CAS3 - ECOLI - GREMLIN Contacts

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CAS3 - CRISPR-associated endonuclease/helicase Cas3

UniProt:	P38036	Sequences: MEPFKYICHYWGKSSKSLTKGNDIHLLIYHCLDVAAVADCWWDQSVVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFDIRFQYKSAESWLKLNPATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLSEQSLGDFFSFFDAAPHPYESWFPWVEAVTGHHGFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDCSSLLAGFCSLADWLGSWTTTNTFLFNEDAPSDINALRTYFQDRQQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPVAPGLTVIEAPTGSGKTETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSPNLILAHGNSRFNHLFQSIKSRAITEQGQEEAWVQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEAVLKAQADVGGSVILLSATLPMKQKQKLLDTYGLHTDPVENNSAYPLINWRGVNGAQRFDLLAHPEQLPPRFSIQPEPICLADMLPDLTMLERMIAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQVDIDLFHARFTLNDRREKENRVISNFGKNGKRNVGRILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRPAGFEIPVATILLPDGEGYGRHEHIYSNVRVMWRTQQHIEELNGASLFFPDAYRQWLDSIYDDAEMDEPEWVGNGMDKFESAECEKRFKARKVLQWAEEYSLQDNDETILAVTRDGEMSLPLLPYVQTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTWKRSFSEVVDEDGLLWLEGKQNLDGWVWQGNSIVITYTGDEGMTRVIPANPK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12634
Length:	888 (724)
Sequences:	1124 (1020)
Seq/√Len:	37.9

ECOLI - CAS3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
634_A	638_V	7.552	1.00
372_L	377_S	5.659	1.00
372_L	375_G	5.243	1.00
372_L	376_N	5.178	1.00
289_N	293_P	4.746	1.00
373_A	376_N	4.696	1.00
373_A	377_S	4.696	1.00
293_P	297_Q	4.437	1.00
283_V	286_L	4.211	1.00
587_L	633_V	4.097	1.00
290_G	293_P	3.951	1.00
328_A	450_I	3.824	1.00
645_D	671_R	3.807	1.00
571_C	649_L	3.680	1.00
371_I	375_G	3.665	1.00
651_T	659_L	3.522	1.00
43_D	64_K	3.473	1.00
322_E	356_R	3.456	1.00
297_Q	300_V	3.441	1.00
537_R	540_I	3.345	1.00
314_A	318_S	3.304	1.00
374_H	377_S	3.283	1.00
294_R	297_Q	3.189	1.00
370_L	375_G	3.153	1.00
372_L	379_F	3.077	1.00
580_A	635_T	2.994	1.00
10_Y	79_F	2.903	1.00
293_P	300_V	2.893	1.00
371_I	377_S	2.892	1.00
194_W	197_V	2.875	1.00
649_L	666_L	2.857	1.00
33_D	232_G	2.825	1.00
338_D	446_R	2.815	1.00
371_I	376_N	2.768	1.00
376_N	379_F	2.662	1.00
571_C	638_V	2.644	1.00
663_L	683_A	2.637	1.00
115_G	118_G	2.631	1.00
113_N	116_A	2.622	1.00
580_A	599_L	2.597	1.00
325_L	357_M	2.594	1.00
616_V	632_L	2.581	1.00
27_L	79_F	2.567	1.00
282_G	286_L	2.536	1.00
584_Y	588_K	2.536	1.00
709_T	712_H	2.534	1.00
574_C	583_C	2.446	1.00
403_C	406_W	2.443	1.00
316_T	727_Y	2.439	1.00
804_S	807_Q	2.413	1.00
804_S	808_L	2.412	1.00
370_L	373_A	2.405	1.00
34_V	232_G	2.329	1.00
638_V	646_F	2.314	1.00
561_I	590_L	2.310	1.00
369_N	372_L	2.299	1.00
733_S	736_D	2.284	1.00
560_M	570_V	2.281	1.00
176_M	179_S	2.281	1.00
574_C	580_A	2.276	0.99
805_G	809_L	2.272	0.99
599_L	604_F	2.264	0.99
681_P	685_I	2.244	0.99
114_H	118_G	2.218	0.99
260_R	274_V	2.194	0.99
341_I	422_C	2.179	0.99
307_P	310_T	2.153	0.99
300_V	304_P	2.140	0.99
370_L	376_N	2.125	0.99
615_R	619_N	2.119	0.99
802_T	805_G	2.107	0.99
681_P	688_P	2.106	0.99
369_N	373_A	2.084	0.99
343_A	427_V	2.065	0.99
35_A	72_A	2.065	0.99
257_F	260_R	2.061	0.99
293_P	296_L	2.057	0.99
32_L	36_A	2.019	0.99
328_A	340_V	2.010	0.99
294_R	300_V	2.004	0.99
804_S	809_L	1.995	0.99
733_S	737_D	1.993	0.99
431_V	468_V	1.988	0.99
374_H	379_F	1.987	0.99
372_L	380_N	1.965	0.98
234_W	238_N	1.949	0.98
649_L	662_R	1.939	0.98
39_D	64_K	1.932	0.98
179_S	182_S	1.917	0.98
11_W	87_S	1.907	0.98
534_L	538_F	1.894	0.98
297_Q	304_P	1.865	0.98
38_A	71_I	1.856	0.98
298_V	302_A	1.847	0.98
467_A	470_K	1.822	0.98
579_V	652_Q	1.820	0.97
683_A	688_P	1.801	0.97
406_W	413_K	1.791	0.97
290_G	297_Q	1.775	0.97
316_T	723_F	1.769	0.97
638_V	644_V	1.766	0.97
468_V	472_Q	1.763	0.97
260_R	264_A	1.754	0.97
651_T	683_A	1.750	0.97
337_A	448_V	1.737	0.97
370_L	379_F	1.732	0.97
620_F	630_R	1.727	0.97
681_P	687_L	1.727	0.97
325_L	361_A	1.726	0.97
473_A	498_Y	1.725	0.97
696_H	699_I	1.724	0.96
39_D	68_L	1.719	0.96
604_F	612_K	1.699	0.96
454_V	481_L	1.679	0.96
626_R	629_G	1.669	0.96
13_K	233_S	1.661	0.96
535_P	538_F	1.653	0.96
174_W	178_A	1.648	0.95
51_T	54_R	1.642	0.95
373_A	378_R	1.634	0.95
327_Y	331_L	1.630	0.95
219_S	223_G	1.628	0.95
374_H	380_N	1.617	0.95
26_L	29_Y	1.610	0.95
114_H	121_W	1.604	0.95
374_H	378_R	1.593	0.95
427_V	468_V	1.589	0.94
370_L	374_H	1.584	0.94
573_I	662_R	1.573	0.94
685_I	688_P	1.571	0.94
25_H	232_G	1.570	0.94
271_S	274_V	1.558	0.94
605_T	608_D	1.548	0.94
73_L	156_V	1.545	0.94
564_A	631_I	1.540	0.93
666_L	683_A	1.532	0.93
331_L	448_V	1.531	0.93
290_G	296_L	1.529	0.93
119_L	157_T	1.527	0.93
584_Y	599_L	1.520	0.93
601_H	604_F	1.516	0.93
728_R	732_D	1.511	0.93
289_N	297_Q	1.487	0.92
571_C	646_F	1.486	0.92
737_D	740_M	1.483	0.92
464_L	472_Q	1.475	0.92
257_F	261_Q	1.470	0.92
270_L	274_V	1.469	0.92
10_Y	27_L	1.466	0.92
516_W	519_V	1.465	0.92
187_D	191_R	1.459	0.91
683_A	686_L	1.457	0.91
339_S	447_S	1.445	0.91
373_A	379_F	1.442	0.91
750_M	754_E	1.431	0.91
351_N	573_I	1.430	0.91
651_T	662_R	1.428	0.91
86_K	110_R	1.426	0.90
458_D	464_L	1.420	0.90
560_M	572_L	1.417	0.90
71_I	228_A	1.416	0.90
293_P	298_V	1.414	0.90
577_V	603_R	1.413	0.90
375_G	379_F	1.408	0.90
332_I	337_A	1.408	0.90
256_Y	260_R	1.407	0.90
87_S	90_S	1.405	0.90
369_N	376_N	1.391	0.89
466_E	493_K	1.387	0.89
369_N	375_G	1.383	0.89
324_A	482_L	1.382	0.89
723_F	727_Y	1.379	0.89
300_V	303_L	1.375	0.89
296_L	300_V	1.363	0.88
424_I	457_Y	1.360	0.88
560_M	564_A	1.359	0.88
67_L	71_I	1.348	0.88
195_I	202_F	1.347	0.88
465_L	471_A	1.346	0.88
558_E	590_L	1.343	0.88
350_A	422_C	1.337	0.87
372_L	378_R	1.332	0.87
187_D	190_A	1.329	0.87
226_S	439_I	1.326	0.87
231_L	234_W	1.326	0.87
604_F	608_D	1.319	0.87
315_P	318_S	1.319	0.87
112_F	115_G	1.313	0.86
294_R	301_D	1.305	0.86
253_L	256_Y	1.301	0.86
194_W	198_L	1.300	0.86
742_E	745_W	1.298	0.86
538_F	541_Q	1.292	0.85
198_L	201_L	1.287	0.85
681_P	686_L	1.287	0.85
753_F	757_E	1.286	0.85
291_Y	297_Q	1.286	0.85
220_L	223_G	1.277	0.85
306_A	309_L	1.272	0.85
582_V	693_Y	1.272	0.85
747_G	751_D	1.272	0.85
425_D	601_H	1.265	0.84
554_L	586_R	1.264	0.84
15_S	21_G	1.263	0.84
293_P	304_P	1.263	0.84
357_M	421_V	1.261	0.84
757_E	760_K	1.257	0.84
297_Q	301_D	1.257	0.84
560_M	563_A	1.252	0.84
260_R	270_L	1.252	0.84
221_L	224_F	1.249	0.83
370_L	377_S	1.248	0.83
175_E	179_S	1.248	0.83
316_T	660_F	1.248	0.83
371_I	374_H	1.245	0.83
768_L	774_Y	1.241	0.83
126_S	130_Q	1.240	0.83
659_L	685_I	1.238	0.83
472_Q	477_G	1.236	0.83
561_I	564_A	1.233	0.83
194_W	202_F	1.230	0.83
347_Q	375_G	1.230	0.83
289_N	296_L	1.229	0.82
233_S	425_D	1.225	0.82
511_Y	515_N	1.225	0.82
113_N	118_G	1.224	0.82
483_S	640_Q	1.223	0.82
59_S	62_R	1.221	0.82
640_Q	658_L	1.220	0.82
197_V	201_L	1.213	0.82
600_F	637_V	1.199	0.81
74_H	78_K	1.189	0.80
75_D	78_K	1.189	0.80
341_I	420_G	1.187	0.80
461_M	464_L	1.181	0.80
71_I	225_C	1.179	0.80
599_L	635_T	1.179	0.80
495_L	515_N	1.179	0.80
294_R	318_S	1.176	0.80
619_N	630_R	1.166	0.79
559_R	563_A	1.165	0.79
441_G	471_A	1.163	0.79
404_C	408_S	1.161	0.79
702_N	705_V	1.156	0.78
10_Y	29_Y	1.150	0.78
679_E	684_T	1.150	0.78
583_C	646_F	1.144	0.78
53_C	56_E	1.140	0.77
260_R	267_V	1.139	0.77
698_H	701_S	1.133	0.77
354_L	386_I	1.131	0.77
449_L	472_Q	1.128	0.77
768_L	771_A	1.119	0.76
667_H	678_F	1.119	0.76
52_F	56_E	1.114	0.76
223_G	415_F	1.113	0.76
722_F	725_D	1.111	0.76
299_L	302_A	1.109	0.75
470_K	500_L	1.108	0.75
371_I	573_I	1.105	0.75
228_A	573_I	1.103	0.75
645_D	789_D	1.100	0.75
226_S	438_F	1.093	0.74
352_A	641_S	1.093	0.74
553_D	582_V	1.093	0.74
42_W	46_V	1.092	0.74
760_K	764_A	1.092	0.74
114_H	117_A	1.090	0.74
119_L	122_F	1.089	0.74
745_W	749_G	1.085	0.74
343_A	451_V	1.083	0.74
757_E	761_R	1.083	0.74
761_R	765_R	1.082	0.74
729_Q	733_S	1.079	0.73
655_P	700_Y	1.072	0.73
161_G	456_A	1.071	0.73
216_D	223_G	1.069	0.73
344_L	353_M	1.065	0.72
805_G	808_L	1.063	0.72
787_T	790_G	1.063	0.72
262_Q	266_R	1.063	0.72
26_L	450_I	1.062	0.72
219_S	222_A	1.059	0.72
114_H	122_F	1.056	0.72
755_S	761_R	1.055	0.72
230_W	669_H	1.054	0.72
197_V	200_A	1.054	0.72
220_L	224_F	1.054	0.72
760_K	763_K	1.054	0.72
755_S	760_K	1.053	0.72
115_G	119_L	1.052	0.71
597_I	631_I	1.051	0.71
648_W	684_T	1.050	0.71
373_A	381_H	1.049	0.71
381_H	614_N	1.043	0.71
311_V	495_L	1.042	0.71
322_E	604_F	1.041	0.71
486_L	491_K	1.041	0.71
67_L	221_L	1.040	0.71
325_L	342_F	1.039	0.70
176_M	180_L	1.039	0.70
322_E	641_S	1.036	0.70
11_W	24_I	1.033	0.70
464_L	468_V	1.031	0.70
37_V	41_W	1.030	0.70
611_E	614_N	1.030	0.70
460_Y	789_D	1.030	0.70
559_R	650_I	1.028	0.70
304_P	310_T	1.026	0.69
781_E	785_A	1.023	0.69
230_W	436_H	1.023	0.69
557_L	564_A	1.023	0.69
347_Q	350_A	1.021	0.69
358_E	572_L	1.018	0.69
754_E	758_C	1.017	0.69
27_L	30_H	1.017	0.69
31_C	194_W	1.015	0.69
73_L	222_A	1.015	0.69
234_W	237_T	1.015	0.69
327_Y	478_S	1.014	0.69
297_Q	425_D	1.014	0.69
25_H	29_Y	1.014	0.69
750_M	753_F	1.013	0.69
620_F	634_A	1.012	0.68
681_P	684_T	1.010	0.68
578_D	582_V	1.007	0.68
745_W	752_K	1.006	0.68
165_H	168_D	1.006	0.68
252_A	260_R	1.000	0.67
176_M	182_S	0.997	0.67
465_L	494_L	0.997	0.67
803_S	807_Q	0.996	0.67
602_A	609_R	0.994	0.67
404_C	407_L	0.994	0.67
536_P	685_I	0.993	0.67
536_P	541_Q	0.993	0.67
602_A	637_V	0.992	0.67
574_C	652_Q	0.992	0.67
762_F	765_R	0.991	0.67
633_V	741_D	0.990	0.67
327_Y	480_I	0.990	0.67
127_L	130_Q	0.989	0.67
465_L	645_D	0.989	0.67
74_H	77_G	0.985	0.66
122_F	371_I	0.983	0.66
233_S	601_H	0.981	0.66
427_V	451_V	0.981	0.66
458_D	472_Q	0.981	0.66
281_E	286_L	0.980	0.66
312_I	315_P	0.978	0.66
649_L	683_A	0.977	0.66
617_I	620_F	0.974	0.65
575_N	653_H	0.973	0.65
291_Y	298_V	0.973	0.65
793_S	796_L	0.973	0.65
268_L	271_S	0.972	0.65
603_R	734_I	0.972	0.65
114_H	119_L	0.964	0.65
328_A	448_V	0.963	0.65
745_W	748_N	0.963	0.65
230_W	640_Q	0.962	0.64
175_E	178_A	0.961	0.64
353_M	641_S	0.961	0.64
110_R	114_H	0.961	0.64
387_K	390_A	0.958	0.64
697_E	702_N	0.958	0.64
265_S	268_L	0.957	0.64
344_L	577_V	0.957	0.64
682_V	687_L	0.957	0.64
431_V	442_L	0.956	0.64
50_N	685_I	0.956	0.64
260_R	265_S	0.956	0.64
111_K	117_A	0.956	0.64
715_E	720_S	0.954	0.64
346_T	425_D	0.952	0.64
356_R	641_S	0.950	0.63
310_T	514_I	0.950	0.63
550_M	555_T	0.949	0.63
552_P	555_T	0.946	0.63
226_S	576_L	0.945	0.63
12_G	26_L	0.943	0.63
356_R	669_H	0.943	0.63
50_N	54_R	0.940	0.63
233_S	237_T	0.939	0.63
602_A	605_T	0.938	0.62
475_V	632_L	0.938	0.62
226_S	442_L	0.936	0.62
284_H	292_Q	0.935	0.62
441_G	632_L	0.935	0.62
656_A	734_I	0.935	0.62
15_S	22_N	0.935	0.62
297_Q	647_D	0.929	0.62
264_A	268_L	0.927	0.62
620_F	632_L	0.926	0.61
355_T	382_L	0.924	0.61
705_V	709_T	0.921	0.61
404_C	614_N	0.920	0.61
39_D	43_D	0.920	0.61
227_L	439_I	0.920	0.61
458_D	461_M	0.918	0.61
631_I	669_H	0.918	0.61
608_D	611_E	0.917	0.61
349_T	641_S	0.917	0.61
735_Y	740_M	0.916	0.61
294_R	298_V	0.915	0.61
705_V	708_R	0.914	0.60
174_W	179_S	0.906	0.60
574_C	686_L	0.901	0.59
170_D	611_E	0.900	0.59
355_T	359_A	0.898	0.59
233_S	604_F	0.898	0.59
267_V	450_I	0.897	0.59
473_A	632_L	0.893	0.59
257_F	265_S	0.892	0.59
34_V	728_R	0.892	0.59
769_Q	774_Y	0.891	0.58
304_P	309_L	0.891	0.58
458_D	462_N	0.891	0.58
444_I	791_E	0.889	0.58
372_L	381_H	0.889	0.58
285_A	541_Q	0.889	0.58
182_S	186_Q	0.887	0.58
651_T	660_F	0.886	0.58
313_E	491_K	0.886	0.58
705_V	715_E	0.884	0.58
641_S	662_R	0.884	0.58
461_M	465_L	0.884	0.58
334_Q	597_I	0.881	0.58
461_M	669_H	0.879	0.57
756_A	763_K	0.878	0.57
356_R	604_F	0.876	0.57
15_S	23_D	0.875	0.57
463_G	466_E	0.875	0.57
468_V	473_A	0.875	0.57
571_C	634_A	0.875	0.57
200_A	285_A	0.873	0.57
732_D	735_Y	0.869	0.57
291_Y	294_R	0.869	0.57
21_G	614_N	0.867	0.56
347_Q	451_V	0.865	0.56
534_L	537_R	0.864	0.56
483_S	658_L	0.863	0.56
27_L	84_Q	0.862	0.56
647_D	700_Y	0.862	0.56
570_V	648_W	0.860	0.56
461_M	468_V	0.857	0.55
300_V	327_Y	0.855	0.55
647_D	652_Q	0.855	0.55
35_A	68_L	0.855	0.55
419_I	447_S	0.854	0.55
194_W	201_L	0.853	0.55
280_Y	283_V	0.852	0.55
156_V	225_C	0.851	0.55
381_H	740_M	0.851	0.55
745_W	750_M	0.847	0.55
311_V	601_H	0.847	0.55
204_T	208_L	0.847	0.55
465_L	472_Q	0.846	0.55
92_L	614_N	0.844	0.54
348_A	641_S	0.842	0.54
233_S	346_T	0.840	0.54
297_Q	601_H	0.840	0.54
267_V	271_S	0.840	0.54
637_V	658_L	0.839	0.54
11_W	33_D	0.838	0.54
17_S	189_Q	0.838	0.54
184_A	187_D	0.836	0.54
26_L	31_C	0.836	0.54
265_S	270_L	0.836	0.54
202_F	518_G	0.834	0.53
176_M	181_A	0.833	0.53
430_S	444_I	0.831	0.53
313_E	657_D	0.830	0.53
559_R	684_T	0.829	0.53
280_Y	286_L	0.827	0.53
527_L	635_T	0.826	0.53
212_D	215_P	0.826	0.53
562_A	679_E	0.825	0.53
683_A	689_D	0.824	0.53
258_Q	261_Q	0.823	0.52
755_S	758_C	0.823	0.52
183_Y	191_R	0.823	0.52
695_R	698_H	0.823	0.52
569_Q	627_N	0.823	0.52
660_F	722_F	0.823	0.52
761_R	764_A	0.822	0.52
658_L	667_H	0.815	0.52
450_I	587_L	0.815	0.52
755_S	759_E	0.814	0.52
390_A	394_Q	0.814	0.52
193_E	197_V	0.814	0.52
458_D	468_V	0.814	0.52
775_S	778_D	0.811	0.51
483_S	486_L	0.811	0.51
710_Q	713_I	0.810	0.51
742_E	746_V	0.810	0.51
600_F	638_V	0.809	0.51
43_D	66_W	0.809	0.51
706_M	709_T	0.809	0.51
584_Y	592_N	0.808	0.51
424_I	602_A	0.806	0.51
163_I	442_L	0.805	0.51
152_W	239_T	0.804	0.51
758_C	763_K	0.803	0.51
27_L	31_C	0.803	0.51
758_C	762_F	0.802	0.51
473_A	478_S	0.801	0.51
754_E	764_A	0.801	0.51
654_C	659_L	0.799	0.50
596_D	629_G	0.799	0.50
442_L	788_R	0.799	0.50
191_R	427_V	0.798	0.50
196_S	725_D	0.797	0.50
24_I	27_L	0.797	0.50
289_N	300_V	0.797	0.50
511_Y	517_R	0.796	0.50
463_G	467_A	0.794	0.50
695_R	699_I	0.794	0.50
806_K	809_L	0.792	0.50
460_Y	645_D	0.791	0.50
471_A	580_A	0.791	0.50
554_L	558_E	0.791	0.50
386_I	389_R	0.789	0.49
682_V	685_I	0.788	0.49
27_L	477_G	0.787	0.49
451_V	465_L	0.785	0.49
342_F	451_V	0.785	0.49
51_T	55_N	0.785	0.49
557_L	590_L	0.783	0.49
116_A	119_L	0.782	0.49
767_V	771_A	0.781	0.49
748_N	752_K	0.781	0.49
329_W	341_I	0.781	0.49
121_W	191_R	0.778	0.48
755_S	763_K	0.775	0.48
230_W	461_M	0.771	0.48
367_S	534_L	0.771	0.48
425_D	662_R	0.769	0.48
214_P	449_L	0.767	0.47
529_A	537_R	0.766	0.47
681_P	690_G	0.764	0.47
356_R	662_R	0.763	0.47
450_I	518_G	0.762	0.47
708_R	712_H	0.762	0.47
641_S	651_T	0.760	0.47
74_H	83_F	0.759	0.47
75_D	83_F	0.759	0.47
78_K	83_F	0.759	0.47
745_W	753_F	0.759	0.47
50_N	60_K	0.758	0.47
436_H	460_Y	0.757	0.47
759_E	763_K	0.754	0.46
494_L	498_Y	0.752	0.46
709_T	734_I	0.752	0.46
313_E	454_V	0.752	0.46
620_F	646_F	0.752	0.46
226_S	230_W	0.752	0.46
35_A	38_A	0.750	0.46
463_G	631_I	0.750	0.46
683_A	687_L	0.749	0.46
25_H	33_D	0.747	0.46
255_T	259_D	0.747	0.46
80_D	117_A	0.746	0.46
442_L	475_V	0.745	0.46
736_D	740_M	0.744	0.45
325_L	419_I	0.744	0.45
613_E	642_L	0.743	0.45
768_L	773_E	0.741	0.45
344_L	608_D	0.740	0.45
161_G	652_Q	0.739	0.45
153_V	157_T	0.738	0.45
13_K	601_H	0.736	0.45
66_W	370_L	0.736	0.45
369_N	377_S	0.736	0.45
223_G	662_R	0.736	0.45
753_F	764_A	0.735	0.45
254_R	725_D	0.735	0.45
598_D	615_R	0.734	0.45
337_A	446_R	0.733	0.44
180_L	184_A	0.733	0.44
55_N	214_P	0.732	0.44
258_Q	262_Q	0.731	0.44
31_C	79_F	0.731	0.44
216_D	224_F	0.729	0.44
457_Y	483_S	0.728	0.44
462_N	490_Q	0.728	0.44
347_Q	438_F	0.728	0.44
381_H	450_I	0.727	0.44
347_Q	414_V	0.726	0.44
160_H	319_G	0.725	0.44
306_A	310_T	0.725	0.44
319_G	661_Q	0.725	0.44
319_G	665_R	0.725	0.44
797_L	800_V	0.724	0.44
349_T	662_R	0.723	0.44
636_Q	699_I	0.723	0.44
614_N	798_P	0.723	0.44
177_P	183_Y	0.723	0.44
191_R	449_L	0.723	0.44
115_G	312_I	0.722	0.43
469_L	472_Q	0.722	0.43
747_G	750_M	0.721	0.43
186_Q	589_E	0.720	0.43
349_T	416_L	0.720	0.43
51_T	56_E	0.719	0.43
34_V	71_I	0.719	0.43
488_M	732_D	0.719	0.43
178_A	181_A	0.719	0.43
574_C	579_V	0.719	0.43
160_H	317_G	0.718	0.43
160_H	320_K	0.718	0.43
160_H	661_Q	0.718	0.43
160_H	665_R	0.718	0.43
317_G	320_K	0.718	0.43
317_G	661_Q	0.718	0.43
317_G	665_R	0.718	0.43
320_K	661_Q	0.718	0.43
320_K	665_R	0.718	0.43
661_Q	665_R	0.718	0.43
118_G	121_W	0.715	0.43
261_Q	268_L	0.715	0.43
798_P	806_K	0.715	0.43
314_A	344_L	0.713	0.43
298_V	540_I	0.711	0.43
801_Q	808_L	0.710	0.42
558_E	564_A	0.709	0.42
148_S	679_E	0.709	0.42
602_A	699_I	0.708	0.42
511_Y	514_I	0.708	0.42
370_L	571_C	0.708	0.42
349_T	353_M	0.704	0.42
429_I	667_H	0.703	0.42
463_G	470_K	0.703	0.42
601_H	662_R	0.701	0.42
158_G	164_L	0.701	0.42
515_N	518_G	0.701	0.42
577_V	602_A	0.701	0.42
353_M	429_I	0.700	0.42
465_L	469_L	0.700	0.42
346_T	644_V	0.698	0.41
282_G	285_A	0.698	0.41
512_P	515_N	0.697	0.41
620_F	644_V	0.696	0.41
457_Y	637_V	0.696	0.41
560_M	631_I	0.695	0.41
10_Y	14_S	0.695	0.41
114_H	120_Y	0.693	0.41
353_M	356_R	0.692	0.41
267_V	270_L	0.692	0.41
492_Q	496_D	0.691	0.41
369_N	379_F	0.691	0.41
672_K	681_P	0.691	0.41
342_F	656_A	0.691	0.41
161_G	464_L	0.691	0.41
10_Y	26_L	0.689	0.41
192_E	196_S	0.689	0.41
731_L	735_Y	0.688	0.41
109_C	221_L	0.687	0.40
586_R	589_E	0.686	0.40
315_P	600_F	0.686	0.40
45_S	442_L	0.686	0.40
564_A	570_V	0.686	0.40
514_I	517_R	0.685	0.40
636_Q	700_Y	0.685	0.40
230_W	428_L	0.685	0.40
324_A	584_Y	0.684	0.40
198_L	202_F	0.684	0.40
455_H	640_Q	0.683	0.40
401_V	404_C	0.683	0.40
302_A	679_E	0.682	0.40
785_A	795_P	0.681	0.40
432_L	642_L	0.681	0.40
224_F	228_A	0.681	0.40
157_T	449_L	0.680	0.40
620_F	638_V	0.680	0.40
230_W	313_E	0.678	0.40
322_E	602_A	0.678	0.40
343_A	346_T	0.678	0.40
113_N	117_A	0.677	0.40
629_G	654_C	0.677	0.40
311_V	425_D	0.676	0.40
748_N	751_D	0.675	0.39
226_S	441_G	0.675	0.39
342_F	659_L	0.674	0.39
568_A	647_D	0.673	0.39
316_T	703_V	0.673	0.39
210_I	659_L	0.672	0.39
362_S	656_A	0.672	0.39
314_A	457_Y	0.671	0.39
346_T	455_H	0.670	0.39
266_R	756_A	0.669	0.39
716_L	726_A	0.669	0.39
771_A	774_Y	0.669	0.39
34_V	603_R	0.668	0.39
158_G	438_F	0.666	0.39
469_L	479_V	0.666	0.39
238_N	621_G	0.665	0.39
536_P	539_S	0.665	0.39
605_T	798_P	0.665	0.39
349_T	443_G	0.665	0.39
368_P	371_I	0.664	0.38
322_E	662_R	0.664	0.38
127_L	622_K	0.663	0.38
326_A	418_Q	0.662	0.38
637_V	655_P	0.662	0.38
428_L	669_H	0.661	0.38
194_W	204_T	0.661	0.38
230_W	655_P	0.660	0.38
479_V	498_Y	0.660	0.38
352_A	646_F	0.660	0.38
238_N	267_V	0.660	0.38
580_A	786_V	0.659	0.38
339_S	342_F	0.657	0.38
251_N	259_D	0.654	0.38
313_E	666_L	0.653	0.38
591_N	594_Q	0.653	0.38
55_N	59_S	0.652	0.37
177_P	359_A	0.652	0.37
428_L	671_R	0.652	0.37
560_M	650_I	0.651	0.37
283_V	560_M	0.651	0.37
110_R	118_G	0.650	0.37
265_S	274_V	0.650	0.37
723_F	726_A	0.650	0.37
588_K	597_I	0.649	0.37
773_E	777_Q	0.648	0.37
292_Q	297_Q	0.647	0.37
163_I	344_L	0.647	0.37
65_A	748_N	0.646	0.37
230_W	652_Q	0.645	0.37
114_H	126_S	0.645	0.37
264_A	267_V	0.644	0.37
29_Y	32_L	0.644	0.37
569_Q	620_F	0.644	0.37
370_L	380_N	0.643	0.37
110_R	113_N	0.643	0.37
693_Y	696_H	0.643	0.37
584_Y	635_T	0.642	0.37
112_F	119_L	0.642	0.37
516_W	520_N	0.642	0.37
340_V	450_I	0.640	0.36
529_A	633_V	0.640	0.36
350_A	361_A	0.640	0.36
802_T	808_L	0.640	0.36
348_A	434_V	0.639	0.36
112_F	122_F	0.638	0.36
352_A	413_K	0.638	0.36
204_T	207_G	0.638	0.36
576_L	652_Q	0.637	0.36
598_D	630_R	0.637	0.36
451_V	461_M	0.637	0.36
461_M	471_A	0.637	0.36
735_Y	792_M	0.637	0.36
790_G	801_Q	0.635	0.36
367_S	554_L	0.635	0.36
612_K	616_V	0.634	0.36
25_H	35_A	0.634	0.36
345_P	428_L	0.634	0.36
483_S	731_L	0.634	0.36
568_A	633_V	0.633	0.36
42_W	63_V	0.632	0.36
459_T	469_L	0.632	0.36
264_A	270_L	0.631	0.36
256_Y	264_A	0.631	0.36
449_L	795_P	0.631	0.36
349_T	637_V	0.631	0.36
801_Q	806_K	0.631	0.36
50_N	53_C	0.630	0.36
227_L	620_F	0.629	0.36
634_A	646_F	0.628	0.35
117_A	122_F	0.628	0.35
265_S	271_S	0.627	0.35
646_F	651_T	0.627	0.35
678_F	681_P	0.626	0.35
537_R	541_Q	0.626	0.35
143_P	540_I	0.625	0.35
458_D	465_L	0.625	0.35
576_L	579_V	0.625	0.35
260_R	263_D	0.624	0.35
255_T	359_A	0.624	0.35
639_E	646_F	0.623	0.35
744_E	764_A	0.623	0.35
112_F	116_A	0.622	0.35
604_F	642_L	0.622	0.35
312_I	630_R	0.621	0.35
679_E	685_I	0.621	0.35
353_M	576_L	0.621	0.35
749_G	752_K	0.619	0.35
416_L	443_G	0.618	0.35
732_D	736_D	0.617	0.35
444_I	807_Q	0.617	0.35
117_A	126_S	0.616	0.35
331_L	337_A	0.616	0.35
27_L	81_I	0.616	0.35
530_H	534_L	0.616	0.35
121_W	483_S	0.615	0.34
627_N	654_C	0.614	0.34
332_I	335_Q	0.613	0.34
112_F	120_Y	0.612	0.34
186_Q	190_A	0.612	0.34
109_C	584_Y	0.612	0.34
158_G	686_L	0.611	0.34
31_C	228_A	0.611	0.34
742_E	752_K	0.611	0.34
567_G	647_D	0.610	0.34
31_C	312_I	0.610	0.34
27_L	514_I	0.610	0.34
591_N	631_I	0.608	0.34
513_L	516_W	0.608	0.34
612_K	615_R	0.608	0.34
473_A	479_V	0.608	0.34
636_Q	654_C	0.608	0.34
351_N	617_I	0.607	0.34
13_K	425_D	0.606	0.34
601_H	642_L	0.606	0.34
339_S	343_A	0.606	0.34
87_S	91_W	0.606	0.34
72_A	198_L	0.605	0.34
662_R	666_L	0.602	0.33
314_A	323_T	0.601	0.33
243_N	540_I	0.601	0.33
600_F	613_E	0.600	0.33
733_S	740_M	0.599	0.33
437_R	441_G	0.598	0.33
351_N	652_Q	0.598	0.33
448_V	657_D	0.598	0.33
347_Q	601_H	0.598	0.33
440_R	655_P	0.598	0.33
456_A	576_L	0.597	0.33
441_G	475_V	0.597	0.33
312_I	527_L	0.597	0.33
803_S	808_L	0.597	0.33
113_N	119_L	0.596	0.33
13_K	346_T	0.596	0.33
347_Q	442_L	0.595	0.33
156_V	729_Q	0.595	0.33
512_P	516_W	0.595	0.33
353_M	482_L	0.594	0.33
28_I	34_V	0.594	0.33
774_Y	777_Q	0.593	0.33
163_I	222_A	0.593	0.33
351_N	613_E	0.592	0.33
375_G	381_H	0.592	0.33
592_N	595_V	0.591	0.33
53_C	60_K	0.591	0.33
300_V	312_I	0.590	0.32
526_D	552_P	0.590	0.32
358_E	620_F	0.589	0.32
464_L	787_T	0.589	0.32
210_I	213_I	0.589	0.32
555_T	558_E	0.589	0.32
190_A	193_E	0.588	0.32
602_A	741_D	0.588	0.32
13_K	662_R	0.588	0.32
28_I	476_G	0.587	0.32
277_K	280_Y	0.586	0.32
192_E	565_N	0.586	0.32
171_K	180_L	0.586	0.32
150_F	454_V	0.586	0.32
791_E	808_L	0.586	0.32
178_A	183_Y	0.585	0.32
368_P	373_A	0.584	0.32
398_E	589_E	0.584	0.32
149_W	153_V	0.584	0.32
192_E	725_D	0.583	0.32
801_Q	804_S	0.582	0.32
92_L	172_S	0.581	0.32
70_F	445_G	0.581	0.32
118_G	608_D	0.581	0.32
422_C	640_Q	0.581	0.32
223_G	443_G	0.579	0.32
297_Q	669_H	0.578	0.32
712_H	716_L	0.578	0.32
349_T	655_P	0.578	0.32
425_D	613_E	0.577	0.31
406_W	415_F	0.577	0.31
237_T	241_L	0.577	0.31
124_Q	555_T	0.576	0.31
422_C	730_W	0.576	0.31
230_W	339_S	0.576	0.31
727_Y	731_L	0.575	0.31
198_L	231_L	0.575	0.31
42_W	45_S	0.575	0.31
557_L	563_A	0.575	0.31
175_E	181_A	0.574	0.31
193_E	206_A	0.573	0.31
270_L	301_D	0.573	0.31
260_R	273_L	0.573	0.31
223_G	425_D	0.571	0.31
341_I	443_G	0.571	0.31
403_C	707_W	0.571	0.31
209_S	214_P	0.571	0.31
38_A	67_L	0.570	0.31
487_P	656_A	0.570	0.31
461_M	482_L	0.569	0.31
322_E	353_M	0.569	0.31
123_N	150_F	0.569	0.31
437_R	478_S	0.567	0.31
347_Q	443_G	0.567	0.31
348_A	577_V	0.567	0.31
327_Y	449_L	0.566	0.31
477_G	727_Y	0.566	0.31
264_A	297_Q	0.565	0.31
202_F	755_S	0.564	0.30
446_R	630_R	0.563	0.30
252_A	255_T	0.563	0.30
413_K	442_L	0.562	0.30
16_K	26_L	0.562	0.30
118_G	158_G	0.562	0.30
570_V	650_I	0.562	0.30
179_S	183_Y	0.561	0.30
226_S	312_I	0.561	0.30
733_S	754_E	0.560	0.30
319_G	668_R	0.560	0.30
438_F	442_L	0.560	0.30
563_A	682_V	0.559	0.30
341_I	415_F	0.559	0.30
678_F	687_L	0.558	0.30
521_G	525_F	0.558	0.30
515_N	519_V	0.558	0.30
313_E	574_C	0.558	0.30
160_H	668_R	0.557	0.30
317_G	668_R	0.557	0.30
320_K	668_R	0.557	0.30
661_Q	668_R	0.557	0.30
665_R	668_R	0.557	0.30
109_C	114_H	0.557	0.30
230_W	349_T	0.556	0.30
306_A	562_A	0.556	0.30
349_T	651_T	0.556	0.30
161_G	230_W	0.556	0.30
459_T	471_A	0.556	0.30
660_F	730_W	0.555	0.30
639_E	658_L	0.555	0.30
368_P	372_L	0.555	0.30
359_A	554_L	0.555	0.30
173_R	504_P	0.553	0.30
352_A	683_A	0.553	0.30
166_S	594_Q	0.552	0.30
598_D	613_E	0.552	0.30
14_S	634_A	0.552	0.30
378_R	381_H	0.551	0.29
161_G	577_V	0.551	0.29
350_A	634_A	0.550	0.29
197_V	539_S	0.548	0.29
61_Q	558_E	0.548	0.29
535_P	677_G	0.548	0.29
706_M	712_H	0.548	0.29
222_A	341_I	0.548	0.29
12_G	15_S	0.548	0.29
115_G	122_F	0.547	0.29
234_W	348_A	0.547	0.29
437_R	461_M	0.547	0.29
230_W	233_S	0.546	0.29
464_L	632_L	0.545	0.29
230_W	456_A	0.545	0.29
724_P	728_R	0.545	0.29
709_T	713_I	0.544	0.29
693_Y	698_H	0.544	0.29
557_L	749_G	0.544	0.29
408_S	808_L	0.544	0.29
196_S	212_D	0.544	0.29
614_N	697_E	0.543	0.29
518_G	618_S	0.543	0.29
12_G	225_C	0.543	0.29
319_G	645_D	0.543	0.29
11_W	14_S	0.542	0.29
770_W	773_E	0.542	0.29
446_R	476_G	0.542	0.29
369_N	417_G	0.542	0.29
403_C	407_L	0.542	0.29
464_L	470_K	0.541	0.29
781_E	784_L	0.541	0.29
236_T	556_M	0.541	0.29
450_I	743_P	0.540	0.29
198_L	214_P	0.539	0.29
55_N	312_I	0.538	0.29
11_W	469_L	0.538	0.29
653_H	706_M	0.538	0.29
284_H	748_N	0.538	0.29
758_C	761_R	0.538	0.29
298_V	301_D	0.537	0.28
256_Y	259_D	0.537	0.28
183_Y	187_D	0.537	0.28
344_L	350_A	0.537	0.28
797_L	801_Q	0.537	0.28
386_I	390_A	0.536	0.28
687_L	690_G	0.536	0.28
414_V	420_G	0.535	0.28
89_E	92_L	0.535	0.28
604_F	613_E	0.534	0.28
436_H	439_I	0.534	0.28
362_S	534_L	0.533	0.28
433_P	644_V	0.533	0.28
518_G	570_V	0.532	0.28
72_A	629_G	0.531	0.28
200_A	295_Q	0.531	0.28
336_I	685_I	0.531	0.28
324_A	655_P	0.530	0.28
599_L	651_T	0.530	0.28
210_I	712_H	0.530	0.28
650_I	687_L	0.530	0.28
297_Q	788_R	0.529	0.28
444_I	499_G	0.529	0.28
382_L	721_L	0.528	0.28
224_F	631_I	0.528	0.28
356_R	643_D	0.528	0.28
313_E	486_L	0.527	0.28
357_M	610_R	0.527	0.28
430_S	441_G	0.526	0.28
26_L	215_P	0.524	0.28
375_G	380_N	0.524	0.28
482_L	655_P	0.524	0.28
745_W	766_K	0.524	0.28
598_D	632_L	0.523	0.27
683_A	746_V	0.523	0.27
123_N	153_V	0.523	0.27
42_W	314_A	0.523	0.27
642_L	662_R	0.521	0.27
436_H	669_H	0.520	0.27
216_D	219_S	0.519	0.27
427_V	481_L	0.519	0.27
50_N	503_D	0.518	0.27
351_N	488_M	0.518	0.27
156_V	499_G	0.518	0.27
565_N	572_L	0.518	0.27
31_C	347_Q	0.518	0.27
461_M	640_Q	0.517	0.27
353_M	413_K	0.517	0.27
286_L	295_Q	0.517	0.27
157_T	164_L	0.516	0.27
197_V	202_F	0.516	0.27
454_V	488_M	0.515	0.27
790_G	793_S	0.515	0.27
265_S	283_V	0.515	0.27
290_G	298_V	0.514	0.27
87_S	721_L	0.514	0.27
222_A	226_S	0.514	0.27
40_C	44_Q	0.514	0.27
714_E	729_Q	0.513	0.27
290_G	300_V	0.513	0.27
80_D	361_A	0.513	0.27
527_L	750_M	0.513	0.27
233_S	311_V	0.512	0.27
367_S	540_I	0.512	0.27
163_I	443_G	0.512	0.27
487_P	637_V	0.512	0.27
744_E	756_A	0.511	0.27
203_L	206_A	0.511	0.27
419_I	479_V	0.510	0.27
324_A	347_Q	0.510	0.27
113_N	121_W	0.510	0.27
223_G	651_T	0.510	0.27
167_Q	170_D	0.509	0.26
356_R	671_R	0.509	0.26
13_K	30_H	0.508	0.26
479_V	495_L	0.508	0.26
174_W	189_Q	0.508	0.26
233_S	647_D	0.508	0.26
614_N	618_S	0.508	0.26
23_D	87_S	0.507	0.26
171_K	299_L	0.507	0.26
620_F	631_I	0.507	0.26
465_L	482_L	0.507	0.26
464_L	471_A	0.507	0.26
461_M	483_S	0.506	0.26
284_H	300_V	0.506	0.26
796_L	801_Q	0.506	0.26
789_D	797_L	0.506	0.26
563_A	648_W	0.505	0.26
347_Q	581_Q	0.505	0.26
194_W	199_E	0.504	0.26
504_P	725_D	0.504	0.26
77_G	84_Q	0.504	0.26
71_I	487_P	0.502	0.26
13_K	641_S	0.502	0.26
103_G	107_Q	0.502	0.26
455_H	483_S	0.501	0.26
375_G	443_G	0.501	0.26
29_Y	33_D	0.501	0.26
355_T	618_S	0.501	0.26
749_G	754_E	0.501	0.26
465_L	648_W	0.500	0.26
789_D	795_P	0.500	0.26
756_A	759_E	0.500	0.26
640_Q	651_T	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qqwA	2	0.9313	100	0.456	Contact Map
4q2cA	1	0.9538	100	0.469	Contact Map
3eiqA	1	0.4043	100	0.818	Contact Map
3peyA	1	0.4245	100	0.819	Contact Map
1xtiA	1	0.4223	100	0.819	Contact Map
4ct4B	1	0.42	100	0.819	Contact Map
1s2mA	1	0.4189	100	0.819	Contact Map
1hv8A	2	0.4032	100	0.819	Contact Map
2i4iA	1	0.4302	100	0.82	Contact Map
1fuuA	2	0.4223	100	0.82	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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