GREMLIN Database
RSPB - Starvation-sensing protein RspB
UniProt: P38105 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12452
Length: 339 (302)
Sequences: 52896 (36236)
Seq/√Len: 2085.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
315_H318_D2.9661.00
32_K137_D2.9151.00
30_K66_D2.8291.00
32_K64_V2.7361.00
28_R66_D2.6481.00
7_E15_V2.6361.00
27_V128_A2.5731.00
163_T188_N2.5421.00
136_A139_Y2.5211.00
181_K208_D2.4341.00
80_R131_I2.3701.00
79_E130_K2.3651.00
76_R79_E2.3631.00
311_F322_L2.3101.00
200_E204_E2.2831.00
61_F116_G2.2781.00
221_I224_E2.2631.00
30_K64_V2.2381.00
19_I120_Y2.2091.00
188_N209_W2.1851.00
138_Q310_T2.1811.00
169_A191_V2.1671.00
7_E13_A2.1641.00
30_K120_Y2.1491.00
294_D298_K2.0921.00
199_L203_K2.0841.00
164_V180_L2.0831.00
309_H322_L2.0751.00
74_S125_A2.0481.00
159_T162_D2.0181.00
312_D315_H2.0131.00
24_A70_E2.0111.00
5_L15_V2.0041.00
23_S26_E1.9781.00
134_A297_S1.9741.00
61_F83_V1.9511.00
177_V207_A1.9491.00
24_A71_G1.9331.00
80_R137_D1.9291.00
25_G71_G1.9101.00
321_S325_Q1.8981.00
62_F137_D1.8791.00
146_F175_T1.8081.00
28_R122_V1.8001.00
21_T67_A1.7921.00
66_D120_Y1.7811.00
45_R324_E1.7791.00
200_E203_K1.7671.00
318_D321_S1.7461.00
165_L192_A1.7361.00
165_L229_P1.7291.00
196_D200_E1.7271.00
199_L210_A1.7231.00
162_D254_R1.7001.00
230_T250_S1.6631.00
190_I229_P1.6561.00
131_I137_D1.6551.00
322_L327_Q1.6461.00
311_F319_A1.6401.00
318_D322_L1.6241.00
254_R278_S1.6141.00
131_I140_A1.5941.00
167_Y245_A1.5821.00
216_T221_I1.5771.00
193_D199_L1.5561.00
69_G72_V1.5521.00
75_A130_K1.5391.00
4_I316_V1.5381.00
201_K204_E1.5311.00
188_N208_D1.5271.00
196_D212_N1.5251.00
156_G231_L1.5251.00
249_A255_I1.5161.00
254_R280_F1.5051.00
68_V77_V1.4901.00
182_G300_L1.4831.00
28_R120_Y1.4821.00
67_A77_V1.4691.00
196_D215_Q1.4671.00
217_P220_E1.4631.00
26_E124_P1.4561.00
31_V61_F1.4541.00
212_N215_Q1.4521.00
249_A277_L1.4511.00
117_F320_I1.4441.00
22_P122_V1.4411.00
75_A79_E1.4351.00
249_A253_A1.4061.00
25_G124_P1.4011.00
64_V80_R1.3931.00
80_R133_E1.3821.00
22_P28_R1.3811.00
26_E122_V1.3711.00
232_I245_A1.3641.00
33_L138_Q1.3551.00
232_I249_A1.3531.00
317_A321_S1.3491.00
65_I75_A1.3411.00
44_Y320_I1.3391.00
308_T322_L1.3201.00
28_R67_A1.3031.00
27_V75_A1.3011.00
220_E224_E1.2911.00
294_D297_S1.2761.00
64_V137_D1.2691.00
177_V191_V1.2681.00
4_I14_I1.2521.00
163_T190_I1.2481.00
176_I233_I1.2471.00
194_R213_N1.2411.00
167_Y192_A1.2351.00
154_G288_K1.2261.00
154_G291_I1.2251.00
3_S17_R1.2201.00
75_A128_A1.1771.00
8_K11_Q1.1761.00
32_K80_R1.1761.00
143_I296_L1.1661.00
203_K210_A1.1571.00
158_P186_V1.1511.00
196_D199_L1.1511.00
199_L212_N1.1481.00
19_I28_R1.1471.00
163_T230_T1.1291.00
25_G125_A1.1121.00
291_I294_D1.1041.00
31_V121_A1.1021.00
22_P26_E1.1011.00
123_V128_A1.0951.00
286_A290_P1.0921.00
178_Q302_K1.0911.00
162_D230_T1.0761.00
66_D77_V1.0751.00
191_V207_A1.0581.00
156_G256_V1.0581.00
14_I314_Q1.0511.00
29_V63_G1.0491.00
36_I319_A1.0471.00
217_P221_I1.0391.00
4_I313_F1.0381.00
151_N288_K1.0371.00
139_Y302_K1.0311.00
316_V335_L1.0251.00
44_Y324_E1.0241.00
203_K209_W1.0221.00
201_K330_C1.0211.00
155_H278_S1.0191.00
33_L137_D1.0171.00
247_T271_G1.0131.00
29_V81_V1.0121.00
295_W300_L1.0061.00
149_A176_I1.0051.00
290_P294_D0.9981.00
215_Q221_I0.9901.00
149_A179_V0.9891.00
34_A117_F0.9891.00
236_A241_I0.9861.00
219_G247_T0.9761.00
204_E305_K0.9741.00
37_C60_E0.9691.00
5_L17_R0.9641.00
37_C59_H0.9611.00
158_P162_D0.9591.00
302_K305_K0.9591.00
32_K62_F0.9541.00
9_P53_Y0.9541.00
7_E11_Q0.9541.00
117_F316_V0.9521.00
194_R199_L0.9501.00
169_A193_D0.9461.00
146_F292_V0.9391.00
34_A116_G0.9381.00
190_I209_W0.9371.00
322_L333_V0.9301.00
321_S324_E0.9251.00
243_K247_T0.9181.00
19_I67_A0.9131.00
234_D237_C0.9121.00
244_E247_T0.9121.00
68_V72_V0.9101.00
152_V258_M0.9101.00
180_L186_V0.9071.00
150_A291_I0.9061.00
5_L56_V0.9051.00
219_G244_E0.9031.00
72_V125_A0.9031.00
166_V176_I0.8981.00
166_V180_L0.8961.00
177_V189_V0.8951.00
25_G69_G0.8931.00
41_S323_F0.8931.00
195_I198_R0.8921.00
182_G295_W0.8921.00
33_L334_L0.8901.00
135_V140_A0.8901.00
222_F229_P0.8861.00
169_A202_A0.8861.00
192_A213_N0.8831.00
190_I211_I0.8811.00
55_R114_D0.8801.00
272_I279_I0.8781.00
167_Y232_I0.8761.00
73_E125_A0.8751.00
165_L248_L0.8731.00
194_R214_S0.8731.00
152_V233_I0.8711.00
3_S56_V0.8711.00
76_R130_K0.8691.00
219_G223_T0.8671.00
30_K119_E0.8651.00
179_V292_V0.8651.00
17_R114_D0.8611.00
174_L201_K0.8591.00
271_G275_K0.8581.00
35_G60_E0.8581.00
197_E200_E0.8551.00
21_T28_R0.8541.00
117_F335_L0.8541.00
19_I66_D0.8511.00
169_A177_V0.8431.00
198_R330_C0.8421.00
61_F121_A0.8421.00
82_A293_I0.8391.00
163_T229_P0.8361.00
4_I12_L0.8331.00
323_F333_V0.8331.00
162_D231_L0.8321.00
191_V202_A0.8281.00
311_F315_H0.8211.00
287_N291_I0.8211.00
193_D210_A0.8211.00
195_I212_N0.8151.00
133_E297_S0.8121.00
291_I295_W0.8121.00
147_T288_K0.8051.00
36_I323_F0.8041.00
4_I317_A0.7991.00
179_V295_W0.7971.00
252_A276_E0.7971.00
220_E223_T0.7931.00
155_H280_F0.7911.00
268_I271_G0.7901.00
37_C40_D0.7881.00
287_N290_P0.7821.00
81_V128_A0.7791.00
202_A207_A0.7781.00
153_T180_L0.7761.00
190_I222_F0.7701.00
23_S122_V0.7691.00
152_V176_I0.7641.00
218_L244_E0.7621.00
149_A175_T0.7621.00
135_V296_L0.7591.00
245_A255_I0.7561.00
10_N44_Y0.7521.00
14_I313_F0.7521.00
164_V186_V0.7511.00
83_V123_V0.7501.00
219_G248_L0.7481.00
39_S59_H0.7461.00
232_I255_I0.7431.00
184_Y291_I0.7411.00
217_P244_E0.7401.00
25_G70_E0.7401.00
129_W290_P0.7381.00
167_Y241_I0.7371.00
27_V125_A0.7341.00
68_V76_R0.7331.00
163_T227_I0.7311.00
272_I277_L0.7311.00
295_W298_K0.7281.00
151_N276_E0.7271.00
157_Q254_R0.7251.00
309_H318_D0.7251.00
149_A172_I0.7241.00
158_P231_L0.7221.00
235_A258_M0.7221.00
322_L325_Q0.7211.00
82_A131_I0.7181.00
295_W299_G0.7111.00
22_P69_G0.7111.00
204_E302_K0.7091.00
180_L189_V0.7071.00
189_V208_D0.7061.00
17_R56_V0.7031.00
62_F141_V0.7021.00
36_I117_F0.7011.00
179_V184_Y0.7011.00
257_L279_I0.7001.00
22_P67_A0.6941.00
129_W289_F0.6931.00
33_L310_T0.6911.00
311_F335_L0.6851.00
150_A292_V0.6851.00
311_F333_V0.6841.00
149_A153_T0.6841.00
186_V231_L0.6841.00
272_I281_S0.6831.00
166_V191_V0.6801.00
116_G121_A0.6791.00
229_P232_I0.6781.00
231_L256_V0.6761.00
186_V189_V0.6741.00
307_I310_T0.6741.00
243_K264_P0.6701.00
309_H333_V0.6681.00
54_P58_G0.6681.00
80_R134_A0.6661.00
227_I250_S0.6651.00
242_L255_I0.6641.00
132_P297_S0.6611.00
74_S286_A0.6601.00
150_A295_W0.6561.00
251_P275_K0.6561.00
293_I297_S0.6561.00
222_F248_L0.6551.00
209_W221_I0.6541.00
157_Q280_F0.6541.00
201_K205_S0.6531.00
148_I172_I0.6521.00
145_P171_P0.6521.00
79_E133_E0.6511.00
62_F131_I0.6491.00
129_W293_I0.6481.00
20_P122_V0.6471.00
25_G126_K0.6451.00
37_C145_P0.6431.00
193_D213_N0.6411.00
177_V205_S0.6401.00
74_S130_K0.6391.00
38_G42_H0.6381.00
8_K13_A0.6321.00
33_L62_F0.6301.00
320_I324_E0.6301.00
27_V65_I0.6291.00
74_S77_V0.6271.00
234_D255_I0.6241.00
243_K271_G0.6241.00
199_L202_A0.6241.00
51_A55_R0.6211.00
243_K266_E0.6201.00
157_Q278_S0.6201.00
223_T228_K0.6171.00
39_S43_I0.6171.00
62_F80_R0.6161.00
144_E148_I0.6151.00
178_Q205_S0.6121.00
31_V34_A0.6111.00
229_P248_L0.6111.00
192_A211_I0.6101.00
193_D212_N0.6101.00
238_H241_I0.6091.00
29_V83_V0.6091.00
41_S324_E0.6051.00
84_D129_W0.6051.00
150_A288_K0.6021.00
156_G254_R0.6011.00
154_G184_Y0.6001.00
176_I258_M0.5971.00
218_L222_F0.5971.00
239_P243_K0.5951.00
231_L254_R0.5941.00
181_K189_V0.5941.00
199_L213_N0.5921.00
82_A144_E0.5911.00
232_I248_L0.5901.00
201_K306_L0.5881.00
143_I292_V0.5841.00
202_A210_A0.5821.00
129_W286_A0.5791.00
20_P120_Y0.5781.00
38_G170_G0.5781.00
148_I258_M0.5771.00
164_V231_L0.5771.00
145_P175_T0.5761.00
37_C332_K0.5761.00
329_H333_V0.5751.00
234_D259_G0.5751.00
264_P268_I0.5751.00
73_E76_R0.5741.00
174_L306_L0.5731.00
241_I245_A0.5731.00
19_I22_P0.5721.00
83_V128_A0.5711.00
18_E21_T0.5701.00
42_H47_H0.5691.00
211_I221_I0.5681.00
9_P46_G0.5671.00
39_S42_H0.5661.00
299_G302_K0.5621.00
20_P26_E0.5591.00
194_R202_A0.5581.00
51_A54_P0.5571.00
177_V202_A0.5561.00
165_L232_I0.5531.00
19_I122_V0.5521.00
58_G117_F0.5521.00
34_A335_L0.5521.00
75_A125_A0.5501.00
153_T179_V0.5501.00
68_V79_E0.5491.00
322_L329_H0.5471.00
12_L320_I0.5471.00
154_G287_N0.5461.00
160_E184_Y0.5461.00
309_H330_C0.5441.00
125_A128_A0.5421.00
274_G283_R0.5421.00
264_P267_V0.5421.00
160_E185_N0.5411.00
142_M334_L0.5391.00
132_P140_A0.5361.00
137_D140_A0.5361.00
14_I316_V0.5361.00
157_Q162_D0.5361.00
154_G157_Q0.5351.00
60_E332_K0.5341.00
31_V83_V0.5331.00
150_A184_Y0.5331.00
22_P71_G0.5331.00
41_S45_R0.5331.00
175_T179_V0.5321.00
308_T331_C0.5321.00
136_A310_T0.5311.00
181_K184_Y0.5291.00
288_K291_I0.5271.00
211_I216_T0.5251.00
20_P28_R0.5251.00
228_K250_S0.5221.00
174_L205_S0.5191.00
163_T209_W0.5191.00
256_V282_S0.5191.00
130_K133_E0.5181.00
36_I335_L0.5171.00
136_A140_A0.5151.00
83_V116_G0.5151.00
194_R212_N0.5141.00
83_V121_A0.5141.00
56_V115_G0.5141.00
29_V128_A0.5111.00
178_Q301_I0.5111.00
26_E113_A0.5101.00
311_F318_D0.5101.00
271_G274_G0.5091.00
203_K207_A0.5091.00
62_F140_A0.5091.00
273_T281_S0.5051.00
296_L301_I0.5021.00
153_T176_I0.5011.00
68_V75_A0.5011.00
163_T228_K0.5001.00
43_I48_N0.5001.00
265_S269_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ilkA 2 0.9882 100 0.106 Contact Map
4ej6A 1 0.9853 100 0.135 Contact Map
2dq4A 4 0.9853 100 0.137 Contact Map
3ukoA 4 0.9882 100 0.148 Contact Map
4oh1A 4 0.9735 100 0.15 Contact Map
4gkvA 4 0.9823 100 0.154 Contact Map
3m6iA 4 0.9882 100 0.156 Contact Map
4uejA 2 0.9823 100 0.157 Contact Map
1f8fA 4 0.9794 100 0.16 Contact Map
1e3iA 2 0.9794 100 0.161 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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