GREMLIN Database
CHBG - UPF0249 protein ChbG
UniProt: P37794 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12198
Length: 249 (237)
Sequences: 1225 (989)
Seq/√Len: 64.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_V144_E5.7451.00
101_T140_R4.8631.00
75_G99_E3.3961.00
62_F104_L2.9691.00
38_V111_F2.9551.00
234_G238_Q2.7091.00
7_V30_I2.5931.00
109_L145_Q2.5821.00
21_G224_L2.5491.00
24_E28_N2.5381.00
26_C56_L2.3921.00
111_F119_P2.3581.00
38_V43_I2.3541.00
37_L63_V2.2571.00
150_R199_E2.2461.00
8_N33_S2.2441.00
101_T105_V2.1501.00
8_N35_T2.1291.00
16_K45_H2.1221.00
19_N45_H2.1071.00
39_N63_V2.1071.00
108_Y141_F2.0761.00
104_L138_V2.0651.00
39_N67_G2.0641.00
105_V109_L2.0631.00
32_T243_L2.0601.00
169_F201_M2.0351.00
71_T106_S1.9651.00
111_F115_F1.8931.00
9_A31_V1.8911.00
207_I211_I1.8261.00
24_E224_L1.7541.00
19_N42_A1.7491.00
25_A224_L1.7120.99
26_C55_S1.7090.99
109_L112_I1.7040.99
137_I141_F1.6750.99
57_A120_T1.6420.99
62_F108_Y1.6060.99
71_T77_T1.6050.99
23_I49_L1.6000.99
9_A204_P1.5780.99
27_R53_E1.5490.99
8_N199_E1.5420.99
45_H49_L1.5390.99
22_I34_T1.5320.99
19_N46_A1.5170.99
127_H201_M1.5110.99
73_M77_T1.5050.99
38_V60_M1.5020.99
8_N121_H1.4930.98
7_V232_L1.4800.98
60_M122_L1.4670.98
221_L225_D1.4640.98
15_S19_N1.4440.98
63_V66_M1.4350.98
9_A22_I1.4350.98
20_Y45_H1.4070.98
103_E106_S1.4070.98
6_I32_T1.4060.98
36_A46_A1.3990.98
104_L141_F1.3870.97
57_A245_S1.3790.97
141_F145_Q1.3780.97
35_T123_D1.3570.97
71_T102_Q1.3480.97
20_Y206_F1.3480.97
21_G25_A1.3140.96
111_F117_R1.3040.96
235_A239_R1.2930.96
108_Y122_L1.2920.96
64_L104_L1.2850.96
25_A228_T1.2840.96
18_Q211_I1.2830.96
202_C227_L1.2790.96
35_T121_H1.2760.96
37_L40_G1.2730.96
17_G208_D1.2730.96
122_L142_A1.2730.96
190_A198_L1.2690.96
8_N123_D1.2580.95
25_A31_V1.2530.95
5_L200_V1.2520.95
20_Y24_E1.2440.95
60_M108_Y1.2230.95
13_G19_N1.2160.95
75_G96_P1.2150.95
70_L110_R1.2030.94
109_L141_F1.2020.94
225_D229_S1.1940.94
39_N70_L1.1870.94
108_Y112_I1.1770.94
105_V145_Q1.1740.93
100_I134_I1.1700.93
219_P222_T1.1700.93
5_L241_Y1.1640.93
60_M111_F1.1600.93
108_Y145_Q1.1450.93
33_S121_H1.1420.93
59_G121_H1.1260.92
34_T50_S1.1220.92
62_F141_F1.1110.91
65_T126_H1.0970.91
69_P77_T1.0960.91
38_V110_R1.0960.91
206_F224_L1.0940.91
73_M76_L1.0940.91
223_E227_L1.0880.91
8_N150_R1.0600.89
43_I115_F1.0590.89
99_E102_Q1.0550.89
73_M99_E1.0460.89
109_L113_E1.0460.89
46_A50_S1.0390.88
24_E206_F1.0350.88
112_I145_Q1.0270.88
14_L18_Q1.0240.88
180_E229_S1.0240.88
105_V141_F1.0170.87
10_D13_G1.0020.87
69_P103_E0.9960.86
117_R120_T0.9950.86
224_L228_T0.9940.86
127_H223_E0.9900.86
205_A224_L0.9830.85
19_N36_A0.9750.85
17_G207_I0.9690.85
22_I150_R0.9660.84
63_V67_G0.9660.84
100_I104_L0.9630.84
12_F22_I0.9610.84
24_E228_T0.9560.84
180_E184_L0.9500.83
19_N37_L0.9420.83
20_Y49_L0.9410.83
19_N40_G0.9410.83
12_F19_N0.9400.83
184_L231_S0.9390.83
139_A158_D0.9360.83
33_S123_D0.9360.83
98_E234_G0.9350.83
166_T199_E0.9330.82
4_L242_R0.9320.82
179_S182_L0.9080.81
104_L134_I0.9020.80
5_L243_L0.9020.80
123_D223_E0.8960.80
8_N201_M0.8960.80
97_L137_I0.8960.80
60_M141_F0.8860.79
8_N57_A0.8810.79
16_K24_E0.8790.78
26_C54_P0.8760.78
18_Q205_A0.8730.78
50_S121_H0.8720.78
7_V31_V0.8710.78
14_L17_G0.8660.77
35_T199_E0.8650.77
184_L235_A0.8630.77
126_H201_M0.8560.77
46_A204_P0.8500.76
69_P80_G0.8370.75
129_H223_E0.8280.74
121_H199_E0.8270.74
47_V117_R0.8220.74
34_T56_L0.8200.73
129_H138_V0.8180.73
124_S127_H0.8180.73
70_L73_M0.8170.73
33_S120_T0.8160.73
138_V142_A0.8130.73
216_Y220_R0.8130.73
47_V52_D0.8010.72
50_S117_R0.8010.72
61_H123_D0.8000.72
27_R52_D0.7960.71
75_G95_L0.7960.71
138_V149_L0.7960.71
16_K42_A0.7930.71
67_G82_L0.7910.71
42_A46_A0.7910.71
188_D239_R0.7900.71
36_A43_I0.7890.71
15_S211_I0.7840.70
36_A115_F0.7820.70
110_R113_E0.7780.69
183_F200_V0.7780.69
124_S129_H0.7750.69
44_D140_R0.7720.69
60_M104_L0.7700.69
25_A30_I0.7620.68
74_P99_E0.7590.68
48_Q52_D0.7560.67
70_L103_E0.7540.67
16_K20_Y0.7540.67
50_S56_L0.7520.67
61_H204_P0.7440.66
126_H216_Y0.7440.66
100_I137_I0.7430.66
190_A196_R0.7410.66
14_L205_A0.7380.65
21_G59_G0.7370.65
214_S220_R0.7350.65
96_P99_E0.7350.65
167_Q196_R0.7340.65
98_E225_D0.7290.64
101_T137_I0.7260.64
19_N49_L0.7220.64
230_A234_G0.7180.63
36_A111_F0.7150.63
6_I121_H0.7090.62
111_F120_T0.7090.62
37_L196_R0.7080.62
8_N120_T0.7060.62
112_I119_P0.7050.62
207_I217_C0.7010.61
97_L140_R0.6990.61
211_I214_S0.6990.61
35_T211_I0.6920.60
211_I217_C0.6890.60
136_P157_F0.6880.60
90_A95_L0.6840.59
194_G198_L0.6810.59
207_I221_L0.6810.59
205_A208_D0.6810.59
221_L224_L0.6780.59
57_A121_H0.6770.59
43_I111_F0.6760.59
237_A240_G0.6670.58
184_L188_D0.6650.57
64_L134_I0.6640.57
195_D198_L0.6630.57
66_M126_H0.6620.57
129_H150_R0.6620.57
38_V47_V0.6610.57
196_R241_Y0.6610.57
178_I183_F0.6600.57
130_M151_A0.6600.57
180_E231_S0.6580.57
90_A93_D0.6580.57
77_T82_L0.6570.56
37_L66_M0.6520.56
43_I110_R0.6520.56
23_I53_E0.6520.56
99_E239_R0.6490.56
127_H131_F0.6490.56
66_M127_H0.6490.56
237_A241_Y0.6470.55
12_F150_R0.6470.55
112_I118_K0.6460.55
115_F119_P0.6440.55
104_L122_L0.6390.54
209_N212_R0.6380.54
150_R204_P0.6370.54
141_F144_E0.6350.54
31_V228_T0.6310.53
30_I232_L0.6300.53
68_K126_H0.6250.53
185_Q188_D0.6210.52
44_D48_Q0.6210.52
170_S200_V0.6200.52
105_V137_I0.6190.52
17_G211_I0.6180.52
62_F137_I0.6150.52
149_L152_D0.6140.51
98_E102_Q0.6120.51
4_L244_G0.6120.51
120_T123_D0.6110.51
122_L141_F0.6090.51
67_G126_H0.6070.51
129_H204_P0.6020.50
173_F216_Y0.5990.50
37_L61_H0.5970.49
140_R143_A0.5940.49
123_D127_H0.5920.49
8_N34_T0.5920.49
201_M223_E0.5890.49
64_L128_V0.5880.48
104_L108_Y0.5860.48
83_G236_I0.5840.48
128_V131_F0.5840.48
150_R223_E0.5820.48
74_P102_Q0.5800.48
205_A216_Y0.5790.47
122_L223_E0.5780.47
184_L232_L0.5760.47
79_D225_D0.5730.47
126_H214_S0.5730.47
127_H150_R0.5710.46
187_L236_I0.5710.46
158_D229_S0.5670.46
172_A186_V0.5640.46
135_F139_A0.5640.46
210_T213_Q0.5640.46
33_S57_A0.5630.46
51_R102_Q0.5620.45
6_I197_S0.5600.45
55_S238_Q0.5580.45
95_L100_I0.5570.45
12_F58_I0.5560.45
157_F161_V0.5560.45
39_N103_E0.5550.45
50_S116_G0.5550.45
76_L99_E0.5550.45
101_T144_E0.5540.45
80_G103_E0.5540.45
12_F43_I0.5540.45
233_K236_I0.5530.44
142_A149_L0.5510.44
231_S237_A0.5500.44
143_A161_V0.5500.44
180_E232_L0.5500.44
226_V235_A0.5490.44
8_N59_G0.5490.44
68_K81_V0.5490.44
43_I47_V0.5490.44
38_V70_L0.5480.44
216_Y219_P0.5460.44
164_R183_F0.5450.43
158_D165_T0.5440.43
197_S244_G0.5440.43
174_Y216_Y0.5430.43
179_S223_E0.5410.43
208_D211_I0.5400.43
175_G178_I0.5390.43
36_A47_V0.5360.42
19_N205_A0.5330.42
178_I182_L0.5320.42
187_L190_A0.5310.42
154_Q172_A0.5300.42
26_C34_T0.5290.42
100_I115_F0.5280.42
35_T120_T0.5270.41
231_S234_G0.5270.41
107_Q125_H0.5260.41
51_R234_G0.5250.41
62_F122_L0.5210.41
67_G103_E0.5190.41
19_N22_I0.5190.41
167_Q199_E0.5190.41
171_S175_G0.5180.40
12_F42_A0.5180.40
35_T126_H0.5160.40
184_L238_Q0.5160.40
80_G99_E0.5140.40
101_T104_L0.5140.40
70_L106_S0.5120.40
61_H203_H0.5120.40
35_T150_R0.5100.40
145_Q197_S0.5060.39
169_F239_R0.5060.39
170_S198_L0.5050.39
205_A220_R0.5030.39
78_R118_K0.5020.39
73_M96_P0.5010.39
4_L197_S0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i5iA 4 0.9799 100 0.105 Contact Map
2e67A 2 0.9157 100 0.187 Contact Map
4m1bA 1 0.743 97.5 0.892 Contact Map
2vyoA 1 0.755 97.3 0.895 Contact Map
2nlyA 1 0.8153 97 0.9 Contact Map
2qv5A 1 0.8394 96.5 0.906 Contact Map
4l1gA 1 0.739 96 0.91 Contact Map
2iw0A 1 0.7631 95.5 0.914 Contact Map
1ny1A 1 0.743 95 0.916 Contact Map
2j13A 1 0.6707 95 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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