GREMLIN Database
MPL - UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
UniProt: P37773 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12440
Length: 457 (403)
Sequences: 18588 (13884)
Seq/√Len: 691.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_I290_A3.5331.00
356_A381_A2.6921.00
127_Q307_S2.6381.00
27_V39_S2.6241.00
104_W179_R2.5611.00
251_K260_E2.5181.00
180_T290_A2.4981.00
408_H419_M2.4891.00
383_E408_H2.4881.00
297_A300_D2.4841.00
288_I301_A2.4471.00
410_S419_M2.4361.00
250_K262_L2.4301.00
182_I286_M2.3871.00
396_V399_V2.3601.00
412_D415_T2.3541.00
419_M423_T2.3451.00
317_L325_T2.3371.00
196_D199_A2.3241.00
260_E270_E2.2941.00
124_I291_A2.2681.00
80_A83_E2.2481.00
383_E423_T2.2131.00
272_K306_G2.1971.00
127_Q304_A2.1931.00
124_I287_A2.1691.00
363_N393_P2.1351.00
221_E245_G2.1271.00
141_G144_E2.1001.00
201_Q228_Q2.0661.00
216_R293_H2.0411.00
195_D199_A2.0021.00
56_S60_P1.9931.00
273_W284_G1.9881.00
239_E286_M1.9771.00
397_A401_E1.9621.00
419_M422_K1.9271.00
56_S59_E1.9201.00
42_L66_I1.9201.00
247_W289_A1.9191.00
208_V217_I1.9151.00
179_R215_G1.9101.00
80_A84_K1.9061.00
127_Q303_N1.8991.00
128_C300_D1.8481.00
338_L342_A1.8391.00
107_A178_P1.8291.00
385_F423_T1.8281.00
123_W307_S1.8031.00
107_A159_A1.7971.00
424_A430_I1.7911.00
121_A287_A1.7811.00
205_H232_M1.7721.00
106_L294_V1.7671.00
317_L327_Y1.7651.00
258_E270_E1.7591.00
58_L76_P1.7181.00
130_Y153_D1.6881.00
260_E267_K1.6841.00
55_A59_E1.6821.00
262_L267_K1.6781.00
201_Q225_N1.6611.00
122_T126_E1.6611.00
292_R298_P1.6561.00
199_A202_K1.6541.00
121_A290_A1.6421.00
284_G305_L1.6401.00
258_E272_K1.6301.00
361_R437_G1.6221.00
385_F419_M1.6181.00
263_L292_R1.6171.00
122_T135_V1.6011.00
187_E335_T1.5981.00
259_W284_G1.5961.00
181_L207_L1.5821.00
278_E346_G1.5691.00
104_W154_F1.5661.00
398_E401_E1.5581.00
180_T294_V1.5571.00
203_Q206_H1.5461.00
108_V121_A1.5421.00
375_A379_G1.5331.00
249_A285_L1.5281.00
128_C296_V1.5161.00
248_Q262_L1.5131.00
121_A291_A1.5101.00
291_A301_A1.5001.00
105_V176_Y1.4911.00
181_L211_V1.4901.00
320_E325_T1.4841.00
161_E194_F1.4821.00
302_A306_G1.4761.00
29_G34_V1.4731.00
355_I423_T1.4671.00
123_W304_A1.4591.00
165_A203_Q1.4541.00
45_Q68_G1.4471.00
106_L121_A1.4431.00
263_L266_E1.4251.00
116_T280_N1.4131.00
211_V215_G1.4081.00
326_V421_V1.4061.00
410_S415_T1.3911.00
303_N307_S1.3911.00
125_L294_V1.3881.00
324_V424_A1.3871.00
398_E402_A1.3811.00
108_V118_A1.3751.00
154_F294_V1.3621.00
237_E240_L1.3611.00
218_I293_H1.3571.00
300_D303_N1.3561.00
238_Q241_V1.3521.00
125_L156_V1.3511.00
186_L201_Q1.3461.00
353_R383_E1.3401.00
278_E342_A1.3331.00
29_G35_Y1.3241.00
117_T184_N1.3201.00
237_E241_V1.3161.00
247_W292_R1.3101.00
120_M308_F1.3061.00
361_R389_P1.3021.00
111_T189_D1.3001.00
274_S309_I1.3001.00
115_T311_A1.3001.00
188_F191_A1.2941.00
145_V149_L1.2871.00
165_A193_I1.2761.00
180_T293_H1.2711.00
395_Q398_E1.2671.00
40_T43_E1.2651.00
399_V403_C1.2631.00
131_K153_D1.2611.00
164_C203_Q1.2601.00
357_V387_L1.2571.00
36_P39_S1.2521.00
291_A296_V1.2491.00
94_W98_F1.2391.00
120_M275_L1.2351.00
220_P282_H1.2321.00
355_I385_F1.2311.00
342_A380_R1.2291.00
183_L186_L1.2281.00
112_H333_H1.2271.00
104_W153_D1.2251.00
79_E82_L1.2241.00
180_T218_I1.2201.00
352_A428_D1.2171.00
249_A252_L1.2111.00
68_G84_K1.2051.00
312_R316_E1.2031.00
315_L344_L1.2011.00
280_N283_N1.1991.00
219_W238_Q1.1951.00
387_L416_L1.1951.00
342_A377_S1.1911.00
415_T418_D1.1881.00
385_F416_L1.1881.00
177_C215_G1.1861.00
29_G39_S1.1851.00
397_A409_W1.1831.00
67_I78_V1.1821.00
261_V288_I1.1761.00
394_W398_E1.1751.00
259_W281_M1.1741.00
317_L320_E1.1671.00
353_R428_D1.1661.00
125_L154_F1.1611.00
315_L327_Y1.1611.00
383_E406_P1.1571.00
228_Q231_A1.1451.00
323_G426_P1.1421.00
253_T258_E1.1421.00
198_K202_K1.1371.00
418_D422_K1.1371.00
219_W226_L1.1351.00
202_K232_M1.1331.00
216_R237_E1.1331.00
241_V278_E1.1321.00
353_R382_D1.1311.00
250_K260_E1.1171.00
205_H229_T1.1111.00
303_N306_G1.1091.00
40_T44_K1.1081.00
179_R212_P1.0981.00
121_A182_I1.0971.00
225_N228_Q1.0951.00
159_A173_F1.0941.00
112_H336_A1.0861.00
278_E282_H1.0831.00
173_F176_Y1.0781.00
130_Y154_F1.0761.00
299_A303_N1.0711.00
355_I383_E1.0631.00
222_N282_H1.0601.00
188_F197_L1.0591.00
106_L290_A1.0571.00
188_F367_M1.0551.00
337_I433_M1.0511.00
218_I289_A1.0491.00
125_L296_V1.0461.00
219_W230_M1.0421.00
197_L225_N1.0421.00
206_H209_R1.0391.00
236_S240_L1.0351.00
386_L409_W1.0351.00
184_N286_M1.0341.00
320_E323_G1.0301.00
183_L208_V1.0241.00
249_A281_M1.0241.00
221_E227_K1.0201.00
415_T419_M1.0181.00
198_K225_N1.0181.00
123_W126_E1.0181.00
128_C304_A1.0151.00
414_D418_D1.0131.00
396_V403_C1.0131.00
332_H337_I1.0091.00
425_Q428_D1.0031.00
131_K151_E0.9981.00
393_P396_V0.9981.00
256_A272_K0.9981.00
296_V300_D0.9981.00
339_A342_A0.9921.00
172_K175_H0.9911.00
40_T64_L0.9901.00
211_V217_I0.9841.00
120_M284_G0.9841.00
356_A433_M0.9811.00
374_L403_C0.9791.00
372_D376_P0.9781.00
320_E324_V0.9781.00
93_Q97_D0.9781.00
70_A80_A0.9771.00
221_E238_Q0.9731.00
201_Q205_H0.9681.00
202_K206_H0.9661.00
247_W263_L0.9651.00
388_Q411_G0.9641.00
238_Q246_H0.9621.00
124_I304_A0.9591.00
316_E328_D0.9591.00
105_V155_F0.9551.00
385_F410_S0.9551.00
144_E147_A0.9511.00
58_L65_V0.9511.00
122_T132_P0.9461.00
374_L378_L0.9351.00
206_H210_I0.9321.00
124_I301_A0.9321.00
79_E83_E0.9321.00
122_T134_F0.9291.00
180_T216_R0.9281.00
123_W308_F0.9251.00
237_E289_A0.9201.00
98_F101_R0.9191.00
366_K369_I0.9191.00
259_W271_V0.9171.00
104_W294_V0.9171.00
54_D57_Q0.9171.00
400_A403_C0.9141.00
84_K87_P0.9141.00
324_V427_G0.9111.00
90_S93_Q0.9101.00
408_H423_T0.9071.00
216_R235_W0.9051.00
134_F138_G0.9031.00
266_E298_P0.9031.00
227_K231_A0.9021.00
32_A35_Y0.9011.00
85_N89_M0.8991.00
313_R328_D0.8981.00
340_T431_L0.8971.00
251_K254_T0.8961.00
127_Q300_D0.8951.00
242_G245_G0.8941.00
385_F420_V0.8941.00
255_D258_E0.8931.00
54_D65_V0.8921.00
209_R232_M0.8901.00
162_Y193_I0.8901.00
109_A204_F0.8851.00
69_N72_T0.8831.00
298_P302_A0.8821.00
271_V302_A0.8811.00
112_H335_T0.8801.00
396_V400_A0.8791.00
224_I228_Q0.8751.00
223_D282_H0.8711.00
370_C373_D0.8681.00
376_P379_G0.8641.00
199_A203_Q0.8621.00
290_A294_V0.8581.00
333_H336_A0.8561.00
183_L229_T0.8551.00
87_P97_D0.8551.00
26_E38_M0.8541.00
399_V402_A0.8531.00
35_Y39_S0.8511.00
131_K152_S0.8491.00
373_D376_P0.8481.00
389_P392_I0.8471.00
128_C297_A0.8471.00
392_I395_Q0.8471.00
54_D58_L0.8431.00
93_Q175_H0.8411.00
411_G415_T0.8411.00
288_I292_R0.8351.00
381_A384_V0.8351.00
348_V429_H0.8321.00
420_V424_A0.8281.00
107_A207_L0.8281.00
134_F137_G0.8271.00
49_L53_Y0.8251.00
348_V352_A0.8221.00
45_Q69_N0.8221.00
250_K267_K0.8191.00
292_R301_A0.8191.00
245_G248_Q0.8181.00
40_T66_I0.8151.00
89_M93_Q0.8141.00
78_V82_L0.8081.00
205_H209_R0.8031.00
164_C199_A0.8021.00
279_H339_A0.7991.00
325_T429_H0.7981.00
218_I290_A0.7961.00
123_W127_Q0.7921.00
141_G145_V0.7891.00
119_G311_A0.7801.00
159_A178_P0.7801.00
220_P223_D0.7781.00
194_F203_Q0.7751.00
355_I424_A0.7741.00
404_V407_A0.7731.00
275_L308_F0.7721.00
268_V302_A0.7701.00
105_V157_I0.7701.00
188_F335_T0.7681.00
112_H187_E0.7671.00
416_L420_V0.7661.00
57_Q62_P0.7651.00
115_T138_G0.7651.00
369_I373_D0.7651.00
335_T339_A0.7641.00
88_Y91_G0.7641.00
337_I358_L0.7621.00
361_R392_I0.7611.00
240_L282_H0.7581.00
117_T287_A0.7581.00
243_E248_Q0.7581.00
237_E293_H0.7571.00
119_G139_V0.7571.00
86_I90_S0.7551.00
235_W293_H0.7551.00
117_T286_M0.7541.00
197_L201_Q0.7521.00
221_E226_L0.7521.00
347_K429_H0.7511.00
177_C212_P0.7511.00
221_E242_G0.7501.00
88_Y92_P0.7501.00
92_P96_H0.7491.00
219_W236_S0.7471.00
392_I396_V0.7451.00
327_Y429_H0.7441.00
410_S416_L0.7421.00
28_T62_P0.7421.00
366_K402_A0.7401.00
164_C202_K0.7391.00
135_V138_G0.7391.00
85_N88_Y0.7341.00
198_K201_Q0.7331.00
87_P91_G0.7331.00
338_L373_D0.7321.00
172_K176_Y0.7271.00
34_V43_E0.7241.00
65_V81_V0.7241.00
136_I140_P0.7241.00
161_E203_Q0.7241.00
250_K254_T0.7221.00
358_L386_L0.7221.00
338_L376_P0.7201.00
417_A421_V0.7201.00
77_C80_A0.7201.00
386_L407_A0.7191.00
253_T270_E0.7181.00
164_C193_I0.7161.00
43_E51_Q0.7151.00
241_V249_A0.7141.00
41_L45_Q0.7141.00
341_L345_R0.7101.00
357_V432_V0.7091.00
259_W262_L0.7091.00
342_A346_G0.7081.00
296_V301_A0.7061.00
368_G372_D0.7051.00
217_I233_G0.7031.00
385_F408_H0.7021.00
122_T156_V0.6991.00
228_Q232_M0.6951.00
241_V252_L0.6931.00
103_R155_F0.6931.00
89_M92_P0.6921.00
128_C291_A0.6911.00
323_G427_G0.6911.00
386_L400_A0.6901.00
338_L379_G0.6891.00
349_G352_A0.6891.00
187_E197_L0.6881.00
145_V148_H0.6881.00
288_I298_P0.6861.00
240_L245_G0.6841.00
137_G140_P0.6821.00
254_T278_E0.6821.00
376_P380_R0.6781.00
125_L291_A0.6781.00
355_I420_V0.6771.00
74_G77_C0.6771.00
322_N426_P0.6771.00
396_V402_A0.6771.00
227_K230_M0.6761.00
42_L88_Y0.6741.00
358_L434_S0.6731.00
338_L377_S0.6731.00
198_K228_Q0.6731.00
344_L431_L0.6721.00
301_A304_A0.6721.00
165_A199_A0.6711.00
396_V401_E0.6711.00
118_A156_V0.6691.00
84_K88_Y0.6671.00
238_Q245_G0.6661.00
202_K205_H0.6641.00
30_S49_L0.6631.00
326_V430_I0.6611.00
197_L200_I0.6591.00
240_L248_Q0.6591.00
372_D402_A0.6571.00
52_G68_G0.6571.00
374_L377_S0.6571.00
382_D425_Q0.6571.00
189_D333_H0.6561.00
226_L229_T0.6551.00
119_G123_W0.6541.00
43_E54_D0.6531.00
35_Y62_P0.6511.00
201_Q229_T0.6511.00
397_A411_G0.6501.00
183_L201_Q0.6491.00
124_I128_C0.6491.00
186_L197_L0.6481.00
375_A378_L0.6431.00
121_A156_V0.6421.00
387_L413_V0.6421.00
92_P159_A0.6411.00
241_V282_H0.6411.00
246_H264_D0.6381.00
39_S43_E0.6341.00
315_L343_A0.6331.00
313_R436_G0.6321.00
89_M97_D0.6311.00
355_I428_D0.6301.00
136_I139_V0.6291.00
349_G429_H0.6291.00
394_W409_W0.6291.00
389_P394_W0.6281.00
135_V140_P0.6261.00
321_A324_V0.6261.00
226_L230_M0.6231.00
261_V285_L0.6211.00
285_L289_A0.6201.00
288_I305_L0.6171.00
357_V420_V0.6161.00
397_A400_A0.6151.00
386_L403_C0.6151.00
119_G140_P0.6131.00
42_L84_K0.6121.00
268_V298_P0.6121.00
31_D34_V0.6111.00
299_A302_A0.6081.00
41_L44_K0.6071.00
236_S239_E0.6051.00
326_V432_V0.6051.00
271_V284_G0.6031.00
275_L280_N0.6021.00
413_V417_A0.6021.00
352_A425_Q0.6021.00
173_F210_I0.6011.00
397_A403_C0.6011.00
264_D292_R0.6001.00
135_V139_V0.5991.00
108_V182_I0.5991.00
257_S261_V0.5981.00
120_M287_A0.5971.00
106_L154_F0.5971.00
50_I69_N0.5971.00
116_T120_M0.5971.00
337_I341_L0.5961.00
372_D375_A0.5961.00
353_R425_Q0.5961.00
93_Q98_F0.5951.00
73_R82_L0.5931.00
50_I57_Q0.5881.00
331_A433_M0.5881.00
65_V76_P0.5881.00
357_V416_L0.5871.00
52_G84_K0.5871.00
383_E419_M0.5871.00
177_C210_I0.5871.00
255_D272_K0.5861.00
164_C194_F0.5861.00
65_V78_V0.5841.00
53_Y57_Q0.5841.00
106_L125_L0.5841.00
74_G79_E0.5831.00
124_I296_V0.5831.00
277_G280_N0.5821.00
394_W397_A0.5811.00
93_Q96_H0.5791.00
257_S260_E0.5791.00
57_Q61_Q0.5781.00
392_I399_V0.5771.00
330_F436_G0.5751.00
251_K270_E0.5731.00
257_S281_M0.5731.00
163_D193_I0.5731.00
74_G78_V0.5721.00
101_R177_C0.5721.00
389_P395_Q0.5711.00
102_D148_H0.5701.00
27_V36_P0.5681.00
278_E281_M0.5671.00
32_A53_Y0.5671.00
400_A409_W0.5671.00
387_L410_S0.5661.00
254_T257_S0.5651.00
338_L380_R0.5651.00
140_P143_F0.5631.00
191_A195_D0.5631.00
184_N239_E0.5581.00
288_I302_A0.5581.00
26_E48_E0.5571.00
34_V40_T0.5571.00
366_K370_C0.5551.00
243_E250_K0.5551.00
388_Q400_A0.5541.00
418_D421_V0.5531.00
242_G278_E0.5531.00
82_L88_Y0.5531.00
331_A340_T0.5531.00
340_T433_M0.5521.00
227_K238_Q0.5521.00
160_D163_D0.5511.00
352_A427_G0.5511.00
289_A293_H0.5491.00
132_P135_V0.5461.00
146_S149_L0.5441.00
116_T308_F0.5421.00
259_W263_L0.5421.00
244_Q248_Q0.5411.00
71_M78_V0.5401.00
281_M285_L0.5401.00
345_R348_V0.5401.00
91_G94_W0.5391.00
273_W305_L0.5381.00
59_E84_K0.5371.00
118_A135_V0.5351.00
89_M175_H0.5331.00
230_M233_G0.5321.00
242_G248_Q0.5311.00
221_E240_L0.5301.00
275_L310_N0.5291.00
179_R214_Q0.5291.00
286_M290_A0.5271.00
359_E438_F0.5261.00
189_D204_F0.5231.00
382_D428_D0.5231.00
361_R439_G0.5211.00
229_T233_G0.5201.00
28_T42_L0.5191.00
362_S393_P0.5191.00
25_H64_L0.5191.00
91_G96_H0.5191.00
132_P156_V0.5181.00
298_P301_A0.5181.00
108_V117_T0.5170.99
356_A384_V0.5170.99
360_P363_N0.5160.99
100_L177_C0.5160.99
290_A293_H0.5150.99
322_N421_V0.5130.99
191_A196_D0.5120.99
142_N145_V0.5110.99
66_I91_G0.5110.99
159_A176_Y0.5100.99
126_E132_P0.5090.99
420_V430_I0.5080.99
116_T283_N0.5070.99
131_K150_G0.5030.99
124_I305_L0.5020.99
181_L214_Q0.5010.99
247_W293_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x5oA 1 0.9344 100 0.23 Contact Map
3hn7A 1 0.9803 100 0.231 Contact Map
3lk7A 1 0.9409 100 0.243 Contact Map
1p3dA 1 0.9562 100 0.25 Contact Map
4hv4A 1 0.9628 100 0.266 Contact Map
1j6uA 1 0.9147 100 0.268 Contact Map
4bucA 1 0.8972 100 0.271 Contact Map
4c12A 2 0.9672 100 0.294 Contact Map
4bubA 1 0.9475 100 0.303 Contact Map
4qdiA 1 0.9344 100 0.315 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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