CHBG - ECOLI - GREMLIN Contacts

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CHBG - UPF0249 protein ChbG

UniProt:	P37794	Sequences: MERLLIVNADDFGLSKGQNYGIIEACRNGIVTSTTALVNGQAIDHAVQLSRDEPSLAIGMHFVLTMGKPLTAMPGLTRDGVLGKWIWQLAEEDALPLEEITQELVSQYLRFIELFGRKPTHLDSHHHVHMFPQIFPIVARFAAEQGIALRADRQMAFDLPVNLRTTQGFSSAFYGEEISESLFLQVLDDAGHRGDRSLEVMCHPAFIDNTIRQSAYCFPRLTELDVLTSASLKGAIAQRGYRLGSYRDV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12198
Length:	249 (237)
Sequences:	1225 (989)
Seq/√Len:	64.2

ECOLI - CHBG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
105_V	144_E	5.745	1.00
101_T	140_R	4.863	1.00
75_G	99_E	3.396	1.00
62_F	104_L	2.969	1.00
38_V	111_F	2.955	1.00
234_G	238_Q	2.709	1.00
7_V	30_I	2.593	1.00
109_L	145_Q	2.582	1.00
21_G	224_L	2.549	1.00
24_E	28_N	2.538	1.00
26_C	56_L	2.392	1.00
111_F	119_P	2.358	1.00
38_V	43_I	2.354	1.00
37_L	63_V	2.257	1.00
150_R	199_E	2.246	1.00
8_N	33_S	2.244	1.00
101_T	105_V	2.150	1.00
8_N	35_T	2.129	1.00
16_K	45_H	2.122	1.00
19_N	45_H	2.107	1.00
39_N	63_V	2.107	1.00
108_Y	141_F	2.076	1.00
104_L	138_V	2.065	1.00
39_N	67_G	2.064	1.00
105_V	109_L	2.063	1.00
32_T	243_L	2.060	1.00
169_F	201_M	2.035	1.00
71_T	106_S	1.965	1.00
111_F	115_F	1.893	1.00
9_A	31_V	1.891	1.00
207_I	211_I	1.826	1.00
24_E	224_L	1.754	1.00
19_N	42_A	1.749	1.00
25_A	224_L	1.712	0.99
26_C	55_S	1.709	0.99
109_L	112_I	1.704	0.99
137_I	141_F	1.675	0.99
57_A	120_T	1.642	0.99
62_F	108_Y	1.606	0.99
71_T	77_T	1.605	0.99
23_I	49_L	1.600	0.99
9_A	204_P	1.578	0.99
27_R	53_E	1.549	0.99
8_N	199_E	1.542	0.99
45_H	49_L	1.539	0.99
22_I	34_T	1.532	0.99
19_N	46_A	1.517	0.99
127_H	201_M	1.511	0.99
73_M	77_T	1.505	0.99
38_V	60_M	1.502	0.99
8_N	121_H	1.493	0.98
7_V	232_L	1.480	0.98
60_M	122_L	1.467	0.98
221_L	225_D	1.464	0.98
15_S	19_N	1.444	0.98
63_V	66_M	1.435	0.98
9_A	22_I	1.435	0.98
20_Y	45_H	1.407	0.98
103_E	106_S	1.407	0.98
6_I	32_T	1.406	0.98
36_A	46_A	1.399	0.98
104_L	141_F	1.387	0.97
57_A	245_S	1.379	0.97
141_F	145_Q	1.378	0.97
35_T	123_D	1.357	0.97
71_T	102_Q	1.348	0.97
20_Y	206_F	1.348	0.97
21_G	25_A	1.314	0.96
111_F	117_R	1.304	0.96
235_A	239_R	1.293	0.96
108_Y	122_L	1.292	0.96
64_L	104_L	1.285	0.96
25_A	228_T	1.284	0.96
18_Q	211_I	1.283	0.96
202_C	227_L	1.279	0.96
35_T	121_H	1.276	0.96
37_L	40_G	1.273	0.96
17_G	208_D	1.273	0.96
122_L	142_A	1.273	0.96
190_A	198_L	1.269	0.96
8_N	123_D	1.258	0.95
25_A	31_V	1.253	0.95
5_L	200_V	1.252	0.95
20_Y	24_E	1.244	0.95
60_M	108_Y	1.223	0.95
13_G	19_N	1.216	0.95
75_G	96_P	1.215	0.95
70_L	110_R	1.203	0.94
109_L	141_F	1.202	0.94
225_D	229_S	1.194	0.94
39_N	70_L	1.187	0.94
108_Y	112_I	1.177	0.94
105_V	145_Q	1.174	0.93
100_I	134_I	1.170	0.93
219_P	222_T	1.170	0.93
5_L	241_Y	1.164	0.93
60_M	111_F	1.160	0.93
108_Y	145_Q	1.145	0.93
33_S	121_H	1.142	0.93
59_G	121_H	1.126	0.92
34_T	50_S	1.122	0.92
62_F	141_F	1.111	0.91
65_T	126_H	1.097	0.91
69_P	77_T	1.096	0.91
38_V	110_R	1.096	0.91
206_F	224_L	1.094	0.91
73_M	76_L	1.094	0.91
223_E	227_L	1.088	0.91
8_N	150_R	1.060	0.89
43_I	115_F	1.059	0.89
99_E	102_Q	1.055	0.89
73_M	99_E	1.046	0.89
109_L	113_E	1.046	0.89
46_A	50_S	1.039	0.88
24_E	206_F	1.035	0.88
112_I	145_Q	1.027	0.88
14_L	18_Q	1.024	0.88
180_E	229_S	1.024	0.88
105_V	141_F	1.017	0.87
10_D	13_G	1.002	0.87
69_P	103_E	0.996	0.86
117_R	120_T	0.995	0.86
224_L	228_T	0.994	0.86
127_H	223_E	0.990	0.86
205_A	224_L	0.983	0.85
19_N	36_A	0.975	0.85
17_G	207_I	0.969	0.85
22_I	150_R	0.966	0.84
63_V	67_G	0.966	0.84
100_I	104_L	0.963	0.84
12_F	22_I	0.961	0.84
24_E	228_T	0.956	0.84
180_E	184_L	0.950	0.83
19_N	37_L	0.942	0.83
20_Y	49_L	0.941	0.83
19_N	40_G	0.941	0.83
12_F	19_N	0.940	0.83
184_L	231_S	0.939	0.83
139_A	158_D	0.936	0.83
33_S	123_D	0.936	0.83
98_E	234_G	0.935	0.83
166_T	199_E	0.933	0.82
4_L	242_R	0.932	0.82
179_S	182_L	0.908	0.81
104_L	134_I	0.902	0.80
5_L	243_L	0.902	0.80
123_D	223_E	0.896	0.80
8_N	201_M	0.896	0.80
97_L	137_I	0.896	0.80
60_M	141_F	0.886	0.79
8_N	57_A	0.881	0.79
16_K	24_E	0.879	0.78
26_C	54_P	0.876	0.78
18_Q	205_A	0.873	0.78
50_S	121_H	0.872	0.78
7_V	31_V	0.871	0.78
14_L	17_G	0.866	0.77
35_T	199_E	0.865	0.77
184_L	235_A	0.863	0.77
126_H	201_M	0.856	0.77
46_A	204_P	0.850	0.76
69_P	80_G	0.837	0.75
129_H	223_E	0.828	0.74
121_H	199_E	0.827	0.74
47_V	117_R	0.822	0.74
34_T	56_L	0.820	0.73
129_H	138_V	0.818	0.73
124_S	127_H	0.818	0.73
70_L	73_M	0.817	0.73
33_S	120_T	0.816	0.73
138_V	142_A	0.813	0.73
216_Y	220_R	0.813	0.73
47_V	52_D	0.801	0.72
50_S	117_R	0.801	0.72
61_H	123_D	0.800	0.72
27_R	52_D	0.796	0.71
75_G	95_L	0.796	0.71
138_V	149_L	0.796	0.71
16_K	42_A	0.793	0.71
67_G	82_L	0.791	0.71
42_A	46_A	0.791	0.71
188_D	239_R	0.790	0.71
36_A	43_I	0.789	0.71
15_S	211_I	0.784	0.70
36_A	115_F	0.782	0.70
110_R	113_E	0.778	0.69
183_F	200_V	0.778	0.69
124_S	129_H	0.775	0.69
44_D	140_R	0.772	0.69
60_M	104_L	0.770	0.69
25_A	30_I	0.762	0.68
74_P	99_E	0.759	0.68
48_Q	52_D	0.756	0.67
70_L	103_E	0.754	0.67
16_K	20_Y	0.754	0.67
50_S	56_L	0.752	0.67
61_H	204_P	0.744	0.66
126_H	216_Y	0.744	0.66
100_I	137_I	0.743	0.66
190_A	196_R	0.741	0.66
14_L	205_A	0.738	0.65
21_G	59_G	0.737	0.65
214_S	220_R	0.735	0.65
96_P	99_E	0.735	0.65
167_Q	196_R	0.734	0.65
98_E	225_D	0.729	0.64
101_T	137_I	0.726	0.64
19_N	49_L	0.722	0.64
230_A	234_G	0.718	0.63
36_A	111_F	0.715	0.63
6_I	121_H	0.709	0.62
111_F	120_T	0.709	0.62
37_L	196_R	0.708	0.62
8_N	120_T	0.706	0.62
112_I	119_P	0.705	0.62
207_I	217_C	0.701	0.61
97_L	140_R	0.699	0.61
211_I	214_S	0.699	0.61
35_T	211_I	0.692	0.60
211_I	217_C	0.689	0.60
136_P	157_F	0.688	0.60
90_A	95_L	0.684	0.59
194_G	198_L	0.681	0.59
207_I	221_L	0.681	0.59
205_A	208_D	0.681	0.59
221_L	224_L	0.678	0.59
57_A	121_H	0.677	0.59
43_I	111_F	0.676	0.59
237_A	240_G	0.667	0.58
184_L	188_D	0.665	0.57
64_L	134_I	0.664	0.57
195_D	198_L	0.663	0.57
66_M	126_H	0.662	0.57
129_H	150_R	0.662	0.57
38_V	47_V	0.661	0.57
196_R	241_Y	0.661	0.57
178_I	183_F	0.660	0.57
130_M	151_A	0.660	0.57
180_E	231_S	0.658	0.57
90_A	93_D	0.658	0.57
77_T	82_L	0.657	0.56
37_L	66_M	0.652	0.56
43_I	110_R	0.652	0.56
23_I	53_E	0.652	0.56
99_E	239_R	0.649	0.56
127_H	131_F	0.649	0.56
66_M	127_H	0.649	0.56
237_A	241_Y	0.647	0.55
12_F	150_R	0.647	0.55
112_I	118_K	0.646	0.55
115_F	119_P	0.644	0.55
104_L	122_L	0.639	0.54
209_N	212_R	0.638	0.54
150_R	204_P	0.637	0.54
141_F	144_E	0.635	0.54
31_V	228_T	0.631	0.53
30_I	232_L	0.630	0.53
68_K	126_H	0.625	0.53
185_Q	188_D	0.621	0.52
44_D	48_Q	0.621	0.52
170_S	200_V	0.620	0.52
105_V	137_I	0.619	0.52
17_G	211_I	0.618	0.52
62_F	137_I	0.615	0.52
149_L	152_D	0.614	0.51
98_E	102_Q	0.612	0.51
4_L	244_G	0.612	0.51
120_T	123_D	0.611	0.51
122_L	141_F	0.609	0.51
67_G	126_H	0.607	0.51
129_H	204_P	0.602	0.50
173_F	216_Y	0.599	0.50
37_L	61_H	0.597	0.49
140_R	143_A	0.594	0.49
123_D	127_H	0.592	0.49
8_N	34_T	0.592	0.49
201_M	223_E	0.589	0.49
64_L	128_V	0.588	0.48
104_L	108_Y	0.586	0.48
83_G	236_I	0.584	0.48
128_V	131_F	0.584	0.48
150_R	223_E	0.582	0.48
74_P	102_Q	0.580	0.48
205_A	216_Y	0.579	0.47
122_L	223_E	0.578	0.47
184_L	232_L	0.576	0.47
79_D	225_D	0.573	0.47
126_H	214_S	0.573	0.47
127_H	150_R	0.571	0.46
187_L	236_I	0.571	0.46
158_D	229_S	0.567	0.46
172_A	186_V	0.564	0.46
135_F	139_A	0.564	0.46
210_T	213_Q	0.564	0.46
33_S	57_A	0.563	0.46
51_R	102_Q	0.562	0.45
6_I	197_S	0.560	0.45
55_S	238_Q	0.558	0.45
95_L	100_I	0.557	0.45
12_F	58_I	0.556	0.45
157_F	161_V	0.556	0.45
39_N	103_E	0.555	0.45
50_S	116_G	0.555	0.45
76_L	99_E	0.555	0.45
101_T	144_E	0.554	0.45
80_G	103_E	0.554	0.45
12_F	43_I	0.554	0.45
233_K	236_I	0.553	0.44
142_A	149_L	0.551	0.44
231_S	237_A	0.550	0.44
143_A	161_V	0.550	0.44
180_E	232_L	0.550	0.44
226_V	235_A	0.549	0.44
8_N	59_G	0.549	0.44
68_K	81_V	0.549	0.44
43_I	47_V	0.549	0.44
38_V	70_L	0.548	0.44
216_Y	219_P	0.546	0.44
164_R	183_F	0.545	0.43
158_D	165_T	0.544	0.43
197_S	244_G	0.544	0.43
174_Y	216_Y	0.543	0.43
179_S	223_E	0.541	0.43
208_D	211_I	0.540	0.43
175_G	178_I	0.539	0.43
36_A	47_V	0.536	0.42
19_N	205_A	0.533	0.42
178_I	182_L	0.532	0.42
187_L	190_A	0.531	0.42
154_Q	172_A	0.530	0.42
26_C	34_T	0.529	0.42
100_I	115_F	0.528	0.42
35_T	120_T	0.527	0.41
231_S	234_G	0.527	0.41
107_Q	125_H	0.526	0.41
51_R	234_G	0.525	0.41
62_F	122_L	0.521	0.41
67_G	103_E	0.519	0.41
19_N	22_I	0.519	0.41
167_Q	199_E	0.519	0.41
171_S	175_G	0.518	0.40
12_F	42_A	0.518	0.40
35_T	126_H	0.516	0.40
184_L	238_Q	0.516	0.40
80_G	99_E	0.514	0.40
101_T	104_L	0.514	0.40
70_L	106_S	0.512	0.40
61_H	203_H	0.512	0.40
35_T	150_R	0.510	0.40
145_Q	197_S	0.506	0.39
169_F	239_R	0.506	0.39
170_S	198_L	0.505	0.39
205_A	220_R	0.503	0.39
78_R	118_K	0.502	0.39
73_M	96_P	0.501	0.39
4_L	197_S	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i5iA	4	0.9799	100	0.105	Contact Map
2e67A	2	0.9157	100	0.187	Contact Map
4m1bA	1	0.743	97.5	0.892	Contact Map
2vyoA	1	0.755	97.3	0.895	Contact Map
2nlyA	1	0.8153	97	0.9	Contact Map
2qv5A	1	0.8394	96.5	0.906	Contact Map
4l1gA	1	0.739	96	0.91	Contact Map
2iw0A	1	0.7631	95.5	0.914	Contact Map
1ny1A	1	0.743	95	0.916	Contact Map
2j13A	1	0.6707	95	0.916	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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