GREMLIN Database
CAS3 - CRISPR-associated endonuclease/helicase Cas3
UniProt: P38036 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12634
Length: 888 (724)
Sequences: 1124 (1020)
Seq/√Len: 37.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
634_A638_V7.5521.00
372_L377_S5.6591.00
372_L375_G5.2431.00
372_L376_N5.1781.00
289_N293_P4.7461.00
373_A376_N4.6961.00
373_A377_S4.6961.00
293_P297_Q4.4371.00
283_V286_L4.2111.00
587_L633_V4.0971.00
290_G293_P3.9511.00
328_A450_I3.8241.00
645_D671_R3.8071.00
571_C649_L3.6801.00
371_I375_G3.6651.00
651_T659_L3.5221.00
43_D64_K3.4731.00
322_E356_R3.4561.00
297_Q300_V3.4411.00
537_R540_I3.3451.00
314_A318_S3.3041.00
374_H377_S3.2831.00
294_R297_Q3.1891.00
370_L375_G3.1531.00
372_L379_F3.0771.00
580_A635_T2.9941.00
10_Y79_F2.9031.00
293_P300_V2.8931.00
371_I377_S2.8921.00
194_W197_V2.8751.00
649_L666_L2.8571.00
33_D232_G2.8251.00
338_D446_R2.8151.00
371_I376_N2.7681.00
376_N379_F2.6621.00
571_C638_V2.6441.00
663_L683_A2.6371.00
115_G118_G2.6311.00
113_N116_A2.6221.00
580_A599_L2.5971.00
325_L357_M2.5941.00
616_V632_L2.5811.00
27_L79_F2.5671.00
282_G286_L2.5361.00
584_Y588_K2.5361.00
709_T712_H2.5341.00
574_C583_C2.4461.00
403_C406_W2.4431.00
316_T727_Y2.4391.00
804_S807_Q2.4131.00
804_S808_L2.4121.00
370_L373_A2.4051.00
34_V232_G2.3291.00
638_V646_F2.3141.00
561_I590_L2.3101.00
369_N372_L2.2991.00
733_S736_D2.2841.00
560_M570_V2.2811.00
176_M179_S2.2811.00
574_C580_A2.2760.99
805_G809_L2.2720.99
599_L604_F2.2640.99
681_P685_I2.2440.99
114_H118_G2.2180.99
260_R274_V2.1940.99
341_I422_C2.1790.99
307_P310_T2.1530.99
300_V304_P2.1400.99
370_L376_N2.1250.99
615_R619_N2.1190.99
802_T805_G2.1070.99
681_P688_P2.1060.99
369_N373_A2.0840.99
343_A427_V2.0650.99
35_A72_A2.0650.99
257_F260_R2.0610.99
293_P296_L2.0570.99
32_L36_A2.0190.99
328_A340_V2.0100.99
294_R300_V2.0040.99
804_S809_L1.9950.99
733_S737_D1.9930.99
431_V468_V1.9880.99
374_H379_F1.9870.99
372_L380_N1.9650.98
234_W238_N1.9490.98
649_L662_R1.9390.98
39_D64_K1.9320.98
179_S182_S1.9170.98
11_W87_S1.9070.98
534_L538_F1.8940.98
297_Q304_P1.8650.98
38_A71_I1.8560.98
298_V302_A1.8470.98
467_A470_K1.8220.98
579_V652_Q1.8200.97
683_A688_P1.8010.97
406_W413_K1.7910.97
290_G297_Q1.7750.97
316_T723_F1.7690.97
638_V644_V1.7660.97
468_V472_Q1.7630.97
260_R264_A1.7540.97
651_T683_A1.7500.97
337_A448_V1.7370.97
370_L379_F1.7320.97
620_F630_R1.7270.97
681_P687_L1.7270.97
325_L361_A1.7260.97
473_A498_Y1.7250.97
696_H699_I1.7240.96
39_D68_L1.7190.96
604_F612_K1.6990.96
454_V481_L1.6790.96
626_R629_G1.6690.96
13_K233_S1.6610.96
535_P538_F1.6530.96
174_W178_A1.6480.95
51_T54_R1.6420.95
373_A378_R1.6340.95
327_Y331_L1.6300.95
219_S223_G1.6280.95
374_H380_N1.6170.95
26_L29_Y1.6100.95
114_H121_W1.6040.95
374_H378_R1.5930.95
427_V468_V1.5890.94
370_L374_H1.5840.94
573_I662_R1.5730.94
685_I688_P1.5710.94
25_H232_G1.5700.94
271_S274_V1.5580.94
605_T608_D1.5480.94
73_L156_V1.5450.94
564_A631_I1.5400.93
666_L683_A1.5320.93
331_L448_V1.5310.93
290_G296_L1.5290.93
119_L157_T1.5270.93
584_Y599_L1.5200.93
601_H604_F1.5160.93
728_R732_D1.5110.93
289_N297_Q1.4870.92
571_C646_F1.4860.92
737_D740_M1.4830.92
464_L472_Q1.4750.92
257_F261_Q1.4700.92
270_L274_V1.4690.92
10_Y27_L1.4660.92
516_W519_V1.4650.92
187_D191_R1.4590.91
683_A686_L1.4570.91
339_S447_S1.4450.91
373_A379_F1.4420.91
750_M754_E1.4310.91
351_N573_I1.4300.91
651_T662_R1.4280.91
86_K110_R1.4260.90
458_D464_L1.4200.90
560_M572_L1.4170.90
71_I228_A1.4160.90
293_P298_V1.4140.90
577_V603_R1.4130.90
375_G379_F1.4080.90
332_I337_A1.4080.90
256_Y260_R1.4070.90
87_S90_S1.4050.90
369_N376_N1.3910.89
466_E493_K1.3870.89
369_N375_G1.3830.89
324_A482_L1.3820.89
723_F727_Y1.3790.89
300_V303_L1.3750.89
296_L300_V1.3630.88
424_I457_Y1.3600.88
560_M564_A1.3590.88
67_L71_I1.3480.88
195_I202_F1.3470.88
465_L471_A1.3460.88
558_E590_L1.3430.88
350_A422_C1.3370.87
372_L378_R1.3320.87
187_D190_A1.3290.87
226_S439_I1.3260.87
231_L234_W1.3260.87
604_F608_D1.3190.87
315_P318_S1.3190.87
112_F115_G1.3130.86
294_R301_D1.3050.86
253_L256_Y1.3010.86
194_W198_L1.3000.86
742_E745_W1.2980.86
538_F541_Q1.2920.85
198_L201_L1.2870.85
681_P686_L1.2870.85
753_F757_E1.2860.85
291_Y297_Q1.2860.85
220_L223_G1.2770.85
306_A309_L1.2720.85
582_V693_Y1.2720.85
747_G751_D1.2720.85
425_D601_H1.2650.84
554_L586_R1.2640.84
15_S21_G1.2630.84
293_P304_P1.2630.84
357_M421_V1.2610.84
757_E760_K1.2570.84
297_Q301_D1.2570.84
560_M563_A1.2520.84
260_R270_L1.2520.84
221_L224_F1.2490.83
370_L377_S1.2480.83
175_E179_S1.2480.83
316_T660_F1.2480.83
371_I374_H1.2450.83
768_L774_Y1.2410.83
126_S130_Q1.2400.83
659_L685_I1.2380.83
472_Q477_G1.2360.83
561_I564_A1.2330.83
194_W202_F1.2300.83
347_Q375_G1.2300.83
289_N296_L1.2290.82
233_S425_D1.2250.82
511_Y515_N1.2250.82
113_N118_G1.2240.82
483_S640_Q1.2230.82
59_S62_R1.2210.82
640_Q658_L1.2200.82
197_V201_L1.2130.82
600_F637_V1.1990.81
74_H78_K1.1890.80
75_D78_K1.1890.80
341_I420_G1.1870.80
461_M464_L1.1810.80
71_I225_C1.1790.80
599_L635_T1.1790.80
495_L515_N1.1790.80
294_R318_S1.1760.80
619_N630_R1.1660.79
559_R563_A1.1650.79
441_G471_A1.1630.79
404_C408_S1.1610.79
702_N705_V1.1560.78
10_Y29_Y1.1500.78
679_E684_T1.1500.78
583_C646_F1.1440.78
53_C56_E1.1400.77
260_R267_V1.1390.77
698_H701_S1.1330.77
354_L386_I1.1310.77
449_L472_Q1.1280.77
768_L771_A1.1190.76
667_H678_F1.1190.76
52_F56_E1.1140.76
223_G415_F1.1130.76
722_F725_D1.1110.76
299_L302_A1.1090.75
470_K500_L1.1080.75
371_I573_I1.1050.75
228_A573_I1.1030.75
645_D789_D1.1000.75
226_S438_F1.0930.74
352_A641_S1.0930.74
553_D582_V1.0930.74
42_W46_V1.0920.74
760_K764_A1.0920.74
114_H117_A1.0900.74
119_L122_F1.0890.74
745_W749_G1.0850.74
343_A451_V1.0830.74
757_E761_R1.0830.74
761_R765_R1.0820.74
729_Q733_S1.0790.73
655_P700_Y1.0720.73
161_G456_A1.0710.73
216_D223_G1.0690.73
344_L353_M1.0650.72
805_G808_L1.0630.72
787_T790_G1.0630.72
262_Q266_R1.0630.72
26_L450_I1.0620.72
219_S222_A1.0590.72
114_H122_F1.0560.72
755_S761_R1.0550.72
230_W669_H1.0540.72
197_V200_A1.0540.72
220_L224_F1.0540.72
760_K763_K1.0540.72
755_S760_K1.0530.72
115_G119_L1.0520.71
597_I631_I1.0510.71
648_W684_T1.0500.71
373_A381_H1.0490.71
381_H614_N1.0430.71
311_V495_L1.0420.71
322_E604_F1.0410.71
486_L491_K1.0410.71
67_L221_L1.0400.71
325_L342_F1.0390.70
176_M180_L1.0390.70
322_E641_S1.0360.70
11_W24_I1.0330.70
464_L468_V1.0310.70
37_V41_W1.0300.70
611_E614_N1.0300.70
460_Y789_D1.0300.70
559_R650_I1.0280.70
304_P310_T1.0260.69
781_E785_A1.0230.69
230_W436_H1.0230.69
557_L564_A1.0230.69
347_Q350_A1.0210.69
358_E572_L1.0180.69
754_E758_C1.0170.69
27_L30_H1.0170.69
31_C194_W1.0150.69
73_L222_A1.0150.69
234_W237_T1.0150.69
327_Y478_S1.0140.69
297_Q425_D1.0140.69
25_H29_Y1.0140.69
750_M753_F1.0130.69
620_F634_A1.0120.68
681_P684_T1.0100.68
578_D582_V1.0070.68
745_W752_K1.0060.68
165_H168_D1.0060.68
252_A260_R1.0000.67
176_M182_S0.9970.67
465_L494_L0.9970.67
803_S807_Q0.9960.67
602_A609_R0.9940.67
404_C407_L0.9940.67
536_P685_I0.9930.67
536_P541_Q0.9930.67
602_A637_V0.9920.67
574_C652_Q0.9920.67
762_F765_R0.9910.67
633_V741_D0.9900.67
327_Y480_I0.9900.67
127_L130_Q0.9890.67
465_L645_D0.9890.67
74_H77_G0.9850.66
122_F371_I0.9830.66
233_S601_H0.9810.66
427_V451_V0.9810.66
458_D472_Q0.9810.66
281_E286_L0.9800.66
312_I315_P0.9780.66
649_L683_A0.9770.66
617_I620_F0.9740.65
575_N653_H0.9730.65
291_Y298_V0.9730.65
793_S796_L0.9730.65
268_L271_S0.9720.65
603_R734_I0.9720.65
114_H119_L0.9640.65
328_A448_V0.9630.65
745_W748_N0.9630.65
230_W640_Q0.9620.64
175_E178_A0.9610.64
353_M641_S0.9610.64
110_R114_H0.9610.64
387_K390_A0.9580.64
697_E702_N0.9580.64
265_S268_L0.9570.64
344_L577_V0.9570.64
682_V687_L0.9570.64
431_V442_L0.9560.64
50_N685_I0.9560.64
260_R265_S0.9560.64
111_K117_A0.9560.64
715_E720_S0.9540.64
346_T425_D0.9520.64
356_R641_S0.9500.63
310_T514_I0.9500.63
550_M555_T0.9490.63
552_P555_T0.9460.63
226_S576_L0.9450.63
12_G26_L0.9430.63
356_R669_H0.9430.63
50_N54_R0.9400.63
233_S237_T0.9390.63
602_A605_T0.9380.62
475_V632_L0.9380.62
226_S442_L0.9360.62
284_H292_Q0.9350.62
441_G632_L0.9350.62
656_A734_I0.9350.62
15_S22_N0.9350.62
297_Q647_D0.9290.62
264_A268_L0.9270.62
620_F632_L0.9260.61
355_T382_L0.9240.61
705_V709_T0.9210.61
404_C614_N0.9200.61
39_D43_D0.9200.61
227_L439_I0.9200.61
458_D461_M0.9180.61
631_I669_H0.9180.61
608_D611_E0.9170.61
349_T641_S0.9170.61
735_Y740_M0.9160.61
294_R298_V0.9150.61
705_V708_R0.9140.60
174_W179_S0.9060.60
574_C686_L0.9010.59
170_D611_E0.9000.59
355_T359_A0.8980.59
233_S604_F0.8980.59
267_V450_I0.8970.59
473_A632_L0.8930.59
257_F265_S0.8920.59
34_V728_R0.8920.59
769_Q774_Y0.8910.58
304_P309_L0.8910.58
458_D462_N0.8910.58
444_I791_E0.8890.58
372_L381_H0.8890.58
285_A541_Q0.8890.58
182_S186_Q0.8870.58
651_T660_F0.8860.58
313_E491_K0.8860.58
705_V715_E0.8840.58
641_S662_R0.8840.58
461_M465_L0.8840.58
334_Q597_I0.8810.58
461_M669_H0.8790.57
756_A763_K0.8780.57
356_R604_F0.8760.57
15_S23_D0.8750.57
463_G466_E0.8750.57
468_V473_A0.8750.57
571_C634_A0.8750.57
200_A285_A0.8730.57
732_D735_Y0.8690.57
291_Y294_R0.8690.57
21_G614_N0.8670.56
347_Q451_V0.8650.56
534_L537_R0.8640.56
483_S658_L0.8630.56
27_L84_Q0.8620.56
647_D700_Y0.8620.56
570_V648_W0.8600.56
461_M468_V0.8570.55
300_V327_Y0.8550.55
647_D652_Q0.8550.55
35_A68_L0.8550.55
419_I447_S0.8540.55
194_W201_L0.8530.55
280_Y283_V0.8520.55
156_V225_C0.8510.55
381_H740_M0.8510.55
745_W750_M0.8470.55
311_V601_H0.8470.55
204_T208_L0.8470.55
465_L472_Q0.8460.55
92_L614_N0.8440.54
348_A641_S0.8420.54
233_S346_T0.8400.54
297_Q601_H0.8400.54
267_V271_S0.8400.54
637_V658_L0.8390.54
11_W33_D0.8380.54
17_S189_Q0.8380.54
184_A187_D0.8360.54
26_L31_C0.8360.54
265_S270_L0.8360.54
202_F518_G0.8340.53
176_M181_A0.8330.53
430_S444_I0.8310.53
313_E657_D0.8300.53
559_R684_T0.8290.53
280_Y286_L0.8270.53
527_L635_T0.8260.53
212_D215_P0.8260.53
562_A679_E0.8250.53
683_A689_D0.8240.53
258_Q261_Q0.8230.52
755_S758_C0.8230.52
183_Y191_R0.8230.52
695_R698_H0.8230.52
569_Q627_N0.8230.52
660_F722_F0.8230.52
761_R764_A0.8220.52
658_L667_H0.8150.52
450_I587_L0.8150.52
755_S759_E0.8140.52
390_A394_Q0.8140.52
193_E197_V0.8140.52
458_D468_V0.8140.52
775_S778_D0.8110.51
483_S486_L0.8110.51
710_Q713_I0.8100.51
742_E746_V0.8100.51
600_F638_V0.8090.51
43_D66_W0.8090.51
706_M709_T0.8090.51
584_Y592_N0.8080.51
424_I602_A0.8060.51
163_I442_L0.8050.51
152_W239_T0.8040.51
758_C763_K0.8030.51
27_L31_C0.8030.51
758_C762_F0.8020.51
473_A478_S0.8010.51
754_E764_A0.8010.51
654_C659_L0.7990.50
596_D629_G0.7990.50
442_L788_R0.7990.50
191_R427_V0.7980.50
196_S725_D0.7970.50
24_I27_L0.7970.50
289_N300_V0.7970.50
511_Y517_R0.7960.50
463_G467_A0.7940.50
695_R699_I0.7940.50
806_K809_L0.7920.50
460_Y645_D0.7910.50
471_A580_A0.7910.50
554_L558_E0.7910.50
386_I389_R0.7890.49
682_V685_I0.7880.49
27_L477_G0.7870.49
451_V465_L0.7850.49
342_F451_V0.7850.49
51_T55_N0.7850.49
557_L590_L0.7830.49
116_A119_L0.7820.49
767_V771_A0.7810.49
748_N752_K0.7810.49
329_W341_I0.7810.49
121_W191_R0.7780.48
755_S763_K0.7750.48
230_W461_M0.7710.48
367_S534_L0.7710.48
425_D662_R0.7690.48
214_P449_L0.7670.47
529_A537_R0.7660.47
681_P690_G0.7640.47
356_R662_R0.7630.47
450_I518_G0.7620.47
708_R712_H0.7620.47
641_S651_T0.7600.47
74_H83_F0.7590.47
75_D83_F0.7590.47
78_K83_F0.7590.47
745_W753_F0.7590.47
50_N60_K0.7580.47
436_H460_Y0.7570.47
759_E763_K0.7540.46
494_L498_Y0.7520.46
709_T734_I0.7520.46
313_E454_V0.7520.46
620_F646_F0.7520.46
226_S230_W0.7520.46
35_A38_A0.7500.46
463_G631_I0.7500.46
683_A687_L0.7490.46
25_H33_D0.7470.46
255_T259_D0.7470.46
80_D117_A0.7460.46
442_L475_V0.7450.46
736_D740_M0.7440.45
325_L419_I0.7440.45
613_E642_L0.7430.45
768_L773_E0.7410.45
344_L608_D0.7400.45
161_G652_Q0.7390.45
153_V157_T0.7380.45
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337_A446_R0.7330.44
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55_N214_P0.7320.44
258_Q262_Q0.7310.44
31_C79_F0.7310.44
216_D224_F0.7290.44
457_Y483_S0.7280.44
462_N490_Q0.7280.44
347_Q438_F0.7280.44
381_H450_I0.7270.44
347_Q414_V0.7260.44
160_H319_G0.7250.44
306_A310_T0.7250.44
319_G661_Q0.7250.44
319_G665_R0.7250.44
797_L800_V0.7240.44
349_T662_R0.7230.44
636_Q699_I0.7230.44
614_N798_P0.7230.44
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191_R449_L0.7230.44
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469_L472_Q0.7220.43
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488_M732_D0.7190.43
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317_G320_K0.7180.43
317_G661_Q0.7180.43
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320_K661_Q0.7180.43
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314_A344_L0.7130.43
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515_N518_G0.7010.42
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282_G285_A0.6980.41
512_P515_N0.6970.41
620_F644_V0.6960.41
457_Y637_V0.6960.41
560_M631_I0.6950.41
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353_M356_R0.6920.41
267_V270_L0.6920.41
492_Q496_D0.6910.41
369_N379_F0.6910.41
672_K681_P0.6910.41
342_F656_A0.6910.41
161_G464_L0.6910.41
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731_L735_Y0.6880.41
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586_R589_E0.6860.40
315_P600_F0.6860.40
45_S442_L0.6860.40
564_A570_V0.6860.40
514_I517_R0.6850.40
636_Q700_Y0.6850.40
230_W428_L0.6850.40
324_A584_Y0.6840.40
198_L202_F0.6840.40
455_H640_Q0.6830.40
401_V404_C0.6830.40
302_A679_E0.6820.40
785_A795_P0.6810.40
432_L642_L0.6810.40
224_F228_A0.6810.40
157_T449_L0.6800.40
620_F638_V0.6800.40
230_W313_E0.6780.40
322_E602_A0.6780.40
343_A346_T0.6780.40
113_N117_A0.6770.40
629_G654_C0.6770.40
311_V425_D0.6760.40
748_N751_D0.6750.39
226_S441_G0.6750.39
342_F659_L0.6740.39
568_A647_D0.6730.39
316_T703_V0.6730.39
210_I659_L0.6720.39
362_S656_A0.6720.39
314_A457_Y0.6710.39
346_T455_H0.6700.39
266_R756_A0.6690.39
716_L726_A0.6690.39
771_A774_Y0.6690.39
34_V603_R0.6680.39
158_G438_F0.6660.39
469_L479_V0.6660.39
238_N621_G0.6650.39
536_P539_S0.6650.39
605_T798_P0.6650.39
349_T443_G0.6650.39
368_P371_I0.6640.38
322_E662_R0.6640.38
127_L622_K0.6630.38
326_A418_Q0.6620.38
637_V655_P0.6620.38
428_L669_H0.6610.38
194_W204_T0.6610.38
230_W655_P0.6600.38
479_V498_Y0.6600.38
352_A646_F0.6600.38
238_N267_V0.6600.38
580_A786_V0.6590.38
339_S342_F0.6570.38
251_N259_D0.6540.38
313_E666_L0.6530.38
591_N594_Q0.6530.38
55_N59_S0.6520.37
177_P359_A0.6520.37
428_L671_R0.6520.37
560_M650_I0.6510.37
283_V560_M0.6510.37
110_R118_G0.6500.37
265_S274_V0.6500.37
723_F726_A0.6500.37
588_K597_I0.6490.37
773_E777_Q0.6480.37
292_Q297_Q0.6470.37
163_I344_L0.6470.37
65_A748_N0.6460.37
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576_L652_Q0.6370.36
598_D630_R0.6370.36
451_V461_M0.6370.36
461_M471_A0.6370.36
735_Y792_M0.6370.36
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483_S731_L0.6340.36
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449_L795_P0.6310.36
349_T637_V0.6310.36
801_Q806_K0.6310.36
50_N53_C0.6300.36
227_L620_F0.6290.36
634_A646_F0.6280.35
117_A122_F0.6280.35
265_S271_S0.6270.35
646_F651_T0.6270.35
678_F681_P0.6260.35
537_R541_Q0.6260.35
143_P540_I0.6250.35
458_D465_L0.6250.35
576_L579_V0.6250.35
260_R263_D0.6240.35
255_T359_A0.6240.35
639_E646_F0.6230.35
744_E764_A0.6230.35
112_F116_A0.6220.35
604_F642_L0.6220.35
312_I630_R0.6210.35
679_E685_I0.6210.35
353_M576_L0.6210.35
749_G752_K0.6190.35
416_L443_G0.6180.35
732_D736_D0.6170.35
444_I807_Q0.6170.35
117_A126_S0.6160.35
331_L337_A0.6160.35
27_L81_I0.6160.35
530_H534_L0.6160.35
121_W483_S0.6150.34
627_N654_C0.6140.34
332_I335_Q0.6130.34
112_F120_Y0.6120.34
186_Q190_A0.6120.34
109_C584_Y0.6120.34
158_G686_L0.6110.34
31_C228_A0.6110.34
742_E752_K0.6110.34
567_G647_D0.6100.34
31_C312_I0.6100.34
27_L514_I0.6100.34
591_N631_I0.6080.34
513_L516_W0.6080.34
612_K615_R0.6080.34
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636_Q654_C0.6080.34
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662_R666_L0.6020.33
314_A323_T0.6010.33
243_N540_I0.6010.33
600_F613_E0.6000.33
733_S740_M0.5990.33
437_R441_G0.5980.33
351_N652_Q0.5980.33
448_V657_D0.5980.33
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441_G475_V0.5970.33
312_I527_L0.5970.33
803_S808_L0.5970.33
113_N119_L0.5960.33
13_K346_T0.5960.33
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156_V729_Q0.5950.33
512_P516_W0.5950.33
353_M482_L0.5940.33
28_I34_V0.5940.33
774_Y777_Q0.5930.33
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375_G381_H0.5920.33
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300_V312_I0.5900.32
526_D552_P0.5900.32
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464_L787_T0.5890.32
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602_A741_D0.5880.32
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277_K280_Y0.5860.32
192_E565_N0.5860.32
171_K180_L0.5860.32
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406_W415_F0.5770.31
237_T241_L0.5770.31
124_Q555_T0.5760.31
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230_W339_S0.5760.31
727_Y731_L0.5750.31
198_L231_L0.5750.31
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557_L563_A0.5750.31
175_E181_A0.5740.31
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270_L301_D0.5730.31
260_R273_L0.5730.31
223_G425_D0.5710.31
341_I443_G0.5710.31
403_C707_W0.5710.31
209_S214_P0.5710.31
38_A67_L0.5700.31
487_P656_A0.5700.31
461_M482_L0.5690.31
322_E353_M0.5690.31
123_N150_F0.5690.31
437_R478_S0.5670.31
347_Q443_G0.5670.31
348_A577_V0.5670.31
327_Y449_L0.5660.31
477_G727_Y0.5660.31
264_A297_Q0.5650.31
202_F755_S0.5640.30
446_R630_R0.5630.30
252_A255_T0.5630.30
413_K442_L0.5620.30
16_K26_L0.5620.30
118_G158_G0.5620.30
570_V650_I0.5620.30
179_S183_Y0.5610.30
226_S312_I0.5610.30
733_S754_E0.5600.30
319_G668_R0.5600.30
438_F442_L0.5600.30
563_A682_V0.5590.30
341_I415_F0.5590.30
678_F687_L0.5580.30
521_G525_F0.5580.30
515_N519_V0.5580.30
313_E574_C0.5580.30
160_H668_R0.5570.30
317_G668_R0.5570.30
320_K668_R0.5570.30
661_Q668_R0.5570.30
665_R668_R0.5570.30
109_C114_H0.5570.30
230_W349_T0.5560.30
306_A562_A0.5560.30
349_T651_T0.5560.30
161_G230_W0.5560.30
459_T471_A0.5560.30
660_F730_W0.5550.30
639_E658_L0.5550.30
368_P372_L0.5550.30
359_A554_L0.5550.30
173_R504_P0.5530.30
352_A683_A0.5530.30
166_S594_Q0.5520.30
598_D613_E0.5520.30
14_S634_A0.5520.30
378_R381_H0.5510.29
161_G577_V0.5510.29
350_A634_A0.5500.29
197_V539_S0.5480.29
61_Q558_E0.5480.29
535_P677_G0.5480.29
706_M712_H0.5480.29
222_A341_I0.5480.29
12_G15_S0.5480.29
115_G122_F0.5470.29
234_W348_A0.5470.29
437_R461_M0.5470.29
230_W233_S0.5460.29
464_L632_L0.5450.29
230_W456_A0.5450.29
724_P728_R0.5450.29
709_T713_I0.5440.29
693_Y698_H0.5440.29
557_L749_G0.5440.29
408_S808_L0.5440.29
196_S212_D0.5440.29
614_N697_E0.5430.29
518_G618_S0.5430.29
12_G225_C0.5430.29
319_G645_D0.5430.29
11_W14_S0.5420.29
770_W773_E0.5420.29
446_R476_G0.5420.29
369_N417_G0.5420.29
403_C407_L0.5420.29
464_L470_K0.5410.29
781_E784_L0.5410.29
236_T556_M0.5410.29
450_I743_P0.5400.29
198_L214_P0.5390.29
55_N312_I0.5380.29
11_W469_L0.5380.29
653_H706_M0.5380.29
284_H748_N0.5380.29
758_C761_R0.5380.29
298_V301_D0.5370.28
256_Y259_D0.5370.28
183_Y187_D0.5370.28
344_L350_A0.5370.28
797_L801_Q0.5370.28
386_I390_A0.5360.28
687_L690_G0.5360.28
414_V420_G0.5350.28
89_E92_L0.5350.28
604_F613_E0.5340.28
436_H439_I0.5340.28
362_S534_L0.5330.28
433_P644_V0.5330.28
518_G570_V0.5320.28
72_A629_G0.5310.28
200_A295_Q0.5310.28
336_I685_I0.5310.28
324_A655_P0.5300.28
599_L651_T0.5300.28
210_I712_H0.5300.28
650_I687_L0.5300.28
297_Q788_R0.5290.28
444_I499_G0.5290.28
382_L721_L0.5280.28
224_F631_I0.5280.28
356_R643_D0.5280.28
313_E486_L0.5270.28
357_M610_R0.5270.28
430_S441_G0.5260.28
26_L215_P0.5240.28
375_G380_N0.5240.28
482_L655_P0.5240.28
745_W766_K0.5240.28
598_D632_L0.5230.27
683_A746_V0.5230.27
123_N153_V0.5230.27
42_W314_A0.5230.27
642_L662_R0.5210.27
436_H669_H0.5200.27
216_D219_S0.5190.27
427_V481_L0.5190.27
50_N503_D0.5180.27
351_N488_M0.5180.27
156_V499_G0.5180.27
565_N572_L0.5180.27
31_C347_Q0.5180.27
461_M640_Q0.5170.27
353_M413_K0.5170.27
286_L295_Q0.5170.27
157_T164_L0.5160.27
197_V202_F0.5160.27
454_V488_M0.5150.27
790_G793_S0.5150.27
265_S283_V0.5150.27
290_G298_V0.5140.27
87_S721_L0.5140.27
222_A226_S0.5140.27
40_C44_Q0.5140.27
714_E729_Q0.5130.27
290_G300_V0.5130.27
80_D361_A0.5130.27
527_L750_M0.5130.27
233_S311_V0.5120.27
367_S540_I0.5120.27
163_I443_G0.5120.27
487_P637_V0.5120.27
744_E756_A0.5110.27
203_L206_A0.5110.27
419_I479_V0.5100.27
324_A347_Q0.5100.27
113_N121_W0.5100.27
223_G651_T0.5100.27
167_Q170_D0.5090.26
356_R671_R0.5090.26
13_K30_H0.5080.26
479_V495_L0.5080.26
174_W189_Q0.5080.26
233_S647_D0.5080.26
614_N618_S0.5080.26
23_D87_S0.5070.26
171_K299_L0.5070.26
620_F631_I0.5070.26
465_L482_L0.5070.26
464_L471_A0.5070.26
461_M483_S0.5060.26
284_H300_V0.5060.26
796_L801_Q0.5060.26
789_D797_L0.5060.26
563_A648_W0.5050.26
347_Q581_Q0.5050.26
194_W199_E0.5040.26
504_P725_D0.5040.26
77_G84_Q0.5040.26
71_I487_P0.5020.26
13_K641_S0.5020.26
103_G107_Q0.5020.26
455_H483_S0.5010.26
375_G443_G0.5010.26
29_Y33_D0.5010.26
355_T618_S0.5010.26
749_G754_E0.5010.26
465_L648_W0.5000.26
789_D795_P0.5000.26
756_A759_E0.5000.26
640_Q651_T0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qqwA 2 0.9313 100 0.456 Contact Map
4q2cA 1 0.9538 100 0.469 Contact Map
3eiqA 1 0.4043 100 0.818 Contact Map
3peyA 1 0.4245 100 0.819 Contact Map
1xtiA 1 0.4223 100 0.819 Contact Map
4ct4B 1 0.42 100 0.819 Contact Map
1s2mA 1 0.4189 100 0.819 Contact Map
1hv8A 2 0.4032 100 0.819 Contact Map
2i4iA 1 0.4302 100 0.82 Contact Map
1fuuA 2 0.4223 100 0.82 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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