GREMLIN Database
SFMF - Uncharacterized fimbrial-like protein SfmF
UniProt: P38052 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12388
Length: 171 (159)
Sequences: 3459 (2702)
Seq/√Len: 214.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_Q156_R3.0201.00
99_L112_A2.9821.00
113_I146_A2.9781.00
114_E147_N2.7951.00
63_N66_D2.7391.00
41_T79_G2.6941.00
85_V168_I2.6271.00
116_R147_N2.6141.00
74_S141_T2.5581.00
114_E149_R2.5451.00
100_L125_L2.5171.00
102_L160_A2.2491.00
148_Y160_A2.2131.00
76_R141_T2.2121.00
43_N78_E2.2071.00
110_T155_V2.1981.00
113_I162_A2.1101.00
62_L66_D2.0451.00
117_N121_S2.0391.00
120_R145_F2.0331.00
124_A127_E1.9311.00
107_M159_V1.9091.00
74_S143_N1.8651.00
99_L149_R1.7681.00
70_L147_N1.7621.00
43_N76_R1.7291.00
23_P26_T1.7171.00
91_G100_L1.7161.00
114_E122_R1.6971.00
98_N124_A1.6521.00
67_T114_E1.6511.00
100_L164_A1.6481.00
72_P145_F1.6131.00
90_T126_G1.5301.00
43_N46_D1.4911.00
54_G71_V1.4901.00
44_T49_K1.4351.00
90_T167_M1.4221.00
56_W68_T1.4051.00
46_D49_K1.3651.00
54_G160_A1.3531.00
49_K75_L1.3321.00
16_S20_A1.3251.00
34_N55_R1.3171.00
86_A169_N1.2861.00
99_L114_E1.2631.00
14_W17_S1.2591.00
17_S21_V1.2481.00
53_L148_Y1.2461.00
64_A153_S1.2331.00
61_L150_A1.2321.00
46_D76_R1.2291.00
73_F115_L1.2241.00
94_A112_A1.2231.00
94_A97_T1.2161.00
54_G69_A1.2011.00
85_V140_V1.1981.00
72_P143_N1.1911.00
17_S20_A1.1761.00
12_L15_S1.1731.00
104_D107_M1.1711.00
93_P98_N1.1491.00
150_A153_S1.1371.00
27_I31_L1.1331.00
62_L150_A1.1331.00
67_T147_N1.1321.00
19_W23_P1.1061.00
88_L128_A1.1061.00
61_L111_V1.1041.00
89_F115_L1.1021.00
60_Q68_T1.0751.00
63_N150_A1.0741.00
67_T116_R1.0671.00
67_T149_R1.0641.00
87_I142_L1.0621.00
93_P125_L1.0571.00
37_D58_T1.0521.00
51_V73_F1.0501.00
53_L160_A1.0471.00
75_L166_F1.0451.00
57_P60_Q1.0411.00
104_D159_V1.0391.00
70_L145_F1.0191.00
89_F144_F1.0131.00
134_V140_V1.0131.00
11_G14_W0.9911.00
115_L164_A0.9771.00
61_L155_V0.9741.00
118_S143_N0.9711.00
53_L113_I0.9671.00
18_G22_D0.9651.00
116_R145_F0.9541.00
150_A155_V0.9521.00
12_L17_S0.9410.99
30_N163_D0.9320.99
88_L169_N0.9300.99
41_T78_E0.9280.99
100_L162_A0.9280.99
19_W22_D0.9260.99
13_L16_S0.9260.99
61_L66_D0.9140.99
112_A151_L0.9060.99
61_L151_L0.8920.99
103_D161_K0.8880.99
10_C13_L0.8830.99
15_S19_W0.8820.99
56_W61_L0.8660.99
27_I166_F0.8570.99
16_S19_W0.8510.99
18_G21_V0.8360.99
116_R122_R0.8310.99
56_W160_A0.8290.99
92_T101_A0.8140.99
11_G17_S0.8020.98
28_N48_D0.8010.98
14_W19_W0.7930.98
21_V25_G0.7880.98
84_S133_E0.7870.98
103_D163_D0.7850.98
53_L71_V0.7850.98
111_V148_Y0.7820.98
77_L140_V0.7710.98
58_T155_V0.7660.98
17_S22_D0.7650.98
13_L18_G0.7590.98
36_V81_P0.7550.98
12_L16_S0.7540.98
108_A111_V0.7500.98
87_I168_I0.7400.97
32_H50_T0.7400.97
37_D81_P0.7390.97
56_W148_Y0.7350.97
115_L125_L0.7290.97
113_I160_A0.7260.97
32_H52_D0.7230.97
110_T154_G0.7220.97
39_S148_Y0.7210.97
64_A110_T0.7210.97
123_L129_S0.7200.97
66_D150_A0.7170.97
52_D71_V0.7140.97
35_V56_W0.7130.97
39_S81_P0.7110.97
70_L116_R0.7080.96
74_S93_P0.7080.96
127_E130_P0.7040.96
84_S131_T0.7000.96
49_K166_F0.6980.96
13_L17_S0.6970.96
53_L146_A0.6950.96
64_A152_A0.6940.96
18_G23_P0.6920.96
45_A49_K0.6880.96
52_D148_Y0.6810.96
45_A76_R0.6790.96
20_A23_P0.6740.95
64_A150_A0.6730.95
13_L20_A0.6730.95
125_L144_F0.6670.95
67_T70_L0.6650.95
76_R139_N0.6580.95
89_F166_F0.6580.95
111_V155_V0.6570.95
102_L106_A0.6550.95
110_T152_A0.6420.94
130_P133_E0.6390.94
78_E139_N0.6370.94
22_D26_T0.6370.94
15_S20_A0.6330.94
88_L127_E0.6320.94
89_F168_I0.6290.93
129_S144_F0.6290.93
86_A129_S0.6210.93
102_L161_K0.6190.93
54_G161_K0.6190.93
149_R153_S0.6130.92
58_T157_P0.6120.92
29_I89_F0.6060.92
53_L147_N0.6050.92
29_I164_A0.6040.92
121_S130_P0.6020.92
22_D25_G0.6010.92
35_V155_V0.6000.92
125_L162_A0.5990.92
148_Y161_K0.5980.92
150_A154_G0.5960.91
53_L114_E0.5920.91
15_S18_G0.5840.91
42_V131_T0.5790.90
61_L110_T0.5740.90
82_P137_N0.5710.90
129_S134_V0.5690.89
29_I45_A0.5690.89
19_W26_T0.5660.89
20_A25_G0.5660.89
68_T148_Y0.5650.89
116_R149_R0.5650.89
27_I34_N0.5620.89
95_S98_N0.5600.89
30_N50_T0.5600.89
52_D55_R0.5590.89
95_S151_L0.5590.89
94_A98_N0.5590.89
14_W20_A0.5560.88
44_T47_I0.5510.88
51_V146_A0.5500.88
90_T165_I0.5480.88
85_V134_V0.5430.87
10_C21_V0.5420.87
60_Q69_A0.5410.87
25_G28_N0.5400.87
87_I166_F0.5400.87
88_L168_I0.5400.87
14_W18_G0.5390.87
50_T165_I0.5390.87
68_T147_N0.5350.86
110_T151_L0.5340.86
140_V144_F0.5340.86
53_L73_F0.5210.85
30_N48_D0.5210.85
15_S62_L0.5180.85
108_A162_A0.5160.84
102_L107_M0.5140.84
52_D86_A0.5140.84
124_A128_A0.5130.84
44_T78_E0.5120.84
27_I33_G0.5100.84
43_N139_N0.5100.84
84_S137_N0.5090.84
95_S152_A0.5090.84
86_A128_A0.5080.83
10_C15_S0.5060.83
16_S21_V0.5050.83
87_I140_V0.5050.83
132_E142_L0.5040.83
91_G163_D0.5040.83
37_D83_G0.5010.83
128_A169_N0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jmrA 1 0.8655 100 0.245 Contact Map
2xg5B 1 0.8012 100 0.256 Contact Map
2jtyA 1 0.8772 100 0.265 Contact Map
2uy6B 2 0.8187 100 0.28 Contact Map
1pdkB 1 0.7895 100 0.295 Contact Map
3bwuF 1 0.7076 100 0.34 Contact Map
2w07B 1 0.6725 99.9 0.361 Contact Map
3bfqG 1 0.7544 99.9 0.369 Contact Map
4dwhB 1 0.7544 99.9 0.373 Contact Map
5afoA 1 0.9649 99.9 0.374 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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