Q	57_D	2.233	1.00
91_I	127_F	2.206	1.00
368_K	376_T	2.200	1.00
271_A	275_Q	2.189	1.00
120_K	399_E	2.155	1.00
33_T	37_M	2.087	1.00
230_D	306_R	2.086	1.00
59_A	90_V	2.048	1.00
116_W	202_L	2.037	1.00
186_H	189_E	2.035	1.00
357_T	428_K	2.007	1.00
477_C	513_V	1.997	1.00
386_A	414_Y	1.987	1.00
402_L	405_R	1.966	1.00
63_L	90_V	1.959	1.00
74_S	189_E	1.943	1.00
57_D	61_S	1.935	1.00
95_C	100_A	1.921	1.00
422_D	428_K	1.920	1.00
400_P	404_A	1.905	1.00
455_Q	502_R	1.901	1.00
527_Q	530_L	1.899	1.00
435_D	528_K	1.898	1.00
230_D	279_T	1.878	1.00
39_D	54_S	1.858	1.00
75_G	189_E	1.836	1.00
422_D	426_Y	1.832	1.00
115_V	119_N	1.809	1.00
60_A	97_K	1.775	1.00
421_M	427_I	1.775	1.00
439_R	444_I	1.760	1.00
68_L	98_I	1.758	1.00
368_K	386_A	1.758	1.00
317_K	321_R	1.752	1.00
448_E	507_K	1.732	1.00
73_E	76_D	1.730	1.00
44_V	50_S	1.711	1.00
259_V	278_C	1.696	1.00
54_S	58_H	1.682	1.00
369_V	419_C	1.680	1.00
420_R	430_T	1.680	1.00
83_P	129_P	1.672	1.00
479_Y	531_L	1.664	1.00
382_E	430_T	1.657	1.00
209_T	212_N	1.656	1.00
530_L	533_K	1.652	1.00
32_Q	36_A	1.651	1.00
89_T	248_V	1.646	1.00
464_V	478_A	1.643	1.00
44_V	276_Q	1.640	1.00
190_L	394_M	1.635	1.00
379_P	421_M	1.632	1.00
454_L	461_D	1.630	1.00
460_H	483_K	1.618	1.00
96_L	191_A	1.608	1.00
450_E	464_V	1.606	1.00
79_A	105_L	1.588	1.00
481_V	518_L	1.578	1.00
277_R	304_A	1.566	1.00
490_S	493_E	1.562	1.00
465_V	479_Y	1.553	1.00
61_S	65_N	1.550	1.00
45_D	86_C	1.548	1.00
321_R	325_Q	1.547	1.00
51_Y	90_V	1.532	1.00
121_C	195_F	1.529	1.00
401_E	405_R	1.528	1.00
283_G	288_V	1.520	1.00
378_P	381_C	1.519	1.00
251_P	256_A	1.514	1.00
212_N	340_S	1.509	1.00
78_I	95_C	1.507	1.00
70_K	153_Q	1.507	1.00
52_T	55_A	1.497	1.00
66_W	172_I	1.491	1.00
45_D	48_G	1.487	1.00
458_K	493_E	1.483	1.00
354_F	424_A	1.482	1.00
188_D	211_N	1.473	1.00
343_A	387_S	1.472	1.00
33_T	36_A	1.470	1.00
419_C	429_I	1.469	1.00
268_A	271_A	1.466	1.00
193_V	397_F	1.459	1.00
41_I	44_V	1.457	1.00
195_F	205_G	1.453	1.00
498_F	502_R	1.444	1.00
115_V	147_Q	1.442	1.00
42_A	56_L	1.441	1.00
41_I	257_R	1.440	1.00
233_M	278_C	1.437	1.00
388_R	412_W	1.437	1.00
286_P	313_T	1.429	1.00
367_I	387_S	1.428	1.00
480_V	512_I	1.414	1.00
274_E	300_A	1.412	1.00
336_S	413_Y	1.411	1.00
230_D	280_C	1.407	1.00
521_T	527_Q	1.401	1.00
75_G	394_M	1.397	1.00
31_Q	97_K	1.394	1.00
120_K	398_D	1.394	1.00
329_K	347_L	1.393	1.00
482_L	514_V	1.392	1.00
288_V	308_F	1.387	1.00
207_M	395_G	1.385	1.00
63_L	94_A	1.385	1.00
94_A	98_I	1.384	1.00
78_I	100_A	1.382	1.00
51_Y	86_C	1.379	1.00
371_D	377_L	1.379	1.00
38_P	54_S	1.376	1.00
40_K	229_Q	1.375	1.00
77_R	101_V	1.370	1.00
221_C	254_I	1.368	1.00
227_T	230_D	1.363	1.00
480_V	514_V	1.363	1.00
79_A	118_L	1.351	1.00
468_S	474_E	1.347	1.00
310_C	315_I	1.346	1.00
495_V	512_I	1.343	1.00
393_F	407_L	1.339	1.00
452_I	502_R	1.336	1.00
406_A	413_Y	1.336	1.00
231_V	278_C	1.332	1.00
50_S	276_Q	1.330	1.00
34_A	57_D	1.322	1.00
222_A	363_A	1.316	1.00
77_R	397_F	1.315	1.00
118_L	123_A	1.312	1.00
207_M	397_F	1.306	1.00
261_L	272_L	1.306	1.00
437_I	446_S	1.305	1.00
72_I	78_I	1.302	1.00
344_V	367_I	1.301	1.00
101_V	190_L	1.290	1.00
469_D	475_R	1.287	1.00
273_L	304_A	1.274	1.00
265_T	268_A	1.273	1.00
231_V	259_V	1.264	1.00
72_I	76_D	1.262	1.00
382_E	420_R	1.260	1.00
385_E	429_I	1.259	1.00
58_H	62_C	1.257	1.00
103_V	121_C	1.253	1.00
77_R	193_V	1.243	1.00
354_F	426_Y	1.241	1.00
105_L	114_L	1.237	1.00
418_L	433_K	1.234	1.00
212_N	392_V	1.232	1.00
479_Y	532_R	1.229	1.00
272_L	276_Q	1.229	1.00
187_G	211_N	1.229	1.00
80_F	91_I	1.224	1.00
500_R	508_Y	1.224	1.00
130_T	158_D	1.215	1.00
93_L	252_F	1.212	1.00
196_T	206_V	1.204	1.00
116_W	120_K	1.202	1.00
111_E	143_P	1.202	1.00
467_M	477_C	1.196	1.00
461_D	481_V	1.195	1.00
281_M	305_L	1.187	1.00
496_A	501_K	1.185	1.00
59_A	62_C	1.183	1.00
360_Y	426_Y	1.179	1.00
46_N	262_D	1.177	1.00
479_Y	515_I	1.176	1.00
478_A	512_I	1.175	1.00
56_L	93_L	1.171	1.00
491_L	514_V	1.170	1.00
242_T	282_L	1.169	1.00
477_C	511_H	1.168	1.00
82_L	157_V	1.165	1.00
57_D	180_T	1.163	1.00
125_M	153_Q	1.160	1.00
60_A	94_A	1.159	1.00
361_A	367_I	1.158	1.00
211_N	390_P	1.156	1.00
482_L	489_L	1.148	1.00
372_D	433_K	1.148	1.00
368_K	412_W	1.146	1.00
193_V	205_G	1.145	1.00
377_L	381_C	1.143	1.00
55_A	58_H	1.141	1.00
46_N	49_A	1.140	1.00
293_N	322_E	1.134	1.00
384_E	433_K	1.133	1.00
447_R	451_D	1.132	1.00
69_A	176_N	1.131	1.00
435_D	447_R	1.130	1.00
119_N	202_L	1.129	1.00
111_E	115_V	1.127	1.00
185_T	189_E	1.127	1.00
63_L	127_F	1.116	1.00
280_C	307_F	1.109	1.00
120_K	202_L	1.108	1.00
208_L	212_N	1.107	1.00
25_S	28_D	1.105	1.00
31_Q	61_S	1.104	1.00
72_I	125_M	1.102	1.00
499_S	508_Y	1.100	1.00
59_A	87_E	1.100	1.00
442_E	506_Y	1.100	1.00
479_Y	535_I	1.084	1.00
207_M	394_M	1.079	1.00
346_N	426_Y	1.069	1.00
116_W	195_F	1.069	1.00
408_D	414_Y	1.068	1.00
475_R	510_E	1.067	1.00
65_N	177_T	1.064	1.00
369_V	377_L	1.063	1.00
88_F	238_L	1.058	1.00
515_I	518_L	1.057	1.00
466_A	474_E	1.056	1.00
452_I	499_S	1.055	1.00
493_E	496_A	1.054	1.00
113_E	507_K	1.053	1.00
259_V	272_L	1.052	1.00
491_L	512_I	1.049	1.00
440_G	472_L	1.049	1.00
51_Y	59_A	1.047	1.00
323_C	326_R	1.045	1.00
66_W	176_N	1.043	1.00
49_A	59_A	1.043	1.00
42_A	53_Y	1.041	1.00
365_V	391_N	1.037	1.00
66_W	69_A	1.035	1.00
367_I	385_E	1.032	1.00
45_D	49_A	1.030	1.00
387_S	415_S	1.027	1.00
358_D	429_I	1.026	1.00
40_K	257_R	1.024	1.00
267_D	294_V	1.023	1.00
518_L	526_I	1.023	1.00
41_I	52_T	1.022	1.00
492_E	496_A	1.021	1.00
58_H	178_S	1.020	1.00
436_I	445_S	1.014	1.00
292_L	322_E	1.011	1.00
64_A	97_K	1.011	1.00
389_G	392_V	1.011	1.00
316_P	319_V	1.011	1.00
76_D	100_A	1.009	1.00
386_A	412_W	1.008	1.00
81_Q	114_L	1.008	1.00
230_D	256_A	1.007	1.00
65_N	181_T	1.006	1.00
231_V	279_T	1.005	1.00
437_I	476_S	1.005	1.00
344_V	427_I	1.004	1.00
44_V	259_V	1.004	1.00
456_H	493_E	1.004	1.00
56_L	90_V	1.004	1.00
402_L	406_A	1.000	1.00
289_Y	319_V	0.998	1.00
188_D	209_T	0.995	1.00
194_L	337_T	0.991	1.00
49_A	86_C	0.991	1.00
197_S	523_S	0.990	1.00
456_H	494_V	0.989	1.00
418_L	431_G	0.988	1.00
388_R	410_E	0.988	1.00
475_R	511_H	0.986	1.00
346_N	357_T	0.984	1.00
215_A	364_G	0.981	1.00
467_M	511_H	0.979	1.00
236_A	242_T	0.979	1.00
504_A	507_K	0.979	1.00
232_F	251_P	0.974	1.00
206_V	393_F	0.973	1.00
72_I	98_I	0.973	1.00
259_V	276_Q	0.972	1.00
450_E	528_K	0.971	1.00
500_R	505_K	0.968	1.00
30_W	34_A	0.968	1.00
367_I	427_I	0.964	1.00
67_M	95_C	0.963	1.00
529_F	533_K	0.963	1.00
458_K	487_H	0.956	1.00
57_D	60_A	0.956	1.00
315_I	320_A	0.954	1.00
515_I	534_D	0.949	1.00
251_P	258_S	0.948	1.00
106_L	239_G	0.946	1.00
463_C	518_L	0.941	1.00
68_L	181_T	0.938	1.00
63_L	91_I	0.934	1.00
51_Y	56_L	0.929	1.00
385_E	427_I	0.926	1.00
56_L	60_A	0.924	1.00
216_S	341_P	0.924	1.00
215_A	390_P	0.922	1.00
290_D	471_R	0.920	1.00
494_V	512_I	0.920	1.00
86_C	90_V	0.917	1.00
43_V	89_T	0.917	1.00
116_W	399_E	0.914	1.00
112_A	115_V	0.913	1.00
371_D	381_C	0.912	1.00
77_R	122_Q	0.910	1.00
264_F	287_F	0.910	1.00
439_R	466_A	0.909	1.00
129_P	132_F	0.907	1.00
452_I	455_Q	0.901	1.00
109_W	117_V	0.896	1.00
112_A	502_R	0.891	1.00
369_V	427_I	0.888	1.00
191_A	210_H	0.887	1.00
354_F	422_D	0.883	1.00
458_K	483_K	0.881	1.00
233_M	261_L	0.881	1.00
455_Q	498_F	0.879	1.00
468_S	471_R	0.878	1.00
82_L	85_W	0.878	1.00
208_L	340_S	0.877	1.00
460_H	481_V	0.876	1.00
65_N	68_L	0.873	1.00
217_E	253_L	0.872	1.00
530_L	534_D	0.871	1.00
339_S	413_Y	0.871	1.00
79_A	126_F	0.870	1.00
190_L	209_T	0.870	1.00
399_E	403_T	0.867	1.00
357_T	426_Y	0.862	1.00
495_V	500_R	0.859	1.00
282_L	342_H	0.856	1.00
370_V	376_T	0.850	1.00
116_W	119_N	0.844	1.00
27_A	185_T	0.842	1.00
498_F	501_K	0.842	1.00
111_E	140_L	0.841	1.00
67_M	127_F	0.841	1.00
112_A	116_W	0.841	1.00
479_Y	534_D	0.841	1.00
44_V	231_V	0.840	1.00
318_K	322_E	0.835	1.00
95_C	102_S	0.835	1.00
80_F	102_S	0.834	1.00
30_W	93_L	0.834	1.00
491_L	495_V	0.830	1.00
463_C	531_L	0.830	1.00
288_V	323_C	0.830	1.00
68_L	73_E	0.827	1.00
241_A	336_S	0.827	1.00
32_Q	35_R	0.825	1.00
49_A	87_E	0.823	1.00
235_P	287_F	0.821	1.00
229_Q	279_T	0.819	1.00
496_A	500_R	0.818	1.00
92_Y	102_S	0.817	1.00
241_A	341_P	0.817	1.00
40_K	228_W	0.816	1.00
43_V	86_C	0.814	1.00
458_K	482_L	0.812	1.00
231_V	277_R	0.808	1.00
92_Y	244_F	0.807	1.00
322_E	325_Q	0.804	1.00
339_S	392_V	0.802	1.00
289_Y	316_P	0.802	1.00
64_A	98_I	0.802	1.00
453_L	462_A	0.797	1.00
388_R	411_G	0.796	1.00
439_R	510_E	0.795	1.00
117_V	205_G	0.793	1.00
55_A	59_A	0.791	1.00
90_V	94_A	0.791	1.00
62_C	177_T	0.789	1.00
89_T	260_L	0.788	1.00
367_I	419_C	0.787	1.00
139_D	142_L	0.787	1.00
56_L	89_T	0.785	1.00
70_K	125_M	0.783	1.00
82_L	127_F	0.783	1.00
62_C	178_S	0.781	1.00
87_E	90_V	0.778	1.00
307_F	331_L	0.773	1.00
130_T	156_G	0.773	1.00
407_L	414_Y	0.769	1.00
208_L	393_F	0.768	1.00
296_E	322_E	0.767	1.00
284_A	287_F	0.766	1.00
29_Y	218_R	0.764	1.00
463_C	526_I	0.764	1.00
300_A	303_S	0.758	1.00
374_R	386_A	0.758	1.00
83_P	131_L	0.755	1.00
31_Q	35_R	0.755	1.00
339_S	387_S	0.755	1.00
309_L	333_V	0.754	1.00
274_E	301_D	0.753	1.00
401_E	404_A	0.752	1.00
122_Q	397_F	0.752	1.00
90_V	169_L	0.752	1.00
29_Y	33_T	0.750	1.00
366_E	412_W	0.750	1.00
79_A	103_V	0.749	1.00
95_C	98_I	0.748	1.00
369_V	385_E	0.748	1.00
468_S	472_L	0.747	1.00
446_S	464_V	0.743	1.00
59_A	86_C	0.743	1.00
191_A	213_I	0.742	1.00
128_A	156_G	0.742	1.00
242_T	311_G	0.742	1.00
216_S	340_S	0.739	1.00
318_K	321_R	0.738	1.00
37_M	54_S	0.738	1.00
128_A	154_I	0.735	1.00
103_V	123_A	0.734	1.00
27_A	210_H	0.734	1.00
112_A	202_L	0.734	1.00
315_I	330_L	0.728	1.00
465_V	535_I	0.726	1.00
28_D	31_Q	0.726	1.00
53_Y	256_A	0.725	1.00
288_V	310_C	0.722	1.00
307_F	329_K	0.722	1.00
192_A	208_L	0.721	1.00
128_A	132_F	0.719	1.00
409_E	414_Y	0.719	1.00
267_D	271_A	0.717	1.00
308_F	323_C	0.715	1.00
480_V	494_V	0.715	1.00
130_T	159_K	0.715	1.00
268_A	272_L	0.713	1.00
226_L	280_C	0.711	1.00
185_T	210_H	0.710	1.00
279_T	306_R	0.710	1.00
240_H	442_E	0.709	1.00
414_Y	433_K	0.709	1.00
305_L	308_F	0.709	1.00
81_Q	126_F	0.709	1.00
403_T	407_L	0.708	1.00
34_A	38_P	0.708	1.00
91_I	95_C	0.707	1.00
489_L	494_V	0.706	1.00
481_V	517_K	0.706	1.00
468_S	473_G	0.704	1.00
419_C	427_I	0.704	1.00
62_C	66_W	0.703	1.00
380_G	423_E	0.702	1.00
28_D	32_Q	0.700	1.00
273_L	278_C	0.700	1.00
216_S	246_H	0.699	1.00
126_F	141_I	0.698	1.00
67_M	125_M	0.697	1.00
419_C	430_T	0.697	1.00
102_S	244_F	0.696	1.00
221_C	250_A	0.696	1.00
271_A	300_A	0.696	1.00
39_D	52_T	0.695	1.00
120_K	397_F	0.691	1.00
261_L	269_C	0.691	1.00
477_C	535_I	0.690	1.00
446_S	528_K	0.689	1.00
282_L	333_V	0.689	1.00
495_V	508_Y	0.686	1.00
82_L	88_F	0.685	1.00
27_A	96_L	0.685	1.00
368_K	388_R	0.685	1.00
235_P	284_A	0.684	1.00
64_A	94_A	0.682	1.00
379_P	423_E	0.681	1.00
369_V	421_M	0.679	1.00
333_V	342_H	0.679	1.00
30_W	57_D	0.678	1.00
71_G	100_A	0.678	1.00
92_Y	96_L	0.675	1.00
73_E	100_A	0.675	1.00
439_R	472_L	0.673	1.00
362_A	365_V	0.672	1.00
289_Y	322_E	0.672	1.00
65_N	178_S	0.670	1.00
63_L	67_M	0.667	1.00
485_P	488_S	0.667	1.00
68_L	183_I	0.666	1.00
81_Q	132_F	0.665	1.00
48_G	275_Q	0.663	1.00
125_M	155_V	0.662	1.00
271_A	274_E	0.661	1.00
223_R	363_A	0.660	1.00
233_M	272_L	0.660	1.00
294_V	297_K	0.659	1.00
79_A	121_C	0.659	1.00
141_I	144_L	0.659	1.00
332_S	356_H	0.657	1.00
273_L	281_M	0.657	1.00
226_L	256_A	0.655	1.00
435_D	450_E	0.655	1.00
274_E	304_A	0.653	1.00
467_M	475_R	0.652	1.00
281_M	308_F	0.652	1.00
101_V	397_F	0.652	1.00
171_Q	174_A	0.650	1.00
27_A	31_Q	0.649	1.00
339_S	343_A	0.649	1.00
474_E	532_R	0.648	1.00
85_W	129_P	0.647	1.00
452_I	498_F	0.646	1.00
73_E	124_K	0.645	1.00
65_N	179_L	0.643	1.00
460_H	482_L	0.642	1.00
439_R	476_S	0.642	1.00
289_Y	293_N	0.639	1.00
434_K	474_E	0.636	1.00
387_S	392_V	0.636	1.00
358_D	419_C	0.635	1.00
519_P	531_L	0.634	1.00
101_V	193_V	0.633	1.00
334_Y	343_A	0.633	1.00
60_A	64_A	0.633	1.00
499_S	503_V	0.633	1.00
216_S	342_H	0.632	1.00
50_S	257_R	0.632	1.00
314_T	429_I	0.631	1.00
61_S	180_T	0.631	1.00
33_T	255_G	0.631	1.00
29_Y	214_L	0.630	1.00
78_I	125_M	0.630	1.00
469_D	472_L	0.630	1.00
66_W	173_I	0.626	1.00
110_R	113_E	0.625	1.00
505_K	508_Y	0.625	1.00
212_N	394_M	0.623	1.00
65_N	176_N	0.623	1.00
459_I	480_V	0.623	1.00
227_T	306_R	0.623	1.00
63_L	169_L	0.621	1.00
142_L	145_Q	0.620	1.00
63_L	66_W	0.620	1.00
180_T	183_I	0.614	1.00
463_C	528_K	0.614	1.00
68_L	182_A	0.613	1.00
145_Q	148_L	0.612	1.00
120_K	205_G	0.612	1.00
173_I	176_N	0.612	1.00
188_D	394_M	0.612	1.00
232_F	256_A	0.612	1.00
69_A	175_D	0.611	1.00
233_M	273_L	0.610	1.00
61_S	179_L	0.610	1.00
87_E	129_P	0.609	1.00
453_L	464_V	0.608	1.00
370_V	412_W	0.606	1.00
269_C	273_L	0.606	1.00
299_P	302_L	0.606	1.00
264_F	269_C	0.606	1.00
82_L	91_I	0.605	1.00
51_Y	55_A	0.604	1.00
236_A	282_L	0.604	1.00
60_A	63_L	0.604	1.00
232_F	280_C	0.603	1.00
470_E	473_G	0.602	1.00
237_P	240_H	0.602	1.00
65_N	180_T	0.601	1.00
274_E	303_S	0.601	1.00
77_R	398_D	0.601	1.00
331_L	347_L	0.600	1.00
68_L	180_T	0.599	1.00
438_V	445_S	0.597	1.00
392_V	413_Y	0.596	1.00
447_R	450_E	0.595	1.00
93_L	249_T	0.595	1.00
103_V	195_F	0.595	1.00
92_Y	249_T	0.595	1.00
74_S	185_T	0.594	1.00
239_G	442_E	0.593	1.00
246_H	282_L	0.593	1.00
308_F	328_I	0.593	1.00
74_S	183_I	0.592	1.00
495_V	499_S	0.590	1.00
273_L	277_R	0.589	1.00
217_E	249_T	0.589	1.00
35_R	57_D	0.588	1.00
234_M	247_G	0.585	1.00
449_V	476_S	0.584	1.00
226_L	230_D	0.581	1.00
289_Y	318_K	0.581	1.00
377_L	380_G	0.581	1.00
460_H	484_A	0.580	1.00
82_L	128_A	0.579	1.00
104_P	194_L	0.579	1.00
247_G	282_L	0.578	1.00
459_I	462_A	0.577	1.00
119_N	147_Q	0.577	1.00
41_I	231_V	0.577	1.00
77_R	123_A	0.577	1.00
181_T	185_T	0.576	1.00
446_S	466_A	0.574	1.00
61_S	68_L	0.574	1.00
311_G	333_V	0.573	1.00
452_I	503_V	0.571	1.00
201_G	445_S	0.571	1.00
344_V	358_D	0.568	1.00
82_L	129_P	0.567	1.00
461_D	518_L	0.567	1.00
399_E	405_R	0.567	1.00
80_F	95_C	0.566	1.00
29_Y	253_L	0.566	1.00
43_V	258_S	0.565	1.00
92_Y	248_V	0.563	1.00
285_T	313_T	0.563	1.00
282_L	311_G	0.560	1.00
386_A	408_D	0.560	1.00
479_Y	513_V	0.560	1.00
393_F	406_A	0.560	1.00
234_M	258_S	0.556	1.00
216_S	220_Y	0.556	1.00
140_L	143_P	0.555	1.00
37_M	255_G	0.554	1.00
508_Y	512_I	0.554	1.00
493_E	498_F	0.554	1.00
370_V	374_R	0.553	1.00
489_L	493_E	0.553	1.00
43_V	51_Y	0.553	1.00
62_C	65_N	0.551	1.00
336_S	415_S	0.550	1.00
336_S	339_S	0.550	1.00
431_G	446_S	0.548	1.00
462_A	499_S	0.547	1.00
192_A	244_F	0.547	1.00
311_G	342_H	0.547	1.00
315_I	332_S	0.547	1.00
192_A	213_I	0.547	1.00
227_T	279_T	0.547	1.00
121_C	205_G	0.547	1.00
400_P	403_T	0.546	1.00
453_L	499_S	0.546	1.00
270_L	302_L	0.546	1.00
458_K	498_F	0.546	1.00
145_Q	149_P	0.545	1.00
491_L	511_H	0.545	1.00
439_R	474_E	0.544	1.00
513_V	534_D	0.544	1.00
70_K	172_I	0.544	1.00
80_F	88_F	0.544	1.00
382_E	433_K	0.543	1.00
372_D	384_E	0.543	1.00
324_Q	329_K	0.541	1.00
395_G	400_P	0.540	1.00
365_V	389_G	0.539	1.00
323_C	330_L	0.538	1.00
193_V	207_M	0.538	1.00
72_I	124_K	0.538	1.00
437_I	466_A	0.537	1.00
272_L	275_Q	0.536	1.00
242_T	309_L	0.536	1.00
31_Q	60_A	0.535	1.00
381_C	420_R	0.535	1.00
116_W	121_C	0.535	1.00
235_P	283_G	0.534	1.00
41_I	276_Q	0.534	1.00
257_R	276_Q	0.534	1.00
31_Q	180_T	0.533	1.00
376_T	421_M	0.532	1.00
310_C	330_L	0.530	1.00
500_R	509_P	0.527	1.00
101_V	104_P	0.526	1.00
27_A	97_K	0.526	1.00
490_S	514_V	0.526	1.00
456_H	459_I	0.526	1.00
321_R	324_Q	0.526	1.00
246_H	342_H	0.525	1.00
62_C	176_N	0.524	1.00
128_A	133_K	0.524	1.00
121_C	193_V	0.524	1.00
310_C	332_S	0.524	1.00
380_G	420_R	0.523	1.00
269_C	287_F	0.521	1.00
450_E	478_A	0.521	1.00
218_R	222_A	0.520	1.00
37_M	228_W	0.520	1.00
127_F	155_V	0.520	1.00
103_V	117_V	0.519	1.00
202_L	399_E	0.519	1.00
53_Y	252_F	0.518	1.00
285_T	319_V	0.518	1.00
333_V	345_V	0.516	1.00
465_V	532_R	0.515	1.00
111_E	147_Q	0.515	1.00
109_W	239_G	0.515	1.00
218_R	253_L	0.513	1.00
105_L	118_L	0.513	1.00
25_S	210_H	0.513	1.00
234_M	260_L	0.512	1.00
216_S	343_A	0.511	1.00
200_E	204_K	0.511	1.00
143_P	146_N	0.511	1.00
295_L	299_P	0.511	1.00
189_E	210_H	0.510	1.00
133_K	156_G	0.510	1.00
408_D	411_G	0.510	1.00
449_V	503_V	0.510	1.00
67_M	100_A	0.509	1.00
66_W	155_V	0.508	1.00
376_T	386_A	0.507	1.00
319_V	322_E	0.507	1.00
310_C	323_C	0.507	1.00
41_I	45_D	0.505	1.00
403_T	406_A	0.505	1.00
45_D	262_D	0.504	1.00
451_D	455_Q	0.502	1.00
75_G	100_A	0.502	1.00
283_G	308_F	0.501	1.00
81_Q	105_L	0.501	1.00
156_G	160_L	0.501	1.00
407_L	413_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1mdbA	1	0.969	100	0.131	Contact Map
3tsyA	2	0.7774	100	0.135	Contact Map
3ni2A	1	0.9434	100	0.143	Contact Map
2d1sA	1	0.9526	100	0.144	Contact Map
3o83A	1	0.781	100	0.155	Contact Map
1v25A	2	0.8942	100	0.157	Contact Map
3etcA	2	0.9288	100	0.157	Contact Map
3rixA	1	0.75	100	0.159	Contact Map
3g7sA	2	0.8668	100	0.161	Contact Map
2vsqA	1	0.9453	100	0.168	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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