GREMLIN Database
GLTI - Glutamate/aspartate periplasmic-binding protein
UniProt: P37902 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12700
Length: 302 (248)
Sequences: 19234 (14087)
Seq/√Len: 894.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_G107_F3.8001.00
41_V89_K3.7701.00
157_V199_A3.6791.00
76_A255_Q2.9571.00
165_E183_S2.4291.00
186_D189_D2.4181.00
101_L107_F2.4031.00
43_V89_K2.3811.00
116_N235_G2.3741.00
128_D254_A2.3611.00
41_V87_Q2.2681.00
184_A193_T2.2491.00
118_V121_Q2.2431.00
263_E267_D2.1821.00
261_E264_K2.1791.00
254_A258_T2.1541.00
165_E169_N2.1451.00
116_N121_Q2.0941.00
72_A75_E2.0761.00
43_V91_I2.0481.00
155_A182_I2.0201.00
124_A237_M2.0141.00
246_K250_D2.0081.00
76_A252_T2.0021.00
103_Q123_Q1.9991.00
125_A246_K1.9861.00
147_D150_N1.9721.00
57_D63_V1.9551.00
238_L246_K1.9551.00
238_L249_M1.8991.00
128_D250_D1.8701.00
44_V70_S1.8601.00
74_V88_V1.8551.00
111_C236_C1.8231.00
146_K150_N1.8051.00
204_M209_L1.7461.00
190_S202_F1.7341.00
155_A180_R1.7281.00
72_A261_E1.6771.00
140_K143_G1.6771.00
138_L209_L1.6741.00
72_A256_V1.6321.00
193_T198_R1.6151.00
72_A76_A1.5951.00
34_D38_K1.5281.00
160_S185_K1.5261.00
243_P247_K1.5231.00
141_K221_N1.5221.00
68_D268_K1.5191.00
239_R242_D1.5171.00
142_G223_E1.4941.00
57_D61_K1.4831.00
101_L106_T1.4821.00
247_K251_D1.4781.00
166_V170_K1.4651.00
140_K197_G1.4491.00
125_A241_D1.4371.00
132_V233_A1.4121.00
248_L251_D1.4031.00
185_K189_D1.3981.00
76_A259_S1.3771.00
99_I124_A1.3551.00
71_N90_L1.3431.00
56_Y92_P1.3341.00
70_S111_C1.3261.00
48_E92_P1.3201.00
55_Y63_V1.3201.00
73_I252_T1.3171.00
93_I101_L1.3151.00
114_T237_M1.3111.00
98_R110_E1.2941.00
169_N183_S1.2891.00
206_D210_A1.2841.00
77_V86_L1.2821.00
152_K178_N1.2801.00
158_V165_E1.2781.00
154_K200_V1.2781.00
193_T199_A1.2751.00
67_Q71_N1.2691.00
40_G86_L1.2651.00
119_E122_K1.2601.00
110_E114_T1.2541.00
155_A200_V1.2481.00
127_S250_D1.2461.00
141_K223_E1.2391.00
137_L201_A1.2341.00
157_V184_A1.2331.00
156_V201_A1.2311.00
105_G239_R1.2121.00
68_D269_W1.2101.00
66_S130_I1.2091.00
61_K71_N1.1981.00
195_E221_N1.1881.00
252_T255_Q1.1821.00
167_L171_L1.1791.00
77_V252_T1.1721.00
34_D37_A1.1531.00
194_L222_W1.1521.00
44_V109_F1.1521.00
255_Q259_S1.1501.00
71_N75_E1.1461.00
136_R206_D1.1421.00
257_Q262_A1.1411.00
248_L252_T1.1331.00
35_K39_N1.1301.00
139_T225_V1.1241.00
135_T164_S1.1171.00
31_S244_Q1.1091.00
192_R195_E1.1071.00
44_V88_V1.1031.00
39_N43_V1.0921.00
100_P103_Q1.0921.00
65_Y265_W1.0841.00
69_Y256_V1.0831.00
136_R224_I1.0821.00
116_N129_T1.0821.00
65_Y270_F1.0741.00
252_T256_V1.0701.00
69_Y262_A1.0661.00
68_D71_N1.0641.00
194_L202_F1.0591.00
251_D255_Q1.0591.00
125_A240_K1.0581.00
93_I107_F1.0561.00
70_S90_L1.0551.00
65_Y266_F1.0411.00
56_Y60_Q1.0371.00
194_L199_A1.0351.00
33_L36_I1.0351.00
15_L18_G1.0311.00
172_N177_M1.0201.00
139_T201_A1.0191.00
94_T97_N1.0141.00
125_A243_P1.0111.00
192_R196_S1.0081.00
261_E265_W1.0071.00
159_T162_T1.0071.00
70_S88_V1.0051.00
172_N179_M1.0001.00
63_V68_D0.9921.00
184_A190_S0.9851.00
256_V261_E0.9781.00
109_F238_L0.9741.00
166_V169_N0.9681.00
267_D271_K0.9671.00
73_I249_M0.9631.00
264_K267_D0.9611.00
18_G21_Q0.9561.00
109_F249_M0.9531.00
157_V190_S0.9501.00
128_D257_Q0.9401.00
117_N120_R0.9371.00
118_V122_K0.9331.00
243_P246_K0.9321.00
264_K268_K0.9321.00
160_S183_S0.9301.00
244_Q248_L0.9281.00
36_I40_G0.9201.00
100_P104_N0.9171.00
188_G192_R0.9171.00
53_F131_F0.9011.00
99_I114_T0.9001.00
126_F237_M0.9001.00
189_D192_R0.8961.00
65_Y262_A0.8951.00
42_I74_V0.8871.00
102_L110_E0.8861.00
262_A266_F0.8851.00
62_V67_Q0.8841.00
139_T143_G0.8831.00
127_S249_M0.8821.00
103_Q124_A0.8701.00
133_V207_A0.8691.00
48_E62_V0.8641.00
95_S98_R0.8581.00
109_F236_C0.8511.00
250_D253_I0.8481.00
76_A261_E0.8471.00
218_K221_N0.8461.00
42_I109_F0.8451.00
255_Q258_T0.8441.00
36_I86_L0.8441.00
70_S236_C0.8431.00
137_L203_M0.8431.00
51_V55_Y0.8421.00
76_A256_V0.8411.00
31_S34_D0.8381.00
127_S238_L0.8371.00
151_L201_A0.8361.00
115_T232_E0.8341.00
33_L37_A0.8341.00
56_Y62_V0.8301.00
149_A152_K0.8301.00
139_T223_E0.8191.00
236_C249_M0.8161.00
144_D223_E0.8131.00
72_A252_T0.8011.00
86_L248_L0.7981.00
120_R126_F0.7981.00
250_D254_A0.7971.00
73_I111_C0.7971.00
22_A25_A0.7911.00
244_Q247_K0.7901.00
187_H204_M0.7881.00
36_I39_N0.7871.00
110_E237_M0.7851.00
42_I86_L0.7851.00
97_N101_L0.7821.00
71_N88_V0.7781.00
70_S109_F0.7761.00
121_Q240_K0.7721.00
172_N178_N0.7691.00
133_V206_D0.7671.00
158_V183_S0.7621.00
167_L170_K0.7611.00
77_V248_L0.7611.00
55_Y269_W0.7571.00
263_E266_F0.7561.00
46_H90_L0.7551.00
37_A40_G0.7531.00
32_T35_K0.7531.00
127_S236_C0.7501.00
256_V259_S0.7481.00
134_G206_D0.7451.00
19_L22_A0.7441.00
182_I193_T0.7431.00
73_I77_V0.7341.00
216_A219_P0.7321.00
69_Y253_I0.7301.00
251_D254_A0.7271.00
14_A17_A0.7221.00
46_H67_Q0.7221.00
266_F270_F0.7211.00
247_K250_D0.7201.00
50_S113_S0.7181.00
30_G35_K0.7121.00
46_H112_G0.7101.00
222_W225_V0.7051.00
191_F222_W0.7031.00
63_V269_W0.7011.00
91_I106_T0.6991.00
72_A265_W0.6961.00
138_L222_W0.6911.00
191_F195_E0.6901.00
256_V260_G0.6861.00
20_A23_D0.6851.00
136_R209_L0.6801.00
46_H62_V0.6801.00
125_A242_D0.6791.00
105_G241_D0.6771.00
12_A15_L0.6761.00
44_V90_L0.6731.00
256_V262_A0.6731.00
128_D253_I0.6711.00
168_L181_I0.6701.00
136_R226_G0.6691.00
189_D193_T0.6681.00
163_T232_E0.6661.00
168_L203_M0.6661.00
157_V193_T0.6641.00
17_A20_A0.6631.00
48_E54_S0.6611.00
47_R54_S0.6581.00
43_V108_D0.6561.00
138_L213_R0.6541.00
132_V231_Q0.6521.00
12_A16_S0.6511.00
184_A199_A0.6491.00
210_A224_I0.6451.00
54_S112_G0.6441.00
126_F235_G0.6421.00
13_L16_S0.6411.00
242_D245_F0.6411.00
18_G22_A0.6391.00
47_R112_G0.6391.00
15_L19_L0.6351.00
106_T198_R0.6341.00
156_V168_L0.6341.00
31_S35_K0.6331.00
91_I107_F0.6331.00
155_A199_A0.6281.00
97_N100_P0.6271.00
254_A257_Q0.6251.00
134_G230_S0.6241.00
45_G110_E0.6231.00
39_N108_D0.6221.00
182_I199_A0.6221.00
47_R95_S0.6201.00
204_M208_L0.6191.00
32_T239_R0.6191.00
45_G98_R0.6171.00
140_K221_N0.6131.00
102_L239_R0.6131.00
145_I150_N0.6131.00
129_T132_V0.6111.00
95_S114_T0.6021.00
116_N126_F0.5981.00
41_V86_L0.5971.00
169_N181_I0.5971.00
73_I236_C0.5951.00
76_A248_L0.5921.00
134_G228_P0.5921.00
219_P222_W0.5911.00
99_I103_Q0.5911.00
127_S253_I0.5891.00
35_K38_K0.5891.00
37_A248_L0.5861.00
115_T120_R0.5851.00
141_K220_D0.5851.00
16_S19_L0.5831.00
159_T187_H0.5811.00
21_Q24_D0.5801.00
103_Q239_R0.5791.00
156_V179_M0.5771.00
152_K177_M0.5771.00
260_G263_E0.5771.00
114_T124_A0.5721.00
68_D265_W0.5691.00
75_E261_E0.5681.00
70_S74_V0.5681.00
160_S165_E0.5661.00
217_K220_D0.5651.00
213_R222_W0.5651.00
135_T203_M0.5641.00
142_G197_G0.5641.00
195_E219_P0.5641.00
66_S113_S0.5641.00
256_V265_W0.5631.00
138_L191_F0.5621.00
98_R114_T0.5601.00
137_L151_L0.5601.00
205_D234_Y0.5571.00
144_D154_K0.5551.00
10_I14_A0.5531.00
67_Q90_L0.5531.00
74_V85_D0.5521.00
98_R107_F0.5521.00
168_L172_N0.5511.00
209_L213_R0.5501.00
30_G34_D0.5491.00
238_L242_D0.5491.00
115_T205_D0.5471.00
10_I13_L0.5461.00
265_W268_K0.5461.00
62_V92_P0.5441.00
52_P55_Y0.5391.00
102_L107_F0.5361.00
47_R159_T0.5361.00
57_D60_Q0.5351.00
206_D228_P0.5341.00
195_E222_W0.5331.00
146_K223_E0.5311.00
213_R224_I0.5281.00
133_V234_Y0.5281.00
74_V86_L0.5251.00
121_Q125_A0.5241.00
77_V245_F0.5241.00
33_L248_L0.5181.00
257_Q263_E0.5171.00
93_I98_R0.5161.00
32_T36_I0.5121.00
167_L230_S0.5111.00
257_Q260_G0.5101.00
14_A18_G0.5081.00
51_V211_G0.5041.00
11_L15_L0.5041.00
134_G229_Q0.5031.00
115_T163_T0.5021.00
121_Q126_F0.5011.00
42_I77_V0.5011.00
236_C253_I0.5011.00
107_F110_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vhaA 2 0.9139 100 0.328 Contact Map
2ylnA 1 0.7815 100 0.354 Contact Map
4ohnA 1 0.8046 100 0.355 Contact Map
4powA 1 0.7483 100 0.356 Contact Map
1pb7A 1 0.8278 100 0.357 Contact Map
4ymxA 1 0.7219 100 0.364 Contact Map
2yjpA 1 0.8146 100 0.364 Contact Map
1xt8A 1 0.8278 100 0.365 Contact Map
3hv1A 2 0.8675 100 0.369 Contact Map
3k4uA 5 0.7616 100 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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