GREMLIN Database
MENF - Isochorismate synthase MenF
UniProt: P38051 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12362
Length: 431 (355)
Sequences: 6525 (4519)
Seq/√Len: 239.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
300_T325_T4.7851.00
345_V369_A4.5711.00
301_Q326_S3.8501.00
258_T316_V3.3831.00
259_V274_W3.3391.00
169_K173_T3.0991.00
249_A324_W2.9991.00
301_Q329_K2.9921.00
182_T187_E2.9631.00
409_D412_Q2.8511.00
261_N268_A2.7111.00
182_T359_R2.6291.00
278_D281_N2.6131.00
173_T411_E2.5951.00
172_W402_A2.5821.00
168_D171_G2.5601.00
373_G382_F2.5391.00
80_Q331_D2.4501.00
169_K411_E2.4401.00
342_T384_V2.3671.00
352_L355_Q2.3651.00
269_Q273_E2.3391.00
198_D395_V2.2851.00
198_D397_R2.2421.00
188_L191_V2.1961.00
312_R317_Q2.1931.00
179_A191_V2.1471.00
181_K185_E2.1211.00
241_R381_E2.1041.00
273_E277_A2.0981.00
234_F367_W2.0881.00
272_G312_R2.0871.00
224_F236_G2.0831.00
190_K403_G2.0801.00
167_P175_L2.0651.00
252_T292_I2.0031.00
262_N267_Q1.9821.00
207_A233_A1.9511.00
100_F354_R1.9421.00
224_F372_A1.8981.00
306_L324_W1.8931.00
174_Q177_E1.8821.00
200_H395_V1.8521.00
296_L300_T1.8511.00
248_K326_S1.8471.00
391_I396_V1.8461.00
196_A397_R1.7681.00
206_N209_A1.7641.00
276_M319_L1.7571.00
310_V319_L1.7541.00
267_Q270_Q1.7371.00
188_L353_A1.7361.00
255_L320_R1.7321.00
249_A326_S1.7151.00
74_T77_D1.6851.00
356_F360_H1.6631.00
299_D338_Q1.6601.00
195_R417_I1.6551.00
272_G310_V1.6421.00
177_E180_T1.6371.00
169_K414_W1.6241.00
253_E311_L1.6181.00
227_A233_A1.6181.00
181_K184_A1.6121.00
311_L320_R1.6031.00
269_Q272_G1.5981.00
101_D358_A1.5611.00
77_D80_Q1.5541.00
191_V357_I1.5331.00
301_Q328_N1.5081.00
179_A193_L1.5061.00
166_W363_F1.5021.00
264_D267_Q1.5001.00
235_L391_I1.4961.00
177_E410_P1.4941.00
98_N102_P1.4791.00
263_P267_Q1.4711.00
376_S379_Q1.4671.00
265_D269_Q1.4621.00
262_N271_L1.4601.00
193_L402_A1.4571.00
389_A396_V1.4511.00
251_R324_W1.4371.00
140_A144_I1.4341.00
414_W418_D1.4231.00
411_E415_Q1.4111.00
415_Q419_N1.3981.00
176_I410_P1.3921.00
246_R379_Q1.3751.00
286_M308_P1.3741.00
75_S86_H1.3671.00
163_E199_L1.3561.00
236_G383_C1.3461.00
367_W385_S1.3361.00
182_T356_F1.3081.00
336_L375_L1.3061.00
207_A391_I1.3041.00
75_S79_A1.2871.00
75_S78_Q1.2871.00
101_D364_T1.2851.00
176_I404_I1.2841.00
90_A93_R1.2801.00
256_A285_N1.2771.00
225_Y233_A1.2771.00
211_M215_R1.2741.00
271_L274_W1.2731.00
224_F234_F1.2711.00
256_A344_A1.2701.00
259_V281_N1.2571.00
171_G174_Q1.2521.00
182_T352_L1.2511.00
296_L325_T1.2481.00
194_A399_Y1.2441.00
270_Q274_W1.2401.00
171_G362_P1.2401.00
199_L396_V1.2381.00
178_L181_K1.2361.00
201_F391_I1.2271.00
400_A421_A1.2261.00
74_T337_H1.2201.00
137_A140_A1.2181.00
250_L300_T1.2181.00
372_A385_S1.2131.00
169_K415_Q1.2071.00
83_L86_H1.2041.00
173_T410_P1.1941.00
222_Y241_R1.1891.00
170_T174_Q1.1891.00
164_Q200_H1.1791.00
415_Q418_D1.1781.00
192_V369_A1.1731.00
188_L356_F1.1681.00
178_L359_R1.1641.00
178_L182_T1.1631.00
259_V271_L1.1621.00
245_R335_C1.1591.00
245_R327_L1.1561.00
73_F76_L1.1471.00
288_V344_A1.1441.00
282_Q308_P1.1411.00
192_V401_G1.1371.00
389_A424_L1.1341.00
253_E322_C1.1261.00
297_Q303_L1.1261.00
256_A288_V1.1231.00
285_N288_V1.1171.00
374_Y381_E1.1171.00
140_A143_F1.1151.00
193_L404_I1.1101.00
402_A417_I1.1091.00
195_R418_D1.1061.00
187_E352_L1.0941.00
327_L335_C1.0931.00
352_L359_R1.0921.00
336_L382_F1.0921.00
210_M235_L1.0911.00
210_M389_A1.0881.00
165_H195_R1.0761.00
177_E181_K1.0751.00
97_L367_W1.0731.00
250_L335_C1.0691.00
75_S80_Q1.0611.00
266_K270_Q1.0601.00
248_K329_K1.0581.00
210_M391_I1.0531.00
250_L296_L1.0481.00
272_G317_Q1.0441.00
173_T177_E1.0421.00
137_A143_F1.0411.00
251_R322_C1.0371.00
412_Q415_Q1.0271.00
195_R414_W1.0261.00
136_D147_L1.0251.00
333_V375_L1.0251.00
345_V386_L1.0161.00
232_N392_S1.0111.00
267_Q271_L1.0081.00
398_L421_A1.0001.00
245_R248_K0.9991.00
358_A364_T0.9981.00
270_Q273_E0.9951.00
144_I147_L0.9921.00
200_H394_N0.9861.00
94_I107_L0.9851.00
273_E276_M0.9801.00
276_M310_V0.9791.00
245_R250_L0.9781.00
113_E124_R0.9781.00
245_R332_D0.9771.00
242_L252_T0.9751.00
218_N237_S0.9751.00
75_S82_F0.9701.00
218_N315_K0.9691.00
180_T406_R0.9681.00
141_K145_A0.9611.00
285_N344_A0.9611.00
244_R251_R0.9591.00
136_D144_I0.9591.00
171_G175_L0.9531.00
101_D104_Q0.9471.00
207_A225_Y0.9461.00
367_W390_K0.9391.00
174_Q178_L0.9371.00
422_A426_T0.9361.00
82_F85_Q0.9361.00
291_D343_A0.9351.00
123_L140_A0.9271.00
231_E392_S0.9261.00
292_I342_T0.9261.00
234_F372_A0.9261.00
184_A406_R0.9261.00
183_I406_R0.9241.00
224_F383_C0.9221.00
104_Q358_A0.9211.00
398_L425_R0.9171.00
242_L339_L0.9151.00
179_A188_L0.9131.00
114_W121_A0.9111.00
78_Q81_R0.9101.00
233_A391_I0.9091.00
281_N412_Q0.9081.00
192_V345_V0.8991.00
259_V419_N0.8891.00
98_N336_L0.8870.99
142_E146_T0.8860.99
242_L256_A0.8860.99
143_F150_I0.8850.99
98_N375_L0.8810.99
136_D139_Q0.8730.99
191_V356_F0.8720.99
164_Q198_D0.8720.99
201_F210_M0.8710.99
73_F77_D0.8700.99
297_Q302_T0.8690.99
208_A225_Y0.8660.99
180_T184_A0.8610.99
389_A398_L0.8610.99
260_A419_N0.8580.99
82_F86_H0.8560.99
176_I180_T0.8540.99
173_T176_I0.8490.99
138_I142_E0.8470.99
285_N369_A0.8430.99
241_R253_E0.8400.99
192_V236_G0.8390.99
296_L339_L0.8360.99
170_T173_T0.8360.99
80_Q86_H0.8310.99
303_L307_P0.8300.99
173_T409_D0.8290.99
76_L79_A0.8280.99
371_S382_F0.8280.99
136_D140_A0.8270.99
90_A95_W0.8270.99
179_A360_H0.8240.99
260_A271_L0.8200.99
139_Q143_F0.8180.99
192_V383_C0.8170.99
137_A144_I0.8170.99
76_L80_Q0.8150.99
197_T425_R0.8110.99
103_S358_A0.8100.99
285_N292_I0.8090.99
163_E425_R0.8070.99
192_V346_A0.8000.99
144_I148_V0.7970.99
75_S85_Q0.7950.99
285_N321_R0.7950.99
201_F396_V0.7940.99
241_R251_R0.7940.99
110_P125_L0.7930.99
93_R377_L0.7870.99
283_R287_L0.7860.99
218_N423_G0.7850.99
351_D355_Q0.7830.99
223_H237_S0.7820.99
234_F388_S0.7810.99
248_K301_Q0.7800.99
332_D380_S0.7790.99
73_F79_A0.7780.99
236_G372_A0.7760.99
79_A86_H0.7730.99
175_L179_A0.7730.99
309_Q322_C0.7710.99
80_Q84_R0.7710.99
175_L362_P0.7710.99
180_T407_G0.7710.99
313_L320_R0.7690.99
137_A141_K0.7690.99
107_L110_P0.7690.99
276_M282_Q0.7680.99
292_I369_A0.7650.98
345_V384_V0.7650.98
194_A417_I0.7630.98
271_L317_Q0.7580.98
224_F388_S0.7570.98
130_E133_L0.7560.98
89_H246_R0.7550.98
192_V342_T0.7500.98
141_K144_I0.7480.98
242_L292_I0.7480.98
243_W380_S0.7420.98
250_L325_T0.7420.98
242_L285_N0.7400.98
167_P362_P0.7390.98
194_A401_G0.7360.98
197_T400_A0.7340.98
79_A83_L0.7330.98
247_D379_Q0.7330.98
74_T78_Q0.7320.98
217_L426_T0.7310.98
314_R423_G0.7310.98
285_N317_Q0.7310.98
139_Q144_I0.7270.98
140_A151_K0.7260.98
112_L121_A0.7220.98
253_E309_Q0.7180.98
414_W417_I0.7180.98
108_L111_R0.7150.98
220_N223_H0.7140.98
342_T383_C0.7140.98
94_I109_L0.7120.98
310_V317_Q0.7110.98
129_S133_L0.7080.98
79_A82_F0.7080.98
243_W335_C0.7080.98
301_Q304_D0.7070.97
136_D143_F0.7070.97
104_Q364_T0.7060.97
214_S237_S0.7050.97
107_L377_L0.7050.97
110_P139_Q0.7040.97
179_A404_I0.7030.97
192_V224_F0.7030.97
129_S132_S0.7000.97
167_P195_R0.6990.97
242_L288_V0.6980.97
308_P319_L0.6960.97
190_K288_V0.6960.97
161_T200_H0.6940.97
278_D412_Q0.6920.97
342_T353_A0.6920.97
288_V292_I0.6910.97
147_L151_K0.6870.97
191_V353_A0.6840.97
342_T369_A0.6830.97
245_R380_S0.6820.97
192_V292_I0.6820.97
137_A147_L0.6810.97
220_N315_K0.6800.97
197_T421_A0.6800.97
252_T339_L0.6780.97
137_A151_K0.6780.97
211_M235_L0.6770.97
227_A230_G0.6770.97
111_R124_R0.6730.97
98_N373_G0.6710.97
255_L386_L0.6700.97
143_F147_L0.6700.97
285_N289_V0.6680.96
148_V151_K0.6660.96
292_I384_V0.6640.96
277_A282_Q0.6620.96
196_A399_Y0.6590.96
274_W277_A0.6580.96
250_L327_L0.6560.96
143_F151_K0.6550.96
425_R429_Q0.6550.96
196_A363_F0.6540.96
363_F399_Y0.6530.96
262_N265_D0.6530.96
138_I141_K0.6520.96
102_P105_G0.6520.96
95_W226_M0.6520.96
177_E184_A0.6510.96
172_W417_I0.6510.96
180_T405_V0.6500.96
252_T296_L0.6490.96
390_K397_R0.6490.96
139_Q147_L0.6490.96
123_L144_I0.6490.96
192_V256_A0.6450.96
75_S83_L0.6420.96
228_F232_N0.6410.96
292_I344_A0.6390.95
190_K405_V0.6380.95
76_L83_L0.6370.95
77_D81_R0.6370.95
266_K269_Q0.6350.95
306_L326_S0.6340.95
256_A405_V0.6340.95
259_V317_Q0.6340.95
173_T414_W0.6320.95
179_A356_F0.6280.95
145_A149_S0.6270.95
268_A317_Q0.6250.95
292_I383_C0.6230.95
342_T345_V0.6230.95
91_D378_Q0.6210.95
165_H417_I0.6200.95
80_Q83_L0.6200.95
81_R84_R0.6190.95
166_W198_D0.6160.95
182_T355_Q0.6160.95
274_W278_D0.6160.95
272_G276_M0.6150.94
290_E293_C0.6140.94
192_V353_A0.6130.94
256_A318_H0.6120.94
299_D335_C0.6110.94
288_V343_A0.6110.94
236_G369_A0.6090.94
73_F80_Q0.6060.94
285_N308_P0.6050.94
426_T429_Q0.6040.94
419_N422_A0.6030.94
288_V384_V0.6030.94
210_M396_V0.6030.94
340_Q369_A0.6030.94
282_Q286_M0.6020.94
340_Q384_V0.6000.94
331_D334_I0.5980.94
110_P115_R0.5980.94
369_A383_C0.5960.94
197_T418_D0.5950.93
207_A227_A0.5940.93
73_F85_Q0.5910.93
373_G380_S0.5910.93
192_V344_A0.5900.93
242_L344_A0.5900.93
266_K273_E0.5900.93
254_A291_D0.5890.93
392_S395_V0.5880.93
290_E294_Q0.5870.93
351_D354_R0.5850.93
98_N382_F0.5840.93
147_L150_I0.5840.93
256_A403_G0.5830.93
219_L237_S0.5820.93
103_S354_R0.5810.93
236_G342_T0.5810.93
356_F359_R0.5800.93
293_C305_V0.5790.93
375_L380_S0.5780.92
262_N268_A0.5770.92
117_C120_K0.5760.92
253_E313_L0.5760.92
295_R350_R0.5750.92
99_A102_P0.5740.92
77_D86_H0.5730.92
135_H138_I0.5710.92
226_M372_A0.5710.92
281_N344_A0.5700.92
260_A412_Q0.5690.92
166_W195_R0.5680.92
189_D287_L0.5670.92
346_A354_R0.5660.92
224_F342_T0.5660.92
84_R331_D0.5660.92
241_R383_C0.5640.92
73_F86_H0.5630.91
126_T377_L0.5620.91
143_F146_T0.5620.91
137_A150_I0.5600.91
402_A412_Q0.5600.91
182_T360_H0.5590.91
334_I338_Q0.5580.91
298_A351_D0.5570.91
352_L356_F0.5570.91
260_A267_Q0.5560.91
283_R407_G0.5550.91
345_V385_S0.5550.91
110_P123_L0.5540.91
264_D270_Q0.5540.91
80_Q85_Q0.5510.91
112_L123_L0.5480.90
144_I149_S0.5480.90
98_N340_Q0.5470.90
362_P399_Y0.5460.90
176_I193_L0.5450.90
336_L380_S0.5450.90
208_A212_A0.5450.90
73_F78_Q0.5440.90
304_D307_P0.5430.90
179_A357_I0.5420.90
234_F385_S0.5420.90
292_I345_V0.5400.90
326_S329_K0.5390.90
190_K343_A0.5390.90
261_N312_R0.5390.90
246_R249_A0.5380.90
391_I394_N0.5370.89
180_T410_P0.5360.89
189_D294_Q0.5340.89
224_F256_A0.5340.89
237_S374_Y0.5330.89
260_A263_P0.5330.89
115_R118_G0.5320.89
142_E145_A0.5320.89
189_D346_A0.5310.89
139_Q142_E0.5310.89
230_G233_A0.5290.89
281_N405_V0.5270.89
175_L193_L0.5250.88
140_A150_I0.5210.88
287_L294_Q0.5200.88
231_E393_G0.5200.88
97_L340_Q0.5180.88
344_A384_V0.5170.88
168_D173_T0.5170.88
355_Q359_R0.5150.87
344_A399_Y0.5140.87
318_H353_A0.5140.87
209_A213_A0.5130.87
236_G292_I0.5110.87
188_L352_L0.5110.87
221_C313_L0.5100.87
72_R75_S0.5100.87
279_D282_Q0.5090.87
194_A363_F0.5090.87
214_S427_L0.5070.87
167_P171_G0.5070.87
179_A192_V0.5070.87
73_F84_R0.5070.87
293_C348_L0.5060.87
243_W339_L0.5050.86
78_Q86_H0.5050.86
78_Q82_F0.5040.86
77_D83_L0.5040.86
260_A415_Q0.5040.86
202_A394_N0.5030.86
192_V288_V0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bzmA 1 0.9954 100 0.14 Contact Map
3gseA 1 0.9745 100 0.143 Contact Map
1qdlA 1 0.8794 100 0.217 Contact Map
3logA 1 0.9374 100 0.222 Contact Map
1i1qA 2 0.9374 100 0.223 Contact Map
1k0eA 1 0.8817 100 0.223 Contact Map
3h9mA 1 0.8561 100 0.228 Contact Map
4grhA 1 0.9072 100 0.229 Contact Map
3os6A 3 0.8329 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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