EAMB - ECOLI - GREMLIN Contacts

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EAMB - Cysteine/O-acetylserine efflux protein

UniProt:	P38101	Sequences: MTPTLLSAFWTYTLITAMTPGPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGISFSLAVIDPAAVHLLSWAGAAYIVWLAWKIATSPTKEDGLQAKPISFWASFALQFVNVKIILYGVTALSTFVLPQTQALSWVVGVSVLLAMIGTFGNVCWALAGHLFQRLFRQYGRQLNIVLALLLVYCAVRIFY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12445
Length:	195 (189)
Sequences:	12487 (8865)
Seq/√Len:	644.8

ECOLI - EAMB RHTB LEUE YAHN RHTC ARGO
BACSU - YISU YRHP YCGF
SULSO - Q97ZW7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
48_L	107_F	5.209	1.00
87_A	187_V	3.570	1.00
88_W	92_T	3.458	1.00
6_L	148_L	3.102	1.00
177_Q	180_I	2.993	1.00
73_H	76_S	2.753	1.00
84_V	190_A	2.639	1.00
104_P	108_W	2.469	1.00
176_R	180_I	2.371	1.00
52_I	111_F	2.332	1.00
77_W	81_A	2.315	1.00
41_R	103_K	2.246	1.00
85_W	89_K	2.230	1.00
91_A	180_I	2.191	1.00
26_L	42_V	2.036	1.00
91_A	183_A	2.009	1.00
31_A	39_S	1.925	1.00
168_Q	172_R	1.849	1.00
10_W	152_I	1.826	1.00
89_K	92_T	1.816	1.00
87_A	183_A	1.810	1.00
39_S	161_A	1.807	1.00
184_L	188_Y	1.806	1.00
12_Y	127_A	1.802	1.00
84_V	187_V	1.782	1.00
94_P	180_I	1.760	1.00
49_G	115_F	1.747	1.00
23_N	46_M	1.735	1.00
70_A	73_H	1.711	1.00
80_A	190_A	1.671	1.00
38_Q	106_S	1.648	1.00
24_N	160_W	1.644	1.00
72_V	76_S	1.637	1.00
73_H	77_W	1.625	1.00
30_S	34_H	1.624	1.00
108_W	112_A	1.547	1.00
95_T	180_I	1.539	1.00
10_W	148_L	1.522	1.00
18_M	156_G	1.510	1.00
51_L	150_A	1.500	1.00
17_A	152_I	1.491	1.00
77_W	80_A	1.446	1.00
84_V	88_W	1.437	1.00
63_S	67_I	1.428	1.00
30_S	42_V	1.421	1.00
166_L	170_L	1.410	1.00
44_A	107_F	1.401	1.00
166_L	169_R	1.398	1.00
43_L	161_A	1.383	1.00
31_A	161_A	1.380	1.00
107_F	111_F	1.368	1.00
70_A	74_L	1.367	1.00
54_M	146_S	1.358	1.00
42_V	110_S	1.353	1.00
177_Q	181_V	1.350	1.00
28_L	164_G	1.320	1.00
39_S	43_L	1.298	1.00
102_A	105_I	1.275	1.00
74_L	78_A	1.257	1.00
82_Y	86_L	1.248	1.00
40_T	162_L	1.241	1.00
111_F	115_F	1.236	1.00
105_I	108_W	1.229	1.00
153_G	157_N	1.228	1.00
55_L	59_G	1.206	1.00
124_G	149_L	1.196	1.00
183_A	187_V	1.189	1.00
36_F	162_L	1.189	1.00
47_S	154_T	1.188	1.00
9_F	145_V	1.181	1.00
23_N	114_Q	1.153	1.00
26_L	113_L	1.143	1.00
187_V	191_V	1.141	1.00
156_G	160_W	1.135	1.00
92_T	95_T	1.133	1.00
45_G	107_F	1.118	1.00
5_L	8_A	1.116	1.00
8_A	11_T	1.115	1.00
34_H	38_Q	1.109	1.00
37_R	41_R	1.108	1.00
30_S	109_A	1.099	1.00
33_S	37_R	1.099	1.00
9_F	13_T	1.087	1.00
87_A	190_A	1.073	1.00
26_L	30_S	1.070	1.00
7_S	11_T	1.068	1.00
170_L	173_Q	1.067	1.00
93_S	179_N	1.066	1.00
52_I	115_F	1.063	1.00
36_F	165_H	1.060	1.00
180_I	184_L	1.058	1.00
17_A	153_G	1.052	1.00
137_Q	140_S	1.052	1.00
82_Y	85_W	1.048	1.00
29_S	33_S	1.043	1.00
13_T	149_L	1.043	1.00
40_T	158_V	1.039	1.00
27_A	31_A	1.034	1.00
27_A	157_N	1.033	1.00
159_C	163_A	1.028	1.00
60_I	65_A	1.024	1.00
8_A	12_Y	1.013	1.00
47_S	150_A	1.008	1.00
32_T	164_G	1.007	1.00
133_L	136_T	1.004	1.00
24_N	157_N	0.992	1.00
23_N	113_L	0.989	1.00
181_V	184_L	0.962	1.00
105_I	109_A	0.962	1.00
23_N	153_G	0.952	1.00
188_Y	192_R	0.951	1.00
50_F	120_I	0.950	1.00
133_L	141_W	0.938	1.00
50_F	114_Q	0.930	1.00
101_Q	105_I	0.929	1.00
136_T	141_W	0.928	1.00
36_F	161_A	0.928	1.00
25_I	182_L	0.920	1.00
169_R	173_Q	0.916	1.00
36_F	158_V	0.916	1.00
49_G	111_F	0.914	1.00
14_L	152_I	0.913	1.00
53_V	121_I	0.910	1.00
48_L	111_F	0.895	1.00
25_I	29_S	0.891	1.00
23_N	50_F	0.880	1.00
54_M	124_G	0.864	1.00
37_R	103_K	0.858	1.00
27_A	161_A	0.852	1.00
10_W	14_L	0.848	1.00
112_A	116_V	0.845	1.00
53_V	115_F	0.835	1.00
50_F	53_V	0.835	1.00
78_A	81_A	0.828	1.00
45_G	111_F	0.823	1.00
158_V	162_L	0.821	1.00
89_K	93_S	0.819	1.00
60_I	67_I	0.819	1.00
65_A	68_D	0.817	1.00
12_Y	15_I	0.809	1.00
100_L	104_P	0.808	1.00
24_N	28_L	0.808	1.00
187_V	190_A	0.807	1.00
106_S	109_A	0.805	1.00
126_T	130_T	0.801	1.00
38_Q	41_R	0.799	1.00
6_L	151_M	0.796	1.00
137_Q	141_W	0.780	1.00
143_V	146_S	0.775	1.00
140_S	143_V	0.768	1.00
154_T	158_V	0.766	1.00
81_A	84_V	0.761	1.00
91_A	187_V	0.754	1.00
24_N	156_G	0.753	1.00
92_T	96_K	0.753	1.00
13_T	17_A	0.752	1.00
85_W	88_W	0.747	1.00
80_A	84_V	0.745	1.00
68_D	72_V	0.745	1.00
11_T	15_I	0.743	1.00
116_V	125_V	0.737	1.00
63_S	66_V	0.737	1.00
43_L	158_V	0.734	1.00
7_S	10_W	0.734	1.00
48_L	52_I	0.733	1.00
178_L	182_L	0.730	1.00
68_D	71_A	0.730	1.00
53_V	120_I	0.729	1.00
71_A	74_L	0.727	1.00
40_T	161_A	0.726	1.00
46_M	50_F	0.722	1.00
23_N	157_N	0.722	1.00
170_L	174_Y	0.720	1.00
58_A	142_V	0.716	1.00
17_A	24_N	0.716	1.00
59_G	63_S	0.713	1.00
88_W	187_V	0.710	1.00
47_S	153_G	0.709	1.00
95_T	176_R	0.703	1.00
62_F	66_V	0.700	1.00
40_T	43_L	0.693	1.00
28_L	160_W	0.691	1.00
17_A	156_G	0.687	1.00
34_H	106_S	0.680	1.00
43_L	47_S	0.679	1.00
6_L	10_W	0.676	1.00
90_I	183_A	0.673	1.00
167_F	170_L	0.673	1.00
27_A	46_M	0.673	1.00
15_I	19_T	0.672	1.00
53_V	125_V	0.671	1.00
12_Y	16_T	0.669	1.00
54_M	157_N	0.665	1.00
69_P	73_H	0.665	1.00
38_Q	103_K	0.661	1.00
41_R	106_S	0.657	1.00
78_A	116_V	0.656	1.00
30_S	33_S	0.654	1.00
157_N	160_W	0.650	1.00
53_V	57_C	0.645	1.00
50_F	150_A	0.641	1.00
31_A	164_G	0.640	1.00
46_M	114_Q	0.639	1.00
50_F	124_G	0.637	1.00
151_M	155_F	0.636	1.00
42_V	106_S	0.636	1.00
29_S	179_N	0.633	1.00
181_V	185_L	0.631	1.00
162_L	166_L	0.629	1.00
97_E	100_L	0.625	1.00
17_A	157_N	0.625	1.00
52_I	55_L	0.623	1.00
74_L	77_W	0.613	1.00
49_G	114_Q	0.612	1.00
80_A	187_V	0.611	1.00
104_P	107_F	0.608	1.00
81_A	85_W	0.608	1.00
53_V	114_Q	0.607	1.00
27_A	42_V	0.605	1.00
79_G	122_L	0.602	1.00
150_A	154_T	0.596	1.00
87_A	91_A	0.596	1.00
57_C	124_G	0.595	1.00
103_K	107_F	0.593	1.00
58_A	146_S	0.592	1.00
100_L	103_K	0.591	1.00
163_A	166_L	0.589	1.00
24_N	113_L	0.589	1.00
144_G	148_L	0.586	1.00
109_A	113_L	0.585	1.00
155_F	159_C	0.582	1.00
160_W	164_G	0.582	1.00
143_V	147_V	0.581	1.00
4_T	7_S	0.579	1.00
50_F	153_G	0.577	1.00
22_P	117_N	0.575	1.00
95_T	179_N	0.574	1.00
23_N	120_I	0.572	1.00
164_G	167_F	0.570	1.00
20_P	119_K	0.570	1.00
17_A	50_F	0.567	1.00
42_V	113_L	0.566	1.00
57_C	62_F	0.566	1.00
171_F	174_Y	0.564	1.00
44_A	47_S	0.564	1.00
114_Q	157_N	0.563	1.00
35_G	38_Q	0.563	1.00
13_T	148_L	0.563	1.00
14_L	18_M	0.559	1.00
188_Y	191_V	0.556	1.00
38_Q	102_A	0.555	1.00
54_M	150_A	0.553	1.00
89_K	109_A	0.552	1.00
114_Q	120_I	0.550	1.00
47_S	157_N	0.550	1.00
156_G	159_C	0.550	1.00
121_I	125_V	0.548	1.00
53_V	62_F	0.547	1.00
50_F	149_L	0.543	1.00
57_C	121_I	0.541	1.00
19_T	24_N	0.541	1.00
68_D	73_H	0.541	1.00
91_A	95_T	0.537	1.00
178_L	181_V	0.537	1.00
127_A	149_L	0.533	0.99
136_T	140_S	0.527	0.99
147_V	151_M	0.527	0.99
33_S	36_F	0.522	0.99
189_C	192_R	0.520	0.99
91_A	184_L	0.520	0.99
169_R	172_R	0.519	0.99
67_I	70_A	0.516	0.99
4_T	8_A	0.515	0.99
16_T	127_A	0.515	0.99
51_L	55_L	0.515	0.99
39_S	42_V	0.513	0.99
45_G	110_S	0.513	0.99
163_A	167_F	0.511	0.99
155_F	158_V	0.511	0.99
120_I	153_G	0.508	0.99
46_M	120_I	0.505	0.99
120_I	157_N	0.504	0.99
149_L	153_G	0.500	0.99
124_G	153_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cfqA	1	0.9128	15.3	0.931	Contact Map
1pw4A	1	0.9128	14.6	0.932	Contact Map
3o7qA	1	0.9436	12.9	0.933	Contact Map
4x5mA	2	0.4769	12.6	0.934	Contact Map
3wdoA	1	0.4769	11.8	0.935	Contact Map
4m64A	1	0.4821	11.7	0.935	Contact Map
4w6vA	1	0.5026	9.4	0.937	Contact Map
4xnjA	1	0.4718	8.4	0.939	Contact Map
4tphA	2	0.4513	7.5	0.94	Contact Map
2gfpA	2	0.9026	6.7	0.941	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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