GREMLIN Database
YJFF - Inner membrane ABC transporter permease protein YjfF
UniProt: P37772 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12439
Length: 331 (275)
Sequences: 31079 (19853)
Seq/√Len: 1197.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_L219_G3.8871.00
99_C215_M3.5571.00
99_C219_G3.0571.00
103_A215_M2.8961.00
75_F97_M2.8811.00
196_A210_T2.7951.00
79_V93_L2.6741.00
189_V213_I2.5501.00
53_T268_T2.5111.00
46_G169_M2.4791.00
205_S208_S2.4761.00
111_A207_R2.4201.00
102_G218_T2.3181.00
208_S212_R2.3071.00
179_L185_F2.3011.00
178_F182_R2.2651.00
177_I181_H2.2561.00
98_G222_T2.2511.00
103_A211_I2.2051.00
105_M123_G2.1921.00
188_Q209_T2.1481.00
246_D279_Q2.1351.00
107_L111_A2.1231.00
185_F212_R2.1081.00
86_S89_L2.0381.00
175_I179_L2.0061.00
70_A131_S1.9851.00
48_I247_A1.9571.00
95_L223_L1.9471.00
76_L94_V1.9171.00
88_L92_P1.9081.00
98_G218_T1.8261.00
76_L226_I1.7771.00
49_A268_T1.7751.00
174_V178_F1.7741.00
192_I209_T1.7431.00
42_N276_G1.7401.00
91_F226_I1.7091.00
191_A199_A1.7051.00
55_V217_S1.6941.00
106_G211_I1.6511.00
125_F128_R1.6471.00
54_F176_G1.6411.00
145_I148_T1.6011.00
46_G272_V1.5631.00
184_R188_Q1.5591.00
42_N273_A1.5521.00
57_L190_Y1.5361.00
95_L226_I1.5311.00
246_D297_I1.5131.00
80_I90_A1.5101.00
71_F101_F1.5011.00
101_F127_L1.5001.00
185_F189_V1.4831.00
67_S128_R1.4741.00
212_R215_M1.4641.00
197_T200_N1.4601.00
111_A211_I1.4601.00
196_A200_N1.4391.00
69_I228_F1.4261.00
123_G127_L1.4261.00
48_I69_I1.4021.00
85_L89_L1.4021.00
78_K134_V1.3731.00
147_D150_S1.3731.00
173_V269_L1.3691.00
188_Q204_I1.3581.00
264_T267_G1.3551.00
58_S213_I1.3471.00
47_I224_A1.3461.00
89_L92_P1.3451.00
79_V85_L1.3351.00
78_K82_D1.3161.00
54_F213_I1.3061.00
188_Q199_A1.3031.00
79_V83_F1.2991.00
51_G220_L1.2971.00
107_L211_I1.2771.00
254_G267_G1.2741.00
199_A204_I1.2731.00
94_V98_G1.2591.00
192_I206_T1.2581.00
146_Y149_L1.2561.00
254_G271_G1.2441.00
78_K135_S1.2401.00
110_D207_R1.2391.00
47_I227_V1.2371.00
211_I215_M1.2241.00
65_V221_A1.2231.00
90_A94_V1.2231.00
204_I209_T1.2191.00
46_G269_L1.2151.00
34_V280_T1.2031.00
92_P96_V1.2011.00
60_G116_A1.1971.00
50_V176_G1.1921.00
52_M251_V1.1911.00
38_I276_G1.1891.00
60_G210_T1.1891.00
192_I199_A1.1841.00
181_H190_Y1.1841.00
38_I277_L1.1831.00
148_T151_S1.1761.00
75_F79_V1.1621.00
85_L93_L1.1541.00
68_V101_F1.1451.00
49_A250_S1.1431.00
96_V99_C1.1371.00
177_I182_R1.1291.00
215_M219_G1.1281.00
52_M247_A1.1251.00
42_N272_V1.1171.00
60_G214_Y1.1151.00
172_V220_L1.0951.00
280_T283_N1.0931.00
157_P160_G1.0931.00
173_V220_L1.0861.00
200_N207_R1.0781.00
238_L241_V1.0671.00
67_S127_L1.0671.00
200_N206_T1.0651.00
76_L230_I1.0621.00
128_R132_Y1.0581.00
108_L119_I1.0581.00
212_R216_L1.0561.00
51_G65_V1.0541.00
94_V226_I1.0541.00
171_A175_I1.0521.00
209_T212_R1.0481.00
174_V177_I1.0461.00
77_A81_G1.0431.00
99_C222_T1.0431.00
176_G216_L1.0391.00
74_V131_S1.0391.00
243_V246_D1.0371.00
49_A251_V1.0361.00
100_A103_A1.0291.00
53_T251_V1.0281.00
218_T222_T1.0211.00
57_L263_G1.0181.00
292_W295_I1.0141.00
36_C40_T1.0131.00
92_P95_L1.0111.00
110_D120_T1.0091.00
48_I224_A1.0041.00
167_L171_A1.0011.00
43_A166_G1.0001.00
124_M128_R1.0001.00
279_Q297_I0.9941.00
149_L152_L0.9921.00
216_L220_L0.9901.00
150_S154_W0.9891.00
250_S271_G0.9871.00
189_V209_T0.9861.00
105_M119_I0.9721.00
107_L112_L0.9711.00
74_V237_A0.9651.00
139_I142_N0.9631.00
146_Y150_S0.9621.00
250_S272_V0.9581.00
177_I266_L0.9561.00
56_I251_V0.9531.00
225_G229_S0.9511.00
79_V90_A0.9491.00
294_K297_I0.9421.00
185_F209_T0.9391.00
164_A167_L0.9381.00
73_G229_S0.9351.00
71_F75_F0.9341.00
266_L270_F0.9341.00
143_H146_Y0.9301.00
72_T98_G0.9221.00
66_G244_E0.9131.00
67_S124_M0.9131.00
53_T263_G0.9051.00
208_S211_I0.9041.00
198_S202_M0.9041.00
74_V135_S0.9031.00
217_S221_A0.9021.00
113_K196_A0.9011.00
169_M173_V0.8991.00
33_R36_C0.8991.00
108_L112_L0.8961.00
282_I296_A0.8961.00
187_N190_Y0.8931.00
140_P143_H0.8911.00
57_L181_H0.8881.00
58_S189_V0.8851.00
41_D45_L0.8851.00
109_I119_I0.8841.00
96_V100_A0.8831.00
44_F224_A0.8821.00
275_Q297_I0.8811.00
49_A272_V0.8781.00
46_G173_V0.8771.00
303_I307_L0.8771.00
281_Y285_D0.8761.00
69_I243_V0.8751.00
170_L174_V0.8751.00
52_M65_V0.8741.00
78_K83_F0.8711.00
72_T94_V0.8711.00
160_G167_L0.8701.00
35_I281_Y0.8681.00
309_R312_T0.8651.00
62_D65_V0.8651.00
50_V172_V0.8651.00
76_L80_I0.8651.00
207_R210_T0.8611.00
69_I240_G0.8611.00
68_V221_A0.8611.00
89_L93_L0.8591.00
73_G235_G0.8581.00
165_M227_V0.8551.00
55_V62_D0.8541.00
150_S153_A0.8521.00
180_A189_V0.8521.00
79_V82_D0.8461.00
54_F216_L0.8461.00
129_G132_Y0.8451.00
47_I169_M0.8431.00
104_F108_L0.8421.00
166_G170_L0.8371.00
264_T268_T0.8341.00
192_I213_I0.8341.00
195_N198_S0.8331.00
206_T210_T0.8331.00
221_A225_G0.8281.00
133_L292_W0.8281.00
75_F78_K0.8221.00
137_E140_P0.8221.00
151_S154_W0.8201.00
163_S167_L0.8191.00
72_T225_G0.8181.00
68_V98_G0.8151.00
50_V268_T0.8081.00
95_L222_T0.8041.00
73_G239_A0.7981.00
48_I65_V0.7951.00
77_A235_G0.7941.00
219_G222_T0.7911.00
192_I210_T0.7911.00
37_N41_D0.7911.00
54_F180_A0.7881.00
280_T284_F0.7841.00
207_R211_I0.7831.00
106_G110_D0.7801.00
146_Y151_S0.7801.00
154_W157_P0.7801.00
262_V266_L0.7781.00
63_L248_I0.7771.00
164_A168_L0.7691.00
219_G223_L0.7611.00
106_G111_A0.7591.00
196_A206_T0.7571.00
179_L182_R0.7561.00
147_D151_S0.7511.00
103_A107_L0.7501.00
175_I178_F0.7441.00
51_G221_A0.7441.00
48_I51_G0.7431.00
128_R241_V0.7431.00
156_I160_G0.7391.00
268_T272_V0.7361.00
299_I303_I0.7361.00
47_I172_V0.7321.00
100_A104_F0.7311.00
95_L99_C0.7311.00
308_Q311_L0.7191.00
126_F130_V0.7191.00
116_A214_Y0.7171.00
45_L246_D0.7141.00
71_F98_G0.7141.00
69_I224_A0.7131.00
249_A301_L0.7121.00
76_L90_A0.7041.00
291_W294_K0.6991.00
188_Q205_S0.6981.00
148_T152_L0.6971.00
55_V214_Y0.6971.00
43_A169_M0.6951.00
145_I149_L0.6921.00
42_N46_G0.6891.00
40_T166_G0.6751.00
279_Q293_T0.6731.00
80_I230_I0.6711.00
110_D211_I0.6691.00
273_A277_L0.6691.00
228_F232_T0.6681.00
91_F95_L0.6671.00
38_I280_T0.6641.00
272_V276_G0.6641.00
68_V105_M0.6601.00
68_V218_T0.6591.00
141_I144_P0.6511.00
85_L90_A0.6511.00
72_T97_M0.6461.00
45_L250_S0.6461.00
102_G215_M0.6451.00
228_F243_V0.6431.00
39_L43_A0.6401.00
71_F127_L0.6381.00
68_V72_T0.6371.00
98_G102_G0.6341.00
178_F181_H0.6341.00
128_R244_E0.6341.00
176_G180_A0.6331.00
206_T209_T0.6321.00
51_G55_V0.6321.00
308_Q312_T0.6311.00
58_S192_I0.6281.00
56_I248_I0.6281.00
72_T221_A0.6271.00
34_V284_F0.6271.00
60_G196_A0.6261.00
40_T231_Y0.6251.00
172_V223_L0.6241.00
216_L219_G0.6241.00
53_T57_L0.6231.00
297_I301_L0.6231.00
185_F216_L0.6221.00
68_V127_L0.6181.00
176_G220_L0.6181.00
38_I42_N0.6181.00
37_N280_T0.6171.00
173_V177_I0.6161.00
45_L272_V0.6141.00
53_T265_V0.6141.00
179_L212_R0.6121.00
306_A310_G0.6121.00
109_I116_A0.6101.00
137_E142_N0.6101.00
50_V177_I0.6071.00
68_V102_G0.6031.00
179_L183_T0.6011.00
222_T226_I0.6011.00
157_P161_R0.6001.00
54_F179_L0.5981.00
151_S155_K0.5961.00
32_T35_I0.5941.00
253_I304_F0.5901.00
109_I214_Y0.5901.00
253_I271_G0.5891.00
44_F228_F0.5881.00
58_S210_T0.5871.00
99_C102_G0.5851.00
288_L292_W0.5831.00
75_F93_L0.5831.00
250_S268_T0.5821.00
218_T221_A0.5791.00
95_L98_G0.5781.00
79_V97_M0.5771.00
131_S135_S0.5761.00
87_P230_I0.5751.00
162_L165_M0.5741.00
246_D294_K0.5691.00
251_V268_T0.5681.00
113_K207_R0.5681.00
267_G271_G0.5671.00
162_L167_L0.5671.00
76_L225_G0.5661.00
50_V173_V0.5641.00
64_S105_M0.5611.00
45_L243_V0.5591.00
171_A174_V0.5571.00
145_I150_S0.5571.00
295_I299_I0.5541.00
177_I264_T0.5531.00
124_M244_E0.5521.00
210_T213_I0.5521.00
125_F129_G0.5471.00
39_L42_N0.5471.00
78_K81_G0.5461.00
144_P147_D0.5461.00
215_M218_T0.5461.00
70_A240_G0.5441.00
34_V37_N0.5441.00
121_L124_M0.5421.00
79_V84_G0.5391.00
99_C218_T0.5391.00
121_L125_F0.5381.00
75_F94_V0.5371.00
254_G268_T0.5351.00
181_H184_R0.5321.00
199_A206_T0.5321.00
50_V174_V0.5321.00
33_R37_N0.5301.00
241_V244_E0.5291.00
55_V60_G0.5281.00
85_L88_L0.5251.00
41_D280_T0.5211.00
250_S275_Q0.5211.00
62_D217_S0.5211.00
247_A251_V0.5201.00
250_S254_G0.5191.00
76_L79_V0.5191.00
44_F231_Y0.5181.00
35_I38_I0.5171.00
46_G170_L0.5141.00
71_F97_M0.5111.00
137_E141_I0.5111.00
138_S142_N0.5091.00
266_L269_L0.5091.00
46_G50_V0.5081.00
197_T201_L0.5081.00
45_L49_A0.5071.00
152_L156_I0.5051.00
139_I143_H0.5051.00
65_V217_S0.5031.00
35_I39_L0.5021.00
87_P91_F0.5011.00
75_F98_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.8278 97.3 0.877 Contact Map
4g1uA 2 0.8006 96.9 0.884 Contact Map
2qi9A 2 0.855 96.7 0.886 Contact Map
2gfpA 2 0.5921 50.9 0.94 Contact Map
2cfqA 1 0.6224 29.2 0.948 Contact Map
1u7gA 3 0.5468 27.5 0.949 Contact Map
3wdoA 1 0.9184 26.3 0.949 Contact Map
4ikvA 1 0.9003 17.1 0.953 Contact Map
2kluA 1 0.1571 15.6 0.954 Contact Map
4j05A 3 0.8912 14.4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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