GREMLIN Database
RSPA - Starvation-sensing protein RspA
UniProt: P38104 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12451
Length: 404 (338)
Sequences: 11586 (6700)
Seq/√Len: 364.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_R69_F3.6711.00
116_G363_Y3.3831.00
253_R282_D3.3121.00
274_Q278_E3.2231.00
250_R254_Q3.0751.00
218_T221_E2.9951.00
62_R65_D2.9701.00
20_L88_A2.7021.00
245_N248_C2.6911.00
28_I96_I2.6391.00
273_K277_E2.6341.00
227_K230_E2.3881.00
23_T29_T2.3681.00
24_T96_I2.3381.00
251_L254_Q2.3201.00
226_G237_M2.2351.00
21_K29_T2.2301.00
45_S49_D2.2211.00
64_E299_R2.1801.00
227_K255_H2.1681.00
7_E23_T2.1341.00
230_E257_V2.1001.00
5_K23_T2.0931.00
7_E21_K2.0781.00
276_I309_V2.0761.00
354_P375_E2.0681.00
250_R278_E2.0561.00
251_L255_H2.0481.00
136_A202_K2.0071.00
283_Y310_R1.9951.00
269_I296_G1.9941.00
291_A300_I1.9871.00
247_E278_E1.9801.00
226_G256_T1.9711.00
90_D295_T1.9551.00
194_K197_D1.9551.00
5_K52_C1.9191.00
28_I100_A1.9071.00
98_A105_L1.9071.00
360_D365_H1.9021.00
44_A48_Q1.8981.00
24_T28_I1.8971.00
26_D100_A1.8641.00
225_F229_I1.8351.00
66_I93_L1.8331.00
118_M144_K1.8301.00
11_T33_D1.7981.00
76_W270_W1.7971.00
208_H235_F1.7891.00
58_R65_D1.7761.00
272_C300_I1.7751.00
223_A255_H1.7571.00
9_F21_K1.7521.00
277_E307_Y1.7291.00
228_S231_D1.7051.00
116_G365_H1.6781.00
241_T252_I1.6491.00
303_F307_Y1.6341.00
22_I93_L1.6311.00
132_L136_A1.6251.00
220_I251_L1.6231.00
197_D232_Y1.6161.00
128_I132_L1.6061.00
50_H80_P1.5941.00
136_A140_E1.5941.00
104_P107_Q1.5851.00
302_D305_S1.5651.00
276_I303_F1.5621.00
103_M107_Q1.5591.00
21_K31_L1.5351.00
275_L281_I1.5341.00
127_S130_E1.5301.00
4_V23_T1.5081.00
139_Q207_E1.5021.00
142_G207_E1.4991.00
28_I99_K1.4961.00
99_K375_E1.4941.00
137_R141_L1.4921.00
197_D201_N1.4661.00
122_H192_M1.4611.00
198_A201_N1.4561.00
6_A22_I1.4561.00
219_P251_L1.4551.00
219_P252_I1.4451.00
298_R302_D1.4261.00
61_H100_A1.4171.00
112_A115_E1.4131.00
191_F194_K1.4121.00
133_D136_A1.4081.00
134_D137_R1.4001.00
223_A251_L1.3971.00
332_L366_P1.3901.00
105_L372_L1.3811.00
58_R66_I1.3681.00
34_A88_A1.3651.00
274_Q277_E1.3631.00
52_C56_I1.3511.00
193_P228_S1.3451.00
241_T248_C1.3401.00
24_T100_A1.3231.00
276_I307_Y1.3101.00
132_L202_K1.3081.00
210_L236_W1.3081.00
49_D53_P1.3001.00
90_D94_W1.2991.00
68_Q72_K1.2931.00
194_K198_A1.2921.00
244_E271_D1.2851.00
203_F209_L1.2841.00
224_R227_K1.2701.00
272_C284_I1.2681.00
273_K303_F1.2671.00
355_H369_K1.2571.00
70_F86_I1.2501.00
224_R228_S1.2391.00
4_V25_E1.2291.00
97_K101_A1.2271.00
297_M330_F1.2191.00
95_D99_K1.2161.00
103_M108_L1.2111.00
302_D306_L1.2111.00
227_K257_V1.2081.00
65_D69_F1.1991.00
197_D231_D1.1961.00
91_M294_I1.1761.00
202_K205_F1.1731.00
221_E224_R1.1711.00
146_I207_E1.1701.00
95_D324_M1.1651.00
200_R204_G1.1651.00
210_L235_F1.1631.00
250_R280_L1.1601.00
19_T31_L1.1441.00
240_P252_I1.1411.00
223_A252_I1.1401.00
137_R140_E1.1401.00
269_I303_F1.1391.00
149_Q214_H1.1381.00
32_G35_T1.1381.00
219_P248_C1.1351.00
240_P260_I1.1331.00
48_Q52_C1.1321.00
61_H97_K1.1301.00
152_I198_A1.1221.00
252_I260_I1.1211.00
50_H53_P1.1161.00
98_A108_L1.1121.00
222_A226_G1.1051.00
126_H130_E1.0981.00
230_E258_T1.0981.00
313_S334_V1.0961.00
118_M363_Y1.0891.00
296_G299_R1.0861.00
188_Y191_F1.0791.00
136_A139_Q1.0771.00
61_H101_A1.0751.00
42_S45_S1.0701.00
211_H234_M1.0651.00
213_M237_M1.0641.00
64_E298_R1.0581.00
271_D274_Q1.0511.00
217_L222_A1.0501.00
279_Q309_V1.0481.00
288_L297_M1.0421.00
6_A52_C1.0411.00
59_D62_R1.0401.00
120_Y139_Q1.0301.00
9_F19_T1.0291.00
284_I304_A1.0291.00
19_T322_V1.0291.00
261_A283_Y1.0231.00
299_R305_S1.0231.00
153_P191_F1.0171.00
193_P232_Y1.0161.00
54_Q69_F1.0151.00
262_V275_L1.0121.00
299_R302_D0.9991.00
253_R279_Q0.9981.00
193_P197_D0.9981.00
139_Q142_G0.9921.00
25_E60_A0.9891.00
94_W295_T0.9831.00
298_R332_L0.9791.00
301_A334_V0.9761.00
239_D285_R0.9671.00
51_L89_V0.9651.00
326_A372_L0.9611.00
291_A297_M0.9611.00
259_P336_N0.9561.00
103_M111_G0.9561.00
107_Q368_D0.9561.00
6_A55_L0.9541.00
200_R206_N0.9541.00
276_I284_I0.9531.00
135_Y146_I0.9531.00
148_V199_V0.9481.00
287_T314_H0.9451.00
129_D133_D0.9441.00
130_E133_D0.9401.00
234_M258_T0.9391.00
261_A285_R0.9361.00
105_L294_I0.9331.00
101_A108_L0.9331.00
246_Q280_L0.9311.00
132_L203_F0.9231.00
190_D194_K0.9211.00
281_I284_I0.9191.00
58_R62_R0.9171.00
153_P194_K0.9171.00
151_G192_M0.9151.00
267_N271_D0.9141.00
199_V203_F0.9131.00
217_L225_F0.9121.00
220_I224_R0.9111.00
63_I97_K0.9091.00
94_W294_I0.9001.00
196_F232_Y0.8971.00
200_R209_L0.8951.00
196_F211_H0.8911.00
247_E274_Q0.8881.00
254_Q279_Q0.8821.00
369_K375_E0.8791.00
203_F207_E0.8771.00
196_F229_I0.8721.00
189_L193_P0.8721.00
60_A93_L0.8691.00
66_I69_F0.8681.00
205_F233_R0.8641.00
8_V48_Q0.8631.00
213_M226_G0.8621.00
193_P231_D0.8621.00
91_M326_A0.8571.00
135_Y203_F0.8551.00
97_K108_L0.8521.00
67_W90_D0.8511.00
301_A311_T0.8471.00
222_A241_T0.8411.00
109_L298_R0.8411.00
66_I70_F0.8341.00
101_A104_P0.8341.00
189_L225_F0.8321.00
241_T249_F0.8291.00
22_I55_L0.8241.00
128_I194_K0.8221.00
41_L45_S0.8201.00
60_A100_A0.8201.00
298_R333_W0.8191.00
24_T60_A0.8121.00
268_S271_D0.8111.00
69_F72_K0.8091.00
249_F260_I0.8091.00
263_G287_T0.8081.00
8_V47_L0.8041.00
106_Y366_P0.8031.00
301_A313_S0.8021.00
139_Q143_F0.7991.00
193_P203_F0.7961.00
273_K307_Y0.7941.00
223_A241_T0.7891.00
106_Y329_H0.7861.00
148_V151_G0.7851.00
294_I298_R0.7851.00
133_D137_R0.7841.00
33_D320_S0.7811.00
116_G361_N0.7801.00
249_F262_V0.7791.00
143_F341_E0.7781.00
246_Q275_L0.7781.00
230_E256_T0.7781.00
47_L52_C0.7781.00
305_S335_P0.7771.00
4_V26_D0.7761.00
139_Q146_I0.7761.00
197_D202_K0.7741.00
286_T297_M0.7731.00
67_W295_T0.7731.00
344_G347_E0.7721.00
288_L327_A0.7681.00
365_H368_D0.7671.00
138_H141_L0.7601.00
247_E250_R0.7601.00
262_V281_I0.7601.00
223_A256_T0.7581.00
60_A97_K0.7581.00
128_I198_A0.7581.00
198_A202_K0.7561.00
190_D228_S0.7541.00
252_I256_T0.7541.00
345_Y348_Q0.7531.00
71_Y296_G0.7521.00
28_I33_D0.7511.00
219_P223_A0.7511.00
266_F271_D0.7501.00
46_Y50_H0.7471.00
343_M348_Q0.7411.00
51_L70_F0.7381.00
23_T31_L0.7361.00
219_P241_T0.7351.00
217_L237_M0.7351.00
55_L58_R0.7321.00
134_D138_H0.7311.00
47_L89_V0.7301.00
67_W71_Y0.7271.00
224_R255_H0.7251.00
77_R80_P0.7241.00
269_I300_I0.7231.00
23_T27_G0.7211.00
344_G348_Q0.7201.00
10_V44_A0.7170.99
298_R334_V0.7160.99
121_C143_F0.7150.99
120_Y123_T0.7140.99
64_E68_Q0.7130.99
109_L294_I0.7120.99
284_I309_V0.7120.99
102_N370_P0.7100.99
343_M346_S0.7090.99
272_C304_A0.7080.99
360_D363_Y0.7080.99
303_F306_L0.7060.99
112_A368_D0.7060.99
60_A96_I0.7060.99
246_Q278_E0.7050.99
301_A305_S0.7050.99
269_I299_R0.7020.99
359_F364_M0.7020.99
196_F209_L0.7020.99
64_E295_T0.7020.99
143_F147_R0.7000.99
44_A47_L0.6990.99
331_D340_Q0.6990.99
142_G145_A0.6990.99
266_F272_C0.6980.99
324_M328_L0.6980.99
253_R260_I0.6950.99
269_I273_K0.6900.99
145_A210_L0.6890.99
54_Q58_R0.6840.99
46_Y85_A0.6840.99
345_Y349_M0.6820.99
94_W105_L0.6820.99
116_G360_D0.6810.99
150_C213_M0.6780.99
272_C286_T0.6760.99
286_T301_A0.6750.99
46_Y81_V0.6750.99
270_W273_K0.6750.99
196_F203_F0.6740.99
29_T375_E0.6730.99
213_M217_L0.6720.99
200_R233_R0.6710.99
328_L366_P0.6710.99
246_Q274_Q0.6710.99
328_L364_M0.6700.99
346_S349_M0.6680.99
31_L322_V0.6660.99
54_Q73_G0.6650.99
29_T32_G0.6630.99
135_Y199_V0.6600.99
281_I309_V0.6570.99
222_A252_I0.6560.99
86_I293_G0.6560.99
133_D202_K0.6560.99
251_L279_Q0.6560.99
226_G258_T0.6560.99
94_W109_L0.6550.99
36_L145_A0.6540.99
148_V152_I0.6500.99
294_I330_F0.6500.99
301_A332_L0.6450.99
63_I93_L0.6450.99
355_H375_E0.6440.99
101_A111_G0.6420.99
71_Y86_I0.6400.99
325_A374_I0.6390.99
29_T99_K0.6380.99
28_I32_G0.6380.99
131_A134_D0.6350.99
358_T365_H0.6350.99
10_V133_D0.6340.99
36_L39_R0.6330.99
191_F195_L0.6330.99
304_A309_V0.6310.99
45_S48_Q0.6300.99
55_L89_V0.6280.99
105_L109_L0.6260.99
98_A101_A0.6250.99
55_L66_I0.6240.99
98_A103_M0.6210.99
286_T311_T0.6210.99
98_A370_P0.6200.99
50_H54_Q0.6200.99
10_V13_P0.6200.99
40_E43_V0.6200.99
256_T260_I0.6200.99
105_L108_L0.6190.99
192_M217_L0.6180.99
9_F31_L0.6150.98
67_W70_F0.6150.98
135_Y139_Q0.6140.98
10_V41_L0.6130.98
311_T334_V0.6120.98
64_E115_E0.6120.98
270_W274_Q0.6100.98
285_R314_H0.6080.98
53_P56_I0.6080.98
272_C309_V0.6070.98
66_I89_V0.6040.98
8_V44_A0.6040.98
119_V122_H0.6030.98
96_I100_A0.6020.98
332_L367_G0.6020.98
62_R107_Q0.6010.98
59_D107_Q0.6010.98
32_G88_A0.6000.98
34_A84_S0.5990.98
97_K100_A0.5980.98
266_F275_L0.5980.98
325_A328_L0.5970.98
280_L309_V0.5930.98
248_C251_L0.5930.98
51_L74_A0.5920.98
106_Y112_A0.5900.98
18_V44_A0.5890.98
68_Q299_R0.5860.98
343_M347_E0.5830.98
42_S47_L0.5830.98
109_L331_D0.5820.98
63_I108_L0.5820.98
107_Q112_A0.5800.98
143_F342_Y0.5800.98
146_I203_F0.5790.98
68_Q71_Y0.5780.98
249_F252_I0.5780.98
18_V43_V0.5780.98
148_V196_F0.5760.98
310_R338_G0.5760.98
121_C138_H0.5750.98
193_P196_F0.5720.98
236_W312_G0.5720.98
145_A208_H0.5710.98
213_M222_A0.5710.98
63_I66_I0.5710.98
144_K361_N0.5680.97
120_Y124_T0.5670.97
95_D323_C0.5660.97
6_A89_V0.5660.97
223_A227_K0.5660.97
20_L47_L0.5650.97
288_L294_I0.5630.97
38_G42_S0.5630.97
271_D280_L0.5620.97
132_L198_A0.5600.97
132_L201_N0.5590.97
226_G229_I0.5580.97
135_Y202_K0.5560.97
106_Y368_D0.5560.97
305_S336_N0.5540.97
42_S46_Y0.5530.97
93_L97_K0.5520.97
111_G114_R0.5520.97
284_I300_I0.5510.97
253_R280_L0.5490.97
149_Q191_F0.5480.97
63_I295_T0.5470.97
305_S311_T0.5460.97
343_M349_M0.5460.97
294_I326_A0.5450.97
99_K369_K0.5450.97
119_V312_G0.5440.97
355_H358_T0.5440.97
26_D60_A0.5440.97
142_G147_R0.5440.97
239_D265_V0.5420.97
315_G324_M0.5410.97
4_V7_E0.5400.97
239_D263_G0.5390.96
321_P353_F0.5370.96
209_L234_M0.5330.96
123_T138_H0.5320.96
304_A311_T0.5300.96
128_I131_A0.5280.96
55_L93_L0.5270.96
190_D205_F0.5270.96
193_P229_I0.5240.96
297_M313_S0.5230.96
119_V364_M0.5200.96
118_M208_H0.5200.96
9_F12_C0.5190.96
132_L135_Y0.5180.96
313_S329_H0.5170.96
328_L367_G0.5170.96
26_D102_N0.5170.96
70_F293_G0.5160.96
76_W79_G0.5150.95
250_R279_Q0.5140.95
125_G134_D0.5140.95
3_I22_I0.5140.95
139_Q144_K0.5130.95
107_Q110_G0.5120.95
20_L89_V0.5050.95
200_R232_Y0.5050.95
331_D337_F0.5040.95
28_I35_T0.5030.95
215_H265_V0.5020.95
125_G131_A0.5020.95
7_E48_Q0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t6cA 5 0.9901 100 0.199 Contact Map
3v3wA 5 0.9802 100 0.199 Contact Map
3vcnA 5 0.9851 100 0.203 Contact Map
3rcyA 5 0.9183 100 0.206 Contact Map
3tjiA 5 0.9728 100 0.207 Contact Map
3sbfA 6 0.9728 100 0.212 Contact Map
4k8gA 5 0.9332 100 0.215 Contact Map
4il2A 5 0.9653 100 0.216 Contact Map
4hnlA 5 0.9678 100 0.226 Contact Map
4it1A 3 0.8911 100 0.229 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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