GREMLIN Database
EAMB - Cysteine/O-acetylserine efflux protein
UniProt: P38101 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12445
Length: 195 (189)
Sequences: 12487 (8865)
Seq/√Len: 644.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_L107_F5.2091.00
87_A187_V3.5701.00
88_W92_T3.4581.00
6_L148_L3.1021.00
177_Q180_I2.9931.00
73_H76_S2.7531.00
84_V190_A2.6391.00
104_P108_W2.4691.00
176_R180_I2.3711.00
52_I111_F2.3321.00
77_W81_A2.3151.00
41_R103_K2.2461.00
85_W89_K2.2301.00
91_A180_I2.1911.00
26_L42_V2.0361.00
91_A183_A2.0091.00
31_A39_S1.9251.00
168_Q172_R1.8491.00
10_W152_I1.8261.00
89_K92_T1.8161.00
87_A183_A1.8101.00
39_S161_A1.8071.00
184_L188_Y1.8061.00
12_Y127_A1.8021.00
84_V187_V1.7821.00
94_P180_I1.7601.00
49_G115_F1.7471.00
23_N46_M1.7351.00
70_A73_H1.7111.00
80_A190_A1.6711.00
38_Q106_S1.6481.00
24_N160_W1.6441.00
72_V76_S1.6371.00
73_H77_W1.6251.00
30_S34_H1.6241.00
108_W112_A1.5471.00
95_T180_I1.5391.00
10_W148_L1.5221.00
18_M156_G1.5101.00
51_L150_A1.5001.00
17_A152_I1.4911.00
77_W80_A1.4461.00
84_V88_W1.4371.00
63_S67_I1.4281.00
30_S42_V1.4211.00
166_L170_L1.4101.00
44_A107_F1.4011.00
166_L169_R1.3981.00
43_L161_A1.3831.00
31_A161_A1.3801.00
107_F111_F1.3681.00
70_A74_L1.3671.00
54_M146_S1.3581.00
42_V110_S1.3531.00
177_Q181_V1.3501.00
28_L164_G1.3201.00
39_S43_L1.2981.00
102_A105_I1.2751.00
74_L78_A1.2571.00
82_Y86_L1.2481.00
40_T162_L1.2411.00
111_F115_F1.2361.00
105_I108_W1.2291.00
153_G157_N1.2281.00
55_L59_G1.2061.00
124_G149_L1.1961.00
183_A187_V1.1891.00
36_F162_L1.1891.00
47_S154_T1.1881.00
9_F145_V1.1811.00
23_N114_Q1.1531.00
26_L113_L1.1431.00
187_V191_V1.1411.00
156_G160_W1.1351.00
92_T95_T1.1331.00
45_G107_F1.1181.00
5_L8_A1.1161.00
8_A11_T1.1151.00
34_H38_Q1.1091.00
37_R41_R1.1081.00
30_S109_A1.0991.00
33_S37_R1.0991.00
9_F13_T1.0871.00
87_A190_A1.0731.00
26_L30_S1.0701.00
7_S11_T1.0681.00
170_L173_Q1.0671.00
93_S179_N1.0661.00
52_I115_F1.0631.00
36_F165_H1.0601.00
180_I184_L1.0581.00
17_A153_G1.0521.00
137_Q140_S1.0521.00
82_Y85_W1.0481.00
29_S33_S1.0431.00
13_T149_L1.0431.00
40_T158_V1.0391.00
27_A31_A1.0341.00
27_A157_N1.0331.00
159_C163_A1.0281.00
60_I65_A1.0241.00
8_A12_Y1.0131.00
47_S150_A1.0081.00
32_T164_G1.0071.00
133_L136_T1.0041.00
24_N157_N0.9921.00
23_N113_L0.9891.00
181_V184_L0.9621.00
105_I109_A0.9621.00
23_N153_G0.9521.00
188_Y192_R0.9511.00
50_F120_I0.9501.00
133_L141_W0.9381.00
50_F114_Q0.9301.00
101_Q105_I0.9291.00
136_T141_W0.9281.00
36_F161_A0.9281.00
25_I182_L0.9201.00
169_R173_Q0.9161.00
36_F158_V0.9161.00
49_G111_F0.9141.00
14_L152_I0.9131.00
53_V121_I0.9101.00
48_L111_F0.8951.00
25_I29_S0.8911.00
23_N50_F0.8801.00
54_M124_G0.8641.00
37_R103_K0.8581.00
27_A161_A0.8521.00
10_W14_L0.8481.00
112_A116_V0.8451.00
53_V115_F0.8351.00
50_F53_V0.8351.00
78_A81_A0.8281.00
45_G111_F0.8231.00
158_V162_L0.8211.00
89_K93_S0.8191.00
60_I67_I0.8191.00
65_A68_D0.8171.00
12_Y15_I0.8091.00
100_L104_P0.8081.00
24_N28_L0.8081.00
187_V190_A0.8071.00
106_S109_A0.8051.00
126_T130_T0.8011.00
38_Q41_R0.7991.00
6_L151_M0.7961.00
137_Q141_W0.7801.00
143_V146_S0.7751.00
140_S143_V0.7681.00
154_T158_V0.7661.00
81_A84_V0.7611.00
91_A187_V0.7541.00
24_N156_G0.7531.00
92_T96_K0.7531.00
13_T17_A0.7521.00
85_W88_W0.7471.00
80_A84_V0.7451.00
68_D72_V0.7451.00
11_T15_I0.7431.00
116_V125_V0.7371.00
63_S66_V0.7371.00
43_L158_V0.7341.00
7_S10_W0.7341.00
48_L52_I0.7331.00
178_L182_L0.7301.00
68_D71_A0.7301.00
53_V120_I0.7291.00
71_A74_L0.7271.00
40_T161_A0.7261.00
46_M50_F0.7221.00
23_N157_N0.7221.00
170_L174_Y0.7201.00
58_A142_V0.7161.00
17_A24_N0.7161.00
59_G63_S0.7131.00
88_W187_V0.7101.00
47_S153_G0.7091.00
95_T176_R0.7031.00
62_F66_V0.7001.00
40_T43_L0.6931.00
28_L160_W0.6911.00
17_A156_G0.6871.00
34_H106_S0.6801.00
43_L47_S0.6791.00
6_L10_W0.6761.00
90_I183_A0.6731.00
167_F170_L0.6731.00
27_A46_M0.6731.00
15_I19_T0.6721.00
53_V125_V0.6711.00
12_Y16_T0.6691.00
54_M157_N0.6651.00
69_P73_H0.6651.00
38_Q103_K0.6611.00
41_R106_S0.6571.00
78_A116_V0.6561.00
30_S33_S0.6541.00
157_N160_W0.6501.00
53_V57_C0.6451.00
50_F150_A0.6411.00
31_A164_G0.6401.00
46_M114_Q0.6391.00
50_F124_G0.6371.00
151_M155_F0.6361.00
42_V106_S0.6361.00
29_S179_N0.6331.00
181_V185_L0.6311.00
162_L166_L0.6291.00
97_E100_L0.6251.00
17_A157_N0.6251.00
52_I55_L0.6231.00
74_L77_W0.6131.00
49_G114_Q0.6121.00
80_A187_V0.6111.00
104_P107_F0.6081.00
81_A85_W0.6081.00
53_V114_Q0.6071.00
27_A42_V0.6051.00
79_G122_L0.6021.00
150_A154_T0.5961.00
87_A91_A0.5961.00
57_C124_G0.5951.00
103_K107_F0.5931.00
58_A146_S0.5921.00
100_L103_K0.5911.00
163_A166_L0.5891.00
24_N113_L0.5891.00
144_G148_L0.5861.00
109_A113_L0.5851.00
155_F159_C0.5821.00
160_W164_G0.5821.00
143_V147_V0.5811.00
4_T7_S0.5791.00
50_F153_G0.5771.00
22_P117_N0.5751.00
95_T179_N0.5741.00
23_N120_I0.5721.00
164_G167_F0.5701.00
20_P119_K0.5701.00
17_A50_F0.5671.00
42_V113_L0.5661.00
57_C62_F0.5661.00
171_F174_Y0.5641.00
44_A47_S0.5641.00
114_Q157_N0.5631.00
35_G38_Q0.5631.00
13_T148_L0.5631.00
14_L18_M0.5591.00
188_Y191_V0.5561.00
38_Q102_A0.5551.00
54_M150_A0.5531.00
89_K109_A0.5521.00
114_Q120_I0.5501.00
47_S157_N0.5501.00
156_G159_C0.5501.00
121_I125_V0.5481.00
53_V62_F0.5471.00
50_F149_L0.5431.00
57_C121_I0.5411.00
19_T24_N0.5411.00
68_D73_H0.5411.00
91_A95_T0.5371.00
178_L181_V0.5371.00
127_A149_L0.5330.99
136_T140_S0.5270.99
147_V151_M0.5270.99
33_S36_F0.5220.99
189_C192_R0.5200.99
91_A184_L0.5200.99
169_R172_R0.5190.99
67_I70_A0.5160.99
4_T8_A0.5150.99
16_T127_A0.5150.99
51_L55_L0.5150.99
39_S42_V0.5130.99
45_G110_S0.5130.99
163_A167_F0.5110.99
155_F158_V0.5110.99
120_I153_G0.5080.99
46_M120_I0.5050.99
120_I157_N0.5040.99
149_L153_G0.5000.99
124_G153_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9128 15.3 0.931 Contact Map
1pw4A 1 0.9128 14.6 0.932 Contact Map
3o7qA 1 0.9436 12.9 0.933 Contact Map
4x5mA 2 0.4769 12.6 0.934 Contact Map
3wdoA 1 0.4769 11.8 0.935 Contact Map
4m64A 1 0.4821 11.7 0.935 Contact Map
4w6vA 1 0.5026 9.4 0.937 Contact Map
4xnjA 1 0.4718 8.4 0.939 Contact Map
4tphA 2 0.4513 7.5 0.94 Contact Map
2gfpA 2 0.9026 6.7 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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