CUSA - ECOLI - GREMLIN Contacts

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CUSA - Cation efflux system protein CusA

UniProt:	P38054	Sequences: MIEWIIRRSVANRFLVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAELGPDATGVGWIYEYALVDRSGKHDLADLRSLQDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSIELAEAEYMVRASGYLQTLDDFNHIVLKASENGVPVYLRDVAKVQIGPEMRRGIAELNGEGEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPPESSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWPLNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQEQWRPGMTMDKIIEELDNTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDAMAEQIEEVARTVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTPMKQQITLADVADIKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAVPSLNNPQTFSEQKLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKLMWLHRHRVRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12367
Length:	1047 (997)
Sequences:	15759 (10033)
Seq/√Len:	317.7

ECOLI - CUSA MDTB MDTC ACRD ACRF MDTF ACRB
BACSU - SWRC SECDF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
968_K	971_E	4.107	1.00
241_D	244_N	4.086	1.00
307_K	310_T	3.948	1.00
309_E	312_K	3.899	1.00
244_N	260_R	3.893	1.00
66_T	91_S	3.763	1.00
727_E	805_K	3.719	1.00
51_T	91_S	3.557	1.00
528_L	1029_F	3.423	1.00
914_L	1018_G	3.352	1.00
589_L	624_V	3.306	1.00
302_A	332_D	3.251	1.00
245_H	260_R	3.162	1.00
152_D	155_D	3.117	1.00
584_E	587_S	3.058	1.00
7_R	11_A	3.056	1.00
530_L	974_Y	3.048	1.00
144_L	160_Q	2.982	1.00
692_D	695_A	2.863	1.00
191_I	206_V	2.835	1.00
689_V	692_D	2.814	1.00
729_N	803_D	2.789	1.00
79_A	95_V	2.782	1.00
757_G	768_I	2.758	1.00
171_I	303_A	2.748	1.00
167_E	307_K	2.739	1.00
66_T	86_S	2.706	1.00
728_I	733_A	2.686	1.00
277_E	593_D	2.683	1.00
733_A	743_V	2.650	1.00
305_K	326_D	2.628	1.00
62_E	820_P	2.598	1.00
739_T	742_D	2.593	1.00
703_V	706_T	2.592	1.00
279_N	604_R	2.583	1.00
244_N	265_V	2.563	1.00
196_L	201_I	2.510	1.00
343_L	347_I	2.507	1.00
896_E	949_R	2.505	1.00
240_L	244_N	2.501	1.00
80_K	96_I	2.471	1.00
586_A	590_Q	2.449	1.00
259_L	265_V	2.430	1.00
312_K	320_E	2.407	1.00
376_I	488_G	2.399	1.00
192_D	195_R	2.376	1.00
695_A	699_Q	2.365	1.00
526_H	978_V	2.363	1.00
967_Q	975_H	2.363	1.00
701_E	705_R	2.363	1.00
156_L	319_V	2.342	1.00
80_K	98_E	2.331	1.00
248_L	262_V	2.324	1.00
640_M	648_E	2.296	1.00
422_Q	441_D	2.285	1.00
299_E	303_A	2.282	1.00
641_T	644_K	2.274	1.00
423_H	437_Q	2.271	1.00
729_N	732_K	2.268	1.00
380_V	484_Y	2.234	1.00
159_L	319_V	2.232	1.00
696_M	854_T	2.223	1.00
781_Q	784_R	2.208	1.00
632_P	635_Q	2.203	1.00
918_M	1014_A	2.192	1.00
704_A	840_L	2.191	1.00
601_E	640_M	2.173	1.00
190_V	266_Q	2.164	1.00
207_K	770_L	2.163	1.00
599_V	648_E	2.135	1.00
727_E	803_D	2.128	1.00
598_S	652_T	2.123	1.00
191_I	203_L	2.106	1.00
832_D	835_S	2.097	1.00
185_K	267_I	2.095	1.00
951_A	965_S	2.087	1.00
951_A	967_Q	2.080	1.00
572_Y	628_I	2.071	1.00
189_V	210_L	2.067	1.00
831_R	839_D	2.062	1.00
701_E	715_A	2.057	1.00
534_H	970_D	2.046	1.00
243_F	259_L	2.044	1.00
952_I	1035_Y	2.042	1.00
249_K	252_E	2.026	1.00
340_G	344_E	2.017	1.00
725_N	807_S	2.017	1.00
973_L	1036_K	2.008	1.00
784_R	799_A	1.999	1.00
728_I	743_V	1.998	1.00
417_R	445_E	1.993	1.00
707_V	839_D	1.991	1.00
999_L	1017_I	1.959	1.00
700_I	844_I	1.954	1.00
437_Q	441_D	1.947	1.00
712_S	827_D	1.945	1.00
797_T	800_D	1.943	1.00
576_T	580_I	1.940	1.00
710_V	713_A	1.932	1.00
303_A	306_D	1.910	1.00
239_T	242_D	1.904	1.00
603_A	631_K	1.902	1.00
698_E	701_E	1.900	1.00
520_F	524_V	1.896	1.00
59_Q	63_N	1.888	1.00
416_K	420_E	1.884	1.00
685_V	700_I	1.882	1.00
69_L	73_M	1.870	1.00
726_V	802_A	1.864	1.00
531_K	535_W	1.850	1.00
11_A	436_W	1.850	1.00
277_E	586_A	1.845	1.00
145_V	322_V	1.843	1.00
596_I	649_L	1.840	1.00
61_V	65_V	1.835	1.00
241_D	245_H	1.830	1.00
738_M	788_I	1.826	1.00
970_D	1036_K	1.820	1.00
779_S	782_A	1.805	1.00
696_M	699_Q	1.805	1.00
14_F	888_Y	1.802	1.00
69_L	93_V	1.799	1.00
951_A	975_H	1.797	1.00
458_T	487_A	1.795	1.00
525_Y	977_A	1.786	1.00
193_P	776_W	1.777	1.00
151_H	318_G	1.776	1.00
520_F	523_R	1.776	1.00
591_K	594_K	1.774	1.00
413_N	445_E	1.771	1.00
28_T	32_I	1.770	1.00
207_K	211_D	1.769	1.00
841_Q	845_A	1.767	1.00
535_W	538_T	1.759	1.00
841_Q	866_E	1.757	1.00
264_K	773_P	1.757	1.00
599_V	652_T	1.755	1.00
545_L	549_T	1.750	1.00
701_E	713_A	1.748	1.00
595_L	652_T	1.745	1.00
369_S	492_L	1.740	1.00
164_L	311_L	1.739	1.00
536_P	1036_K	1.734	1.00
7_R	440_T	1.732	1.00
710_V	836_V	1.730	1.00
697_A	822_S	1.729	1.00
184_V	270_E	1.728	1.00
73_M	95_V	1.721	1.00
33_N	382_H	1.720	1.00
186_E	769_N	1.719	1.00
920_F	1014_A	1.706	1.00
149_G	281_E	1.701	1.00
238_Q	242_D	1.695	1.00
732_K	735_R	1.694	1.00
590_Q	594_K	1.690	1.00
302_A	306_D	1.686	1.00
839_D	842_K	1.685	1.00
725_N	805_K	1.682	1.00
196_L	262_V	1.680	1.00
12_N	892_R	1.671	1.00
679_S	826_I	1.667	1.00
589_L	607_G	1.666	1.00
299_E	302_A	1.665	1.00
202_S	205_E	1.661	1.00
95_V	110_V	1.656	1.00
336_D	340_G	1.650	1.00
526_H	530_L	1.649	1.00
949_R	953_E	1.644	1.00
648_E	652_T	1.641	1.00
305_K	323_T	1.638	1.00
594_K	598_S	1.632	1.00
694_D	698_E	1.629	1.00
540_L	544_A	1.626	1.00
838_H	841_Q	1.622	1.00
66_T	84_G	1.618	1.00
417_R	422_Q	1.606	1.00
78_G	101_T	1.600	1.00
531_K	534_H	1.598	1.00
192_D	264_K	1.597	1.00
839_D	843_A	1.592	1.00
773_P	776_W	1.582	1.00
699_Q	702_E	1.581	1.00
24_S	375_C	1.581	1.00
73_M	93_V	1.579	1.00
386_L	480_F	1.578	1.00
245_H	258_Y	1.577	1.00
69_L	117_V	1.574	1.00
709_G	839_D	1.566	1.00
738_M	801_V	1.562	1.00
551_L	555_N	1.554	1.00
570_L	628_I	1.552	1.00
201_I	205_E	1.552	1.00
143_A	278_L	1.551	1.00
384_Q	484_Y	1.551	1.00
595_L	654_R	1.549	1.00
703_V	843_A	1.536	1.00
574_P	589_L	1.533	1.00
592_T	653_V	1.533	1.00
547_V	551_L	1.532	1.00
208_S	212_A	1.530	1.00
214_N	757_G	1.529	1.00
30_T	379_I	1.520	1.00
416_K	979_L	1.515	1.00
559_G	834_V	1.513	1.00
204_A	208_S	1.508	1.00
528_L	531_K	1.507	1.00
743_V	801_V	1.507	1.00
650_D	712_S	1.505	1.00
417_R	420_E	1.502	1.00
414_A	501_M	1.494	1.00
102_D	105_W	1.491	1.00
237_L	243_F	1.488	1.00
574_P	592_T	1.485	1.00
305_K	309_E	1.484	1.00
524_V	527_P	1.481	1.00
733_A	738_M	1.480	1.00
487_A	491_L	1.479	1.00
576_T	588_M	1.478	1.00
702_E	706_T	1.476	1.00
413_N	416_K	1.474	1.00
191_I	196_L	1.473	1.00
295_K	300_V	1.469	1.00
86_S	91_S	1.467	1.00
726_V	804_I	1.466	1.00
195_R	199_Y	1.466	1.00
647_E	651_N	1.459	1.00
552_W	555_N	1.457	1.00
82_V	95_V	1.457	1.00
692_D	696_M	1.452	1.00
594_K	597_M	1.451	1.00
540_L	1037_L	1.450	1.00
789_L	795_Q	1.450	1.00
210_L	246_I	1.448	1.00
208_S	211_D	1.447	1.00
835_S	838_H	1.447	1.00
755_M	767_P	1.446	1.00
480_F	484_Y	1.444	1.00
884_F	897_A	1.444	1.00
903_S	941_G	1.443	1.00
970_D	974_Y	1.443	1.00
51_T	125_V	1.442	1.00
585_A	624_V	1.437	1.00
144_L	164_L	1.426	1.00
205_E	208_S	1.419	1.00
237_L	246_I	1.410	1.00
595_L	599_V	1.409	1.00
864_L	867_R	1.408	1.00
699_Q	703_V	1.403	1.00
580_I	584_E	1.397	1.00
838_H	842_K	1.396	1.00
231_V	751_V	1.395	1.00
756_V	770_L	1.395	1.00
51_T	69_L	1.395	1.00
337_N	340_G	1.394	1.00
587_S	591_K	1.389	1.00
101_T	106_A	1.387	1.00
51_T	66_T	1.383	1.00
195_R	198_Q	1.377	1.00
548_L	552_W	1.377	1.00
790_T	794_Q	1.377	1.00
247_V	256_P	1.376	1.00
524_V	528_L	1.375	1.00
377_A	485_A	1.375	1.00
145_V	320_E	1.370	1.00
205_E	789_L	1.368	1.00
526_H	975_H	1.368	1.00
631_K	635_Q	1.366	1.00
702_E	705_R	1.364	1.00
65_V	125_V	1.362	1.00
410_M	443_S	1.361	1.00
570_L	646_I	1.360	1.00
640_M	645_I	1.358	1.00
599_V	645_I	1.348	1.00
212_A	734_A	1.347	1.00
47_V	110_V	1.346	1.00
18_M	885_V	1.345	1.00
165_K	169_K	1.344	1.00
685_V	693_I	1.342	1.00
258_Y	261_D	1.342	1.00
303_A	307_K	1.342	1.00
687_G	854_T	1.341	1.00
590_Q	593_D	1.341	1.00
574_P	624_V	1.339	1.00
952_I	1039_W	1.338	1.00
275_I	586_A	1.337	1.00
326_D	329_Q	1.336	1.00
992_I	1021_I	1.336	1.00
601_E	645_I	1.336	1.00
315_L	321_I	1.334	1.00
593_D	597_M	1.333	1.00
347_I	351_V	1.333	1.00
70_T	815_T	1.332	1.00
38_A	567_E	1.332	1.00
49_I	73_M	1.331	1.00
596_I	602_V	1.330	1.00
992_I	1017_I	1.327	1.00
350_A	367_I	1.316	1.00
788_I	801_V	1.315	1.00
697_A	715_A	1.315	1.00
406_A	939_E	1.314	1.00
172_P	303_A	1.310	1.00
67_Y	815_T	1.308	1.00
26_W	379_I	1.308	1.00
710_V	826_I	1.305	1.00
380_V	384_Q	1.304	1.00
148_S	318_G	1.301	1.00
605_V	626_T	1.300	1.00
560_E	921_H	1.296	1.00
23_L	376_I	1.296	1.00
81_T	817_N	1.295	1.00
971_E	975_H	1.286	1.00
81_T	96_I	1.284	1.00
597_M	605_V	1.274	1.00
61_V	86_S	1.272	1.00
684_K	816_E	1.271	1.00
7_R	444_V	1.270	1.00
57_A	60_I	1.270	1.00
190_V	264_K	1.269	1.00
549_T	553_P	1.267	1.00
242_D	245_H	1.267	1.00
167_E	314_S	1.266	1.00
205_E	249_K	1.264	1.00
73_M	110_V	1.263	1.00
602_V	628_I	1.262	1.00
570_L	649_L	1.261	1.00
31_I	339_S	1.260	1.00
30_T	382_H	1.260	1.00
78_G	98_E	1.259	1.00
952_I	969_L	1.257	1.00
609_T	624_V	1.254	1.00
601_E	631_K	1.254	1.00
967_Q	971_E	1.250	1.00
441_D	444_V	1.248	1.00
640_M	644_K	1.245	1.00
541_L	545_L	1.243	1.00
306_D	310_T	1.243	1.00
47_V	107_R	1.242	1.00
62_E	815_T	1.241	1.00
159_L	163_F	1.241	1.00
552_W	556_K	1.240	1.00
17_L	894_V	1.239	1.00
372_L	496_V	1.238	1.00
948_L	973_L	1.236	1.00
527_P	530_L	1.234	1.00
10_V	440_T	1.233	1.00
707_V	843_A	1.232	1.00
532_V	1033_A	1.232	1.00
202_S	789_L	1.231	1.00
158_S	766_Y	1.230	1.00
556_K	916_W	1.230	1.00
115_N	118_Q	1.226	1.00
647_E	650_D	1.225	1.00
536_P	1040_L	1.224	1.00
49_I	95_V	1.221	1.00
307_K	311_L	1.218	1.00
782_A	785_Q	1.217	1.00
527_P	531_K	1.215	1.00
844_I	856_V	1.212	1.00
308_L	321_I	1.211	1.00
118_Q	127_A	1.210	1.00
937_A	1023_A	1.209	1.00
723_Y	809_G	1.208	1.00
911_G	930_F	1.203	1.00
309_E	313_S	1.201	1.00
151_H	155_D	1.200	1.00
915_L	926_T	1.200	1.00
541_L	548_L	1.197	1.00
196_L	206_V	1.197	1.00
985_A	989_A	1.197	1.00
526_H	974_Y	1.196	1.00
588_M	591_K	1.196	1.00
576_T	585_A	1.195	1.00
8_R	15_L	1.195	1.00
244_N	264_K	1.192	1.00
302_A	305_K	1.191	1.00
603_A	629_Q	1.190	1.00
417_R	441_D	1.186	1.00
969_L	973_L	1.184	1.00
221_S	228_E	1.184	1.00
174_V	300_V	1.182	1.00
247_V	258_Y	1.179	1.00
686_S	821_T	1.175	1.00
10_V	499_I	1.174	1.00
700_I	824_I	1.171	1.00
819_R	855_S	1.170	1.00
738_M	791_P	1.170	1.00
145_V	281_E	1.167	1.00
741_A	745_L	1.166	1.00
863_E	867_R	1.165	1.00
142_Y	321_I	1.165	1.00
168_L	177_V	1.164	1.00
276_A	285_A	1.163	1.00
595_L	598_S	1.160	1.00
199_Y	257_V	1.157	1.00
61_V	91_S	1.156	1.00
758_E	767_P	1.154	1.00
283_E	287_G	1.153	1.00
532_V	539_T	1.153	1.00
151_H	319_V	1.153	1.00
975_H	978_V	1.150	1.00
920_F	1010_S	1.148	1.00
144_L	321_I	1.148	1.00
996_L	1017_I	1.148	1.00
73_M	82_V	1.145	1.00
685_V	696_M	1.144	1.00
219_G	233_A	1.140	1.00
245_H	731_E	1.140	1.00
589_L	609_T	1.137	1.00
306_D	309_E	1.136	1.00
748_T	754_A	1.135	1.00
282_G	287_G	1.135	1.00
698_E	702_E	1.134	1.00
523_R	527_P	1.133	1.00
113_Y	116_Q	1.131	1.00
140_Y	304_V	1.131	1.00
704_A	710_V	1.130	1.00
69_L	114_L	1.128	1.00
591_K	595_L	1.125	1.00
332_D	336_D	1.123	1.00
24_S	28_T	1.123	1.00
72_T	117_V	1.120	1.00
142_Y	323_T	1.118	1.00
707_V	842_K	1.117	1.00
591_K	657_G	1.116	1.00
62_E	813_L	1.114	1.00
644_K	648_E	1.113	1.00
20_A	496_V	1.112	1.00
80_K	867_R	1.112	1.00
296_N	299_E	1.111	1.00
436_W	440_T	1.111	1.00
310_T	313_S	1.109	1.00
816_E	859_S	1.109	1.00
454_L	490_A	1.109	1.00
749_S	754_A	1.109	1.00
413_N	947_Y	1.107	1.00
870_H	873_K	1.106	1.00
301_I	328_S	1.103	1.00
209_A	246_I	1.100	1.00
591_K	655_L	1.097	1.00
949_R	952_I	1.097	1.00
643_D	647_E	1.097	1.00
377_A	484_Y	1.097	1.00
153_L	183_V	1.095	1.00
538_T	541_L	1.093	1.00
602_V	610_G	1.093	1.00
386_L	392_S	1.085	1.00
543_A	1030_I	1.085	1.00
79_A	82_V	1.084	1.00
787_P	795_Q	1.082	1.00
696_M	850_L	1.081	1.00
686_S	857_A	1.081	1.00
639_G	644_K	1.080	1.00
167_E	311_L	1.080	1.00
455_L	886_L	1.080	1.00
828_A	836_V	1.080	1.00
204_A	742_D	1.078	1.00
83_R	96_I	1.076	1.00
337_N	1009_M	1.075	1.00
560_E	923_S	1.074	1.00
692_D	854_T	1.073	1.00
587_S	590_Q	1.072	1.00
368_I	500_L	1.068	1.00
947_Y	951_A	1.068	1.00
859_S	863_E	1.067	1.00
691_A	694_D	1.065	1.00
188_Q	771_R	1.063	1.00
5_I	9_S	1.062	1.00
989_A	993_A	1.060	1.00
157_R	182_G	1.060	1.00
15_L	889_L	1.059	1.00
53_Y	56_Q	1.058	1.00
730_R	740_V	1.058	1.00
501_M	505_I	1.057	1.00
687_G	692_D	1.056	1.00
785_Q	799_A	1.052	1.00
950_H	953_E	1.050	1.00
593_D	607_G	1.050	1.00
544_A	548_L	1.049	1.00
140_Y	305_K	1.048	1.00
913_W	917_W	1.047	1.00
312_K	321_I	1.047	1.00
595_L	655_L	1.046	1.00
232_R	723_Y	1.046	1.00
190_V	773_P	1.043	1.00
9_S	16_V	1.042	1.00
529_L	533_L	1.040	1.00
72_T	116_Q	1.039	1.00
111_L	115_N	1.039	1.00
85_F	94_Y	1.039	1.00
118_Q	126_S	1.037	1.00
914_L	1014_A	1.036	1.00
186_E	270_E	1.034	1.00
50_K	90_D	1.028	1.00
84_G	815_T	1.028	1.00
548_L	551_L	1.027	1.00
705_R	713_A	1.026	1.00
537_K	541_L	1.025	1.00
599_V	649_L	1.024	1.00
177_V	286_G	1.024	1.00
277_E	590_Q	1.022	1.00
82_V	818_A	1.021	1.00
49_I	69_L	1.021	1.00
516_P	520_F	1.020	1.00
564_Q	643_D	1.020	1.00
140_Y	301_I	1.019	1.00
519_R	523_R	1.018	1.00
70_T	84_G	1.017	1.00
453_S	490_A	1.017	1.00
259_L	263_A	1.017	1.00
437_Q	440_T	1.017	1.00
682_G	823_W	1.016	1.00
206_V	262_V	1.015	1.00
988_V	1024_P	1.014	1.00
101_T	109_R	1.013	1.00
906_F	1026_L	1.011	1.00
282_G	285_A	1.011	1.00
790_T	793_K	1.011	1.00
840_L	858_F	1.010	1.00
258_Y	731_E	1.006	1.00
706_T	843_A	1.004	1.00
592_T	655_L	1.004	1.00
17_L	21_L	1.003	1.00
648_E	651_N	1.003	1.00
570_L	630_L	1.003	1.00
534_H	537_K	1.003	1.00
517_L	520_F	1.003	1.00
452_I	886_L	1.002	1.00
771_R	777_R	1.001	1.00
532_V	1029_F	0.999	1.00
413_N	417_R	0.997	1.00
105_W	109_R	0.997	1.00
947_Y	979_L	0.997	1.00
701_E	824_I	0.996	1.00
553_P	913_W	0.995	1.00
369_S	407_A	0.994	1.00
709_G	829_R	0.994	1.00
992_I	1020_M	0.994	1.00
418_L	435_R	0.993	1.00
683_I	704_A	0.992	1.00
545_L	548_L	0.991	1.00
421_W	438_V	0.991	1.00
219_G	747_V	0.990	1.00
572_Y	596_I	0.990	1.00
950_H	965_S	0.988	1.00
189_V	756_V	0.987	1.00
588_M	655_L	0.986	1.00
592_T	626_T	0.986	1.00
581_S	584_E	0.985	1.00
243_F	768_I	0.985	1.00
369_S	497_I	0.985	1.00
596_I	628_I	0.983	1.00
143_A	283_E	0.983	1.00
157_R	161_D	0.981	1.00
368_I	496_V	0.979	1.00
339_S	343_L	0.979	1.00
180_V	287_G	0.977	1.00
584_E	657_G	0.977	1.00
24_S	372_L	0.976	1.00
981_V	985_A	0.976	1.00
34_T	378_F	0.975	1.00
457_I	939_E	0.974	1.00
217_A	744_Q	0.974	1.00
574_P	660_N	0.972	1.00
697_A	701_E	0.969	1.00
380_V	488_G	0.969	1.00
301_I	305_K	0.969	1.00
649_L	653_V	0.969	1.00
596_I	626_T	0.968	1.00
165_K	177_V	0.967	1.00
542_V	549_T	0.967	1.00
447_G	451_F	0.967	1.00
533_L	1036_K	0.965	1.00
642_M	646_I	0.965	1.00
248_L	257_V	0.964	1.00
228_E	273_R	0.962	1.00
201_I	248_L	0.962	1.00
84_G	93_V	0.962	1.00
52_S	90_D	0.962	1.00
899_L	1034_A	0.961	1.00
537_K	1037_L	0.960	1.00
468_E	871_K	0.958	1.00
459_L	882_I	0.957	1.00
923_S	926_T	0.956	1.00
148_S	151_H	0.955	1.00
685_V	854_T	0.952	1.00
413_N	446_V	0.952	1.00
891_F	942_V	0.951	1.00
975_H	979_L	0.951	1.00
305_K	312_K	0.950	1.00
778_D	782_A	0.950	1.00
644_K	647_E	0.950	1.00
974_Y	978_V	0.947	1.00
415_H	419_E	0.946	1.00
150_K	318_G	0.945	1.00
836_V	839_D	0.945	1.00
837_V	862_F	0.944	1.00
993_A	996_L	0.944	1.00
988_V	992_I	0.943	1.00
358_W	515_N	0.942	1.00
522_I	526_H	0.942	1.00
688_T	854_T	0.942	1.00
965_S	975_H	0.942	1.00
423_H	435_R	0.941	1.00
525_Y	529_L	0.941	1.00
445_E	950_H	0.939	1.00
724_I	780_P	0.938	1.00
539_T	542_V	0.937	1.00
11_A	440_T	0.935	1.00
549_T	552_W	0.934	1.00
365_V	500_L	0.934	1.00
6_I	443_S	0.933	1.00
738_M	743_V	0.933	1.00
710_V	840_L	0.931	1.00
536_P	1037_L	0.931	1.00
165_K	179_S	0.931	1.00
435_R	439_I	0.931	1.00
716_E	814_K	0.930	1.00
171_I	307_K	0.930	1.00
243_F	265_V	0.930	1.00
550_V	912_I	0.927	1.00
593_D	605_V	0.925	1.00
278_L	283_E	0.924	1.00
452_I	890_A	0.923	1.00
555_N	558_G	0.922	1.00
188_Q	266_Q	0.921	1.00
144_L	156_L	0.921	1.00
360_V	364_L	0.920	1.00
440_T	444_V	0.919	1.00
755_M	769_N	0.918	1.00
649_L	662_W	0.918	1.00
914_L	918_M	0.916	1.00
758_E	765_R	0.916	1.00
410_M	450_L	0.912	1.00
733_A	801_V	0.911	1.00
414_A	442_A	0.911	1.00
583_A	587_S	0.911	1.00
280_G	593_D	0.911	1.00
381_M	386_L	0.910	1.00
20_A	372_L	0.908	1.00
691_A	695_A	0.908	1.00
873_K	877_P	0.907	1.00
898_L	902_S	0.906	1.00
210_L	756_V	0.904	1.00
154_A	269_P	0.903	1.00
439_I	502_G	0.902	1.00
240_L	267_I	0.902	1.00
784_R	804_I	0.902	1.00
97_F	110_V	0.901	1.00
372_L	492_L	0.901	1.00
742_D	745_L	0.900	1.00
72_T	120_K	0.899	1.00
948_L	1035_Y	0.896	1.00
813_L	820_P	0.896	1.00
176_E	290_I	0.895	1.00
966_E	972_A	0.894	1.00
783_L	804_I	0.893	1.00
305_K	328_S	0.893	1.00
726_V	747_V	0.893	1.00
336_D	339_S	0.893	1.00
909_V	1022_T	0.890	1.00
278_L	604_R	0.890	1.00
419_E	422_Q	0.890	1.00
244_N	263_A	0.889	1.00
948_L	976_G	0.885	1.00
973_L	977_A	0.884	1.00
204_A	745_L	0.884	1.00
249_K	257_V	0.883	1.00
877_P	881_M	0.883	1.00
704_A	713_A	0.883	1.00
699_Q	849_Q	0.882	1.00
996_L	1000_W	0.882	1.00
311_L	315_L	0.882	1.00
300_V	303_A	0.881	1.00
546_S	909_V	0.881	1.00
105_W	108_S	0.881	1.00
74_L	818_A	0.880	1.00
759_T	768_I	0.878	1.00
155_D	158_S	0.877	1.00
52_S	126_S	0.876	1.00
682_G	821_T	0.876	1.00
601_E	648_E	0.876	1.00
683_I	700_I	0.875	1.00
700_I	843_A	0.874	1.00
392_S	477_P	0.871	1.00
525_Y	533_L	0.870	1.00
206_V	770_L	0.869	1.00
911_G	1015_P	0.868	1.00
530_L	970_D	0.867	1.00
655_L	658_L	0.866	1.00
685_V	824_I	0.865	1.00
724_I	806_V	0.864	1.00
192_D	776_W	0.864	1.00
522_I	978_V	0.864	1.00
189_V	263_A	0.863	1.00
447_G	494_I	0.860	1.00
212_A	739_T	0.858	1.00
711_A	829_R	0.857	1.00
831_R	835_S	0.854	1.00
158_S	162_W	0.854	1.00
226_E	584_E	0.853	1.00
607_G	626_T	0.853	1.00
736_Y	796_I	0.853	1.00
420_E	441_D	0.852	1.00
906_F	1030_I	0.850	1.00
168_L	307_K	0.850	1.00
570_L	642_M	0.849	1.00
880_L	901_I	0.849	1.00
686_S	855_S	0.848	1.00
575_S	659_A	0.847	1.00
884_F	894_V	0.847	1.00
645_I	648_E	0.846	1.00
187_Y	759_T	0.845	1.00
850_L	856_V	0.845	1.00
210_L	243_F	0.844	1.00
693_I	854_T	0.843	1.00
422_Q	437_Q	0.840	1.00
75_S	113_Y	0.836	1.00
1027_S	1031_I	0.836	1.00
161_D	165_K	0.835	1.00
473_R	476_G	0.835	1.00
780_P	784_R	0.834	1.00
85_F	812_M	0.834	1.00
683_I	856_V	0.833	1.00
270_E	767_P	0.831	1.00
817_N	857_A	0.829	1.00
207_K	749_S	0.827	1.00
123_A	127_A	0.826	1.00
206_V	259_L	0.826	1.00
81_T	816_E	0.826	1.00
169_K	176_E	0.826	1.00
193_P	772_Y	0.826	1.00
653_V	660_N	0.825	1.00
604_R	629_Q	0.825	1.00
837_V	858_F	0.824	1.00
48_I	94_Y	0.824	1.00
141_E	287_G	0.823	1.00
592_T	595_L	0.823	1.00
457_I	486_M	0.822	1.00
530_L	534_H	0.822	1.00
553_P	916_W	0.822	1.00
344_E	347_I	0.822	1.00
458_T	483_T	0.822	1.00
969_L	1036_K	0.821	1.00
709_G	842_K	0.820	1.00
694_D	822_S	0.819	1.00
516_P	519_R	0.818	1.00
8_R	12_N	0.818	1.00
196_L	199_Y	0.817	1.00
1021_I	1025_L	0.815	1.00
533_L	974_Y	0.814	1.00
275_I	582_A	0.814	1.00
201_I	206_V	0.812	1.00
191_I	770_L	0.812	1.00
194_Q	785_Q	0.812	1.00
530_L	971_E	0.812	1.00
436_W	502_G	0.810	1.00
509_I	512_E	0.809	1.00
17_L	503_Y	0.808	1.00
862_F	866_E	0.808	1.00
837_V	866_E	0.807	1.00
540_L	1033_A	0.807	1.00
275_I	609_T	0.806	1.00
515_N	518_N	0.805	1.00
693_I	822_S	0.805	1.00
421_W	441_D	0.805	1.00
54_P	126_S	0.805	1.00
713_A	826_I	0.805	1.00
753_G	771_R	0.804	1.00
580_I	585_A	0.804	1.00
203_L	749_S	0.804	1.00
29_W	33_N	0.804	1.00
359_H	362_S	0.803	1.00
680_P	827_D	0.803	1.00
918_M	1018_G	0.801	1.00
517_L	521_L	0.800	1.00
308_L	312_K	0.800	1.00
98_E	101_T	0.800	1.00
267_I	761_E	0.798	1.00
586_A	609_T	0.797	1.00
160_Q	286_G	0.797	1.00
696_M	700_I	0.796	1.00
379_I	383_F	0.794	1.00
750_A	786_L	0.794	1.00
329_Q	332_D	0.793	1.00
140_Y	323_T	0.793	1.00
197_A	787_P	0.793	1.00
692_D	853_G	0.792	1.00
738_M	790_T	0.791	1.00
557_V	912_I	0.790	1.00
574_P	658_L	0.789	1.00
543_A	547_V	0.787	1.00
51_T	128_E	0.786	1.00
650_D	662_W	0.784	1.00
49_I	93_V	0.784	1.00
835_S	839_D	0.783	1.00
630_L	645_I	0.783	1.00
953_E	965_S	0.782	1.00
685_V	689_V	0.782	1.00
207_K	754_A	0.782	1.00
732_K	800_D	0.781	1.00
50_K	92_Y	0.781	1.00
533_L	1033_A	0.780	1.00
66_T	93_V	0.779	1.00
97_F	106_A	0.779	1.00
250_A	256_P	0.778	1.00
243_F	246_I	0.778	1.00
749_S	770_L	0.778	1.00
194_Q	197_A	0.778	1.00
206_V	209_A	0.778	1.00
539_T	1030_I	0.777	1.00
519_R	522_I	0.776	1.00
869_N	873_K	0.776	1.00
922_L	927_G	0.773	1.00
518_N	522_I	0.771	1.00
572_Y	626_T	0.770	1.00
143_A	324_T	0.770	1.00
335_I	393_L	0.768	0.99
750_A	772_Y	0.768	0.99
14_F	894_V	0.768	0.99
496_V	500_L	0.766	0.99
73_M	114_L	0.765	0.99
229_Y	724_I	0.765	0.99
247_V	250_A	0.765	0.99
923_S	1011_R	0.764	0.99
333_R	336_D	0.762	0.99
584_E	588_M	0.761	0.99
179_S	182_G	0.761	0.99
940_F	1023_A	0.761	0.99
521_L	525_Y	0.759	0.99
53_Y	61_V	0.759	0.99
142_Y	286_G	0.758	0.99
874_L	877_P	0.758	0.99
191_I	263_A	0.757	0.99
139_I	300_V	0.757	0.99
212_A	741_A	0.756	0.99
381_M	481_T	0.756	0.99
237_L	759_T	0.756	0.99
206_V	248_L	0.756	0.99
724_I	804_I	0.756	0.99
446_V	454_L	0.755	0.99
1036_K	1040_L	0.754	0.99
755_M	758_E	0.754	0.99
533_L	973_L	0.753	0.99
344_E	348_V	0.753	0.99
476_G	480_F	0.752	0.99
143_A	285_A	0.751	0.99
414_A	439_I	0.751	0.99
188_Q	268_G	0.751	0.99
523_R	978_V	0.751	0.99
204_A	207_K	0.749	0.99
402_A	991_I	0.749	0.99
86_S	93_V	0.749	0.99
170_T	307_K	0.749	0.99
389_N	392_S	0.748	0.99
139_I	301_I	0.746	0.99
411_I	501_M	0.745	0.99
456_I	939_E	0.744	0.99
746_F	788_I	0.744	0.99
121_L	125_V	0.743	0.99
841_Q	858_F	0.740	0.99
743_V	798_L	0.740	0.99
681_I	840_L	0.739	0.99
310_T	314_S	0.739	0.99
67_Y	71_T	0.738	0.99
187_Y	240_L	0.738	0.99
171_I	300_V	0.737	0.99
53_Y	125_V	0.736	0.99
46_Q	96_I	0.736	0.99
717_R	822_S	0.735	0.99
748_T	752_G	0.734	0.99
570_L	662_W	0.734	0.99
574_P	626_T	0.734	0.99
547_V	550_V	0.734	0.99
465_F	483_T	0.734	0.99
140_Y	308_L	0.732	0.99
87_Q	90_D	0.732	0.99
842_K	845_A	0.732	0.99
688_T	819_R	0.732	0.99
716_E	821_T	0.732	0.99
377_A	488_G	0.731	0.99
10_V	439_I	0.731	0.99
633_Q	636_W	0.730	0.99
192_D	773_P	0.729	0.99
402_A	990_V	0.729	0.99
944_M	977_A	0.729	0.99
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895_G	1041_H	0.544	0.95
450_L	454_L	0.544	0.95
145_V	278_L	0.544	0.95
28_T	31_I	0.543	0.95
341_K	345_E	0.542	0.95
690_L	694_D	0.542	0.95
751_V	786_L	0.542	0.95
308_L	323_T	0.542	0.95
595_L	653_V	0.542	0.95
167_E	819_R	0.542	0.95
287_G	290_I	0.542	0.95
138_W	290_I	0.541	0.95
28_T	375_C	0.541	0.95
365_V	505_I	0.541	0.95
139_I	297_A	0.540	0.95
216_E	236_Y	0.540	0.95
123_A	126_S	0.540	0.95
709_G	835_S	0.540	0.95
271_M	777_R	0.540	0.95
700_I	840_L	0.539	0.95
775_S	778_D	0.539	0.95
593_D	609_T	0.539	0.95
902_S	1031_I	0.539	0.95
248_L	261_D	0.539	0.95
324_T	606_F	0.539	0.95
914_L	1022_T	0.539	0.95
939_E	943_V	0.538	0.95
353_C	990_V	0.538	0.95
212_A	742_D	0.538	0.95
784_R	803_D	0.538	0.95
909_V	913_W	0.538	0.95
454_L	493_A	0.537	0.95
585_A	609_T	0.537	0.95
36_V	335_I	0.537	0.95
969_L	972_A	0.536	0.95
142_Y	305_K	0.536	0.95
282_G	286_G	0.534	0.95
875_M	878_M	0.534	0.95
524_V	531_K	0.533	0.95
453_S	457_I	0.533	0.95
591_K	654_R	0.533	0.95
76_V	113_Y	0.532	0.94
980_R	987_T	0.531	0.94
651_N	706_T	0.531	0.94
566_N	636_W	0.531	0.94
686_S	819_R	0.531	0.94
572_Y	592_T	0.531	0.94
171_I	304_V	0.531	0.94
515_N	519_R	0.530	0.94
435_R	502_G	0.530	0.94
168_L	171_I	0.529	0.94
308_L	311_L	0.529	0.94
435_R	438_V	0.528	0.94
880_L	934_A	0.528	0.94
831_R	836_V	0.527	0.94
915_L	921_H	0.527	0.94
857_A	863_E	0.526	0.94
715_A	824_I	0.526	0.94
7_R	437_Q	0.526	0.94
344_E	351_V	0.525	0.94
107_R	111_L	0.525	0.94
25_I	29_W	0.525	0.94
13_R	502_G	0.525	0.94
349_V	363_A	0.524	0.94
685_V	697_A	0.524	0.94
446_V	991_I	0.524	0.94
916_W	919_G	0.523	0.94
612_A	615_A	0.522	0.94
341_K	406_A	0.522	0.94
408_I	986_M	0.521	0.94
267_I	766_Y	0.520	0.94
76_V	79_A	0.520	0.94
520_F	531_K	0.520	0.94
141_E	325_Y	0.520	0.94
353_C	404_V	0.519	0.94
142_Y	304_V	0.518	0.94
219_G	726_V	0.518	0.94
491_L	495_V	0.518	0.94
402_A	457_I	0.518	0.94
409_V	994_G	0.517	0.94
418_L	507_G	0.517	0.94
104_Y	131_P	0.516	0.94
395_G	481_T	0.515	0.93
61_V	66_T	0.515	0.93
149_G	320_E	0.514	0.93
736_Y	800_D	0.514	0.93
944_M	976_G	0.514	0.93
334_A	390_I	0.514	0.93
450_L	494_I	0.513	0.93
107_R	131_P	0.513	0.93
14_F	17_L	0.512	0.93
553_P	556_K	0.512	0.93
780_P	806_V	0.512	0.93
373_G	377_A	0.512	0.93
977_A	981_V	0.512	0.93
119_G	126_S	0.512	0.93
117_V	121_L	0.512	0.93
943_V	991_I	0.512	0.93
900_I	944_M	0.511	0.93
615_A	619_A	0.511	0.93
77_P	109_R	0.511	0.93
348_V	993_A	0.511	0.93
524_V	535_W	0.511	0.93
346_F	349_V	0.510	0.93
599_V	653_V	0.510	0.93
374_L	396_I	0.510	0.93
531_K	538_T	0.510	0.93
836_V	840_L	0.509	0.93
62_E	86_S	0.509	0.93
544_A	547_V	0.509	0.93
60_I	216_E	0.508	0.93
600_P	631_K	0.508	0.93
731_E	735_R	0.508	0.93
488_G	491_L	0.508	0.93
36_V	388_A	0.508	0.93
883_I	934_A	0.507	0.93
744_Q	747_V	0.507	0.93
602_V	630_L	0.507	0.93
380_V	480_F	0.507	0.93
212_A	745_L	0.507	0.93
20_A	23_L	0.506	0.93
196_L	203_L	0.506	0.93
537_K	542_V	0.506	0.93
68_P	120_K	0.505	0.93
158_S	764_A	0.504	0.93
517_L	527_P	0.504	0.93
872_L	927_G	0.504	0.93
210_L	768_I	0.503	0.93
45_V	97_F	0.503	0.93
108_S	111_L	0.503	0.93
461_F	482_K	0.503	0.93
646_I	649_L	0.503	0.93
722_R	808_T	0.503	0.93
1037_L	1040_L	0.502	0.93
753_G	769_N	0.502	0.93
54_P	128_E	0.502	0.93
696_M	856_V	0.502	0.93
926_T	1011_R	0.502	0.93
68_P	72_T	0.502	0.93
561_F	868_A	0.501	0.93
73_M	76_V	0.501	0.93
690_L	717_R	0.501	0.93
655_L	660_N	0.500	0.92
199_Y	262_V	0.500	0.92
365_V	501_M	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k0jA	3	0.9274	100	0.213	Contact Map
3ne5A	3	0.9704	100	0.277	Contact Map
4mt1A	3	0.9436	100	0.302	Contact Map
3w9iA	3	0.9608	100	0.308	Contact Map
4dx5A	3	0.9637	100	0.32	Contact Map
3aqpA	1	0.659	100	0.735	Contact Map
4r86A	1	0.276	100	0.755	Contact Map
4n8nA	1	0.0955	79.6	0.982	Contact Map
2ew9A	1	0.1414	79.5	0.982	Contact Map
4q2lA	1	0.0611	75.5	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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