ETK - ECOLI - GREMLIN Contacts

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ETK - Tyrosine-protein kinase etk

UniProt:	P38134	Sequences: MTTKNMNTPPGSTQENEIDLLRLVGELWDHRKFIISVTALFTLIAVAYSLLSTPIYQADTLVQVEQKQGNAILSGLSDMIPNSSPESAPEIQLLQSRMILGKTIAELNLRDIVEQKYFPIVGRGWARLTKEKPGELAISWMHIPQLNGQDQQLTLTVGENGHYTLEGEEFTVNGMVGQRLEKDGVALTIADIKAKPGTQFVLSQRTELEAINALQETFTVSERSKESGMLELTMTGDDPQLITRILNSIANNYLQQNIARQAAQDSQSLEFLQRQLPEVRSELDQAEEKLNVYRQQRDSVDLNLEAKAVLEQIVNVDNQLNELTFREAEISQLYKKDHPTYRALLEKRQTLEQERKRLNKRVSAMPSTQQEVLRLSRDVEAGRAVYLQLLNRQQELSISKSSAIGNVRIIDPAVTQPQPVKPKKALNVVLGFILGLFISVGAVLARAMLRRGVEAPEQLEEHGISVYATIPMSEWLDKRTRLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGATPDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKVIQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVVGRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGYSYSEKE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11826
Length:	726 (683)
Sequences:	1625 (1269)
Seq/√Len:	48.5

ECOLI - ETK WZC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
610_D	641_Y	8.668	1.00
327_E	331_S	6.074	1.00
236_G	242_I	5.767	1.00
472_M	702_G	5.614	1.00
564_L	637_A	5.246	1.00
596_E	599_K	4.675	1.00
598_N	640_H	4.584	1.00
247_N	413_A	4.556	1.00
105_A	207_E	4.413	1.00
232_L	246_L	4.365	1.00
600_V	612_I	4.051	1.00
533_I	634_L	4.028	1.00
590_Y	600_V	3.879	1.00
470_I	548_V	3.573	1.00
634_L	646_V	3.520	1.00
392_R	395_E	3.470	1.00
45_A	431_G	3.397	1.00
319_Q	322_E	3.290	1.00
60_T	250_A	3.260	1.00
327_E	330_I	3.259	1.00
175_M	178_Q	3.222	1.00
100_L	245_I	3.097	1.00
158_G	164_T	3.097	1.00
568_A	646_V	3.070	1.00
321_N	325_F	3.045	1.00
106_E	248_S	3.008	1.00
568_A	587_L	2.978	1.00
333_L	339_P	2.967	1.00
323_L	327_E	2.959	1.00
307_K	311_E	2.942	1.00
566_I	633_L	2.926	1.00
141_M	153_L	2.880	1.00
520_T	655_S	2.875	1.00
612_I	633_L	2.823	1.00
48_Y	52_S	2.804	1.00
159_E	162_H	2.734	1.00
535_M	648_T	2.732	1.00
38_T	436_L	2.726	1.00
58_A	242_I	2.708	1.00
618_P	621_P	2.666	1.00
589_E	616_Q	2.646	1.00
129_T	244_R	2.545	1.00
205_R	210_A	2.531	1.00
255_Q	259_A	2.520	1.00
236_G	241_L	2.487	1.00
535_M	661_G	2.474	1.00
104_I	210_A	2.467	1.00
248_S	251_N	2.459	1.00
182_K	185_V	2.412	1.00
549_S	645_I	2.400	1.00
570_L	588_S	2.334	1.00
321_N	324_T	2.314	1.00
331_S	341_Y	2.261	1.00
602_Q	613_T	2.257	1.00
603_H	610_D	2.246	1.00
566_I	646_V	2.233	1.00
156_T	199_Q	2.207	1.00
557_A	609_F	2.205	1.00
19_D	22_R	2.196	1.00
590_Y	612_I	2.141	1.00
564_L	641_Y	2.133	1.00
459_L	681_V	2.124	1.00
348_R	355_R	2.124	1.00
327_E	345_L	2.120	1.00
220_V	230_L	2.114	1.00
41_F	438_I	2.104	1.00
532_N	638_N	2.098	1.00
37_V	41_F	2.091	1.00
468_A	518_L	2.085	1.00
162_H	173_N	2.081	1.00
334_Y	339_P	2.075	1.00
597_L	601_I	2.073	1.00
570_L	649_P	2.056	1.00
320_L	325_F	2.052	1.00
533_I	638_N	2.052	1.00
57_Q	233_T	2.042	1.00
334_Y	338_H	2.024	1.00
158_G	162_H	2.021	1.00
155_L	189_I	2.020	1.00
51_L	121_V	1.990	0.99
636_W	640_H	1.984	0.99
75_G	78_D	1.980	0.99
336_K	339_P	1.976	0.99
519_R	623_E	1.971	0.99
206_T	210_A	1.961	0.99
89_P	228_G	1.950	0.99
90_E	253_Y	1.931	0.99
92_Q	229_M	1.931	0.99
348_R	354_E	1.920	0.99
335_K	339_P	1.910	0.99
34_I	440_V	1.874	0.99
581_V	611_V	1.865	0.99
590_Y	597_L	1.860	0.99
134_G	200_F	1.827	0.99
291_N	370_Q	1.823	0.99
383_R	387_L	1.820	0.99
556_I	643_L	1.814	0.99
214_L	234_M	1.800	0.99
156_T	164_T	1.794	0.99
595_D	600_V	1.791	0.99
341_Y	345_L	1.785	0.99
207_E	211_I	1.785	0.99
327_E	332_Q	1.781	0.99
556_I	645_I	1.771	0.99
637_A	644_V	1.765	0.99
42_T	432_F	1.762	0.99
46_V	428_V	1.751	0.99
164_T	173_N	1.746	0.99
628_D	632_Q	1.709	0.98
286_A	382_G	1.696	0.98
216_E	418_Q	1.678	0.98
294_R	369_Q	1.673	0.98
49_S	428_V	1.667	0.98
315_N	318_N	1.667	0.98
304_L	307_K	1.659	0.98
98_M	411_D	1.646	0.98
535_M	660_V	1.645	0.98
564_L	644_V	1.635	0.98
630_M	660_V	1.630	0.98
320_L	324_T	1.616	0.98
320_L	327_E	1.607	0.98
55_I	237_D	1.606	0.98
335_K	341_Y	1.602	0.97
101_G	105_A	1.600	0.97
590_Y	633_L	1.597	0.97
471_P	514_A	1.594	0.97
62_V	94_L	1.590	0.97
121_V	125_W	1.588	0.97
163_Y	180_L	1.584	0.97
248_S	252_N	1.563	0.97
450_R	454_E	1.560	0.97
51_L	123_R	1.554	0.97
127_R	241_L	1.549	0.97
538_G	543_S	1.547	0.97
635_E	639_D	1.543	0.97
339_P	355_R	1.541	0.97
634_L	663_S	1.539	0.97
470_I	518_L	1.528	0.97
348_R	352_E	1.525	0.97
45_A	49_S	1.514	0.96
560_D	607_G	1.514	0.96
320_L	326_R	1.513	0.96
380_E	384_A	1.511	0.96
603_H	641_Y	1.508	0.96
597_L	612_I	1.506	0.96
320_L	348_R	1.505	0.96
303_N	369_Q	1.504	0.96
102_K	106_E	1.497	0.96
638_N	665_G	1.497	0.96
329_E	332_Q	1.491	0.96
92_Q	223_R	1.487	0.96
106_E	252_N	1.485	0.96
320_L	329_E	1.482	0.96
629_R	632_Q	1.453	0.95
630_M	634_L	1.452	0.95
62_V	250_A	1.451	0.95
49_S	427_N	1.439	0.95
324_T	327_E	1.438	0.95
633_L	637_A	1.426	0.95
174_G	180_L	1.422	0.95
154_T	199_Q	1.417	0.95
327_E	348_R	1.415	0.95
293_Y	372_V	1.411	0.95
579_F	609_F	1.405	0.95
537_T	688_L	1.400	0.94
716_N	721_S	1.394	0.94
668_L	699_I	1.376	0.94
655_S	659_V	1.374	0.94
532_N	644_V	1.369	0.94
612_I	637_A	1.367	0.94
632_Q	636_W	1.367	0.94
631_R	662_R	1.359	0.94
438_I	442_A	1.357	0.93
333_L	337_D	1.355	0.93
45_A	427_N	1.351	0.93
327_E	341_Y	1.350	0.93
325_F	329_E	1.349	0.93
566_I	644_V	1.345	0.93
321_N	329_E	1.336	0.93
539_A	543_S	1.336	0.93
535_M	657_A	1.336	0.93
157_V	176_V	1.334	0.93
162_H	175_M	1.328	0.93
50_L	121_V	1.327	0.93
712_S	716_N	1.324	0.93
110_R	204_Q	1.321	0.93
291_N	295_Q	1.319	0.92
65_E	260_R	1.311	0.92
235_T	421_K	1.310	0.92
462_H	698_A	1.309	0.92
553_A	565_F	1.308	0.92
27_L	440_V	1.302	0.92
158_G	173_N	1.301	0.92
380_E	383_R	1.301	0.92
46_V	50_L	1.300	0.92
33_F	37_V	1.293	0.92
604_F	609_F	1.289	0.92
313_I	362_V	1.287	0.92
217_T	234_M	1.281	0.91
270_E	274_R	1.276	0.91
50_L	123_R	1.274	0.91
669_L	684_S	1.269	0.91
92_Q	95_Q	1.261	0.91
370_Q	374_R	1.260	0.91
664_V	667_S	1.256	0.91
119_P	122_G	1.255	0.90
631_R	635_E	1.254	0.90
631_R	663_S	1.242	0.90
163_Y	177_G	1.237	0.90
671_A	681_V	1.235	0.90
628_D	631_R	1.235	0.90
269_L	396_L	1.233	0.90
273_Q	393_Q	1.227	0.89
591_L	624_L	1.223	0.89
41_F	431_G	1.221	0.89
163_Y	176_V	1.218	0.89
234_M	245_I	1.216	0.89
651_M	658_A	1.216	0.89
48_Y	427_N	1.215	0.89
633_L	644_V	1.215	0.89
597_L	637_A	1.213	0.89
104_I	109_L	1.212	0.89
100_L	103_T	1.211	0.89
327_E	339_P	1.205	0.89
635_E	638_N	1.202	0.88
351_L	354_E	1.200	0.88
566_I	587_L	1.199	0.88
352_E	355_R	1.198	0.88
47_A	51_L	1.195	0.88
266_S	270_E	1.194	0.88
549_S	565_F	1.190	0.88
520_T	659_V	1.183	0.88
423_K	426_L	1.180	0.88
28_W	31_R	1.178	0.87
57_Q	235_T	1.178	0.87
326_R	329_E	1.176	0.87
60_T	246_L	1.173	0.87
18_I	23_L	1.173	0.87
26_E	447_A	1.168	0.87
266_S	400_K	1.165	0.87
214_L	236_G	1.164	0.87
321_N	327_E	1.164	0.87
212_N	215_Q	1.158	0.87
240_Q	243_T	1.154	0.86
178_Q	296_Q	1.152	0.86
333_L	336_K	1.146	0.86
328_A	331_S	1.143	0.86
564_L	601_I	1.142	0.86
155_L	202_L	1.139	0.86
716_N	720_Y	1.139	0.86
388_Q	395_E	1.137	0.86
334_Y	337_D	1.136	0.85
137_A	190_A	1.135	0.85
501_F	550_S	1.132	0.85
116_K	199_Q	1.128	0.85
293_Y	297_R	1.128	0.85
103_T	252_N	1.127	0.85
438_I	441_G	1.119	0.85
323_L	331_S	1.119	0.85
76_L	79_M	1.118	0.85
320_L	351_L	1.117	0.84
50_L	428_V	1.104	0.84
63_Q	89_P	1.103	0.84
24_V	28_W	1.102	0.84
263_A	267_Q	1.099	0.84
543_S	573_G	1.097	0.83
58_A	415_T	1.089	0.83
223_R	231_E	1.082	0.83
243_T	415_T	1.080	0.82
518_L	699_I	1.068	0.82
240_Q	244_R	1.067	0.82
179_R	188_T	1.066	0.82
565_F	611_V	1.065	0.82
372_V	376_S	1.064	0.81
568_A	630_M	1.061	0.81
623_E	654_V	1.061	0.81
503_A	512_V	1.060	0.81
533_I	664_V	1.058	0.81
341_Y	348_R	1.057	0.81
371_E	374_R	1.057	0.81
241_L	245_I	1.054	0.81
337_D	342_R	1.051	0.81
466_V	700_L	1.049	0.81
101_G	211_I	1.046	0.80
220_V	599_K	1.045	0.80
345_L	348_R	1.042	0.80
97_R	411_D	1.041	0.80
379_V	394_Q	1.039	0.80
378_D	382_G	1.039	0.80
505_D	702_G	1.038	0.80
38_T	435_G	1.035	0.80
213_A	217_T	1.034	0.80
100_L	104_I	1.034	0.80
550_S	611_V	1.032	0.79
99_I	249_I	1.031	0.79
102_K	252_N	1.031	0.79
333_L	338_H	1.031	0.79
606_K	609_F	1.031	0.79
41_F	434_L	1.027	0.79
282_E	382_G	1.027	0.79
283_L	379_V	1.026	0.79
341_Y	344_L	1.023	0.79
305_E	310_L	1.022	0.79
109_L	245_I	1.019	0.79
509_D	512_V	1.018	0.79
153_L	534_L	1.011	0.78
601_I	641_Y	1.009	0.78
590_Y	629_R	1.008	0.78
430_L	434_L	1.007	0.78
531_N	665_G	1.005	0.78
517_A	655_S	1.004	0.78
336_K	341_Y	1.004	0.78
272_L	393_Q	1.001	0.77
592_A	619_P	1.001	0.77
661_G	693_V	1.001	0.77
567_D	573_G	0.999	0.77
30_H	443_V	0.993	0.77
117_Y	123_R	0.992	0.77
161_G	175_M	0.992	0.77
581_V	602_Q	0.990	0.77
99_I	410_I	0.987	0.76
172_V	180_L	0.986	0.76
292_V	296_Q	0.986	0.76
49_S	431_G	0.985	0.76
267_Q	270_E	0.981	0.76
434_L	441_G	0.981	0.76
537_T	667_S	0.981	0.76
597_L	640_H	0.980	0.76
462_H	678_A	0.979	0.76
570_L	655_S	0.978	0.76
539_A	676_N	0.978	0.76
224_S	227_S	0.974	0.75
275_Q	394_Q	0.973	0.75
601_I	637_A	0.971	0.75
547_F	551_T	0.970	0.75
553_A	566_I	0.967	0.75
413_A	509_D	0.965	0.75
349_Q	562_K	0.964	0.75
325_F	332_Q	0.962	0.74
716_N	719_G	0.961	0.74
118_F	127_R	0.961	0.74
623_E	626_M	0.960	0.74
598_N	636_W	0.960	0.74
584_E	602_Q	0.960	0.74
181_E	186_A	0.958	0.74
667_S	695_I	0.956	0.74
102_K	105_A	0.954	0.74
546_T	641_Y	0.953	0.74
470_I	511_A	0.947	0.73
460_E	686_Q	0.945	0.73
641_Y	644_V	0.943	0.73
225_K	253_Y	0.941	0.73
157_V	192_I	0.939	0.73
60_T	232_L	0.939	0.73
179_R	182_K	0.938	0.73
568_A	660_V	0.936	0.72
637_A	640_H	0.934	0.72
668_L	697_G	0.934	0.72
467_Y	668_L	0.933	0.72
217_T	236_G	0.930	0.72
318_N	321_N	0.929	0.72
287_E	294_R	0.925	0.71
282_E	317_D	0.924	0.71
325_F	330_I	0.923	0.71
92_Q	224_S	0.923	0.71
53_T	237_D	0.916	0.71
524_F	619_P	0.915	0.71
271_F	283_L	0.915	0.71
456_P	459_L	0.914	0.71
106_E	255_Q	0.914	0.71
212_N	216_E	0.913	0.70
17_E	20_L	0.912	0.70
565_F	575_S	0.909	0.70
438_I	660_V	0.907	0.70
158_G	161_G	0.906	0.70
21_L	25_G	0.906	0.70
152_Q	203_S	0.905	0.70
61_L	229_M	0.905	0.70
166_E	169_E	0.905	0.70
590_Y	595_D	0.904	0.70
138_I	150_D	0.903	0.70
632_Q	635_E	0.897	0.69
339_P	346_E	0.895	0.69
588_S	621_P	0.894	0.69
583_N	616_Q	0.894	0.69
350_T	354_E	0.893	0.69
685_M	689_E	0.892	0.69
49_S	424_K	0.889	0.68
243_T	247_N	0.889	0.68
550_S	578_L	0.888	0.68
97_R	211_I	0.883	0.68
470_I	515_V	0.879	0.68
519_R	626_M	0.879	0.68
636_W	639_D	0.872	0.67
255_Q	258_I	0.871	0.67
163_Y	174_G	0.870	0.67
208_L	212_N	0.869	0.67
548_V	670_V	0.863	0.66
672_R	702_G	0.862	0.66
522_L	553_A	0.858	0.66
526_M	666_T	0.856	0.65
410_I	524_F	0.855	0.65
710_A	714_G	0.854	0.65
34_I	38_T	0.852	0.65
541_P	574_Y	0.851	0.65
138_I	202_L	0.846	0.65
379_V	382_G	0.846	0.65
386_Y	390_L	0.844	0.64
62_V	313_I	0.844	0.64
593_G	629_R	0.843	0.64
180_L	185_V	0.836	0.64
214_L	245_I	0.836	0.64
458_Q	461_E	0.836	0.64
128_L	132_K	0.835	0.64
673_F	707_A	0.835	0.64
567_D	657_A	0.832	0.63
242_I	294_R	0.831	0.63
421_K	424_K	0.831	0.63
516_R	623_E	0.831	0.63
339_P	345_L	0.828	0.63
324_T	352_E	0.827	0.63
265_D	575_S	0.827	0.63
641_Y	699_I	0.826	0.63
267_Q	298_D	0.825	0.63
333_L	355_R	0.824	0.63
278_E	293_Y	0.823	0.62
620_N	654_V	0.821	0.62
453_V	678_A	0.820	0.62
429_V	433_I	0.820	0.62
323_L	326_R	0.819	0.62
37_V	439_S	0.819	0.62
49_S	52_S	0.818	0.62
206_T	209_E	0.816	0.62
103_T	324_T	0.814	0.62
444_L	448_M	0.814	0.62
199_Q	234_M	0.814	0.62
501_F	580_T	0.813	0.61
155_L	194_A	0.812	0.61
460_E	466_V	0.812	0.61
165_L	174_G	0.810	0.61
311_E	315_N	0.809	0.61
261_Q	380_E	0.809	0.61
520_T	524_F	0.809	0.61
39_A	156_T	0.808	0.61
465_S	698_A	0.807	0.61
319_Q	326_R	0.805	0.61
541_P	652_L	0.803	0.61
322_E	326_R	0.803	0.61
601_I	610_D	0.800	0.60
473_S	651_M	0.799	0.60
456_P	469_T	0.799	0.60
323_L	347_K	0.795	0.60
598_N	601_I	0.795	0.60
516_R	654_V	0.794	0.60
568_A	652_L	0.794	0.60
439_S	443_V	0.794	0.60
294_R	400_K	0.794	0.60
587_L	633_L	0.793	0.60
239_P	293_Y	0.793	0.60
714_G	720_Y	0.792	0.59
124_G	128_L	0.790	0.59
597_L	633_L	0.790	0.59
204_Q	573_G	0.789	0.59
339_P	354_E	0.787	0.59
282_E	458_Q	0.787	0.59
100_L	215_Q	0.784	0.59
220_V	246_L	0.784	0.59
339_P	342_R	0.783	0.59
32_K	36_S	0.783	0.59
563_V	608_G	0.782	0.58
52_S	427_N	0.781	0.58
328_A	582_S	0.781	0.58
323_L	332_Q	0.778	0.58
286_A	375_L	0.777	0.58
63_Q	408_R	0.775	0.58
651_M	688_L	0.774	0.58
20_L	153_L	0.774	0.58
401_S	591_L	0.774	0.58
437_F	441_G	0.772	0.57
473_S	509_D	0.772	0.57
565_F	609_F	0.772	0.57
305_E	460_E	0.770	0.57
550_S	575_S	0.770	0.57
295_Q	367_S	0.769	0.57
564_L	612_I	0.768	0.57
514_A	524_F	0.767	0.57
260_R	275_Q	0.764	0.57
13_T	40_L	0.763	0.57
649_P	657_A	0.763	0.57
586_G	615_G	0.762	0.56
321_N	332_Q	0.757	0.56
35_I	689_E	0.757	0.56
241_L	358_L	0.757	0.56
570_L	590_Y	0.757	0.56
717_Y	720_Y	0.756	0.56
573_G	653_A	0.756	0.56
382_G	393_Q	0.756	0.56
525_A	697_G	0.755	0.56
98_M	365_M	0.755	0.56
301_D	304_L	0.752	0.55
455_A	700_L	0.751	0.55
423_K	427_N	0.748	0.55
587_L	630_M	0.748	0.55
570_L	708_S	0.747	0.55
64_V	470_I	0.745	0.55
392_R	399_S	0.745	0.55
236_G	294_R	0.743	0.55
42_T	438_I	0.742	0.54
57_Q	420_V	0.742	0.54
433_I	599_K	0.742	0.54
275_Q	382_G	0.741	0.54
550_S	577_N	0.741	0.54
299_S	372_V	0.741	0.54
275_Q	387_L	0.740	0.54
354_E	357_R	0.740	0.54
618_P	654_V	0.739	0.54
262_A	403_A	0.738	0.54
343_A	346_E	0.737	0.54
715_Y	720_Y	0.737	0.54
51_L	125_W	0.735	0.54
33_F	442_A	0.735	0.54
718_Y	721_S	0.732	0.53
376_S	392_R	0.731	0.53
236_G	245_I	0.730	0.53
30_H	446_R	0.729	0.53
546_T	610_D	0.729	0.53
104_I	199_Q	0.728	0.53
214_L	410_I	0.728	0.53
371_E	644_V	0.728	0.53
405_G	408_R	0.727	0.53
339_P	343_A	0.727	0.53
116_K	201_V	0.723	0.53
545_K	647_D	0.723	0.53
597_L	636_W	0.720	0.52
411_D	625_L	0.719	0.52
395_E	403_A	0.719	0.52
159_E	196_P	0.719	0.52
178_Q	188_T	0.719	0.52
617_V	633_L	0.717	0.52
117_Y	124_G	0.717	0.52
712_S	719_G	0.717	0.52
641_Y	670_V	0.716	0.52
31_R	268_S	0.716	0.52
58_A	236_G	0.715	0.52
330_I	339_P	0.715	0.52
36_S	39_A	0.714	0.52
681_V	685_M	0.713	0.52
31_R	35_I	0.712	0.51
565_F	645_I	0.710	0.51
65_E	257_N	0.710	0.51
293_Y	501_F	0.707	0.51
138_I	441_G	0.707	0.51
518_L	668_L	0.706	0.51
221_S	231_E	0.703	0.51
66_Q	219_T	0.702	0.50
220_V	234_M	0.700	0.50
63_Q	93_L	0.700	0.50
472_M	704_I	0.698	0.50
111_D	682_S	0.698	0.50
104_I	207_E	0.696	0.50
164_T	170_F	0.696	0.50
534_L	686_Q	0.696	0.50
321_N	326_R	0.695	0.50
253_Y	422_P	0.694	0.50
337_D	340_T	0.693	0.50
27_L	34_I	0.692	0.49
164_T	424_K	0.691	0.49
556_I	699_I	0.691	0.49
388_Q	392_R	0.690	0.49
102_K	256_Q	0.690	0.49
305_E	625_L	0.689	0.49
39_A	566_I	0.689	0.49
95_Q	667_S	0.686	0.49
559_S	626_M	0.686	0.49
244_R	247_N	0.686	0.49
537_T	602_Q	0.685	0.49
441_G	445_A	0.685	0.49
260_R	408_R	0.684	0.49
570_L	618_P	0.683	0.49
42_T	428_V	0.682	0.48
419_P	424_K	0.682	0.48
552_L	648_T	0.681	0.48
88_A	93_L	0.680	0.48
167_G	170_F	0.680	0.48
453_V	537_T	0.679	0.48
95_Q	430_L	0.679	0.48
292_V	297_R	0.679	0.48
585_H	595_D	0.676	0.48
540_T	676_N	0.674	0.48
326_R	347_K	0.674	0.48
106_E	453_V	0.673	0.48
100_L	211_I	0.673	0.48
521_S	692_G	0.673	0.48
23_L	445_A	0.672	0.47
117_Y	126_A	0.672	0.47
177_G	190_A	0.671	0.47
539_A	669_L	0.671	0.47
331_S	345_L	0.670	0.47
465_S	637_A	0.667	0.47
247_N	251_N	0.667	0.47
509_D	573_G	0.667	0.47
569_D	650_P	0.666	0.47
524_F	651_M	0.666	0.47
638_N	644_V	0.664	0.47
258_I	262_A	0.663	0.47
550_S	579_F	0.661	0.46
75_G	79_M	0.660	0.46
103_T	248_S	0.659	0.46
97_R	414_V	0.658	0.46
323_L	329_E	0.658	0.46
396_L	555_V	0.658	0.46
621_P	654_V	0.657	0.46
262_A	362_V	0.655	0.46
204_Q	210_A	0.655	0.46
324_T	329_E	0.654	0.46
593_G	618_P	0.654	0.46
561_Q	590_Y	0.653	0.46
342_R	345_L	0.653	0.46
287_E	377_R	0.652	0.45
588_S	619_P	0.652	0.45
324_T	331_S	0.650	0.45
505_D	699_I	0.650	0.45
128_L	591_L	0.649	0.45
461_E	614_R	0.649	0.45
367_S	371_E	0.649	0.45
465_S	672_R	0.649	0.45
393_Q	397_S	0.648	0.45
601_I	640_H	0.648	0.45
352_E	409_I	0.648	0.45
235_T	420_V	0.647	0.45
410_I	549_S	0.646	0.45
300_V	655_S	0.645	0.45
60_T	109_L	0.645	0.45
595_D	599_K	0.644	0.45
459_L	698_A	0.644	0.45
402_S	405_G	0.643	0.45
87_S	250_A	0.643	0.45
601_I	612_I	0.643	0.45
153_L	202_L	0.643	0.45
525_A	632_Q	0.642	0.44
579_F	691_A	0.642	0.44
511_A	514_A	0.641	0.44
334_Y	341_Y	0.641	0.44
82_N	669_L	0.641	0.44
35_I	593_G	0.641	0.44
275_Q	458_Q	0.640	0.44
170_F	173_N	0.640	0.44
575_S	578_L	0.640	0.44
566_I	632_Q	0.640	0.44
153_L	165_L	0.640	0.44
45_A	218_F	0.640	0.44
326_R	330_I	0.639	0.44
546_T	647_D	0.639	0.44
513_E	571_R	0.638	0.44
618_P	622_S	0.638	0.44
570_L	593_G	0.638	0.44
130_K	315_N	0.636	0.44
156_T	166_E	0.636	0.44
426_L	430_L	0.635	0.44
261_Q	362_V	0.635	0.44
241_L	244_R	0.634	0.44
452_G	538_G	0.633	0.44
512_V	682_S	0.633	0.44
424_K	428_V	0.633	0.44
337_D	341_Y	0.631	0.43
262_A	267_Q	0.631	0.43
20_L	52_S	0.630	0.43
289_K	375_L	0.629	0.43
524_F	620_N	0.629	0.43
320_L	446_R	0.629	0.43
525_A	619_P	0.628	0.43
564_L	587_L	0.628	0.43
369_Q	668_L	0.627	0.43
33_F	565_F	0.626	0.43
58_A	243_T	0.626	0.43
129_T	133_P	0.624	0.43
257_N	375_L	0.624	0.43
550_S	712_S	0.623	0.43
33_F	443_V	0.623	0.43
42_T	49_S	0.622	0.42
520_T	622_S	0.621	0.42
326_R	539_A	0.620	0.42
545_K	654_V	0.620	0.42
629_R	646_V	0.619	0.42
320_L	323_L	0.618	0.42
87_S	402_S	0.618	0.42
467_Y	525_A	0.617	0.42
338_H	345_L	0.617	0.42
260_R	655_S	0.616	0.42
273_Q	397_S	0.616	0.42
258_I	403_A	0.615	0.42
245_I	249_I	0.614	0.42
309_V	313_I	0.613	0.42
565_F	641_Y	0.613	0.42
64_V	89_P	0.613	0.42
161_G	176_V	0.613	0.42
449_L	674_G	0.613	0.42
223_R	227_S	0.613	0.42
41_F	428_V	0.612	0.41
338_H	351_L	0.611	0.41
571_R	621_P	0.611	0.41
613_T	618_P	0.610	0.41
567_D	617_V	0.610	0.41
524_F	618_P	0.610	0.41
372_V	391_N	0.610	0.41
535_M	646_V	0.609	0.41
315_N	319_Q	0.608	0.41
178_Q	434_L	0.608	0.41
324_T	332_Q	0.608	0.41
38_T	42_T	0.607	0.41
164_T	171_T	0.606	0.41
623_E	655_S	0.606	0.41
334_Y	351_L	0.606	0.41
700_L	703_V	0.606	0.41
330_I	354_E	0.605	0.41
88_A	227_S	0.605	0.41
684_S	687_R	0.605	0.41
419_P	422_P	0.604	0.41
331_S	336_K	0.603	0.41
389_L	702_G	0.603	0.41
436_L	561_Q	0.602	0.40
100_L	214_L	0.601	0.40
161_G	221_S	0.600	0.40
413_A	419_P	0.599	0.40
216_E	562_K	0.599	0.40
453_V	607_G	0.599	0.40
73_L	78_D	0.598	0.40
511_A	515_V	0.598	0.40
532_N	665_G	0.597	0.40
512_V	669_L	0.596	0.40
76_L	80_I	0.596	0.40
333_L	354_E	0.596	0.40
254_L	394_Q	0.596	0.40
688_L	696_K	0.595	0.40
242_I	403_A	0.595	0.40
275_Q	309_V	0.595	0.40
538_G	545_K	0.595	0.40
434_L	440_V	0.595	0.40
64_V	244_R	0.594	0.40
178_Q	187_L	0.594	0.40
714_G	721_S	0.594	0.40
163_Y	193_K	0.593	0.40
110_R	207_E	0.593	0.40
358_L	718_Y	0.593	0.40
279_V	385_V	0.592	0.40
121_V	126_A	0.591	0.39
652_L	697_G	0.590	0.39
51_L	124_G	0.590	0.39
353_Q	360_K	0.590	0.39
390_L	393_Q	0.590	0.39
137_A	188_T	0.590	0.39
376_S	383_R	0.590	0.39
50_L	122_G	0.589	0.39
239_P	242_I	0.589	0.39
541_P	560_D	0.588	0.39
466_V	676_N	0.588	0.39
430_L	448_M	0.588	0.39
681_V	688_L	0.588	0.39
40_L	137_A	0.588	0.39
604_F	610_D	0.588	0.39
250_A	254_L	0.587	0.39
24_V	559_S	0.587	0.39
176_V	191_D	0.587	0.39
205_R	213_A	0.587	0.39
104_I	518_L	0.587	0.39
159_E	163_Y	0.586	0.39
657_A	680_E	0.586	0.39
428_V	432_F	0.585	0.39
575_S	611_V	0.585	0.39
470_I	632_Q	0.585	0.39
221_S	434_L	0.585	0.39
49_S	351_L	0.583	0.39
232_L	293_Y	0.583	0.39
502_L	511_A	0.583	0.39
320_L	355_R	0.582	0.39
48_Y	410_I	0.581	0.38
471_P	576_H	0.581	0.38
218_F	249_I	0.580	0.38
709_T	715_Y	0.580	0.38
91_I	220_V	0.580	0.38
309_V	362_V	0.579	0.38
365_M	394_Q	0.579	0.38
104_I	626_M	0.578	0.38
349_Q	353_Q	0.578	0.38
406_N	559_S	0.578	0.38
63_Q	228_G	0.577	0.38
16_N	23_L	0.576	0.38
581_V	644_V	0.576	0.38
618_P	624_L	0.576	0.38
232_L	633_L	0.575	0.38
287_E	666_T	0.575	0.38
264_Q	384_A	0.574	0.38
48_Y	548_V	0.574	0.38
64_V	431_G	0.574	0.38
526_M	534_L	0.574	0.38
101_G	207_E	0.573	0.38
217_T	632_Q	0.573	0.38
453_V	580_T	0.572	0.38
379_V	391_N	0.572	0.38
436_L	440_V	0.571	0.37
193_K	199_Q	0.571	0.37
338_H	524_F	0.571	0.37
61_L	231_E	0.570	0.37
514_A	652_L	0.570	0.37
258_I	406_N	0.569	0.37
254_L	407_V	0.568	0.37
23_L	443_V	0.567	0.37
677_T	680_E	0.567	0.37
333_L	345_L	0.566	0.37
248_S	640_H	0.566	0.37
262_A	392_R	0.566	0.37
19_D	34_I	0.566	0.37
437_F	667_S	0.565	0.37
620_N	623_E	0.564	0.37
709_T	714_G	0.563	0.37
157_V	196_P	0.563	0.37
376_S	458_Q	0.563	0.37
163_Y	575_S	0.563	0.37
343_A	355_R	0.562	0.37
40_L	44_I	0.562	0.37
632_Q	699_I	0.561	0.37
709_T	716_N	0.561	0.37
24_V	549_S	0.560	0.36
334_Y	355_R	0.560	0.36
384_A	391_N	0.560	0.36
717_Y	721_S	0.560	0.36
170_F	719_G	0.559	0.36
519_R	571_R	0.559	0.36
471_P	567_D	0.558	0.36
564_L	610_D	0.558	0.36
543_S	702_G	0.557	0.36
202_L	397_S	0.557	0.36
276_L	681_V	0.557	0.36
268_S	385_V	0.557	0.36
435_G	439_S	0.557	0.36
343_A	350_T	0.555	0.36
536_I	668_L	0.555	0.36
446_R	589_E	0.555	0.36
471_P	541_P	0.554	0.36
22_R	461_E	0.553	0.36
275_Q	397_S	0.553	0.36
530_E	566_I	0.553	0.36
535_M	667_S	0.552	0.36
528_E	666_T	0.551	0.36
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295_Q	348_R	0.551	0.36
341_Y	355_R	0.551	0.36
236_G	293_Y	0.551	0.36
557_A	560_D	0.550	0.36
242_I	415_T	0.550	0.36
254_L	382_G	0.549	0.35
517_A	579_F	0.549	0.35
74_S	85_P	0.548	0.35
156_T	234_M	0.548	0.35
67_K	261_Q	0.548	0.35
44_I	418_Q	0.548	0.35
35_I	156_T	0.547	0.35
351_L	355_R	0.547	0.35
15_E	20_L	0.546	0.35
212_N	246_L	0.545	0.35
535_M	539_A	0.545	0.35
353_Q	470_I	0.544	0.35
45_A	428_V	0.544	0.35
122_G	200_F	0.544	0.35
209_E	607_G	0.544	0.35
553_A	567_D	0.543	0.35
130_K	244_R	0.543	0.35
510_S	517_A	0.543	0.35
289_K	393_Q	0.542	0.35
542_D	603_H	0.542	0.35
714_G	719_G	0.542	0.35
292_V	295_Q	0.541	0.35
216_E	219_T	0.541	0.35
29_D	451_R	0.541	0.35
183_D	438_I	0.540	0.35
105_A	634_L	0.540	0.35
600_V	629_R	0.540	0.35
181_E	438_I	0.540	0.35
430_L	437_F	0.540	0.35
330_I	358_L	0.539	0.35
304_L	308_A	0.539	0.35
708_S	712_S	0.539	0.35
464_I	529_T	0.539	0.35
141_M	202_L	0.539	0.35
26_E	30_H	0.539	0.35
342_R	346_E	0.538	0.34
384_A	560_D	0.538	0.34
397_S	400_K	0.538	0.34
385_V	390_L	0.538	0.34
562_K	705_K	0.538	0.34
449_L	570_L	0.538	0.34
383_R	514_A	0.538	0.34
32_K	561_Q	0.537	0.34
444_L	660_V	0.537	0.34
667_S	693_V	0.537	0.34
571_R	654_V	0.537	0.34
621_P	624_L	0.537	0.34
285_Q	289_K	0.536	0.34
156_T	197_G	0.536	0.34
109_L	234_M	0.536	0.34
691_A	699_I	0.536	0.34
257_N	339_P	0.536	0.34
299_S	557_A	0.536	0.34
103_T	588_S	0.536	0.34
257_N	407_V	0.535	0.34
318_N	325_F	0.535	0.34
168_E	418_Q	0.535	0.34
160_N	342_R	0.535	0.34
94_L	218_F	0.535	0.34
338_H	341_Y	0.535	0.34
65_E	228_G	0.535	0.34
148_G	153_L	0.534	0.34
680_E	697_G	0.534	0.34
574_Y	577_N	0.533	0.34
287_E	306_A	0.532	0.34
581_V	613_T	0.532	0.34
375_L	439_S	0.530	0.34
259_A	470_I	0.530	0.34
294_R	368_T	0.529	0.34
558_Q	652_L	0.529	0.34
294_R	323_L	0.528	0.34
556_I	570_L	0.528	0.34
544_G	647_D	0.528	0.34
118_F	348_R	0.526	0.33
457_E	700_L	0.526	0.33
139_S	219_T	0.526	0.33
42_T	218_F	0.526	0.33
83_S	241_L	0.525	0.33
545_K	571_R	0.525	0.33
540_T	653_A	0.525	0.33
67_K	433_I	0.525	0.33
360_K	363_S	0.525	0.33
364_A	612_I	0.524	0.33
218_F	234_M	0.523	0.33
341_Y	383_R	0.523	0.33
105_A	110_R	0.523	0.33
671_A	698_A	0.523	0.33
645_I	699_I	0.522	0.33
43_L	169_E	0.522	0.33
570_L	663_S	0.522	0.33
318_N	323_L	0.521	0.33
221_S	440_V	0.521	0.33
36_S	220_V	0.521	0.33
220_V	441_G	0.521	0.33
27_L	649_P	0.521	0.33
537_T	657_A	0.520	0.33
157_V	160_N	0.520	0.33
655_S	660_V	0.520	0.33
209_E	418_Q	0.520	0.33
18_I	426_L	0.519	0.33
290_L	652_L	0.519	0.33
202_L	455_A	0.519	0.33
294_R	305_E	0.518	0.33
309_V	579_F	0.518	0.33
282_E	286_A	0.518	0.33
95_Q	232_L	0.518	0.33
614_R	617_V	0.517	0.33
39_A	68_Q	0.517	0.33
622_S	655_S	0.517	0.33
310_L	314_V	0.517	0.33
450_R	681_V	0.517	0.33
273_Q	686_Q	0.517	0.33
167_G	441_G	0.516	0.32
713_Y	717_Y	0.516	0.32
59_D	231_E	0.516	0.32
118_F	125_W	0.515	0.32
453_V	681_V	0.515	0.32
154_T	639_D	0.514	0.32
72_I	265_D	0.514	0.32
230_L	581_V	0.514	0.32
169_E	173_N	0.514	0.32
272_L	525_A	0.514	0.32
221_S	425_A	0.513	0.32
316_V	320_L	0.513	0.32
326_R	333_L	0.513	0.32
583_N	614_R	0.513	0.32
35_I	596_E	0.513	0.32
156_T	205_R	0.512	0.32
176_V	217_T	0.512	0.32
223_R	580_T	0.512	0.32
674_G	704_I	0.511	0.32
456_P	460_E	0.511	0.32
571_R	656_D	0.511	0.32
234_M	514_A	0.511	0.32
528_E	631_R	0.510	0.32
545_K	650_P	0.510	0.32
35_I	644_V	0.510	0.32
118_F	121_V	0.510	0.32
255_Q	296_Q	0.510	0.32
432_F	437_F	0.509	0.32
140_W	186_A	0.509	0.32
513_E	569_D	0.509	0.32
646_V	693_V	0.509	0.32
55_I	420_V	0.508	0.32
560_D	612_I	0.508	0.32
373_L	541_P	0.508	0.32
94_L	361_R	0.508	0.32
36_S	682_S	0.507	0.32
25_G	28_W	0.507	0.32
189_I	655_S	0.507	0.32
123_R	126_A	0.507	0.32
189_I	192_I	0.507	0.32
327_E	335_K	0.506	0.32
570_L	651_M	0.506	0.32
133_P	187_L	0.506	0.32
450_R	470_I	0.505	0.31
225_K	438_I	0.505	0.31
43_L	173_N	0.505	0.31
89_P	264_Q	0.505	0.31
162_H	445_A	0.505	0.31
300_V	306_A	0.504	0.31
142_H	186_A	0.504	0.31
229_M	520_T	0.504	0.31
513_E	654_V	0.504	0.31
519_R	622_S	0.503	0.31
459_L	479_R	0.503	0.31
230_L	549_S	0.502	0.31
370_Q	382_G	0.502	0.31
230_L	245_I	0.502	0.31
244_R	542_D	0.501	0.31
587_L	591_L	0.501	0.31
346_E	355_R	0.500	0.31
465_S	702_G	0.500	0.31
629_R	633_L	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cioA	2	0.3554	100	0.677	Contact Map
3la6A	4	0.3623	100	0.69	Contact Map
4jlvA	1	0.3127	100	0.712	Contact Map
4jmpA	1	0.3099	100	0.717	Contact Map
4wl1A	3	0.3003	100	0.825	Contact Map
4rz3A	2	0.2686	100	0.84	Contact Map
3fkqA	2	0.4187	100	0.844	Contact Map
3ug7A	4	0.2865	100	0.847	Contact Map
1g3qA	1	0.2686	100	0.851	Contact Map
1hyqA	1	0.2658	100	0.855	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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