GREMLIN Database
PUUB - Gamma-glutamylputrescine oxidoreductase
UniProt: P37906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11822
Length: 426 (348)
Sequences: 24845 (17695)
Seq/√Len: 948.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_I199_G4.7371.00
28_C54_V3.8871.00
58_A206_A3.2921.00
29_D228_K2.9301.00
31_C218_V2.8821.00
31_C227_A2.8591.00
209_Q219_R2.7601.00
29_D52_D2.7581.00
206_A221_A2.7191.00
160_I172_A2.6971.00
54_V202_Y2.6861.00
108_R122_P2.5481.00
211_Q219_R2.4951.00
48_E113_R2.4641.00
261_E331_K2.4621.00
217_V224_Q2.4591.00
156_D159_A2.4321.00
211_Q217_V2.4011.00
30_V46_L2.3741.00
219_R224_Q2.2871.00
47_A197_N2.2591.00
31_C56_L2.2481.00
51_F383_R2.2281.00
52_D200_R2.2141.00
102_E376_R2.1971.00
56_L225_V2.1681.00
134_L171_G2.0831.00
47_A199_G2.0331.00
229_Y358_Y2.0161.00
159_A162_R2.0141.00
27_T226_T2.0121.00
42_S231_I1.9911.00
151_Q177_S1.9691.00
153_E159_A1.9561.00
27_T228_K1.9311.00
45_H376_R1.9251.00
44_L193_A1.9031.00
255_T340_F1.9021.00
40_L187_A1.8971.00
30_V51_F1.8751.00
40_L191_A1.8471.00
109_E113_R1.8281.00
61_I203_E1.8251.00
138_E154_L1.8111.00
106_I376_R1.8031.00
48_E197_N1.7821.00
380_E385_D1.7611.00
314_R318_P1.7461.00
360_M374_A1.7281.00
360_M378_I1.7261.00
31_C225_V1.7251.00
157_A161_R1.7041.00
217_V226_T1.6841.00
45_H375_G1.6841.00
44_L48_E1.6821.00
142_E146_R1.6781.00
193_A196_L1.6711.00
363_Y374_A1.6601.00
28_C200_R1.6521.00
141_K145_E1.6431.00
49_A383_R1.6381.00
238_L361_Q1.6321.00
153_E176_H1.6271.00
358_Y378_I1.6061.00
107_I186_L1.5931.00
231_I382_L1.5911.00
358_Y382_L1.5841.00
138_E142_E1.5831.00
35_G61_I1.5801.00
153_E174_L1.5671.00
193_A197_N1.5501.00
142_E145_E1.5361.00
47_A194_I1.5351.00
208_T219_R1.5341.00
232_V238_L1.5291.00
207_V218_V1.5281.00
261_E333_D1.5171.00
49_A385_D1.5041.00
28_C31_C1.5021.00
220_T223_G1.4891.00
38_T360_M1.4871.00
213_T217_V1.4741.00
229_Y382_L1.4651.00
61_I191_A1.4621.00
134_L138_E1.4601.00
277_C280_D1.4571.00
202_Y205_S1.4501.00
317_V321_L1.4431.00
208_T221_A1.4381.00
191_A201_V1.4281.00
106_I109_E1.4281.00
232_V357_I1.4261.00
182_H185_N1.4241.00
135_A138_E1.4181.00
192_D196_L1.4081.00
35_G55_V1.4071.00
60_R203_E1.4071.00
192_D195_R1.4021.00
38_T363_Y1.3971.00
310_D314_R1.3911.00
59_S63_F1.3881.00
131_D170_T1.3761.00
380_E388_R1.3701.00
102_E105_E1.3651.00
37_Y371_T1.3621.00
30_V229_Y1.3411.00
59_S64_G1.3361.00
45_H48_E1.3321.00
119_D185_N1.3281.00
31_C54_V1.3281.00
220_T225_V1.3251.00
42_S360_M1.3241.00
155_L159_A1.3211.00
205_S220_T1.3191.00
46_L379_A1.3181.00
217_V220_T1.3111.00
211_Q224_Q1.3011.00
54_V225_V1.2891.00
45_H49_A1.2731.00
191_A195_R1.2581.00
260_T263_L1.2571.00
353_L359_Y1.2491.00
232_V359_Y1.2431.00
41_S45_H1.2421.00
49_A379_A1.2381.00
33_V234_G1.2361.00
43_A53_V1.2341.00
40_L55_V1.2261.00
40_L194_I1.2221.00
163_E174_L1.2191.00
105_E109_E1.2131.00
158_N162_R1.2081.00
56_L227_A1.1941.00
131_D135_A1.1931.00
139_E142_E1.1901.00
227_A230_V1.1891.00
234_G242_V1.1881.00
32_V43_A1.1861.00
376_R380_E1.1791.00
62_G187_A1.1781.00
29_D51_F1.1721.00
358_Y381_L1.1601.00
159_A163_E1.1551.00
210_I230_V1.1521.00
213_T226_T1.1461.00
375_G379_A1.1351.00
234_G238_L1.1341.00
155_L163_E1.1321.00
41_S190_E1.1241.00
29_D54_V1.1221.00
114_Y193_A1.1191.00
377_L380_E1.1151.00
313_E335_R1.1131.00
109_E112_K1.1121.00
360_M363_Y1.1051.00
56_L207_V1.1041.00
56_L202_Y1.1011.00
33_V230_V1.0981.00
352_R355_T1.0951.00
28_C52_D1.0831.00
212_H216_A1.0721.00
134_L170_T1.0701.00
184_L188_I1.0601.00
130_N133_Q1.0551.00
61_I201_V1.0511.00
35_G57_E1.0511.00
55_V201_V1.0501.00
120_Y179_G1.0481.00
42_S375_G1.0471.00
141_K154_L1.0451.00
348_P351_G1.0441.00
215_P226_T1.0431.00
151_Q176_H1.0411.00
319_K322_K1.0401.00
124_G174_L1.0391.00
153_E163_E1.0381.00
42_S233_A1.0311.00
350_F374_A1.0231.00
44_L197_N1.0221.00
181_I186_L1.0211.00
348_P352_R1.0211.00
216_A230_V1.0191.00
43_A55_V1.0151.00
229_Y352_R1.0091.00
141_K173_L1.0081.00
135_A139_E1.0051.00
128_A137_L1.0011.00
111_I118_C1.0011.00
41_S371_T1.0001.00
108_R112_K0.9861.00
41_S375_G0.9861.00
49_A380_E0.9811.00
104_G108_R0.9801.00
134_L154_L0.9801.00
46_L51_F0.9721.00
102_E106_I0.9681.00
205_S222_K0.9671.00
107_I371_T0.9661.00
240_D244_P0.9631.00
313_E317_V0.9601.00
117_D185_N0.9531.00
54_V200_R0.9491.00
166_S169_Y0.9491.00
276_Y279_E0.9491.00
102_E373_L0.9451.00
32_V42_S0.9441.00
68_R336_W0.9431.00
318_P321_L0.9421.00
189_G193_A0.9401.00
309_P312_V0.9341.00
103_G107_I0.9321.00
229_Y356_N0.9281.00
181_I368_V0.9231.00
232_V243_E0.9191.00
295_R333_D0.9171.00
43_A199_G0.9151.00
56_L220_T0.9151.00
298_Y320_L0.9111.00
40_L201_V0.9091.00
264_S267_L0.9051.00
286_D289_R0.9051.00
379_A382_L0.9051.00
210_I216_A0.9031.00
202_Y225_V0.9021.00
154_L171_G0.8961.00
53_V199_G0.8961.00
212_H356_N0.8921.00
45_H106_I0.8841.00
161_R166_S0.8821.00
318_P322_K0.8791.00
321_L328_K0.8781.00
186_L368_V0.8761.00
186_L372_H0.8761.00
286_D290_L0.8711.00
215_P228_K0.8641.00
348_P353_L0.8561.00
260_T298_Y0.8551.00
116_I189_G0.8501.00
230_V356_N0.8501.00
189_G192_D0.8481.00
205_S225_V0.8451.00
145_E152_L0.8451.00
98_S102_E0.8431.00
110_R114_Y0.8411.00
233_A360_M0.8411.00
33_V207_V0.8391.00
212_H215_P0.8381.00
60_R204_L0.8341.00
43_A194_I0.8331.00
259_T297_L0.8311.00
258_I332_I0.8301.00
60_R63_F0.8291.00
352_R358_Y0.8251.00
256_Q303_V0.8191.00
352_R381_L0.8171.00
210_I218_V0.8171.00
103_G373_L0.8161.00
207_V210_I0.8151.00
185_N188_I0.8141.00
276_Y280_D0.8111.00
37_Y66_S0.8111.00
30_V231_I0.8051.00
229_Y232_V0.8041.00
27_T52_D0.8031.00
74_V366_H0.7981.00
137_L141_K0.7981.00
57_E60_R0.7941.00
261_E295_R0.7911.00
107_I372_H0.7901.00
259_T334_Y0.7881.00
348_P354_D0.7881.00
128_A134_L0.7881.00
138_E141_K0.7871.00
154_L173_L0.7861.00
51_F229_Y0.7821.00
194_I201_V0.7821.00
160_I169_Y0.7811.00
42_S382_L0.7781.00
99_M377_L0.7781.00
125_L128_A0.7751.00
157_A160_I0.7741.00
101_F105_E0.7721.00
212_H355_T0.7711.00
315_L319_K0.7711.00
131_D134_L0.7691.00
315_L318_P0.7691.00
28_C228_K0.7681.00
243_E359_Y0.7671.00
37_Y187_A0.7661.00
55_V199_G0.7641.00
65_A236_A0.7631.00
253_C342_L0.7621.00
68_R338_G0.7601.00
158_N161_R0.7591.00
44_L190_E0.7571.00
106_I373_L0.7561.00
71_G183_P0.7531.00
352_R356_N0.7511.00
250_S341_L0.7501.00
206_A240_D0.7441.00
350_F353_L0.7421.00
350_F378_I0.7361.00
186_L190_E0.7351.00
343_T362_G0.7351.00
380_E387_E0.7341.00
74_V369_T0.7341.00
136_T139_E0.7341.00
155_L160_I0.7321.00
46_L382_L0.7321.00
350_F354_D0.7291.00
254_G337_T0.7291.00
254_G303_V0.7271.00
260_T332_I0.7261.00
75_N101_F0.7181.00
195_R201_V0.7171.00
148_G151_Q0.7141.00
194_I198_G0.7141.00
216_A357_I0.7131.00
33_V232_V0.7121.00
205_S221_A0.7091.00
41_S372_H0.7081.00
143_N146_R0.7081.00
216_A356_N0.7041.00
321_L329_G0.7041.00
251_M304_Y0.7031.00
276_Y281_C0.7031.00
366_H369_T0.7021.00
259_T295_R0.7001.00
387_E390_D0.7001.00
42_S378_I0.6921.00
228_K356_N0.6911.00
99_M373_L0.6911.00
351_G354_D0.6891.00
215_P355_T0.6861.00
52_D228_K0.6841.00
105_E108_R0.6841.00
187_A191_A0.6801.00
231_I378_I0.6791.00
49_A376_R0.6791.00
373_L376_R0.6781.00
122_P177_S0.6761.00
58_A64_G0.6721.00
303_V312_V0.6701.00
208_T220_T0.6691.00
258_I316_V0.6681.00
125_L160_I0.6681.00
37_Y368_V0.6681.00
111_I117_D0.6661.00
161_R167_D0.6621.00
66_S187_A0.6621.00
121_R180_H0.6611.00
111_I114_Y0.6601.00
31_C230_V0.6591.00
58_A237_Y0.6561.00
207_V220_T0.6531.00
252_P339_N0.6531.00
26_I202_Y0.6511.00
155_L174_L0.6481.00
349_Q352_R0.6471.00
141_K152_L0.6471.00
47_A52_D0.6451.00
41_S186_L0.6431.00
29_D226_T0.6421.00
45_H379_A0.6401.00
237_Y240_D0.6401.00
287_Y299_G0.6401.00
66_S69_N0.6391.00
190_E371_T0.6391.00
277_C281_C0.6391.00
379_A383_R0.6351.00
191_A203_E0.6341.00
317_V335_R0.6321.00
163_E276_Y0.6311.00
70_G287_Y0.6301.00
106_I372_H0.6291.00
139_E143_N0.6291.00
314_R317_V0.6271.00
387_E391_A0.6261.00
210_I232_V0.6251.00
100_M370_C0.6231.00
160_I163_E0.6231.00
48_E193_A0.6221.00
55_V191_A0.6211.00
195_R200_R0.6211.00
38_T374_A0.6201.00
256_Q309_P0.6161.00
185_N189_G0.6161.00
134_L137_L0.6151.00
256_Q337_T0.6151.00
343_T349_Q0.6141.00
103_G106_I0.6111.00
97_G101_F0.6101.00
175_D178_G0.6081.00
285_L288_Y0.6081.00
99_M103_G0.6081.00
217_V230_V0.6071.00
144_W147_Y0.6061.00
156_D160_I0.6051.00
188_I192_D0.6031.00
49_A384_G0.6011.00
244_P247_A0.6011.00
111_I116_I0.5991.00
301_G304_Y0.5971.00
319_K323_T0.5941.00
57_E203_E0.5941.00
124_G176_H0.5931.00
257_V336_W0.5901.00
144_W152_L0.5891.00
32_V53_V0.5891.00
114_Y189_G0.5891.00
215_P356_N0.5881.00
371_T375_G0.5871.00
168_R322_K0.5871.00
210_I357_I0.5861.00
207_V242_V0.5861.00
72_Q287_Y0.5801.00
26_I54_V0.5801.00
297_L300_G0.5791.00
73_L107_I0.5771.00
156_D162_R0.5761.00
253_C302_V0.5761.00
44_L110_R0.5741.00
143_N147_Y0.5741.00
205_S223_G0.5741.00
321_L327_L0.5741.00
343_T346_R0.5731.00
98_S101_F0.5731.00
101_F104_G0.5721.00
275_N280_D0.5721.00
77_Y369_T0.5701.00
302_V365_G0.5701.00
44_L194_I0.5701.00
26_I52_D0.5681.00
73_L181_I0.5671.00
125_L155_L0.5641.00
232_V242_V0.5621.00
105_E177_S0.5611.00
47_A53_V0.5591.00
341_L363_Y0.5581.00
108_R120_Y0.5571.00
309_P313_E0.5571.00
138_E171_G0.5571.00
96_L100_M0.5551.00
275_N279_E0.5541.00
363_Y371_T0.5541.00
29_D227_A0.5521.00
275_N278_V0.5511.00
360_M375_G0.5501.00
56_L205_S0.5501.00
332_I335_R0.5481.00
26_I200_R0.5481.00
343_T364_S0.5471.00
285_L289_R0.5451.00
236_A339_N0.5451.00
242_V245_E0.5451.00
140_Q144_W0.5441.00
310_D313_E0.5431.00
69_N368_V0.5401.00
231_I358_Y0.5401.00
308_D313_E0.5391.00
144_W148_G0.5391.00
238_L250_S0.5371.00
243_E357_I0.5371.00
351_G359_Y0.5361.00
311_D314_R0.5351.00
62_G184_L0.5331.00
287_Y290_L0.5331.00
45_H110_R0.5311.00
280_D283_Y0.5311.00
106_I110_R0.5311.00
380_E384_G0.5301.00
100_M369_T0.5281.00
308_D335_R0.5281.00
208_T211_Q0.5271.00
212_H217_V0.5271.00
314_R329_G0.5271.00
157_A167_D0.5261.00
278_V281_C0.5251.00
77_Y126_F0.5251.00
75_N175_D0.5251.00
353_L357_I0.5241.00
64_G68_R0.5211.00
194_I197_N0.5211.00
72_Q178_G0.5201.00
377_L391_A0.5201.00
202_Y223_G0.5191.00
325_P328_K0.5191.00
77_Y178_G0.5171.00
73_L369_T0.5161.00
373_L377_L0.5151.00
55_V194_I0.5151.00
119_D292_A0.5141.00
129_M133_Q0.5141.00
209_Q212_H0.5141.00
76_S80_D0.5141.00
284_L290_L0.5141.00
107_I111_I0.5131.00
100_M104_G0.5121.00
119_D182_H0.5111.00
204_L222_K0.5111.00
155_L172_A0.5101.00
37_Y186_L0.5101.00
44_L113_R0.5091.00
254_G339_N0.5091.00
388_R391_A0.5081.00
316_V319_K0.5071.00
101_F177_S0.5071.00
296_L299_G0.5071.00
372_H375_G0.5071.00
160_I164_V0.5051.00
258_I313_E0.5041.00
217_V356_N0.5031.00
44_L47_A0.5031.00
276_Y282_N0.5021.00
255_T301_G0.5021.00
211_Q226_T0.5021.00
218_V230_V0.5021.00
301_G340_F0.5021.00
54_V227_A0.5001.00
220_T224_Q0.5001.00
125_L174_L0.5001.00
152_L175_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h1bA 1 0.8427 100 0.364 Contact Map
1y56B 1 0.8404 100 0.401 Contact Map
3axbA 2 0.8545 100 0.405 Contact Map
2gagB 1 0.8944 100 0.407 Contact Map
4x9mA 1 0.8427 100 0.409 Contact Map
3pvcA 1 0.8944 100 0.409 Contact Map
2gf3A 1 0.8521 100 0.41 Contact Map
4rslA 1 0.8897 100 0.415 Contact Map
3ps9A 1 0.8897 100 0.418 Contact Map
1ryiA 4 0.8192 100 0.42 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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