GREMLIN Database
USPF - Universal stress protein F
UniProt: P37903 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12674
Length: 144 (132)
Sequences: 19871 (16008)
Seq/√Len: 1393.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_H89_H3.1381.00
6_L108_A2.8251.00
96_K131_A2.7061.00
4_T36_H2.6991.00
34_E87_H2.5501.00
23_H141_L2.5401.00
4_T34_E2.4041.00
89_H102_L2.2971.00
110_M141_L2.2871.00
36_H87_H1.9681.00
113_I132_V1.9401.00
111_I138_C1.9341.00
93_G98_R1.9231.00
76_I88_V1.9231.00
36_H108_A1.8761.00
130_A134_R1.8471.00
91_E98_R1.8401.00
34_E85_R1.7641.00
36_H102_L1.7601.00
103_A111_I1.7511.00
8_P113_I1.6691.00
7_V24_V1.6691.00
40_V98_R1.6571.00
38_L102_L1.6551.00
22_S78_K1.5831.00
8_P99_I1.5221.00
39_T68_A1.5181.00
98_R101_E1.5121.00
76_I80_K1.5021.00
104_K137_E1.4481.00
111_I136_A1.4191.00
27_E31_D1.4191.00
65_K69_K1.3691.00
91_E102_L1.3691.00
69_K73_E1.3471.00
33_A109_H1.3461.00
100_L135_H1.3441.00
18_Q78_K1.3381.00
7_V21_I1.3241.00
131_A135_H1.3181.00
103_A137_E1.2841.00
4_T109_H1.2631.00
24_V28_A1.2371.00
111_I132_V1.2171.00
38_L91_E1.1941.00
95_P128_N1.1801.00
40_V95_P1.1601.00
120_I124_L1.1591.00
102_L108_A1.1111.00
78_K81_L1.1091.00
9_I75_I1.0991.00
73_E88_V1.0961.00
73_E76_I1.0961.00
136_A140_V1.0941.00
115_S142_V1.0441.00
103_A138_C1.0391.00
4_T108_A1.0371.00
5_I110_M1.0311.00
11_I39_T1.0281.00
26_E30_I1.0221.00
41_I92_E1.0111.00
113_I129_A1.0091.00
73_E77_K1.0041.00
71_Q75_I0.9951.00
29_K82_P0.9941.00
23_H27_E0.9901.00
17_T20_V0.9851.00
100_L103_A0.9771.00
103_A108_A0.9601.00
18_Q74_E0.9591.00
61_M65_K0.9571.00
62_D66_A0.9501.00
39_T71_Q0.9421.00
122_T130_A0.9401.00
37_F86_V0.9381.00
72_L88_V0.9371.00
133_V142_V0.9321.00
21_I37_F0.9221.00
38_L99_I0.9191.00
120_I123_Y0.9181.00
71_Q74_E0.9061.00
28_A35_V0.8921.00
66_A70_S0.8901.00
75_I79_F0.8861.00
23_H26_E0.8831.00
31_D109_H0.8821.00
115_S129_A0.8691.00
25_E79_F0.8621.00
75_I78_K0.8561.00
9_I37_F0.8541.00
37_F75_I0.8541.00
23_H139_S0.8531.00
68_A71_Q0.8531.00
24_V112_I0.8521.00
24_V35_V0.8521.00
21_I75_I0.8481.00
12_S17_T0.8421.00
129_A142_V0.8381.00
6_L102_L0.8251.00
100_L132_V0.8251.00
9_I20_V0.8251.00
100_L136_A0.8221.00
64_L67_E0.8211.00
8_P114_A0.8111.00
68_A90_V0.8081.00
41_I90_V0.8071.00
68_A72_L0.8071.00
118_P121_T0.8061.00
6_L38_L0.8061.00
94_S97_D0.8051.00
56_A59_P0.7971.00
25_E84_D0.7941.00
77_K81_L0.7771.00
77_K80_K0.7701.00
67_E70_S0.7681.00
23_H143_V0.7661.00
54_Y57_E0.7651.00
25_E82_P0.7621.00
9_I21_I0.7611.00
18_Q22_S0.7571.00
29_K83_T0.7571.00
63_D66_A0.7511.00
21_I25_E0.7501.00
99_I132_V0.7491.00
19_R22_S0.7461.00
96_K128_N0.7441.00
117_R125_L0.7441.00
112_I141_L0.7441.00
6_L111_I0.7331.00
41_I68_A0.7331.00
74_E78_K0.7331.00
24_V33_A0.7321.00
74_E77_K0.7311.00
28_A33_A0.7301.00
9_I18_Q0.7241.00
7_V35_V0.7211.00
12_S117_R0.7201.00
107_P138_C0.7071.00
79_F86_V0.7001.00
98_R102_L0.7001.00
58_L62_D0.6981.00
65_K92_E0.6961.00
67_E71_Q0.6951.00
66_A69_K0.6891.00
125_L129_A0.6881.00
18_Q75_I0.6821.00
37_F79_F0.6781.00
70_S74_E0.6761.00
57_E60_A0.6751.00
11_I71_Q0.6751.00
27_E30_I0.6741.00
28_A31_D0.6721.00
59_P63_D0.6651.00
60_A63_D0.6581.00
11_I75_I0.6541.00
69_K88_V0.6511.00
55_S59_P0.6491.00
76_I86_V0.6481.00
40_V93_G0.6421.00
5_I28_A0.6421.00
113_I142_V0.6371.00
26_E29_K0.6361.00
112_I143_V0.6351.00
63_D67_E0.6341.00
72_L90_V0.6271.00
9_I17_T0.6271.00
38_L98_R0.6261.00
62_D65_K0.6191.00
5_I112_I0.6191.00
7_V20_V0.6111.00
25_E29_K0.6061.00
64_L68_A0.5981.00
59_P62_D0.5931.00
14_S19_R0.5881.00
104_K138_C0.5871.00
115_S124_L0.5851.00
133_V140_V0.5821.00
96_K100_L0.5821.00
61_M92_E0.5791.00
10_D17_T0.5791.00
27_E112_I0.5731.00
89_H92_E0.5721.00
96_K132_V0.5611.00
58_L61_M0.5601.00
97_D101_E0.5581.00
70_S73_E0.5491.00
132_V140_V0.5491.00
20_V112_I0.5481.00
116_H129_A0.5481.00
72_L76_I0.5411.00
45_P48_A0.5391.00
25_E78_K0.5371.00
69_K90_V0.5211.00
114_A143_V0.5201.00
27_E141_L0.5141.00
43_S92_E0.5091.00
78_K82_P0.5011.00
57_E61_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hgmA 2 0.9792 99.9 0.146 Contact Map
3s3tA 4 0.9722 99.9 0.147 Contact Map
1mjhA 2 0.9444 99.9 0.15 Contact Map
5ahwA 4 0.9792 99.9 0.154 Contact Map
4wnyA 2 0.875 99.9 0.155 Contact Map
2dumA 2 0.9514 99.9 0.161 Contact Map
2gm3A 2 0.8681 99.9 0.164 Contact Map
3fg9A 3 0.9583 99.9 0.168 Contact Map
3fdxA 2 0.8819 99.9 0.175 Contact Map
4r2kA 2 0.9861 99.9 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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