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MENF - Isochorismate synthase MenF

UniProt:	P38051	Sequences: MQSLTTALENLLRHLSQEIPATPGIRVIDIPFPLKDAFDALSWLASQQTYPQFYWQQRNGDEEAVVLGAITRFTSLDQAQRFLRQHPEHADLRIWGLNAFDPSQGNLLLPRLEWRRCGGKATLRLTLFSESSLQHDAIQAKEFIATLVSIKPLPGLHLTTTREQHWPDKTGWTQLIELATKTIAEGELDKVVLARATDLHFASPVNAAAMMAASRRLNLNCYHFYMAFDGENAFLGSSPERLWRRRDKALRTEALAGTVANNPDDKQAQQLGEWLMADDKNQRENMLVVEDICQRLQADTQTLDVLPPQVLRLRKVQHLRRCIWTSLNKADDVICLHQLQPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQQSEFCVSLRSAKISGNVVRLYAGAGIVRGSDPEQEWQEIDNKAAGLRTLLQME	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12362
Length:	431 (355)
Sequences:	6525 (4519)
Seq/√Len:	239.8

ECOLI - MENF TRPE PABB ENTC
BACSU - MENF TRPE PABB DHBC
HALSA - TRPE2 Q9HQN2 TRPE1
SULSO - TRPE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
300_T	325_T	4.785	1.00
345_V	369_A	4.571	1.00
301_Q	326_S	3.850	1.00
258_T	316_V	3.383	1.00
259_V	274_W	3.339	1.00
169_K	173_T	3.099	1.00
249_A	324_W	2.999	1.00
301_Q	329_K	2.992	1.00
182_T	187_E	2.963	1.00
409_D	412_Q	2.851	1.00
261_N	268_A	2.711	1.00
182_T	359_R	2.629	1.00
278_D	281_N	2.613	1.00
173_T	411_E	2.595	1.00
172_W	402_A	2.582	1.00
168_D	171_G	2.560	1.00
373_G	382_F	2.539	1.00
80_Q	331_D	2.450	1.00
169_K	411_E	2.440	1.00
342_T	384_V	2.367	1.00
352_L	355_Q	2.365	1.00
269_Q	273_E	2.339	1.00
198_D	395_V	2.285	1.00
198_D	397_R	2.242	1.00
188_L	191_V	2.196	1.00
312_R	317_Q	2.193	1.00
179_A	191_V	2.147	1.00
181_K	185_E	2.121	1.00
241_R	381_E	2.104	1.00
273_E	277_A	2.098	1.00
234_F	367_W	2.088	1.00
272_G	312_R	2.087	1.00
224_F	236_G	2.083	1.00
190_K	403_G	2.080	1.00
167_P	175_L	2.065	1.00
252_T	292_I	2.003	1.00
262_N	267_Q	1.982	1.00
207_A	233_A	1.951	1.00
100_F	354_R	1.942	1.00
224_F	372_A	1.898	1.00
306_L	324_W	1.893	1.00
174_Q	177_E	1.882	1.00
200_H	395_V	1.852	1.00
296_L	300_T	1.851	1.00
248_K	326_S	1.847	1.00
391_I	396_V	1.846	1.00
196_A	397_R	1.768	1.00
206_N	209_A	1.764	1.00
276_M	319_L	1.757	1.00
310_V	319_L	1.754	1.00
267_Q	270_Q	1.737	1.00
188_L	353_A	1.736	1.00
255_L	320_R	1.732	1.00
249_A	326_S	1.715	1.00
74_T	77_D	1.685	1.00
356_F	360_H	1.663	1.00
299_D	338_Q	1.660	1.00
195_R	417_I	1.655	1.00
272_G	310_V	1.642	1.00
177_E	180_T	1.637	1.00
169_K	414_W	1.624	1.00
253_E	311_L	1.618	1.00
227_A	233_A	1.618	1.00
181_K	184_A	1.612	1.00
311_L	320_R	1.603	1.00
269_Q	272_G	1.598	1.00
101_D	358_A	1.561	1.00
77_D	80_Q	1.554	1.00
191_V	357_I	1.533	1.00
301_Q	328_N	1.508	1.00
179_A	193_L	1.506	1.00
166_W	363_F	1.502	1.00
264_D	267_Q	1.500	1.00
235_L	391_I	1.496	1.00
177_E	410_P	1.494	1.00
98_N	102_P	1.479	1.00
263_P	267_Q	1.471	1.00
376_S	379_Q	1.467	1.00
265_D	269_Q	1.462	1.00
262_N	271_L	1.460	1.00
193_L	402_A	1.457	1.00
389_A	396_V	1.451	1.00
251_R	324_W	1.437	1.00
140_A	144_I	1.434	1.00
414_W	418_D	1.423	1.00
411_E	415_Q	1.411	1.00
415_Q	419_N	1.398	1.00
176_I	410_P	1.392	1.00
246_R	379_Q	1.375	1.00
286_M	308_P	1.374	1.00
75_S	86_H	1.367	1.00
163_E	199_L	1.356	1.00
236_G	383_C	1.346	1.00
367_W	385_S	1.336	1.00
182_T	356_F	1.308	1.00
336_L	375_L	1.306	1.00
207_A	391_I	1.304	1.00
75_S	79_A	1.287	1.00
75_S	78_Q	1.287	1.00
101_D	364_T	1.285	1.00
176_I	404_I	1.284	1.00
90_A	93_R	1.280	1.00
256_A	285_N	1.277	1.00
225_Y	233_A	1.277	1.00
211_M	215_R	1.274	1.00
271_L	274_W	1.273	1.00
224_F	234_F	1.271	1.00
256_A	344_A	1.270	1.00
259_V	281_N	1.257	1.00
171_G	174_Q	1.252	1.00
182_T	352_L	1.251	1.00
296_L	325_T	1.248	1.00
194_A	399_Y	1.244	1.00
270_Q	274_W	1.240	1.00
171_G	362_P	1.240	1.00
199_L	396_V	1.238	1.00
178_L	181_K	1.236	1.00
201_F	391_I	1.227	1.00
400_A	421_A	1.226	1.00
74_T	337_H	1.220	1.00
137_A	140_A	1.218	1.00
250_L	300_T	1.218	1.00
372_A	385_S	1.213	1.00
169_K	415_Q	1.207	1.00
83_L	86_H	1.204	1.00
173_T	410_P	1.194	1.00
222_Y	241_R	1.189	1.00
170_T	174_Q	1.189	1.00
164_Q	200_H	1.179	1.00
415_Q	418_D	1.178	1.00
192_V	369_A	1.173	1.00
188_L	356_F	1.168	1.00
178_L	359_R	1.164	1.00
178_L	182_T	1.163	1.00
259_V	271_L	1.162	1.00
245_R	335_C	1.159	1.00
245_R	327_L	1.156	1.00
73_F	76_L	1.147	1.00
288_V	344_A	1.144	1.00
282_Q	308_P	1.141	1.00
192_V	401_G	1.137	1.00
389_A	424_L	1.134	1.00
253_E	322_C	1.126	1.00
297_Q	303_L	1.126	1.00
256_A	288_V	1.123	1.00
285_N	288_V	1.117	1.00
374_Y	381_E	1.117	1.00
140_A	143_F	1.115	1.00
193_L	404_I	1.110	1.00
402_A	417_I	1.109	1.00
195_R	418_D	1.106	1.00
187_E	352_L	1.094	1.00
327_L	335_C	1.093	1.00
352_L	359_R	1.092	1.00
336_L	382_F	1.092	1.00
210_M	235_L	1.091	1.00
210_M	389_A	1.088	1.00
165_H	195_R	1.076	1.00
177_E	181_K	1.075	1.00
97_L	367_W	1.073	1.00
250_L	335_C	1.069	1.00
75_S	80_Q	1.061	1.00
266_K	270_Q	1.060	1.00
248_K	329_K	1.058	1.00
210_M	391_I	1.053	1.00
250_L	296_L	1.048	1.00
272_G	317_Q	1.044	1.00
173_T	177_E	1.042	1.00
137_A	143_F	1.041	1.00
251_R	322_C	1.037	1.00
412_Q	415_Q	1.027	1.00
195_R	414_W	1.026	1.00
136_D	147_L	1.025	1.00
333_V	375_L	1.025	1.00
345_V	386_L	1.016	1.00
232_N	392_S	1.011	1.00
267_Q	271_L	1.008	1.00
398_L	421_A	1.000	1.00
245_R	248_K	0.999	1.00
358_A	364_T	0.998	1.00
270_Q	273_E	0.995	1.00
144_I	147_L	0.992	1.00
200_H	394_N	0.986	1.00
94_I	107_L	0.985	1.00
273_E	276_M	0.980	1.00
276_M	310_V	0.979	1.00
245_R	250_L	0.978	1.00
113_E	124_R	0.978	1.00
245_R	332_D	0.977	1.00
242_L	252_T	0.975	1.00
218_N	237_S	0.975	1.00
75_S	82_F	0.970	1.00
218_N	315_K	0.969	1.00
180_T	406_R	0.968	1.00
141_K	145_A	0.961	1.00
285_N	344_A	0.961	1.00
244_R	251_R	0.959	1.00
136_D	144_I	0.959	1.00
171_G	175_L	0.953	1.00
101_D	104_Q	0.947	1.00
207_A	225_Y	0.946	1.00
367_W	390_K	0.939	1.00
174_Q	178_L	0.937	1.00
422_A	426_T	0.936	1.00
82_F	85_Q	0.936	1.00
291_D	343_A	0.935	1.00
123_L	140_A	0.927	1.00
231_E	392_S	0.926	1.00
292_I	342_T	0.926	1.00
234_F	372_A	0.926	1.00
184_A	406_R	0.926	1.00
183_I	406_R	0.924	1.00
224_F	383_C	0.922	1.00
104_Q	358_A	0.921	1.00
398_L	425_R	0.917	1.00
242_L	339_L	0.915	1.00
179_A	188_L	0.913	1.00
114_W	121_A	0.911	1.00
78_Q	81_R	0.910	1.00
233_A	391_I	0.909	1.00
281_N	412_Q	0.908	1.00
192_V	345_V	0.899	1.00
259_V	419_N	0.889	1.00
98_N	336_L	0.887	0.99
142_E	146_T	0.886	0.99
242_L	256_A	0.886	0.99
143_F	150_I	0.885	0.99
98_N	375_L	0.881	0.99
136_D	139_Q	0.873	0.99
191_V	356_F	0.872	0.99
164_Q	198_D	0.872	0.99
201_F	210_M	0.871	0.99
73_F	77_D	0.870	0.99
297_Q	302_T	0.869	0.99
208_A	225_Y	0.866	0.99
180_T	184_A	0.861	0.99
389_A	398_L	0.861	0.99
260_A	419_N	0.858	0.99
82_F	86_H	0.856	0.99
176_I	180_T	0.854	0.99
173_T	176_I	0.849	0.99
138_I	142_E	0.847	0.99
285_N	369_A	0.843	0.99
241_R	253_E	0.840	0.99
192_V	236_G	0.839	0.99
296_L	339_L	0.836	0.99
170_T	173_T	0.836	0.99
80_Q	86_H	0.831	0.99
303_L	307_P	0.830	0.99
173_T	409_D	0.829	0.99
76_L	79_A	0.828	0.99
371_S	382_F	0.828	0.99
136_D	140_A	0.827	0.99
90_A	95_W	0.827	0.99
179_A	360_H	0.824	0.99
260_A	271_L	0.820	0.99
139_Q	143_F	0.818	0.99
192_V	383_C	0.817	0.99
137_A	144_I	0.817	0.99
76_L	80_Q	0.815	0.99
197_T	425_R	0.811	0.99
103_S	358_A	0.810	0.99
285_N	292_I	0.809	0.99
163_E	425_R	0.807	0.99
192_V	346_A	0.800	0.99
144_I	148_V	0.797	0.99
75_S	85_Q	0.795	0.99
285_N	321_R	0.795	0.99
201_F	396_V	0.794	0.99
241_R	251_R	0.794	0.99
110_P	125_L	0.793	0.99
93_R	377_L	0.787	0.99
283_R	287_L	0.786	0.99
218_N	423_G	0.785	0.99
351_D	355_Q	0.783	0.99
223_H	237_S	0.782	0.99
234_F	388_S	0.781	0.99
248_K	301_Q	0.780	0.99
332_D	380_S	0.779	0.99
73_F	79_A	0.778	0.99
236_G	372_A	0.776	0.99
79_A	86_H	0.773	0.99
175_L	179_A	0.773	0.99
309_Q	322_C	0.771	0.99
80_Q	84_R	0.771	0.99
175_L	362_P	0.771	0.99
180_T	407_G	0.771	0.99
313_L	320_R	0.769	0.99
137_A	141_K	0.769	0.99
107_L	110_P	0.769	0.99
276_M	282_Q	0.768	0.99
292_I	369_A	0.765	0.98
345_V	384_V	0.765	0.98
194_A	417_I	0.763	0.98
271_L	317_Q	0.758	0.98
224_F	388_S	0.757	0.98
130_E	133_L	0.756	0.98
89_H	246_R	0.755	0.98
192_V	342_T	0.750	0.98
141_K	144_I	0.748	0.98
242_L	292_I	0.748	0.98
243_W	380_S	0.742	0.98
250_L	325_T	0.742	0.98
242_L	285_N	0.740	0.98
167_P	362_P	0.739	0.98
194_A	401_G	0.736	0.98
197_T	400_A	0.734	0.98
79_A	83_L	0.733	0.98
247_D	379_Q	0.733	0.98
74_T	78_Q	0.732	0.98
217_L	426_T	0.731	0.98
314_R	423_G	0.731	0.98
285_N	317_Q	0.731	0.98
139_Q	144_I	0.727	0.98
140_A	151_K	0.726	0.98
112_L	121_A	0.722	0.98
253_E	309_Q	0.718	0.98
414_W	417_I	0.718	0.98
108_L	111_R	0.715	0.98
220_N	223_H	0.714	0.98
342_T	383_C	0.714	0.98
94_I	109_L	0.712	0.98
310_V	317_Q	0.711	0.98
129_S	133_L	0.708	0.98
79_A	82_F	0.708	0.98
243_W	335_C	0.708	0.98
301_Q	304_D	0.707	0.97
136_D	143_F	0.707	0.97
104_Q	364_T	0.706	0.97
214_S	237_S	0.705	0.97
107_L	377_L	0.705	0.97
110_P	139_Q	0.704	0.97
179_A	404_I	0.703	0.97
192_V	224_F	0.703	0.97
129_S	132_S	0.700	0.97
167_P	195_R	0.699	0.97
242_L	288_V	0.698	0.97
308_P	319_L	0.696	0.97
190_K	288_V	0.696	0.97
161_T	200_H	0.694	0.97
278_D	412_Q	0.692	0.97
342_T	353_A	0.692	0.97
288_V	292_I	0.691	0.97
147_L	151_K	0.687	0.97
191_V	353_A	0.684	0.97
342_T	369_A	0.683	0.97
245_R	380_S	0.682	0.97
192_V	292_I	0.682	0.97
137_A	147_L	0.681	0.97
220_N	315_K	0.680	0.97
197_T	421_A	0.680	0.97
252_T	339_L	0.678	0.97
137_A	151_K	0.678	0.97
211_M	235_L	0.677	0.97
227_A	230_G	0.677	0.97
111_R	124_R	0.673	0.97
98_N	373_G	0.671	0.97
255_L	386_L	0.670	0.97
143_F	147_L	0.670	0.97
285_N	289_V	0.668	0.96
148_V	151_K	0.666	0.96
292_I	384_V	0.664	0.96
277_A	282_Q	0.662	0.96
196_A	399_Y	0.659	0.96
274_W	277_A	0.658	0.96
250_L	327_L	0.656	0.96
143_F	151_K	0.655	0.96
425_R	429_Q	0.655	0.96
196_A	363_F	0.654	0.96
363_F	399_Y	0.653	0.96
262_N	265_D	0.653	0.96
138_I	141_K	0.652	0.96
102_P	105_G	0.652	0.96
95_W	226_M	0.652	0.96
177_E	184_A	0.651	0.96
172_W	417_I	0.651	0.96
180_T	405_V	0.650	0.96
252_T	296_L	0.649	0.96
390_K	397_R	0.649	0.96
139_Q	147_L	0.649	0.96
123_L	144_I	0.649	0.96
192_V	256_A	0.645	0.96
75_S	83_L	0.642	0.96
228_F	232_N	0.641	0.96
292_I	344_A	0.639	0.95
190_K	405_V	0.638	0.95
76_L	83_L	0.637	0.95
77_D	81_R	0.637	0.95
266_K	269_Q	0.635	0.95
306_L	326_S	0.634	0.95
256_A	405_V	0.634	0.95
259_V	317_Q	0.634	0.95
173_T	414_W	0.632	0.95
179_A	356_F	0.628	0.95
145_A	149_S	0.627	0.95
268_A	317_Q	0.625	0.95
292_I	383_C	0.623	0.95
342_T	345_V	0.623	0.95
91_D	378_Q	0.621	0.95
165_H	417_I	0.620	0.95
80_Q	83_L	0.620	0.95
81_R	84_R	0.619	0.95
166_W	198_D	0.616	0.95
182_T	355_Q	0.616	0.95
274_W	278_D	0.616	0.95
272_G	276_M	0.615	0.94
290_E	293_C	0.614	0.94
192_V	353_A	0.613	0.94
256_A	318_H	0.612	0.94
299_D	335_C	0.611	0.94
288_V	343_A	0.611	0.94
236_G	369_A	0.609	0.94
73_F	80_Q	0.606	0.94
285_N	308_P	0.605	0.94
426_T	429_Q	0.604	0.94
419_N	422_A	0.603	0.94
288_V	384_V	0.603	0.94
210_M	396_V	0.603	0.94
340_Q	369_A	0.603	0.94
282_Q	286_M	0.602	0.94
340_Q	384_V	0.600	0.94
331_D	334_I	0.598	0.94
110_P	115_R	0.598	0.94
369_A	383_C	0.596	0.94
197_T	418_D	0.595	0.93
207_A	227_A	0.594	0.93
73_F	85_Q	0.591	0.93
373_G	380_S	0.591	0.93
192_V	344_A	0.590	0.93
242_L	344_A	0.590	0.93
266_K	273_E	0.590	0.93
254_A	291_D	0.589	0.93
392_S	395_V	0.588	0.93
290_E	294_Q	0.587	0.93
351_D	354_R	0.585	0.93
98_N	382_F	0.584	0.93
147_L	150_I	0.584	0.93
256_A	403_G	0.583	0.93
219_L	237_S	0.582	0.93
103_S	354_R	0.581	0.93
236_G	342_T	0.581	0.93
356_F	359_R	0.580	0.93
293_C	305_V	0.579	0.93
375_L	380_S	0.578	0.92
262_N	268_A	0.577	0.92
117_C	120_K	0.576	0.92
253_E	313_L	0.576	0.92
295_R	350_R	0.575	0.92
99_A	102_P	0.574	0.92
77_D	86_H	0.573	0.92
135_H	138_I	0.571	0.92
226_M	372_A	0.571	0.92
281_N	344_A	0.570	0.92
260_A	412_Q	0.569	0.92
166_W	195_R	0.568	0.92
189_D	287_L	0.567	0.92
346_A	354_R	0.566	0.92
224_F	342_T	0.566	0.92
84_R	331_D	0.566	0.92
241_R	383_C	0.564	0.92
73_F	86_H	0.563	0.91
126_T	377_L	0.562	0.91
143_F	146_T	0.562	0.91
137_A	150_I	0.560	0.91
402_A	412_Q	0.560	0.91
182_T	360_H	0.559	0.91
334_I	338_Q	0.558	0.91
298_A	351_D	0.557	0.91
352_L	356_F	0.557	0.91
260_A	267_Q	0.556	0.91
283_R	407_G	0.555	0.91
345_V	385_S	0.555	0.91
110_P	123_L	0.554	0.91
264_D	270_Q	0.554	0.91
80_Q	85_Q	0.551	0.91
112_L	123_L	0.548	0.90
144_I	149_S	0.548	0.90
98_N	340_Q	0.547	0.90
362_P	399_Y	0.546	0.90
176_I	193_L	0.545	0.90
336_L	380_S	0.545	0.90
208_A	212_A	0.545	0.90
73_F	78_Q	0.544	0.90
304_D	307_P	0.543	0.90
179_A	357_I	0.542	0.90
234_F	385_S	0.542	0.90
292_I	345_V	0.540	0.90
326_S	329_K	0.539	0.90
190_K	343_A	0.539	0.90
261_N	312_R	0.539	0.90
246_R	249_A	0.538	0.90
391_I	394_N	0.537	0.89
180_T	410_P	0.536	0.89
189_D	294_Q	0.534	0.89
224_F	256_A	0.534	0.89
237_S	374_Y	0.533	0.89
260_A	263_P	0.533	0.89
115_R	118_G	0.532	0.89
142_E	145_A	0.532	0.89
189_D	346_A	0.531	0.89
139_Q	142_E	0.531	0.89
230_G	233_A	0.529	0.89
281_N	405_V	0.527	0.89
175_L	193_L	0.525	0.88
140_A	150_I	0.521	0.88
287_L	294_Q	0.520	0.88
231_E	393_G	0.520	0.88
97_L	340_Q	0.518	0.88
344_A	384_V	0.517	0.88
168_D	173_T	0.517	0.88
355_Q	359_R	0.515	0.87
344_A	399_Y	0.514	0.87
318_H	353_A	0.514	0.87
209_A	213_A	0.513	0.87
236_G	292_I	0.511	0.87
188_L	352_L	0.511	0.87
221_C	313_L	0.510	0.87
72_R	75_S	0.510	0.87
279_D	282_Q	0.509	0.87
194_A	363_F	0.509	0.87
214_S	427_L	0.507	0.87
167_P	171_G	0.507	0.87
179_A	192_V	0.507	0.87
73_F	84_R	0.507	0.87
293_C	348_L	0.506	0.87
243_W	339_L	0.505	0.86
78_Q	86_H	0.505	0.86
78_Q	82_F	0.504	0.86
77_D	83_L	0.504	0.86
260_A	415_Q	0.504	0.86
202_A	394_N	0.503	0.86
192_V	288_V	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bzmA	1	0.9954	100	0.14	Contact Map
3gseA	1	0.9745	100	0.143	Contact Map
1qdlA	1	0.8794	100	0.217	Contact Map
3logA	1	0.9374	100	0.222	Contact Map
1i1qA	2	0.9374	100	0.223	Contact Map
1k0eA	1	0.8817	100	0.223	Contact Map
3h9mA	1	0.8561	100	0.228	Contact Map
4grhA	1	0.9072	100	0.229	Contact Map
3os6A	3	0.8329	100	0.236	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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